Warning: mkdir(): Permission denied in /home/virtual/lib/view_data.php on line 81 Warning: fopen(/home/virtual/e-kjs/journal/upload/ip_log/ip_log_2024-03.txt): failed to open stream: No such file or directory in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Hinge Fracture during Cervical Open-door Laminoplasty: Does it Affect Clinical and Radiographic Outcomes?
Korean J Spine Search

CLOSE


Cho, Lee, Chough, Joo, Park, Lee, and Rha: Hinge Fracture during Cervical Open-door Laminoplasty: Does it Affect Clinical and Radiographic Outcomes?

Abstract

Objective

The purpose of this study was to determine whether the status of the hinge gutter affected clinical and radiographic outcomes of cervical open door laminoplasty.

Methods

We retrospectively analyzed 43 patients who had undergone cervical open door laminoplasty. 23 CT scans were performed at 2 days post-operation. The number of CT scans at 3, 6, 12 and 24 months were 16, 12, 21 and 11, respectively. We collected perioperative and follow-up data, including clinical and radiographic results.

Results

There were 7 patients without a hinge fracture and 16 patients with one or more hinge fractures at 2 days postoperation. There were 90 hinges, and the rate of ideal greenstick deformation of the hinge was 63% on 2-day-postoperative CT scans. Postoperative VAS scores of neck pain (p=0.012) in patients without a hinge fracture were higher than in patients with hinge fractures. The hinge healing rates were 37% at 3 months, 57.4% at 6 months, 86.4% at 12 months, and 85.4% at 24 months. Among the patients, 14 patients had healed hinges, and 7 patients had one or more hinge(s) that was/were not healed at 12 months post-operation. However, in clinical and radiographic outcomes, there was no difference between these patients.

Conclusion

Cervical open door laminoplasty was safe and provided stable reconstruction of laminar expansion. In radiographs, the difference between hinges that had healed and hinges that had not healed was statistically negligible. Hinge fractures might not influence the clinical and radiographic outcomes of cervical open door laminoplasty.

INTRODUCTION

Cervical open-door laminoplasty is a suitable treatment option for patients with cervical compressive myelopathy7,8). Although several techniques have been introduced, the basic procedure of this operation is to open one side of the lamina and make a greenstick deformation on the opposite lamina5,6). These deformed laminae are called hinges. Regardless of the degree of caution undertaken while performing surgery, hinge fractures (HFs) sometimes occur. Moreover, a delayed fracture can occur because of a mechanical weakness in the deformed lamina, even if an ideal greenstick deformation was made. Fortunately, many papers have reported that the hinges heal, in most cases, without serious complications1,6,9). However, there is little information regarding the overall status of the hinge and its clinical and radiographic implications. The purpose of this study was to determine the correlation between fractured and not fractured hinges using clinical and radiographic measurements.

MATERIALS AND METHODS

1. Patient's Data

From January 2004 to December 2012, 75 patients with cervical compressive myelopathy were treated with open-door laminoplasty. Among them, 43 patients had one or more available postoperative computed tomography (CT) scans. There were 28 men and 15 women. The mean age at the time of the surgery was 62.1 (range, 43-80 years). There were 21 patients with symptomatic ossification of the posterior longitudinal ligaments, and the other patients were diagnosed with spondylotic myelopathy. Table 1 summarizes the demographics of the enrolled patients.

2. Surgical Procedure

A standard posterior approach of the cervical spine was used for the open door laminoplasty. The number of laminoplasty segments depended on the extent of spinal cord compression. At first, the junction of the lateral mass and lamina was drilled into with a 3-mm match head burr, and a linear laminectomy was made. The ligament flavum was split with a Kerrison rongeur. Next, on the opposite side, the dorsal cortex was removed and the ventral cortex was thinned until a greenstick deformation of the hinge was attained. The laminae were elevated and the open side was stabilized with plates and screws (Centerpiece, Medtronic Sofamor Daneck, Memphis, Tennessee; Arch, Synthes, Paoli, Penssylvania). Bone grafting was not performed on the hinge. Postoperatively, the patients were encouraged to move their necks without a brace unless they felt severe neck pain.

3. Clinical Measurement

For clinical assessment, visual analog scale (VAS) scores of neck pain (VASn), VAS scores of arm pain (VASa), and neck disability index (NDI) scores were obtained during the preoperative and postoperative periods10). The severity of the myelopathy was evaluated by the Japanese Orthopaedic Association (JOA) cervical myelopathy score (Table 2). The recovery rate (RR) of the JOA score [(postoperative JOA score - preoperative JOA score)]/(17-preoperative JOA score) ×100%] was evaluated using a formula suggested by Hirabayashi, et al.2). The achieved JOA score (postoperative JOA score - preoperative JOA score) was also evaluated. Postoperative outcomes were evaluated 12 months after the surgery.

4. Radiographic Measurement

Pre- and postoperative lateral radiographs including neutral, maximum flexion, and extension views of the cervical spine were taken. The angles were measured by a line parallel to the inferior aspect of the C2 vertebral body and a line parallel to that of the C7 vertebral body. The cervical lordotic angle was evaluated by these angles of neutral view. Range of motion (ROM) of the cervical spine was assessed by measuring the difference in these angles at flexion and extension4). ROM change rates were calculated in the following manner: (ROM change rate, %) = (postoperative ROM - preoperative ROM)/(preoperative ROM) ×100. Postoperative outcomes were evaluated 12 months after the surgery.
Cervical CT scans were obtained at 2 days, 3 months, 6 months, 12 months, and 24 months post-operation (Table 1). After evaluating the initial status of the hinges using 2-day-postoperative CT scans, the hinges were classified into two groups: 'Deformed' and 'Fractured'. 'Deformed' indicated that the ventral cortex remained intact and demonstrated a favorable greenstick deformation. 'Fractured' indicated that the ventral cortex was broken and demonstrated unfavorable greenstick deformation (Fig. 1). The overall healing status of the hinges was determined by evaluating the status of each cortex (dorsal and ventral) according to the matrix presented in Table 36). A hinge was defined as being 'healed' only if both the dorsal and ventral cortices were bridged by bone (Fig. 2). If the ventral cortex had cortical bridging, but the dorsal cortex had neither cortical nor cancellous bridging, the hinge was defined as 'not healed' (Fig. 3).
The lordotic angles and ROMs were performed twice, with a week interval in between the two measurements, by two of the authors, and the mean data was evaluated. The status of each hinge was determined by a consensus of two or more of the three reviewers. All measurements were made using a picture-archiving communications system(Maroview, version 5.4; Marotech, Inc., Seoul, Korea).
Twenty-three 2-day-postoperative CT scans were sorted by their clinical and radiographic outcomes into two groups based on the existence of 'fractured' hinges or lack thereof. At 12 months post-operation, new CT scans were once again sorted, using the same methods, into two groups according to the existence or nonexistence of 'not healed' hinges. The healing status of each hinge was measured at every evaluation.

5. Statistical Analysis

Statistical analysis was performed using SPSS statistical software package 18.0 for Windows (SPSS Inc, Chicago, USA). The Mann-Whitney U-test and Fisher's exact test were used to analyze differences and evaluate statistical significance, which was set at the p=0.05 level.

RESULTS

1. 'Deformed' versus 'Fractured' Hinges

There were 7 patients who did not have any 'fractured' hinges, and 16 patients who had one or more 'fractured' hinges. Seven patients had only one 'fractured' hinge, 4 patients had two, 3 patients had three, and 2 patients had four. Table 4 shows preoperative and postoperative clinical and radiographic parameters for both groups. Several factors were statistically different, but most of the parameters were similar. Postoperative VASn in the 'deformed' group was higher than that of the 'fractured' group (p=0.047), but NDI scores did not have any statistical variance. Preoperative and postoperative lordotic angles in the 'fractured' group were lower than those in the 'deformed' group (p=0.012, 0.008). The degrees of angle change were similar (p=0.974).

2. 'Healed' versus 'Not Healed' Hinges at 12 Months Postoperative

In 14 patients, all hinges had healed by 12 months postoperation. The other 7 patients had 'not healed' hinges: 3 patients had one, and 4 patients had two. Preoperative and postoperative clinicoradiographic parameters for both groups are summarized in Table 5. There was no significant difference between the two groups.

3. The Hinge Status According to Time

The numbers of available hinges were 64, 47, 81 and 41 at 3, 6, 12, and 24 months respectively.
At 3, 6, 12, and 24 months 37.5, 57.4, 86.4%, and 85.4% had healed, respectively (Fig. 4). The healing rate of each 'deformed' and 'fractured' hinge was calculated. At 3 months, 56% of the 'deformed' hinges were healed, but only 7.1% of the 'fractured' hinges were healed; at 6 months, 85.7% and 14.3%; at 12 months, 89.7% and 86.7%; at 24 months, 95.5% and 86.7% respectively (Fig. 5). At 3 months, 56% of the 'deformed' hinges were healed, but only 7.1% of the 'fractured' hinges were healed; at 6 months, 85.7% and 14.3%; at 12 months, 89.7% and 86.7%; at 24 months, 95.5% and 86.7%(Fig. 5).

4. Risk Factors of Hinge Status

To evaluate the risk factors associated with hinge fracture and healing, the following variables were analyzed: age, gender, level of laminoplasty, smoking history, bone mineral density (BMD), and lamina thickness. The 'not healed' hinge group had low lamina thickness (Table 7). However, there was no statistical significance between the 'fractured' hinge group and the 'deformed' hinge group (Table 6).

DISCUSSION

In the present study, it was found that hinge fractures or the status of hinge healing may not affect clinical and radiographic outcomes of open-door laminoplasty. Postoperative VASa, postoperative JOA scores, RR of JOA score, and the achieved JOA score were not statistically different between the 'deformed' and 'fractured' groups. VASn scores in the 'deformed' group were higher than those of the 'fractured' group (p=0.047). However, NDI scores, another parameter associated with neck pain, did not have a statistical difference. Therefore, it is difficult to conclude that patients without 'fractured' hinges have more severe postoperative neck pain. Postoperative ROM and ROM change of the 'fractured' group were not statistically different from those of the 'deformed' group. Postoperative lordotic angles in the 'fractured' group were lower than those of the 'deformed' group; however, the degrees of angle change were not significantly different. These lower lordotic angles may have been due to lower preoperative lordotic angles. Therefore, there was no statistical difference between the 'healed' and 'not healed' group regarding the clinical and radiographic outcomes.
There was no relationship between neck pain at 1 year post-operation for 'fractured' and 'not healed' hinges in our series. However, several papers reported that HFs may be a source of postoperative pain. Hirabayashi, et al. warned that HFs could cause transient paresis as well as pain3). Satomi, et al. described how displacement of osteotomized laminae may lead to severe neck pain7). Park, et al. reported that the presence of three or more 'unfavorable' hinges was associated with increased postoperative neck pain5). However, the criteria for 'unfavorable' hinge status are different from 'not healed' criteria, and there are no three or more 'not healed' hinges in our series. As a consequence of this discrepancy, further studies are needed.
As for the frequency of hinge fractures, the location of the hinge, the width of the hinge, and the presence of traumatic handling have been proposed to be important variables3,5). Age, BMD, smoking history, and gender, however, were not hinge-fracture risk factors in this study. Nonetheless, hinge healing was associated with the lamina's thickness. To avoid hinge breakdown, the open side must be detached before drilling; the hinge side and hinge stability must be frequently checked while elevating the spinous process3). When thin laminae are identified in preoperative image studies, a more circumspect stratagem is needed during the elevation process.
The actual incidence of HFs and the healing rate of hinges had rarely been reported before this study. Park, et al. reported that ~10% of hinges had been broken as early as 1 week postoperative.5 Rhee, et al. found hinge healing rates of 55% at 3 months, 77% at 6 months, and 93% at 12 months6). The proportion of hinge fractures at 2 days post-operation was slightly high (36.7%), and overall hinge healing occurred in 37.5% of hinges at 3 months, 57.4% at 6 months, 86.4% at 12 months, and 85.4% at 24 months in this study.
The healing rate of 'fractured' hinges was lower than the healing rate of 'deformed' hinges. In order to heal hinges, some authors have used bone grafting on hinges.11 Bone grafting on 'fractured' hinges may help to increase the healing rate; however, Rhee, et al. reported that the hinge healing rate was high in cervical open door laminoplasty with plates, so plate-only laminoplasty could avoid the added cost and operative time associated with the use of bone grafting6). In this study, the healing rate of 'fractured' hinges was similar to that of 'deformed' hinges at 12 months, and there was no difference in clinical and radiographic outcomes between the 'fractured' and the 'deformed' groups. For this reason, additional bone grafting for 'fractured' hinges may not be necessary.
This study has several limitations. First, this study is retrospective. Some clinical data, such as shoulder pain or serial changes in neck pain, were not precisely recorded. Another limitation is the lack of published criteria for determining hinge status. Finally, our small population size and short-term follow-up period preclude more meaningful statistical data. Therefore, a longer-term study that encompasses a larger population needs to confirm these results.

CONCLUSION

Cervical open door laminoplasty is safe and provides stable reconstruction of the laminar expansion. In radiographs, the difference between hinges that had healed and hinges that had not healed was statistically negligible. The hinge status may not influence the clinical and radiographic outcomes of cervical open door laminoplasty. However, fractured hinges delay healing and decrease healing rate, and many non-healed hinges may cause postoperative neck pain. Therefore, the process of making hinges requires a fastidious procedure. Even if hinge fractures are identified during the surgery, bone grafting for hinge healing may not be necessary.

References

1. Goto T, Ohata K, Takami T, Nishikawa M, Tsuyuguchi N, Morino M, et al. Hydroxyapatite laminar spacers and titanium miniplates in cervical laminoplasty. J Neurosurg 2002 97:323-329. PMID: 12408386.
crossref pmid
2. Hirabayashi K, Miyakawa J, Satomi K, Maruyama T, Wakano K. Operative results and postoperative progression of ossification among patients with ossification of cervical posterior longitudinal ligament. Spine (Phila Pa 1976) 1981 6:354-364. PMID: 6792717.
crossref pmid
3. Hirabayashi K, Satomi K. Operative procedure and results of expansive open-door laminoplasty. Spine (Phila Pa 1976) 1988 13:870-876. PMID: 3143157.
crossref pmid
4. Kang SH, Rhim SC, Roh SW, Jeon SR, Baek HC. Postlaminoplasty cervical range of motion: early results. J Neurosurg Spine 2007 6:386-390. PMID: 17542502.
crossref pmid
5. Park YK, Lee DY, Hur JW, Moon HJ. Delayed hinge fracture after plate-augmented, cervical open-door laminoplasty and its clinical significance. Spine J 2013.
crossref
6. Rhee JM, Register B, Hamasaki T, Franklin B. Plate-only open door laminoplasty maintains stable spinal canal expansion with high rates of hinge union and no plate failures. Spine (Phila Pa 1976) 2011 36:9-14. PMID: 21192219.
crossref pmid
7. Satomi K, Nishu Y, Kohno T, Hirabayashi K. Long-term follow-up studies of open-door expansive laminoplasty for cervical stenotic myelopathy. Spine (Phila Pa 1976) 1994 19:507-510. PMID: 8184342.
crossref pmid
8. Seichi A, Takeshita K, Ohishi I, Kawaguchi H, Akune T, Anamizu Y, et al. Long-term results of double-door laminoplasty for cervical stenotic myelopathy. Spine (Phila Pa 1976) 2001 26:479-487. PMID: 11242374.
crossref pmid
9. Tanaka N, Nakanishi K, Fujimoto Y, Sasaki H, Kamei N, Hamasaki T, et al. Expansive laminoplasty for cervical myelopathy with interconnected porous calcium hydroxyapatite ceramic spacers: comparison with autogenous bone spacers. J Spinal Disord Tech 2008 21:547-552. PMID: 19057246.
crossref pmid
10. Vernon H, Mior S. The Neck Disability Index: a study of reliability and validity. J Manipulative Physiol Ther 1991 14:409-415. PMID: 1834753.
pmid
11. Xia Y, Xia Y, Shen Q, Li H, Xu T. Influence of hinge position on the effectiveness of expansive open-door laminoplasty for cervical spondylotic myelopathy. J Spinal Disord Tech 2011 24:514-520. PMID: 21336170.
crossref pmid
Fig. 1
CT scans taken on postoperative 2 days. (A) Deformed. The ventral cortex remained intact. (B) Fractured. The ventral cortex was broken.
kjs-11-45-g001.jpg
Fig. 2
(A) Cortically remodeled hinge. (B) The ventral and dorsal cortices are bridged by cancellous bone.
kjs-11-45-g002.jpg
Fig. 3
Hinge nonunion with no bone bridging either dorsal or ventral cortices of the hinge.
kjs-11-45-g003.jpg
Fig. 4
The overall proportion of healed hinges at each time point.
kjs-11-45-g004.jpg
Fig. 5
The healing rate of 'Deformed' and 'Fractured' hinges identified at postoperative 2 days CT scan. Healing rates of hinges were similar after 1 year.
kjs-11-45-g005.jpg
Table 1.
Patient demographics
Parameters Number
Total patients 43
Age (years) 62.1 (43-80)
Sex (male/female) 28/15
OPLL/CSM 21/22
Laminoplasty range
 C3-C5 5
 C3-C6 26
 C3-C7 2
 C4-C6 8
 C4-C7 2
CT scans obtained 83 (total)
 2 days 23
 3 months 16
 6 months 12
 12 months 21
 24 months 11

OPLL, ossification of posterior longitudinal ligament; CSM, cervical spondylotic myelopathy; CT, computed tomography.

Table 2.
Evaluation of cervical myelopathy using the scoring system proposed by the Japanese Orthopaedic Association (JOA) score*
Function Grade
Motor function
 Upper extremity
  Impossible to eat with chopsticks or spoon 0
  Possible to eat with a spoon but not chopsticks 1
  Possible to eat with chopsticks, but inadequate 2
  Possible to eat with chopsticks, awkward 3
 Lower extremity
  Impossible to walk 0
  Needs a cane or aid on flat ground 1
  Needs a cane or aid only on stairs 2
  Possible to walk without a cane or aid but slowly 3
  Normal 4
Sensory function
 Upper extremity
  Apparent sensory loss 0
  Minimal sensory loss 1
  Normal 2
 Lower extremity
  Apparent sensory loss 0
  Minimal sensory loss 1
  Normal 2
 Trunk
  Apparent sensory loss 0
  Minimal sensory loss 1
  Normal 2
Bladder function
 Complete retention 0
 Severe disturbance (sense of retention, dribbling, incomplete continence) 1
 Mild disturbance (urinary frequency, urinary hesitancy) 2
 Normal 3

* A cumulative normal grade in a healthy individual is 17

Table 3.
Definitions of hinge healing status*
Ventral cortex
Bridged Not bridged
Dorsal cortex Bridged Healed Not healed
Not bridged Not healed Not healed

* Both the ventral and dorsal cortices must be bridged with bone to be considered healed

Table 4.
Clinical and radiographic outcome parameters of the patients to be available CT scans at postoperative 2 days
No fractured hinge Fractured hinge p-value
Number of patients 7 16
Age 61.1±16 62.4±8.8 1.000
Sex (M/F) 3/4 13/3 0.137
OPLL/CSM 5/2 9/7 0.657
Preop VASn 6.0±1.7 4.3±2.6 0.154
Postop VASn 2.6±1.1 1.4±1.4 0.047
Preop VASa 5.4±1.3 5.1±2.1 0.720
Postop VASa 1.4±1.8 1.6±1.6 0.820
Preop NDI 54.6±15.8 34.7±24.6 0.065
Postop NDI 21.1±12.6 16.3±11.6 0.341
Preop JOA 10.0±3.3 12.7±2.4 0.076
Postop JOA 14.7±2.1 15.9±1.1 0.249
JOA score achieve 4.7±3.1 3.1±2.1 0.175
JOA score recovery rate (%) 77.9±24.4 72.8±27.8 0.769
Preop lordotic angle (°) 29.5±15.9 11.0±8.4 0.012
Postop lordotic angle (°) 24.9±12.0 7.2±11.6 0.008
Lordotic angle change (°) 4.5±6.7 3.9±8.8 0.974
Preop ROM (°) 46.0±2.5 34.9±14.1 0.012
Postop ROM (°) 27.4±13.8 16.0±11.1 0.065
ROM change (°) 18.6±12.8 18.8±11.9 0.820
ROM change rate (%) 41.0±28.9 55.9±25.8 0.308

Note: Values are mean±SD.

OPLL, Ossification of the posterior longitudinal ligament; CSM, cervical spondylotic myelopathy; Preop, preoperative; VASn, visual analog system of neck pain; Postop, postoperative; VASa, visual analog system of arm pain; NDI, neck disability index; JOA, Japanese Orthopaedic Association; ROM, range of motion; SD, standard deviation.

Table 5.
Clinical and radiographic outcome parameters of the patients to be available CT scans at postoperative 12 months.
Healed Not healed p-value
Number of patients 14 7
Age 64.7±11.0 59.3±12.3 0.443
Sex (M/F) 6/8 4/3 0.659
OPLL/CSM 6/8 4/3 0.659
Preop VASn 4.1±2.7 4.0±2.4 1.000
Postop VASn 1.4±0.8 2.0±0.8 0.224
Preop VASa 5.5±1.8 4.7±2.4 0.488
Postop VASa 1.4±1.4 2.1±2.1 0.535
Preop NDI 35.8±23.5 36.9±24.5 0.971
Postop NDI 16.0±10.0 15.1±8.0 0.689
Preop JOA 12.3±2.6 13.0±0.6 0.535
Postop JOA 15.9±0.9 15.6±1.3 0.689
JOA score achieve 3.6±2.4 2.6±1.4 0.585
JOA score recovery rate (%) 74.3±20.6 63.9±31.9 0.585
Preop lordotic angle (°) 13.9±12.8 6.7±10.3 0.287
Postop lordotic angle (°) 8.4±16.2 8.0±13.3 0.689
Lordotic angle change (°) 1.5±11.6 -1.24±4.3 0.094
Preop ROM (°) 39.5±12.4 36.4±7.5 0.856
Postop ROM (°) 27.2±15.1 23.6±9.4 0.743
ROM change (°) 12.5±10.3 12.8±9.6 0.913
ROM change rate (%) 33.7±25.9 34.2±21.1 0.971

Note: Values are mean±SD.

OPLL, Ossification of the posterior longitudinal ligament; CSM, cervical spondylotic myelopathy; Preop, preoperative; VASn, visual analog system of neck pain; Postop, postoperative; VASa, visual analog system of arm pain; NDI, neck disability index; JOA, Japanese Orthopaedic Association; ROM, range of motion; SD, standard deviation.

Table 6.
Univariate comparison between ‘fractured’ group and ‘deformed’ group
Fractured (n=33) Deformed (n=57) p-value
Age (years) 61.88±7.33 62.7±12.56 0.732
Level 0.692
C3 5 (15.2%) 14 (24.6%)
C4 9 (27.3%) 14 24.6%)
C5 8 (24.2%) 15 (26.3%)
C6 8 (24.2%) 12 (21.1%)
C7 3 (9.1%) 2 (3.5%)
Gender (Male) 19 (57.7%) 33 (57.8%) 0.743
Smoking 1 (3.0%) 8 (14.0%) 0.147
BMD(T-score) 0.6±1.72 -0.05±1.96 0.196
Thickness of lamina (mm) 4.4±1.15 4.07±1.02 0.177

Note: Values are mean±SD.

BMD, bone mineral density; SD, standard deviation.

Table 7.
Univariate comparison between ‘not healed’ group and ‘healed’ group
Not healed (n=10) Healed (n=71) p-value
Age (years) 58.3±11.13 64.21±10.88 0.142
Level 0.332
C3 1 (10%) 15 (21.13%)
C4 3 (30%) 18 (25.35%)
C5 5 (50%) 16 (22.54%)
C6 1 (10%) 19 (27.14%)
C7 0 (0%) 3 (4.23%)
Gender (Male) 6 (60%) 32 (45.71%) 0.503
Smoking 0 (0%) 0 (0%)
BMD (T-score) 1.92±1.76 0.01±1.74 0.027
Thickness of lamina (mm) 3.1±0.55 3.85±1.08 0.036

Note: Values are mean±SD.

BMD, bone mineral density; SD, standard deviation.



Editorial Office
CHA University, CHA School of Medicine Bundang Medical Center
59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13496, Korea
Tel: +82-31-780-1924  Fax: +82-31-780-5269  E-mail: support@e-neurospine.org
The Korean Spinal Neurosurgery Society
#407, Dong-A Villate 2nd Town, 350 Seocho-daero, Seocho-gu, Seoul 06631, Korea
Tel: +82-2-585-5455  Fax: +82-2-2-523-6812  E-mail: ksns1987@gmail.com
Business License No.: 209-82-62443

Copyright © The Korean Spinal Neurosurgery Society.

Developed in M2PI

Close layer
prev next