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"Narihito Nagoshi"

Original Article

Deformity

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Proximal Thoracic Alignment Change Influences Cervical Sagittal Alignment After Correction Surgery in Patients With Lenke Type 2 Adolescent Idiopathic Scoliosis
Neurospine. 2025;22(2):354-363.   Published online June 30, 2025
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Proximal Thoracic Alignment Change Influences Cervical Sagittal Alignment After Correction Surgery in Patients With Lenke Type 2 Adolescent Idiopathic Scoliosis
Neurospine. 2025;22(2):354-363.   Published online June 30, 2025
Close
Objective
To examine the factors influencing cervical sagittal alignment (CSA) after posterior correction and fusion surgery (PSF) for patients with Lenke type 2 adolescent idiopathic scoliosis (AIS).
Methods
A total of 102 female patients with Lenke 2 AIS and a minimum 2-year follow-up were included. The upper instrumented vertebra was T2 in all patients. Sagittal and coronal parameters were measured before and 2 years after surgery. Patients were categorized into cervical malalignment (CM) and noncervical malalignment (NCM) groups following Passias’ criteria. Radiographic factors influencing CSA were analyzed.
Results
Preoperatively, 57 patients (55.9%) were assigned to the CM group and 45 patients (44.1%) to the NCM groups. The cervical lordosis (CL) in CM group was more kyphotic (19.3° vs. 3.3°), smaller proximal thoracic kyphosis (PTK; 9.7° vs. 15.4°), and smaller T1 slope (7.1° vs. 14.0°) than those in the NCM group. Main thoracic kyphosis (MTK) did not show significantly difference between the 2 groups (11.3° vs. 14.4°). Two years after surgery, the CM group demonstrated significant improvements in CSA. PTK increased from 9.7° to 13.5°, T1 slope increased from 7.1° to 10.5°, and cervical kyphosis improved from -19.3° to -8.8°, while MTK remained unchanged (11.3° vs. 11.6°).
Conclusion
PSF significantly improved CSA in patients with preoperative CM. Increased PTK, correlated with improved CL, suggests that PSF-induced PTK enhancement, rather than MTK, drives T1 slope and subsequent CSA improvement.

Citations

Citations to this article as recorded by  Crossref logo
  • In Correction Surgery for Adolescent Idiopathic Scoliosis with Lenke Type 1 and 2 curves, Obtaining Kyphosis in the Upper Thoracic Spine Is Important for Preventing Postoperative Cervical Kyphosis
    Kanji Mori, Jun Takahashi, Hiroki Oba, Shinji Sasao, Shota Ikegami, Tetsuhiko Mimura, Shinji Imai
    Spine Surgery and Related Research.2026; 10(1): 89.     CrossRef
  • From the Editor-in-Chief: Featured Articles in the June 2025 Issue
    Inbo Han
    Neurospine.2025; 22(2): 309.     CrossRef
  • A Commentary on “Proximal Thoracic Alignment Change Influences Cervical Sagittal Alignment After Correction Surgery in Patients With Lenke Type 2 Adolescent Idiopathic Scoliosis”
    Seung Woo Suh
    Neurospine.2025; 22(2): 364.     CrossRef
  • 3,276 View
  • 66 Download
  • 3 Crossref

Review Article

Regular Issue

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A Narrative Review of Advances in Neural Precursor Cell Transplantation Therapies for Spinal Cord Injury
Neurospine. 2022;19(4):935-945.   Published online December 31, 2022
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A Narrative Review of Advances in Neural Precursor Cell Transplantation Therapies for Spinal Cord Injury
Neurospine. 2022;19(4):935-945.   Published online December 31, 2022
Close
A spinal cord injury (SCI) is a destructive event that causes a permanent deficit in neurological function because of poor regenerative potential. Transplantation therapies have attracted attention for restoration of the injured spinal cord, and transplantation of neural precursor cells (NPCs) has been studied worldwide. Several groups have demonstrated functional recovery via this therapeutic intervention due to the multiple beneficial effects of NPC transplantation, such as reconstruction of neuronal circuits, remyelination of axons, and neuroprotection by trophic factors. Our group developed a method to induce NPCs from human induced pluripotent stem cells (hiPSCs) and established a transplantation strategy for SCI. Functional improvement in SCI animals treated with hiPSC-NPCs was observed, and the safety of transplanting these cells was evaluated from multiple perspectives. With selection of a safe cell line and pretreatment of the cells to encourage maturation and differentiation, hiPSC-NPC transplantation therapy is now in the clinical phase of testing for subacute SCI. In addition, a research challenge will be to expand the efficacy of transplantation therapy for chronic SCI. More comprehensive strategies involving combination treatments are required to treat this problematic situation.

Citations

Citations to this article as recorded by  Crossref logo
  • A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation
    Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané
    Advanced Science.2026;[Epub]     CrossRef
  • Stem Cell-Based Approaches for Spinal Cord Injury: The Promise of iPSCs
    Chih-Wei Zeng
    Biology.2025; 14(3): 314.     CrossRef
  • Cell replacement with stem cell-derived retinal ganglion cells from different protocols
    Ziming Luo, Kun-Che Chang
    Neural Regeneration Research.2024; 19(4): 807.     CrossRef
  • Transplantation of Predegenerated Peripheral Nerves after Complete Spinal Cord Transection in Rats: Effect of Neural Precursor Cells and Pharmacological Treatment with the Sulfoglycolipid Tol-51
    Alejandro Arriero-Cabañero, Elisa García-Vences, Stephanie Sánchez-Torres, Sergio Aristizabal-Hernandez, Concepción García-Rama, Enrique Pérez-Rizo, Alfonso Fernández-Mayoralas, Israel Grijalva, Vinnitsa Buzoianu-Anguiano, Ernesto Doncel-Pérez, Jörg Mey
    Cells.2024; 13(16): 1324.     CrossRef
  • Therapeutic Transplantation of Human Central Nervous System Organoids for Neural Reconstruction
    Sung Jun Hong, Minsung Bock, Songzi Zhang, Seong Bae An, Inbo Han
    International Journal of Molecular Sciences.2024; 25(15): 8540.     CrossRef
  • Repeated intrathecal injections of peripheral nerve-derived stem cell spheroids improve outcomes in a rat model of traumatic brain injury
    Hae Eun Shin, Won-Jin Lee, Kwang-Sook Park, Yerin Yu, Gyubin Kim, Eun Ji Roh, Byeong Gwan Song, Joon-Hyuk Jung, Kwangrae Cho, Young-hu Ha, Young-Il Yang, Inbo Han
    Stem Cell Research & Therapy.2024;[Epub]     CrossRef
  • Multimodal therapy strategy based on a bioactive hydrogel for repair of spinal cord injury
    Eun Ji Roh, Da-Seul Kim, Jun Hyuk Kim, Chang Su Lim, Hyemin Choi, Su Yeon Kwon, So-Yeon Park, Jun Yong Kim, Hyun-Mun Kim, Dong-Youn Hwang, Dong Keun Han, Inbo Han
    Biomaterials.2023; 299: 122160.     CrossRef
  • Co-Administration of Resolvin D1 and Peripheral Nerve-Derived Stem Cell Spheroids as a Therapeutic Strategy in a Rat Model of Spinal Cord Injury
    Seung-Young Jeong, Hye-Lan Lee, SungWon Wee, HyeYeong Lee, GwangYong Hwang, SaeYeon Hwang, SolLip Yoon, Young-Il Yang, Inbo Han, Keung-Nyun Kim
    International Journal of Molecular Sciences.2023; 24(13): 10971.     CrossRef
  • Transplantation of Chemical Compound-Induced Cells from Human Fibroblasts Improves Locomotor Recovery in a Spinal Cord Injury Rat Model
    Toshihiro Kurahashi, Chiyoko Nishime, Eiko Nishinaka, Yuji Komaki, Fumiko Seki, Koji Urano, Yoshinori Harada, Toshikazu Yoshikawa, Ping Dai
    International Journal of Molecular Sciences.2023; 24(18): 13853.     CrossRef
  • 9,063 View
  • 191 Download
  • 10 Web of Science
  • 9 Crossref

Original Articles

Spine and Spinal Cord Tumors DSPN-Neurospine Special Issue

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Remnant Tumor Margin as Predictive Factor for Its Growth After Incomplete Resection of Cervical Dumbbell-Shaped Schwannomas
Neurospine. 2022;19(1):32-40.   Published online January 30, 2022
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Remnant Tumor Margin as Predictive Factor for Its Growth After Incomplete Resection of Cervical Dumbbell-Shaped Schwannomas
Neurospine. 2022;19(1):32-40.   Published online January 30, 2022
Close
Objective
The purpose of our study was to investigate the risk factors of remnant tumor growth after incomplete resection (IR) of cervical dumbbell-shaped schwannomas (DS).
Methods
Twenty-one patients with IR of cervical DS with at least 2 years of follow-up were included and were divided into 2 groups: the remnant tumor growth (G) (n = 10) and no growth (NG) (n = 11) groups. The tumor location in the axial plane according to Toyama classification, the location of the remnant tumor margin, and the tumor growth rate (MIB-1 index) index were compared.
Results
No significant differences in Toyama classification and MIB-1 index were found. Age was significantly higher in the G group (61.4 years vs. 47.6 years; p = 0.030), but univariate logistic regression analysis revealed little correlation to the growth (odds ratio [OR], 1.08; 95% confidence interval [CI], 1.001–1.166; p = 0.047). Seventeen patients (9 in the G and 8 in the NG group) underwent the posterior one-way approach, and significant differences in the location of the remnant tumor margin were confirmed: within the spinal canal in 1 and 0 case, at the entrance of the intervertebral foramen in 7 and 1 cases, and in the foramen distal from the entrance in 1 and 7 cases, in the G and NG groups, respectively (p = 0.007). The proximal margin was identified as a significant predictor of the growth (OR, 56.0; 95% CI, 2.93–1,072; p = 0.008).
Conclusion
Remnant tumors with margins distally away from the entrance of the foramen were less likely to grow after IR of cervical DS.

Citations

Citations to this article as recorded by  Crossref logo
  • Predictive factors with the growth of remnant tumor after incomplete resection of thoracic dumbbell-shaped schwannomas
    Keita Tokunaga, Narihito Nagoshi, Toshiki Okubo, Masahiro Ozaki, Satoshi Suzuki, Kazuki Takeda, Takahito Iga, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
    Spinal Cord.2026;[Epub]     CrossRef
  • Cervical Schwannoma: A case report
    Sahal Mohammedali Jaber, Karrar Ibrahim Mahmood, Ashraf Sami Mohammed
    Medical Journal of Babylon.2025; 22(Suppl 1): S196.     CrossRef
  • Resection of Cervical Dumbbell-Shaped Schwannoma Using Posterior Unilateral Approach: Impact on Postoperative Cervical Function and Clinical Outcomes
    Toshiki Okubo, Narihito Nagoshi, Osahiko Tsuji, Satoshi Suzuki, Yohei Takahashi, Mitsuru Yagi, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
    Global Spine Journal.2024; 14(8): 2317.     CrossRef
  • Quantitative Analysis of the Effect of Stereotactic Radiosurgery for Postoperative Residual Cervical Dumbbell Tumors: A Multicenter Retrospective Cohort Study
    Sang Hyub Lee, Sun Woo Jang, Hong Kyung Shin, Jeoung Hee Kim, Danbi Park, Chang-Min Ha, Sun-Ho Lee, Dong Ho Kang, Young Hyun Cho, Sang Ryong Jeon, Sung Woo Roh, Jin Hoon Park
    Neurospine.2024; 21(1): 293.     CrossRef
  • A Novel and Reproducible Classification of Cervical Dumbbell Tumors to Inform Surgical Approach and Reconstruction Techniques
    Minglei Yang, Nanzhe Zhong, Yan Lou, Dongjie Jiang, Yujie Liu, Zeyu Dai, Wei Wan, Jian Jiao, Xinghai Yang, Jianru Xiao
    Spine.2024; 49(10): 715.     CrossRef
  • A Complete Facet Resection and Cervical Pedicle Screw Placement Enhances Both Gross Total Resection and Motion Preservation for the Cervical Spinal Dumbbell Tumor
    Sungsoo Bae, Dae-Jean Jo, Sun Woo Jang, Danbi Park, Sang Hyub Lee, Jinuk Kim, Chongman Kim, Jin Hoon Park
    World Neurosurgery.2024; 192: e486.     CrossRef
  • Clinical Implications of Surgical Resection without Spinal Fixation in Lumbar Dumbbell Tumors: Evaluating Postoperative Lumbar Alignment and Patient Outcomes
    Toshiki Okubo, Narihito Nagoshi, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
    World Neurosurgery.2024; 192: e547.     CrossRef
  • Clinical Features of Recurrent Spinal Cord Tumors
    Osahiko Tsuji, Narihito Nagoshi, Satoshi Suzuki, Yohei Takahashi, Satoshi Nori, Mitsuru Yagi, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
    Spine Surgery and Related Research.2023; 7(3): 225.     CrossRef
  • Commentary on “Remnant Tumor Margin as Predictive Factor for Its Growth After Incomplete Resection of Cervical Dumbbell-Shaped Schwannomas”
    Toshiki Endo
    Neurospine.2022; 19(1): 41.     CrossRef
  • 7,571 View
  • 287 Download
  • 8 Web of Science
  • 9 Crossref

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Surgical and Functional Outcomes of Expansive Open-Door Laminoplasty for Patients With Mild Kyphotic Cervical Alignment
Neurospine. 2021;18(4):749-757.   Published online December 31, 2021
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Surgical and Functional Outcomes of Expansive Open-Door Laminoplasty for Patients With Mild Kyphotic Cervical Alignment
Neurospine. 2021;18(4):749-757.   Published online December 31, 2021
Close
Objective
To evaluate the cervical dynamics, neurological function, pain, and quality of life in patients with mild cervical kyphotic alignment who underwent expansive unilateral open-door laminoplasty (ELAP).
Methods
In this retrospective single-center study, we reviewed the surgical outcomes of 80 patients with cervical spondylotic myelopathy who were followed for at least 2 years. The patients were categorized into the preoperative kyphotic group (C2–7 angle < 0°) and nonkyphotic group (angle ≥ 0°). We compared clinical information, radiographic parameters, Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) scores, and cervical Japanese Orthopaedic Association (JOA) scores between the groups.
Results
The kyphotic and nonkyphotic groups comprised 17 and 63 patients, respectively. The preoperative C2–7 angles were -3.7° in the kyphotic group and 15.4° in the nonkyphotic group (p < 0.01). In the kyphotic group, kyphotic alignment improved to lordosis at the final follow-up (2.6°, p = 0.01). The preoperative (16.4° vs. 24.1°, p < 0.01) and finalfollow-up (17.8° vs. 24.5°, p < 0.01) C7 slopes were significantly smaller in the kyphotic group. ELAP reduced pain in the arms or hands (p = 0.02) and improved the JOA scores (p < 0.01) in the kyphotic group. Patient-reported outcomes assessed using the JOACMEQ showed comparable effective rates in both groups.
Conclusion
Patients with mild cervical kyphosis showed smaller C7 slopes as a compensatory mechanism. Kyphotic angles significantly improved to lordosis after ELAP, resulting in favorable clinical outcomes. ELAP is a useful surgical option for patients even if they present mild kyphotic cervical angles.

Citations

Citations to this article as recorded by  Crossref logo
  • Analysis of Risk Factors for Cervical Kyphotic Deformity Despite Laminar Reconstruction in Cervical Intradural Tumor Surgery
    Hangeul Park, Woojin Kim, Jungbo Sim, Ho Sung Myeong, Jun-Hoe Kim, Chang-Hyun Lee, Chun Kee Chung, Chi Heon Kim
    Operative Neurosurgery.2026; 30(6): 850.     CrossRef
  • Lower extremity deep sensory disturbance as a risk factor for postlaminoplasty kyphosis in patients with cervical ossification of the posterior longitudinal ligament
    Tomoya Kanto, Haruki Ueda, Takuya Iimura, Tsuyoshi Sorimachi, Hiroshi Moridaira, Shotaro Fukada, Hiroyuki Hasebe, Miki Komatsu, Satoshi Inami, Satoshi Takada, Masahiro Kanayama, Itaru Oda, Katsuhisa Yamada, Norimasa Iwasaki, Hiroshi Taneichi, Masahiko Tak
    The Spine Journal.2026; 26(4): 685.     CrossRef
  • Long-Term Functional Results and Predictors of Clinical-Functional Outcomes After Unilateral Open-Door Laminoplasty in Patients With Cervical Spondylotic Myelopathy
    Filippo Gagliardi, Pierfrancesco De Domenico, Andrea Bisoglio, Francesca Roncelli, Micol Angela Valle, Silvia Snider, Pietro Mortini
    Clinical Spine Surgery.2026;[Epub]     CrossRef
  • Duration of symptoms before diagnosis in degenerative cervical myelopathy: A systematic review and meta-analysis
    Ailish Malone, Maram Sofiany, Ghalia Dawood, James Wright, Rody Ryan, Caroline Treanor, Conor Gallagher, Warren Lenehan, Frank Doyle, Ciaran Bolger
    Brain and Spine.2025; 5: 104252.     CrossRef
  • Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Chang Kyu Lee, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Joongkyum Shin, Yoon Ha
    Neurospine.2025; 22(4): 937.     CrossRef
  • Favorable cervical extension capacity preventing loss of cervical lordosis after laminoplasty due to spontaneous restoration of initial lordosis
    Xiaofei Cheng, Zhiqian Chen, Xiaojiang Sun, Changqing Zhao, Jie Zhao
    The Spine Journal.2024; 24(1): 94.     CrossRef
  • Current Concepts of Cervical Spine Alignment, Sagittal Deformity, and Cervical Spine Surgery
    Hidenori Suzuki, Masahiro Funaba, Kazuhiro Fujimoto, Yusuke Ichihara, Norihiro Nishida, Takashi Sakai
    Journal of Clinical Medicine.2024; 13(5): 1196.     CrossRef
  • Machine-learning-based models for the optimization of post-cervical spinal laminoplasty outpatient follow-up schedules
    Yechan Seo, Seoi Jeong, Siyoung Lee, Tae-Shin Kim, Jun-Hoe Kim, Chun Kee Chung, Chang-Hyun Lee, John M. Rhee, Hyoun-Joong Kong, Chi Heon Kim
    BMC Medical Informatics and Decision Making.2024;[Epub]     CrossRef
  • Nationwide sample data analysis of additional surgery rate after anterior or posterior cervical spinal surgery
    Woon Tak Yuh, Minjung Kim, Yunhee Choi, Junghoon Han, Junhoe Kim, Taeshin Kim, Chun Kee Chung, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Moon Soo Park, Chi Heon Kim
    Scientific Reports.2023;[Epub]     CrossRef
  • The Optimal Time between Embolization and Surgery for Hypervascular Spinal Metastatic Tumors : A Systematic Review and Meta-Analysis
    Woon Tak Yuh, Junghoon Han, Chang-Hyun Lee, Chi Heon Kim, Hyun-Seung Kang, Chun Kee Chung
    Journal of Korean Neurosurgical Society.2023; 66(4): 438.     CrossRef
  • Cases requiring reoperation for recurrence of myelopathy by lamina closure after a double-door laminoplasty using a modified Kirita–Miyazaki suture method
    Hideki Jimbayashi, Keiichiro Iida, Kobayakawa Kazu, Hirokazu Saiwai, Kenichi Kawaguchi, Yoshihiro Matsumoto, Yasuharu Nakashima
    Journal of Orthopaedics.2023; 44: 12.     CrossRef
  • 7,935 View
  • 163 Download
  • 13 Web of Science
  • 11 Crossref

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Metabolic Syndrome is a Predisposing Factor for Diffuse Idiopathic Skeletal Hyperostosis
Neurospine. 2021;18(1):109-116.   Published online November 17, 2020
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Metabolic Syndrome is a Predisposing Factor for Diffuse Idiopathic Skeletal Hyperostosis
Neurospine. 2021;18(1):109-116.   Published online November 17, 2020
Close
Objective
Diffuse idiopathic skeletal hyperostosis (DISH) causes spinal ankylosis, which can result in patients suffering specific spinal fractures that lead to a reduction in the activities of daily life in older patients. Currently, DISH is associated with diabetes mellitus and cardiovascular disease; however, the association between DISH and metabolic syndrome has not been established. The purpose of this study was to investigate a potential association between DISH and metabolic syndrome.
Methods
We retrospectively reviewed clinical data from consecutive subjects undergoing the musculoskeletal health medical checkups, and enrolled 327 subjects (174 men and 153 women; mean, 63.4 ± 13.7-years). Subjects who had spinal ankylosis at least 4 contiguous vertebral bodies were classified as the DISH group (n = 39) while the others were part of the non-DISH group (n = 288). The definition of the metabolic syndrome comes from diagnostic criteria used by the Japanese Society for Internal Medicine. Age, sex, body max index (BMI), hematological evaluation, blood pressure, presence of metabolic syndrome, the visceral fat area on abdominal computed tomography, and spinal epidural lipomatosis (SEL) on magnetic resonance imaging were evaluated.
Results
Compared to the non-DISH group, in the DISH group, mean age (DISH group, 74.3 years; non-DISH group, 1.9 years; p < 0.001), male prevalence were higher (DISH group, 82.1%; non-DISH group, 49.3%; p < 0.001), and BMI was greater (DISH group, 24.8; non-DISH group, 23.0; p = 0.006). the metabolic syndrome was more frequently observed in DISH group (28.9%) than in the non-DISH group (16.0%) (p = 0.045). The visceral fat area was significantly larger in the DISH group than in the non-DISH group (DISH group, 130.7 ± 58.2 cm2; Non-DISH group, 89.0 ± 48.1 cm2; p < 0.001). The prevalence of SEL was similar between the 2 groups (10.3% in the DISH group vs. 8.7% in the nonDISH group; p = 0.464). Poisson regression analysis revealed that the metabolic syndrome was significantly associated with DISH with odds ratio of 2.0 (95% confidence interval, 1.0–3.7; p = 0.004).
Conclusion
Metabolic syndrome was significantly associated with DISH. Our data showed metabolic syndrome is potentially related to DISH.

Citations

Citations to this article as recorded by  Crossref logo
  • Association between body roundness index and the prevalence of diffuse idiopathic skeletal hyperostosis in elderly patients: the Bunkyo health study
    Yuta Sugawara, Hidetoshi Nojiri, Masashi Nagao, Yoshifumi Tamura, Shota Tamagawa, Muneaki Ishijima
    Scientific Reports.2026;[Epub]     CrossRef
  • Impact of Ankylosing Spondylitis/Diffuse Idiopathic Skeletal Hyperostosis on Postoperative and Patient-Reported Outcomes Following Elective Cervical and Lumbar Surgery
    Adam Fano, Joydeep Baidya, Gregorio Baek, Mitchell Ng, Alec Giakas, Jonathan Dalton, Rajkishen Narayanan, Rachel Huang, Chloe Herczeg, Robert J. Oris, Jarod Olson, Yasmine Eichbaum, William Green, Joshua Mathew, Michael Carter, Nicholas Pohl, Matthew Sabi
    Global Spine Journal.2026;[Epub]     CrossRef
  • Maladie hyperostosante. Maladie de Forestier et Rotés-Querol
    B. Mazières
    EMC - Appareil locomoteur.2026; 40(2): 1.     CrossRef
  • Concomitant Diffuse Idiopathic Skeletal Hyperostosis and Cervical Ossification of the Posterior Longitudinal Ligament: A U.S. Database Study of Clinical Prevalence, Surgical Intervention, Patient Characteristics, and Postoperative Complications
    Audrey L. Litvak, Douglas M. Zhang, Henry Seidel, Dillon Benson, Cody S. Lee, Michael J. Lee, Mostafa H. El Dafrawy
    World Neurosurgery.2025; 195: 123506.     CrossRef
  • Prevalence of diffuse idiopathic skeletal hyperostosis and association with coronary artery calcifications in Slovenia
    Vesna Lesjak, Timea Hebar, Maja Pirnat
    Radiology and Oncology.2025; 59(1): 54.     CrossRef
  • Global prevalence estimates of diffuse idiopathic skeletal hyperostosis: a systematic review and meta-analysis
    Rui Weng, Haiwei Guo, Le Ma, Tianye Lin, Wenjun Han, Xianxing Zhong, Caijun Liu, Yikai Li, Genfu Zhu, Xuecheng Huang
    Frontiers in Endocrinology.2025;[Epub]     CrossRef
  • Clearer Map Flow of Diffuse Idiopathic Skeletal Hyperostosis: A Concise Review
    Mazen Mamoun Abu-Khader, Basel Mazen Abu Khader
    European Journal of Medical and Health Research.2025; 3(4): 4.     CrossRef
  • The association between cervical diffuse idiopathic skeletal hyperostosis and dysphagia
    Alaa Safia, Razi Najjar, Uday Abdelhadi, Sara Maman, Ahmad Khalaily, Yaniv Avraham, Shlomo Merchavy, Taiser Bishara
    Scientific Reports.2025;[Epub]     CrossRef
  • Spinal ankylosis and sex-specific predisposing factors in type II odontoid fractures: a comparison with sub-axial fractures
    Ryo Fujita, Aman Singh, Marcus Björklund, Paul Gerdhem, Anna MacDowall
    Asian Spine Journal.2025; 19(6): 957.     CrossRef
  • Rheumatic complications in patients with diabetes mellitus
    V.M. Zhdan, H.V. Volchenko, M.Yu. Babanina, Ye.M. Kitura, M.V. Tkachenko, O.A. Kiryan, I.V. Ivanitsky, V.G. Lebed
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2025; 21(5): 559.     CrossRef
  • Research hotspots and trends in the studies of diffuse idiopathic skeletal hyperostosis: A bibliometric analysis from 2000 to 2023
    Luming Kong, Wenzhe Bai, Zelin Yue, Nianhu Li
    Medicine.2025; 104(38): e43960.     CrossRef
  • Diffuse idiopathic skeletal hyperostosis in patients with prediabetes
    Ayfer Altıntas, Emre Ali Acar, Sadettin Uslu, Ihsan Sebnem Orgüc, Zeliha Hekimsoy, Timur Pirildar
    Reumatología Clínica.2025; 21(10): 502017.     CrossRef
  • Diffuse idiopathic skeletal hyperostosis in patients with prediabetes
    Ayfer Altıntas, Emre Ali Acar, Sadettin Uslu, Ihsan Sebnem Orgüc, Zeliha Hekimsoy, Timur Pirildar
    Reumatología Clínica (English Edition).2025; 21(10): 502017.     CrossRef
  • When bone bridges become barriers—a case of DISH-related dysphagia
    Diomidis C Ioannidis, Eleana Ntatsaki
    Oxford Medical Case Reports.2025;[Epub]     CrossRef
  • Whole Spine and Sacroiliac Joint MRI of Patients With and Without Metabolic Syndrome: A Preliminary Study
    Amir Bieber, Shay Brikman, Mohamad Nujeidat, Irina Novofasovsky, Reuven Mader, Iris Eshed
    Diagnostics.2025; 16(1): 108.     CrossRef
  • Thoracolumbar Spine Trauma Outcomes: Effect of Ankylosing Spondylitis and Diffuse Idiopathic Skeletal Hyperostosis
    Josh Callaway, Hania Shahzad, Rahul Bhale, Audrey Zhao, Stevin Lu, Westin Mace, Kelsey Hideshima, Devan Higginbotham, Yashar Javidan, Safdar N. Khan, Wyatt Vander Voort, Rolando Roberto, Eric Klineberg, Hai Le
    Journal of the American Academy of Orthopaedic Surgeons.2025;[Epub]     CrossRef
  • Forestiere disease and fracture risk
    Pavol Masaryk
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Case Report

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Chin on Chest Deformity Caused by Upper Cervical Kyphosis Associated With Ankylosing Spondylitis: A Case Report
Neurospine. 2020;17(3):666-671.   Published online September 30, 2020
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Chin on Chest Deformity Caused by Upper Cervical Kyphosis Associated With Ankylosing Spondylitis: A Case Report
Neurospine. 2020;17(3):666-671.   Published online September 30, 2020
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Chin on chest deformity caused by upper cervical kyphosis associated with ankylosing spondylitis is rare. A 66-year-old woman presented at our institute with chief complaints of difficulty in horizontal gaze and opening her mouth. Cervical radiographs showed a C0–2 angle of 1° on flexion and 7° on extension, and her chin-brow vertical angle was 49°. We planned fixation surgery at C0–5 posteriorly to prevent the progression of kyphosis, with slight correction of the kyphosis at C0–2. The correction was performed by pushing down the over lordotically contoured titanium rods connected to an occipital plate onto the C3–5 lateral mass screws, just like cantilever technique. No palpable cracking or loss of resistance was noticed during the correction. However, intraoperative radiographs revealed apparent anterior separation of the vertebral bodies between C3 and C4. Postoperative computed tomography images at the C3/4 level suggested hemorrhage from the fracture site. Tracheostomy was performed because of massive edema around the pharynx. To secure solid bone fusion, staged surgery to extend the fusion to T3 and to graft an additional iliac bone was performed. Fortunately, the C2–7 angle was corrected to 40°, and her chin-brow vertical angle was restored to 17° without any catastrophic complications. Although the patient finally obtained an ideal sagittal alignment, the surgeon should be aware that the technique had a higher perioperative risk for iatrogenic fracture, resulting in neurological and vascular injuries.

Citations

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    International Journal of Surgery Case Reports.2024;[Epub]     CrossRef
  • Iatrogenic Fracture in a Patient of Ankylosing Spondylitis Planned for Surgical Correction of Chin-on-Chest Deformity
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    Indian Spine Journal.2022; 5(2): 231.     CrossRef
  • 9,777 View
  • 180 Download
  • 2 Web of Science
  • 3 Crossref