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"Chin-Chu Ko"

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The Quantitative Evaluation of Automatic Segmentation in Lumbar Magnetic Resonance Images
Neurospine. 2024;21(2):665-675.   Published online June 30, 2024
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The Quantitative Evaluation of Automatic Segmentation in Lumbar Magnetic Resonance Images
Neurospine. 2024;21(2):665-675.   Published online June 30, 2024
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Objective
This study aims to overcome challenges in lumbar spine imaging, particularly lumbar spinal stenosis, by developing an automated segmentation model using advanced techniques. Traditional manual measurement and lesion detection methods are limited by subjectivity and inefficiency. The objective is to create an accurate and automated segmentation model that identifies anatomical structures in lumbar spine magnetic resonance imaging scans.
Methods
Leveraging a dataset of 539 lumbar spinal stenosis patients, the study utilizes the residual U-Net for semantic segmentation in sagittal and axial lumbar spine magnetic resonance images. The model, trained to recognize specific tissue categories, employs a geometry algorithm for anatomical structure quantification. Validation metrics, like Intersection over Union (IOU) and Dice coefficients, validate the residual U-Net’s segmentation accuracy. A novel rotation matrix approach is introduced for detecting bulging discs, assessing dural sac compression, and measuring yellow ligament thickness.
Results
The residual U-Net achieves high precision in segmenting lumbar spine structures, with mean IOU values ranging from 0.82 to 0.93 across various tissue categories and views. The automated quantification system provides measurements for intervertebral disc dimensions, dural sac diameter, yellow ligament thickness, and disc hydration. Consistency between training and testing datasets assures the robustness of automated measurements.
Conclusion
Automated lumbar spine segmentation with residual U-Net and deep learning exhibits high precision in identifying anatomical structures, facilitating efficient quantification in lumbar spinal stenosis cases. The introduction of a rotation matrix enhances lesion detection, promising improved diagnostic accuracy, and supporting treatment decisions for lumbar spinal stenosis patients.

Citations

Citations to this article as recorded by  Crossref logo
  • External validation of SpineNetv2 deep learning system for automated lumbar spine MRI analysis: A multi-pathology diagnostic agreement study
    Xingkai Wu, Qianbo Song, Jiaxiang Zhou, Zhiyu Zhou, Guangru Cao, Kebing Jin, Qian Du
    European Spine Journal.2026; 35(3): 1238.     CrossRef
  • Enhancing lumbar disc herniation classification through region-of-interest guidance and geometric shape features
    Cong Zhang, Kunjin He, Wei Xu, Xiaoqing Gu, Zhengming Chen, Yiping Weng
    Biomedical Physics & Engineering Express.2026; 12(1): 015038.     CrossRef
  • Deep learning for lumbar spine segmentation in magnetic resonance imaging—A systematic review
    Diogo Mendes, João Manuel R.S. Tavares
    Biomedical Signal Processing and Control.2026; 118: 109700.     CrossRef
  • Clinical Application of Deep Learning for Spine MRI Interpretation: A Multicenter Evaluation of Artificial-Intelligence-Assisted versus Manual Reading on Diagnostic Agreement with the Reference Standard
    Xing Cheng, Maoping Zhang, Zhenxiao Ren, Tang Tang, Xiaolin Meng, Zhong Huang, Hongwei Bran Li, Weiguo Li, Qiuchan Yan, Haixiong Chen, Jie Jia, Ce Wang, Cheng Li, Chunshan Yang, Guifeng Shi, Guohua Li, Kaixin Zeng, Wei Chen, Haoxuan Gao, Xiaobo Wang, Xin
    Research.2026;[Epub]     CrossRef
  • Anatomy-Aware Text-Visual Fusion with Dual-Perspective Prompts for Fine-Grained Lumbar Spine Segmentation
    Sheng Lian, Jianlong Cai, Dengfeng Pan, Guang-Yong Chen, Hao Xu, Fan Zhang, Guodong Fan, Jialun Pei, Shuo Li
    International Journal of Computer Vision.2026;[Epub]     CrossRef
  • Automated Quantitative Analysis of the Lumbar Spine: a Comprehensive Approach
    Purushottam Kumar, Suyash Singh, Bunil Kumar Balabantaray, Rajashree Nayak
    Journal of Imaging Informatics in Medicine.2025; 39(1): 229.     CrossRef
  • Taiwan’s Smart Healthcare Value Chain: AI Innovation from R&D to Industry Deployment
    Tzu-Min Lin, Hui-Wen Yang, Ching-Cheng Han, Chih-Sheng Lin
    Healthcare.2025; 14(1): 23.     CrossRef
  • 7,955 View
  • 172 Download
  • 8 Web of Science
  • 7 Crossref

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Comparison of Cortical Bone Trajectory to Pedicle-Based Dynamic Stabilization: An Analysis of 291 Patients
Neurospine. 2023;20(1):308-316.   Published online March 31, 2023
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Comparison of Cortical Bone Trajectory to Pedicle-Based Dynamic Stabilization: An Analysis of 291 Patients
Neurospine. 2023;20(1):308-316.   Published online March 31, 2023
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Objective
Pedicle-based dynamic stabilization (DS) has gained popularity outside of America. Although pedicle screw (PS) loosening has always been a concern, it is reportedly innocuous. Cortical bone trajectory (CBT) screw is an emerging option with less invasiveness and similar effectiveness to PS in short-segment lumbar fusion. This study aimed to verify the use of CBT for DS by comparing the outcomes between pedicle- and CBT-based DS.
Methods
Consecutive patients with lumbar spondylosis or low-grade spondylolisthesis who underwent 1- or 2-level DS between L3–5 with a minimum follow-up of 24 months were reviewed. Screw loosening was determined by computed tomography and the incidences were compared.
Results
A total of 291 patients who underwent Dynesys DS (235 pedicle- and 56 CBT-based, respectively) were compared. The demographics and preoperative conditions were similar. All the clinical outcomes improved at 24-month postoperation, while the CBT-based group had less operation time and blood loss than the pedicle-based group. The rates of screw loosening were lower in the CBT-based (5.4% per screw and 12.5% per patient) than the pedicle-based group (9% per screw and 26.4% per patient). Furthermore, there were no differences in the clinical outcomes and complication profiles.
Conclusion
The CBT-based DS for 1- or 2-level lumbar degeneration demonstrated equivalent clinical improvement as the pedicle-based DS. The adaption of CBT-based screws for DS could be a less invasive approach (shorter operation time and less blood loss), with lower chances of screw loosening than the conventional PS-based DS.

Citations

Citations to this article as recorded by  Crossref logo
  • Comparative CT-Based Bone Density of Traditional Pedicle Screw Trajectory, Cortical Bone Trajectory, and Modified Cortical Bone Trajectory — Radiographic Analysis of 3500 Simulated Pedicle-Screw Trajectories in 1750 Lumbar Vertebrae
    Sathish Muthu, Kavya Priyadharshini Natarajan, Vibhu Krishnan Viswanathan, Dhibin Vikash Kolarpatti Ponnusamy, Sathish Kumar Rajappan Chandra, Khan Sharun
    Global Spine Journal.2026;[Epub]     CrossRef
  • The Effect of Osteopenia and Osteoporosis on Screw Loosening in MIS-TLIF and Dynamic Stabilization
    Hsuan-Kan Chang, Chih-Chang Chang, Yu-Wen Cheng, Ching-Lan Wu, Tsung-Hsi Tu, Jau-Ching Wu, Wen-Cheng Huang
    Global Spine Journal.2025; 15(4): 2209.     CrossRef
  • Comparative Analysis Between Cortical Bone Trajectory (CBT) Screw Fixation and Traditional Pedicle Screw Fixation in Lumbar Spine Surgery: A Systematic Review and Meta-Analysis
    Vivek Sanker, Amr Badary, Aliza Asad, Barabara Buccilli, Ahed H Kattaa, David J Park, Steven D. Chang, Atman Desai, Harminder Singh
    Cureus.2025;[Epub]     CrossRef
  • Robot-assisted cortical bone trajectory versus traditional pedicle screws in the treatment of lumbar spinal stenosis with osteoporosis: A retrospective cohort study
    Ruizhao Zhao, Yuyu Fan, Junjie Qiao, Lixiang Ding, Wei Qu, Xiutong Fang
    Asian Journal of Surgery.2025; 48(10): 6062.     CrossRef
  • Screening patients requiring secondary lumbar surgery for degenerative lumbar spine diseases: a nationwide sample cohort study
    Hangeul Park, Juhee Lee, Yunhee Choi, Jun-Hoe Kim, Sum Kim, Young-Rak Kim, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Chi Heon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Comparative Biomechanical Stability of the Fixation of Different Miniplates in Restorative Laminoplasty after Laminectomy: A Finite Element Study
    Guoyin Liu, Weiqian Huang, Nannan Leng, Peng He, Xin Li, Muliang Lin, Zhonghua Lian, Yong Wang, Jianmin Chen, Weihua Cai
    Bioengineering.2024; 11(5): 519.     CrossRef
  • Clinical study on freehand of bicortical sacral screw fixation with the assistance of torque measurement device
    Guozheng Jiang, Luchun Xu, Yukun Ma, Jianbin Guan, Ningning Feng, Ziye Qiu, Shibo Zhou, Wenhao Li, Yongdong Yang, Yi Qu, He Zhao, Zeyu Li, Xing Yu
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • Expert consensus on the clinical application of cortical bone trajectory for lumbar pedicle screws: results from a modified Delphi study
    Yiqi Zhang, Jingwei Liu, Honghao Yang, Qiang Wang, Yong Hai, Yuzeng Liu
    Asian Spine Journal.2024; 18(5): 690.     CrossRef
  • Diabetes‐related Screw Loosening: The Distinction of Surgical Sites and the Relationship among Diabetes, Implant Stabilization and Clinical Outcomes
    Tianji Wang, Jing Wang, Xiaofan Hu, Kaili Hao, Geng Xiang, Zixiang Wu, Zhensheng Ma, Tianqing Li, Yu Chen, Xiong Zhao, Yang Zhang, Tiancheng Ma, Jingjuan Ren, Wei Lei, Yafei Feng
    Orthopaedic Surgery.2023; 15(12): 3136.     CrossRef
  • 8,274 View
  • 205 Download
  • 8 Web of Science
  • 9 Crossref

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Measurement of Deformity at the Craniovertebral Junction: Correlation of Triangular Area and Myelopathy
Neurospine. 2022;19(4):889-895.   Published online December 31, 2022
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Measurement of Deformity at the Craniovertebral Junction: Correlation of Triangular Area and Myelopathy
Neurospine. 2022;19(4):889-895.   Published online December 31, 2022
Close
Objective
Diseases of the craniovertebral junction (CVJ) are commonly associated with deformity, malalignment, and subsequent myelopathy. The misaligned CVJ might cause compression of neuronal tissues and subsequently clinical symptoms. The triangular area (TA), measured by magnetic resonance imaging/images (MRI/s), is a novel measurement for quantification of the severity of compression to the brain stem. This study aimed to assess the normal and pathological values of TA by a comparison of patients with CVJ disease to age- and sex-matched controls. Moreover, postoperative TAs were correlated with outcomes.
Methods
Consecutive patients who underwent surgery for CVJ disease were included for comparison to an age- and sex-matched cohort of normal CVJ persons as controls. The demographics, perioperative information, and pre- and postoperative 2-year cervical MRIs were collected for analysis. Cervical TAs were measured and compared.
Results
A total of 201 patients, all of whom had pre- or postoperative MRI, were analyzed. The TA of the CVJ deformity group was larger than the healthy control group (1.62 ± 0.57 cm2 vs. 1.01 ± 0.18 cm2, p < 0.001). Moreover, patients who had combined anterior odontoidectomy and posterior laminectomy with fixation had the greatest reduction in the TA (1.18 ± 0.58 cm2).
Conclusion
In CVJ deformity, the measurement of the cervical TA could indicate the severity of brain stem compression. After surgery, the TA had a varying degree of improvement, which could represent the efficacy of surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • 3D printing enabled biomechanical evaluation of a novel expandable wedge spacer for atlantoaxial reduction
    Chih-Chang Chang, Shao-Fu Huang, Rong-Chen Lin, Chun-Li Lin
    3D Printing in Medicine.2026;[Epub]     CrossRef
  • Prognostic Factors in Craniocervical Realignment for Crainovertebral Junction Kyphosis With Negative Cervical Imbalance: A Comprehensive Study
    Dong Hun Kim, Jae Taek Hong, Jin Young Kim, Kang Bin Koo, Dae Hee Lee, Jung Woo Hur, Ho Jin Lee, Il Sup Kim
    Neurospine.2025; 22(3): 725.     CrossRef
  • Evaluation of Cervicomedullary Compression Around the Craniovertebral Junction: Commentary on “Measurement of Deformity at the Craniovertebral Junction: Correlation of Triangular Area and Myelopathy”
    Jae Taek Hong
    Neurospine.2022; 19(4): 896.     CrossRef
  • 6,364 View
  • 229 Download
  • 3 Web of Science
  • 3 Crossref

Review Article

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Acidic Fibroblast Growth Factor in Spinal Cord Injury
Neurospine. 2019;16(4):728-738.   Published online January 15, 2019
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Acidic Fibroblast Growth Factor in Spinal Cord Injury
Neurospine. 2019;16(4):728-738.   Published online January 15, 2019
Close
Spinal cord injury (SCI), with an incidence rate of 246 per million person-years among adults in Taiwan, remains a devastating disease in the modern day. Elderly men with lower socioeconomic status have an even higher risk for SCI. Despite advances made in medicine and technology to date, there are few effective treatments for SCI due to limitations in the regenerative capacity of the adult central nervous system. Experiments and clinical trials have explored neuro-regeneration in human SCI, encompassing cell- and molecule-based therapies. Furthermore, strategies have aimed at restoring connections, including autologous peripheral nerve grafts and biomaterial scaffolds that theoretically promote axonal growth. Most molecule-based therapies target the modulation of inhibitory molecules to promote axonal growth, degrade glial scarring obstacles, and stimulate intrinsic regenerative capacity. Among them, acidic fibroblast growth factor (aFGF) has been investigated for nerve repair; it is mitogenic and pluripotent in nature and could enhance axonal growth and mitigate glial scarring. For more than 2 decades, the authors have conducted multiple trials, including human and animal experiments, using aFGF to repair nerve injuries, including central and peripheral nerves. In these trials, aFGF has shown promise for neural regeneration, and in the future, more trials and applications should investigate aFGF as a neurotrophic factor. Focusing on aFGF, the current review aimed to summarize the historical evolution of the utilization of aFGF in SCI and nerve injuries, to present applications and trials, to summarize briefly its possible mechanisms, and to provide future perspectives.

Citations

Citations to this article as recorded by  Crossref logo
  • Incorporation and release of epidermal growth factor for spinal cord injury using emulsion based nanofibrous scaffolds
    Meliha Gunes, Gizem Kaftan Öcal, Guliz Armagan, David S. Jones, Sinem Yaprak Karavana
    Journal of Drug Delivery Science and Technology.2026; 115: 107714.     CrossRef
  • Primary peripheral nerve repair: A systematic review of sutures, fibrin glue, and biologic-augmented approaches
    Dan Yan, Peter M. Murray, Johana Klasova, Zhen Wang, Said EI Hage, Morsaleh Ganji, Elias F. Wakim, Tyler V. Rice, Steven R. Clendenen, Wenchun Qu
    JPRAS Open.2026; 49: 366.     CrossRef
  • Sodium Alginate/Poly (Acrylicacid) Hydrogel Composite, Potential Carrier for Fibroblast Growth Factor1 (FGF1) Delivery
    Mahsa Mollapour Sisakht, Fatemeh Gholizadeh, Zahra Shahravi, Yasaman Kiani Doust‐Vaghe, Mohammad Ali Nilforoushzadeh, Mohammad Amir Amirkhani
    Chemistry & Biodiversity.2025;[Epub]     CrossRef
  • Potential therapeutic targets for Alzheimer’s disease: Fibroblast growth factors and their regulation of ferroptosis, pyroptosis and autophagy
    Yiwei Li, Chenbo Yang, Xiaonan Liu, Jiao Shu, Na Zhao, Zexin Sun, Muhammad Saud Tabish, Yichen Hong, Enjie Liu, Na Wei, Miaomiao Sun
    Neuroscience.2025; 573: 42.     CrossRef
  • Current and emergent therapies targeting spinal cord injury
    Giovanni Grasso, Luigi Cusimano, Manfredi Noto, Rosario Maugeri, Domenico Gerardo Iacopino
    Brain and Spine.2025; 5: 104243.     CrossRef
  • RNA-sequencing-based elucidation of the mechanism underlying aFGF mediated regulation of BMSCs via the PI3K-AKT pathway and its implications for rotator cuff injury repair
    Haonan Liu, Zhichuan Jiang, Xin Guo, Xiaowei Liu, Chaoxiang Lu, Daifeng Lu
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Sustained activation of the FGF1–MEK–ERK pathway inhibits proliferation, invasion and migration and enhances radiosensitivity in mouse angiosarcoma cells
    Taichi Miura, Junko Kado, Kazuma Ashisuke, Mikio Masuzawa, Fumiaki Nakayama
    Journal of Radiation Research.2024; 65(3): 303.     CrossRef
  • Recombinant Acidic Fibroblast Growth Factor Facilitates Motor Recovery and Reduces Myelomalacia in Traumatic American Spinal Injury Association Impairment Scale A Spinal Cord Injured Patients
    Wan-Ya Chang, Wen-Cheng Huang, Yun-An Tsai, Lin-Hsue Yang, Yi-Tien Su, Shih-Fong Huang, Chiau-Li Huang, Ya-Hui Lee, Shu-Shong Hsu, Li-Yu Fay
    Neurotrauma Reports.2024; 5(1): 910.     CrossRef
  • Fabrication Techniques of Nerve Guidance Conduits for Nerve Regeneration
    Nae-Un Kang, Seung-Jae Lee, So-Jung Gwak
    Yonsei Medical Journal.2022; 63(2): 114.     CrossRef
  • Effect of Implantation of a Fibrin Matrix Associated with Neonatal Brain Cells on the Course of an Experimental Spinal Cord Injury
    V. V. Medvediev, N. P. Oleksenko, L. D. Pichkur, S. A. Verbovska, S. I. Savosko, N. G. Draguntsova, Yu. A. Lontkovskiy, V. V. Vaslovych, V. I. Tsymbalyuk
    Cytology and Genetics.2022; 56(2): 125.     CrossRef
  • The Role of Growth Factors in the Repair of Motor Injury
    Qiaoyin Tan, Jiayu Li, Yanmin Yin, Weide Shao
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Synaptic Cell Adhesion Molecule 3 (SynCAM3) Deletion Promotes Recovery from Spinal Cord Injury by Limiting Glial Scar Formation
    Byeong Gwan Song, Su Yeon Kwon, Jae Won Kyung, Eun Ji Roh, Hyemin Choi, Chang Su Lim, Seong Bae An, Seil Sohn, Inbo Han
    International Journal of Molecular Sciences.2022; 23(11): 6218.     CrossRef
  • Established and Emerging Therapies in Acute Spinal Cord Injury
    Ron Gadot, David N. Smith, Marc Prablek, Joey K. Grochmal, Alfonso Fuentes, Alexander E. Ropper
    Neurospine.2022; 19(2): 283.     CrossRef
  • Management of acute spinal cord injuries
    Sultan Mohammed Alanazi, Hatim Faihan Alotaibi, Ibrahim Mohammed Alanazi, Adel Mohammad Aldukhain, Rakan Faisal Albasri, Salman Abdullah Alharbi, Hamoud Ghayyadh Alanizi, Yussef Falah Alharbi, ‏Diyanah Bander Almutairi, ‏Aseel Hasson Alhasson, ‏Alaa Ibrah
    International journal of health sciences.2022; 6(S10): 1816.     CrossRef
  • Resolvin D3 Promotes Inflammatory Resolution, Neuroprotection, and Functional Recovery After Spinal Cord Injury
    Juri Kim, Hari Prasad Joshi, Seung Hun Sheen, Kyoung-Tae Kim, Jae Won Kyung, Hyemin Choi, Ye Won Kim, Su Yeon Kwon, Eun Ji Roh, Un Yong Choi, Seil Sohn, Yong Ho Kim, Chul-Kyu Park, Hemant Kumar, In-Bo Han
    Molecular Neurobiology.2021; 58(1): 424.     CrossRef
  • Acidic fibroblast growth factor attenuates type 2 diabetes-induced demyelination via suppressing oxidative stress damage
    Rui Li, Beini Wang, Chengbiao Wu, Duohui Li, Yanqing Wu, Libing Ye, Luxia Ye, Xiongjian Chen, Peifeng Li, Yuan Yuan, Hongyu Zhang, Ling Xie, Xiaokun Li, Jian Xiao, Jian Wang
    Cell Death & Disease.2021;[Epub]     CrossRef
  • Biomaterials and strategies for repairing spinal cord lesions
    Hun-Jin Jeong, Yeomin Yun, Seung-Jae Lee, Yoon Ha, So-Jung Gwak
    Neurochemistry International.2021; 144: 104973.     CrossRef
  • Reduction in post-spinal cord injury spasticity by combination of peripheral nerve grafting and acidic fibroblast growth factor infusion in monkeys
    Wei-Ming Sun, Chao-Lin Ma, Jiang Xu, Ji-Ping He
    Journal of International Medical Research.2021;[Epub]     CrossRef
  • The Application of an Omentum Graft or Flap in Spinal Cord Injury
    Li-Yu Fay, Yan-Ru Lin, Dann-Ying Liou, Chuan-Wen Chiu, Mei-Yin Yeh, Wen-Cheng Huang, Jau-Ching Wu, May-Jywan Tsai, Henrich Cheng
    International Journal of Molecular Sciences.2021; 22(15): 7930.     CrossRef
  • An Assessment of Which Sociodemographic and Spinal Cord Injury–Specific Characteristics Influence Engagement With Experimental Therapies and Participation in Clinical Trials
    Carlotta Pazzi, Clara Farrehi, Maclain Capron, Kim Anderson, Bonnie Richardson, Michael Stillman
    Topics in Spinal Cord Injury Rehabilitation.2021; 27(4): 28.     CrossRef
  • Diamond Concept as Principle for the Development of Spinal Cord Scaffold: A Literature Review
    Yudha M. Sakti, Rusdy Ghazali Malueka, Ery Kus Dwianingsih, Ahmad Kusumaatmaja, Akbar Mafaza, Deas Makalingga Emiri
    Open Access Macedonian Journal of Medical Sciences.2021; 9(F): 754.     CrossRef
  • Thermosensitive heparin‐poloxamer hydrogel encapsulated bFGF and NGF to treat spinal cord injury
    Xiaoli Hu, Rui Li, Yanqing Wu, Yi Li, Xingfeng Zhong, Guanyinsheng Zhang, Yanmin Kang, Shuhua Liu, Ling Xie, Junming Ye, Jian Xiao
    Journal of Cellular and Molecular Medicine.2020; 24(14): 8166.     CrossRef
  • How individuals with spinal cord injury in the United States access and assess information about experimental therapies and clinical trials: results of a clinical survey
    Clara Farrehi, Carlotta Pazzi, Maclain Capron, Kim Anderson, Bonnie Richardson, Michael Stillman
    Spinal Cord Series and Cases.2020;[Epub]     CrossRef
  • Acidic Fibroblast Growth Factor in Spinal Cord Injury: A Potential Therapy Which Merits Further Investigation
    Kazuya Yokota, Michael G. Fehlings
    Neurospine.2019; 16(4): 739.     CrossRef
  • 12,188 View
  • 257 Download
  • 22 Web of Science
  • 24 Crossref