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"Darryl Lau"

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Utility of the MISDEF2 Algorithm and Extent of Fusion in Open Adult Spinal Deformity Surgery With Minimum 2-Year Follow-up
Neurospine. 2021;18(4):824-832.   Published online December 31, 2021
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Utility of the MISDEF2 Algorithm and Extent of Fusion in Open Adult Spinal Deformity Surgery With Minimum 2-Year Follow-up
Neurospine. 2021;18(4):824-832.   Published online December 31, 2021
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Objective
Long-segment fusion in adult spinal deformity (ASD) is often needed, but more focal surgeries may provide significant relief with less morbidity. The minimally invasive spinal deformity surgery (MISDEF2) algorithm guides minimally invasive ASD surgery, but it may be useful in open ASD surgery. We classified ASD patients undergoing focal decompression, limited decompression and fusion, and full correction according to MISDEF2 and correlated outcomes.
Methods
A retrospective study of ASD patients treated by 2 surgeons at our hospital was performed. Inclusion criteria were: age > 50, minimum 2-year follow-up, and open ASD surgery. Tumor, trauma, and infections were excluded. Patients had open surgery including focal decompression, short segment fusion, or full scoliosis correction. All patients were categorized by MISDEF2 into 4 classes based upon spinopelvic parameters. Perioperative metrics were assessed. Radiographic correction, complications and reoperation were recorded.
Results
A total of 136 patients met inclusion criteria. Mean follow-up was 46 ± 15.8 months (range, 24–118 months). Forty-seven underwent full deformity correction, 71 underwent short segment fusion, and 18 underwent decompression alone. There were 24 cases of class I, 66 cases of class II, 23 cases of class III, and 23 cases of class IV patients. Patients in class I and II had perioperative complication rates of 0% and 16.7% and revision rates of 8% and 21.2% when undergoing focal decompression or limited fusion. However, class II patients undergoing full correction had higher perioperative complications rate (p = 0.03) and revision surgery rates (p = 0.047). This difference was not seen in class III patients (p > 0.05). All class IV patients underwent full correction, but they had higher perioperative complication rates (p < 0.019), comparable revision surgery rates (p = 0.27), and better radiographic realignment (p < 0.001). In addition, full deformity correction was associated with longer length of stay, increased blood loss, and longer operative time (p < 0.001).
Conclusion
The MISDEF2 algorithm may help guide ASD surgical decision making even in open surgery, with focal treatment used in class I and II patients as a viable alternative and full correction implemented in class IV patients because of severe malalignment. However, class II patients with ASD undergoing full deformity correction do have higher complication rates.

Citations

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  • Passive surgical correction of rigid adult spine deformities to normative alignment and balance
    Crescenzo Capone, Tobias Pötzel, Denis Bratelj, Marcel Rudnick, Rajeev K. Verma, Michael Fiechter
    Scientific Reports.2026;[Epub]     CrossRef
  • Outcome and complication following single-staged posterior minimally invasive surgery in adult spinal deformity
    Chun Yeh, Pang-Hsuan Hsiao, Michael Jian-Wen Chen, Yuan-Shun Lo, Chun Tseng, Chia-Yu Lin, Ling-Yi Li, Chien-Ying Lai, Chien-Chun Chang, Hsien-Te Chen
    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
  • Moderate sagittal plane deformity patients have similar radiographic and functional outcomes with either anterior or posterior surgery
    Anton Denisov, Andrea Rowland, Nikita Zaborovskii, Dmitrii Ptashnikov, Dimitriy Kondrashov
    European Spine Journal.2024; 33(2): 620.     CrossRef
  • Limited Intervention in Adult Scoliosis—A Systematic Review
    Zuhair Jameel Mohammed, John Worley, Luke Hiatt, Sakthivel Rajan Rajaram Manoharan, Steven Theiss
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  • Comparison of the effects between oblique lateral interbody fusion (OLIF) and minimally invasive transforaminal interbody fusion (MIS-TLIF) in the treatment of adult degenerative lumbar scoliosis
    Li Jun, Tao Zou, Jia J. Wei, Tianqun Huo, Wen Min, Chengjian Wei, Hong Zhao
    Journal of Orthopaedics.2024; 58: 58.     CrossRef
  • Complication Rates and Utilization Trends of 3-Level Posterior Column Osteotomy Compared to Single-Level Pedicle Subtraction Osteotomy
    Emily S. Mills, Kevin Mertz, Ethan Faye, Jennifer A. Bell, Andy T. Ton, Jeffrey C. Wang, Ram K. Alluri, Raymond J. Hah
    Neurospine.2023; 20(2): 662.     CrossRef
  • Surgical outcome of minimal invasive oblique lateral interbody fusion with percutaneous pedicle screw fixation in the treatment of adult degenerative scoliosis
    Jun Seok Lee, Dong Wuk Son, Su Hun Lee, Soon Ki Sung, Sang Weon Lee, Geun Sung Song, Young Ha Kim, Chang Hwa Choi
    Medicine.2022; 101(48): e31879.     CrossRef
  • 7,235 View
  • 131 Download
  • 7 Web of Science
  • 7 Crossref

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Three-Column Osteotomy for the Treatment of Rigid Cervical Deformity
Neurospine. 2020;17(3):525-533.   Published online September 30, 2020
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Three-Column Osteotomy for the Treatment of Rigid Cervical Deformity
Neurospine. 2020;17(3):525-533.   Published online September 30, 2020
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Adult cervical deformity (ACD) has been shown to have a substantial impact on quality of life and overall health, with moderate to severe deformities resulting in significant disability and dysfunction. Fortunately, surgical management and correction of cervical sagittal imbalance can offer significant benefits and improvement in pain and disability. ACD is a heterogenous disease and specific surgical correction strategies should reflect deformity type (driver of deformity) and patient-related factors. Spinal rigidity is one of the most important considerations as soft tissue releases and osteotomies play a crucial role in cervical deformity correction. For ankylosed, fixed, and severe deformity, 3-column osteotomy (3CO) is often warranted. A 3CO can be done through combined anteriorposterior (vertebral body resection) and posterior-only approaches (open or closed wedge pedicle subtraction osteotomies [PSOs]). This article reviews the literature for currently published studies that report results on the use of 3CO for ACD, with a special concentration on posterior based 3CO (open and closed wedge PSO). More specifically, this review discusses the indications, radiographic corrective ability, and associated complications.

Citations

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    Harsh Jain, Hani Chanbour, Tyler Zeoli, Aaron M. Yengo-Kahn, Scott L. Zuckerman
    Neurosurgery Practice.2026;[Epub]     CrossRef
  • Comparison of pedicle subtraction osteotomy and vertebral column resection in adolescent congenital kyphoscoliosis and the influencing factors on intraoperative hemorrhage: a retrospective study
    Baina Shi
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    Alexa Semonche, Anthony L. Mikula, Justin K. Scheer, Vedat Deviren, Christopher P. Ames
    Clinical Spine Surgery.2025; 38(9): 466.     CrossRef
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  • Contemporary utilization of three-column osteotomy techniques in a prospective complex spinal deformity multicenter database: implications on full-body alignment and perioperative course
    Tyler K. Williamson, Jamshaid M. Mir, Justin S. Smith, Virginie Lafage, Renaud Lafage, Breton Line, Bassel G. Diebo, Alan H. Daniels, Jeffrey L. Gum, D. Kojo Hamilton, Justin K. Scheer, Robert Eastlack, Andreas K. Demetriades, Khaled M. Kebaish, Stephen L
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    Venu M. Nemani, Philip K. Louie, Caroline E. Drolet, John M. Rhee
    Neurospine.2022; 19(4): 876.     CrossRef
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    Journal of Korean Neurosurgical Society.2021; 64(5): 808.     CrossRef
  • 7,835 View
  • 188 Download
  • 10 Web of Science
  • 9 Crossref

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Artificial Intelligence for Adult Spinal Deformity
Neurospine. 2019;16(4):686-694.   Published online December 31, 2019
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Artificial Intelligence for Adult Spinal Deformity
Neurospine. 2019;16(4):686-694.   Published online December 31, 2019
Close
Adult spinal deformity (ASD) is a complex disease that significantly affects the lives of many patients. Surgical correction has proven to be effective in achieving improvement of spinopelvic parameters as well as improving quality of life (QoL) for these patients. However, given the relatively high complication risk associated with ASD correction, it is of paramount importance to develop robust prognostic tools for predicting risk profile and outcomes. Historically, statistical models such as linear and logistic regression models were used to identify preoperative factors associated with postoperative outcomes. While these tools were useful for looking at simple associations, they represent generalizations across large populations, with little applicability to individual patients. More recently, predictive analytics utilizing artificial intelligence (AI) through machine learning for comprehensive processing of large amounts of data have become available for surgeons to implement. The use of these computational techniques has given surgeons the ability to leverage far more accurate and individualized predictive tools to better inform individual patients regarding predicted outcomes after ASD correction surgery. Applications range from predicting QoL measures to predicting the risk of major complications, hospital readmission, and reoperation rates. In addition, AI has been used to create a novel classification system for ASD patients, which will help surgeons identify distinct patient subpopulations with unique risk-benefit profiles. Overall, these tools will help surgeons tailor their clinical practice to address patients’ individual needs and create an opportunity for personalized medicine within spine surgery.

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  • 256 Download
  • 47 Web of Science
  • 50 Crossref

Introduction

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Artificial Intelligence and the Future of Spine Surgery
Neurospine. 2019;16(4):637-639.   Published online December 31, 2019
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Artificial Intelligence and the Future of Spine Surgery
Neurospine. 2019;16(4):637-639.   Published online December 31, 2019
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Citations

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