Objective The objective of the current study was to perform a retrospective review of a national database to assess the safety of cement augmentation for vertebral compression fractures in geriatric populations in varying age categories.
Methods The 2005–2016 National Surgical Quality Improvement Program databases were queried to identify patients undergoing kyphoplasty or vertebroplasty in the following age categories: 60–69, 70–79, 80–89, and 90+ years old. Demographic variables, comorbidity status, procedure type, provider specialty, inpatient/outpatient status, number of procedure levels, and periprocedure complications were compared between age categories using chi-square analysis. Multivariate logistic regressions controlling for patient and procedural variables were then performed to assess the relative periprocedure risks of adverse outcomes of patients in the different age categories relative to those who were 60–69 years old.
Results For the 60–69, 70–79, 80–89, and 90+ years old cohorts, 486, 822, 937, and 215 patients were identified, respectively. After controlling for patient and procedural variables, 30-day any adverse events, serious adverse events, reoperation, readmission, and mortality were not different for the respective age categories. Cases in the 80- to 89-year-old cohort were at increased risk of minor adverse events compared to cases in the 60- to 69-year-old cohort.
Conclusion As the population ages, cement augmentation is being considered as a treatment for vertebral compression fractures in increasingly older patients. These results suggest that even the very elderly may be appropriately considered for these procedures (level of evidence: 3).
Citations
Citations to this article as recorded by
Surgical management of spinal metastases from primary lung carcinoma: demographics, clinical characteristics, and outcomes—A retrospective analysis Jun Li, Yuhan Zheng, Xiaohua Lv, Rong Zeng, Yating Zhao, Yucheng Xiang, Ke Zhan, Congcong Liu, Houqing Long, Ke Chen Frontiers in Surgery.2026;[Epub] CrossRef
Advantages of TiRobot-assisted surgery in the treatment of osteoporotic thoracolumbar compression fractures: a meta-analysis based on multiple clinical indicators Yu Liu, Zidong Xia, Huiling Chen, Jian Wang, Mengtian Cao, Guohang Shen, Mingyuan Fan, Kaiyong Wang, Yang Chen, Yupei Dai Journal of Robotic Surgery.2025;[Epub] CrossRef
Spinal augmentation for vertebral body fractures in the elderly population Alexander R. Evans, Taylor Niznik, Chao Li, Zachary A. Smith GeroScience.2025;[Epub] CrossRef
The future of ambulatory surgery for geriatric patients Mary Ann Vann Best Practice & Research Clinical Anaesthesiology.2023; 37(3): 343. CrossRef
What are the risk factors for a second osteoporotic vertebral compression fracture? Sang Hoon Hwang, Pyung Goo Cho, Kyoung-Tae Kim, Keung Nyun Kim, Sang Hyun Kim, Sung Hyun Noh The Spine Journal.2023; 23(11): 1586. CrossRef
Beyond Pain Relief: An In-Depth Review of Vertebral Height Restoration After Balloon Kyphoplasty in Vertebral Compression Fractures Siddharth K Patel, Sohael Khan, Ventaktesh Dasari, Suvarn Gupta Cureus.2023;[Epub] CrossRef
Risk of Revision After Vertebral Augmentation for Osteoporotic Vertebral Fracture: A Narrative Review Shinji Takahashi, Hiroyuki Inose, Koji Tamai, Masayoshi Iwamae, Hidetomi Terai, Hiroaki Nakamura Neurospine.2023; 20(3): 852. CrossRef
The Effectiveness of Vertebral Height Restoration Based on the Vertebroplasty Procedure Used to Treat Osteoporotic Vertebral Fractures Kunio Yokoyama, Naokado Ikeda, Hidekazu Tanaka, Yutaka Ito, Akira Sugie, Makoto Yamada, Masahiko Wanibuchi, Masahiro Kawanishi Neurospine.2023; 20(4): 1159. CrossRef
Treatment for Osteoporotic Vertebral Fracture - A Short Review of Orthosis and Percutaneous Vertebroplasty and Balloon Kyphoplasty Masahiro Kawanishi, Hidekazu Tanaka, Yutaka Ito, Makoto Yamada, Kunio Yokoyama, Akira Sugie, Naokado Ikeda Neurospine.2023; 20(4): 1124. CrossRef
Commentary on “Utilization of Vertebroplasty/Kyphoplasty in the Management of Compression Fractures: National Trends and Predictors of Vertebroplasty/Kyphoplasty” Sahir S. Jabbouri, Peter G. Whang Neurospine.2023; 20(4): 1140. CrossRef
Difference in the Cobb Angle Between Standing and Supine Position as a Prognostic Factor After Vertebral Augmentation in Osteoporotic Vertebral Compression Fractures In-Suk Bae, Byung Gwan Moon, Hee In Kang, Jae Hoon Kim, Cheolsu Jwa, Deok Ryeong Kim Neurospine.2022; 19(2): 357. CrossRef
Kyphoplasty: why, when and how? Umile Giuseppe Longo, Rocco Papalia, Sergio De Salvatore, Valentina Piccioni, Vincenzo Denaro International Journal of Bone Fragility.2022; 2(1): 41. CrossRef
Objective To compare the perioperative morbidity of 2-level anterior cervical discectomy and fusion (ACDF) with that of 1-level anterior cervical corpectomy and fusion (ACCF) for the treatment of cervical degenerative conditions.
Methods A retrospective study of the 2005–2016 National Surgical Quality Improvement Program database for patients undergoing 2-level ACDF and 1-level ACCF was performed. Patient data included: age, sex, body mass index (BMI), functional status, and American Society of Anesthesiologists (ASA) physical status (PS) classification. Hospital data included: operative time and length of hospital stay (LOS). Thirty-day outcome data included: any, serious, and minor adverse events, return to the operating room, readmission, and mortality. After propensity matching for age, sex, ASA PS classification, functional status, and BMI, multivariate logistic regression analysis was used to compare outcomes between the 2 propensity-matched subcohorts. Finally, multivariate logistic regression that additionally controlled for operative time was performed to compare the 2 propensity-matched subcohorts.
Results A total of 17,497 cases were identified, with 90.20% undergoing 2-level ACDF and 9.80% undergoing 1-level ACCF. Patients undergoing 2-level ACDF were younger, more likely to be female, had higher functional status, and had shorter operative time and LOS (p < 0.001). After propensity score matching, cases undergoing 1-level ACCF had a statistically significant higher rate of serious adverse events (p = 0.005). This difference was no longer significant after controlling for operative time.
Conclusion While there was noted to be additional morbidity in 1-level ACCF cases relative to 2-level ACDF cases, the lack of difference once controlling for the surgical time supports using the procedure that best accomplishes the surgical objectives.
Citations
Citations to this article as recorded by
Association of frailty with healthcare resource utilization after open thoracic/thoracolumbar posterior spinal fusion for adult spinal deformity Aladine A. Elsamadicy, Andrew B. Koo, Josiah J. Z. Sherman, Margot Sarkozy, Benjamin C. Reeves, Samuel Craft, Sumaiya Sayeed, Mani Ratnesh S. Sandhu, Andrew M. Hersh, Sheng-Fu Larry Lo, John H. Shin, Ehud Mendel, Daniel M. Sciubba European Spine Journal.2026; 35(6): 3027. CrossRef
A Meta-Analysis of Surgical Outcomes in 25727 Patients Undergoing Anterior Cervical Discectomy and Fusion or Anterior Cervical Corpectomy and Fusion for Cervical Deformity Karma Barot, Miguel A. Ruiz-Cardozo, Som Singh, Gabriel Trevino, Michael R. Kann, Samuel Brehm, Tim Bui, Karan Joseph, Rujvee Patel, Angela Hardi, Alexander T. Yahanda, Julio J. Jauregui, Magalie Cadieux, Brenton Pennicooke, Camilo A. Molina Global Spine Journal.2025; 15(2): 1390. CrossRef
Association of malnutrition with surgical outcomes after spine surgery for spinal epidural abscess Aladine A. Elsamadicy, Paul Serrato, Shaila D. Ghanekar, Lucas P. Mitre, Syed I. Khalid, Sheng-fu Larry Lo, Daniel M. Sciubba Clinical Neurology and Neurosurgery.2025; 249: 108754. CrossRef
Anterior Cervical Discectomy and Fusion vs. Anterior Cervical Corpectomy and Fusion for 2-Level Degenerative Cervical Myelopathy Aman Verma, Anil Kumar, Utsav Anand, Siddharth Sekhar Sethy, Aakash Jain, Vibhor Abrol, Kaustubh Ahuja, Bhaskar Sarkar, Pankaj Kandwal JBJS Reviews.2025;[Epub] CrossRef
Comparison of Recent Efficacy of Two Surgical Techniques for Multi-Stage Radiculopathy Cervical Spondylosis 斌 闫 Advances in Clinical Medicine.2025; 15(04): 758. CrossRef
Composite RAI, Malnutrition, and Anemia Model Superiorly Predicts 30-Day Morbidity and Mortality After Surgery for Adult Spinal Deformity Aladine A. Elsamadicy, Paul Serrato, Shaila D. Ghanekar, Justice Hansen, Ethan D. L. Brown, Syed I. Khalid, Daniel Schneider, Sheng-fu Larry Lo, Daniel M. Sciubba Journal of Clinical Medicine.2025; 14(15): 5379. CrossRef
Utilization of Machine Learning to Model Important Features of 30-day Readmissions following Surgery for Metastatic Spinal Column Tumors: The Influence of Frailty Aladine A. Elsamadicy, Andrew B. Koo, Benjamin C. Reeves, James L. Cross, Andrew Hersh, Astrid C. Hengartner, Aditya V. Karhade, Zach Pennington, Oluwaseun O. Akinduro, Sheng-Fu Larry Lo, Ziya L. Gokaslan, John H. Shin, Ehud Mendel, Daniel M. Sciubba Global Spine Journal.2024; 14(4): 1227. CrossRef
Association of Malnutrition with Surgical and Hospital Outcomes after Spine Surgery for Spinal Metastases: A National Surgical Quality Improvement Program Study of 1613 Patients Aladine A. Elsamadicy, John Havlik, Benjamin C. Reeves, Josiah J. Z. Sherman, Samuel Craft, Paul Serrato, Sumaiya Sayeed, Andrew B. Koo, Syed I. Khalid, Sheng-Fu Larry Lo, John H. Shin, Ehud Mendel, Daniel M. Sciubba Journal of Clinical Medicine.2024; 13(6): 1542. CrossRef
A Comparison of Short-Term Outcomes after Surgical Treatment of Multilevel Degenerative Cervical Myelopathy in the Geriatric Patient Population: An Analysis of the National Surgical Quality Improvement Program Database 2010–2020 Jeffrey Hyun-Kyu Choi, Paramveer Singh Birring, Joshua Lee, Sohaib Zafar Hashmi, Nitin Narain Bhatia, Yu-po Lee Asian Spine Journal.2024; 18(2): 190. CrossRef
Does the novel artificial cervical joint complex resolve the conflict between stability and mobility after anterior cervical surgery? a finite element study Bing Meng, Xiong Zhao, Xin-Li Wang, Jian Wang, Chao Xu, Wei Lei Frontiers in Bioengineering and Biotechnology.2024;[Epub] CrossRef
Safety of anterior cervical corpectomy and fusion (ACCF) for the treatment of subaxial cervical spine injuries, a single center comparative matched analysis Victor Gabriel El-Hajj, Aman Singh, Alexander Fletcher-Sandersjöö, Simon Blixt, Vasilios Stenimahitis, Gunnar Nilsson, Paul Gerdhem, Erik Edström, Adrian Elmi-Terander Acta Neurochirurgica.2024;[Epub] CrossRef
Association of inpatient opioid consumption on postoperative outcomes after open posterior spinal fusion for adult spine deformity Aladine A. Elsamadicy, Mani Ratnesh S. Sandhu, Benjamin C. Reeves, Isaac G. Freedman, Andrew B. Koo, Christina Jayaraj, Astrid C. Hengartner, John Havlik, Andrew M. Hersh, Zach Pennington, Sheng-Fu Larry Lo, John H. Shin, Ehud Mendel, Daniel M. Sciubba Spine Deformity.2023; 11(2): 439. CrossRef
Geriatric relationship with inpatient opioid consumption and hospital outcomes after open posterior spinal fusion for adult spine deformity Aladine A. Elsamadicy, Mani Ratnesh S. Sandhu, Benjamin C. Reeves, Josiah J.Z. Sherman, Samuel Craft, Mica Williams, John H. Shin, Daniel M. Sciubba Clinical Neurology and Neurosurgery.2023; 224: 107532. CrossRef
Correction and Maintenance of Cervical Alignment Chad Campion, Charles H. Crawford, Steven D. Glassman, Fehmi Berkay, Tino Mkorombindo, Leah Y. Carreon Clinical Spine Surgery.2023; 36(4): E118. CrossRef
Comparison of anterior cervical discectomy and fusion versus anterior cervical corpectomy and fusion in the treatment of localized ossification of the posterior longitudinal ligament Tangyiheng Chen, Yujie Wang, Hong Zhou, Cheng Lin, Xuefeng Li, Huilin Yang, Yijie Liu, Weimin Jiang Journal of Orthopaedic Surgery.2023;[Epub] CrossRef
MRI T2WI High Signal Is a Risk Factor for Perioperative Complications in Patients with Cervical Spondylosis with Spinal Cord Compression: A Propensity Matching Score Analysis Shengsheng Huang, Xuhua Sun, Liyi Chen, Ming Yi, Tuo Liang, Jie Jiang, Jiarui Chen, Chong Liu, Xinli Zhan, Kai Uwe Lewandrowski BioMed Research International.2022;[Epub] CrossRef
Automatic Localization and Brand Detection of Cervical Spine Hardware on Radiographs Using Weakly Supervised Machine Learning Raman Dutt, Dylan Mendonca, Huai Ming Phen, Samuel Broida, Marzyeh Ghassemi, Judy Gichoya, Imon Banerjee, Tim Yoon, Hari Trivedi Radiology: Artificial Intelligence.2022;[Epub] CrossRef
Marfan syndrome and adolescent idiopathic scoliosis patients have similar 90-day postoperative outcomes and 5-year reoperation rates after spinal deformity surgery Peter Y. Joo, Dennis L. Caruana, Michael J. Gouzoulis, Harold G. Moore, Justin R. Zhu, Bijan Ameri, Jonathan N. Grauer Spine Deformity.2022; 10(5): 1169. CrossRef
Critical analysis of the evaluation of postoperative dysphagia following an anterior cervical discectomy and fusion Matthew Kaufman, Jennifer Shearer, Claudia I. Cabrera, Morgan Terry, Elizabeth Jackson, Rachel Kominsky, Innocent Njoku, Todd Otteson, Christopher Furey, N. Scott Howard American Journal of Otolaryngology.2022; 43(3): 103466. CrossRef
Anterior Cervical Corpectomy and Fusion for Degenerative Cervical Spondylotic Myelopathy Philip K. Louie, Venu M. Nemani, Jean-Christophe A. Leveque Clinical Spine Surgery.2022; 35(10): 440. CrossRef
Biomechanics of a novel artificial cervical vertebra from an in vivo caprine cervical spine non-fusion model Jun Dong, Baobao Liang, Yuan Sun, Xi Li, Pei Han, Chen Wang, Yabing Song, Hao Wu, Ruoxi Liu, Sihua Huang, Sen Yu, Lei Jin, Zhentao Yu, Liying Fan, Huanjin Song, Chun Zhang, Xijing He Journal of Orthopaedic Translation.2022; 37: 61. CrossRef
Comparison of postoperative outcomes in patients with and without osteoporosis undergoing single-level anterior cervical discectomy and fusion Alexander J. Kammien, Anoop R. Galivanche, Peter Y. Joo, Ali Elaydi, Peter Whang, Comron Saifi, Jonathan N. Grauer, Arya Varthi North American Spine Society Journal (NASSJ).2022; 12: 100174. CrossRef
Launching a quality improvement project in neurosurgery: How to get started Matthew T. Neal, Alexandra E. Richards, Kara L. Curley, Mark K. Lyons Interdisciplinary Neurosurgery.2021; 25: 101206. CrossRef
Effects of preoperative nutritional status on complications and readmissions after posterior lumbar decompression and fusion for spondylolisthesis: A propensity-score analysis Aladine A. Elsamadicy, John Havlik, Benjamin C. Reeves, Andrew B. Koo, Josiah Sherman, Sheng-Fu Larry Lo, John H. Shin, Daniel M. Sciubba Clinical Neurology and Neurosurgery.2021; 211: 107017. CrossRef