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"Sun-Ho Lee"

Review Article

Health Services Research

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Socioeconomic Implications of Recurrent Lumbar Disc Herniation: A Narrative Review
Neurospine. 2026;23(1):94-108.   Published online January 31, 2026
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Socioeconomic Implications of Recurrent Lumbar Disc Herniation: A Narrative Review
Neurospine. 2026;23(1):94-108.   Published online January 31, 2026
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Recurrent lumbar disc herniation (RLDH) is a common complication after discectomy, occurring in 2%–25% of patients and contributing to higher reoperation rates, reduced satisfaction, and substantial direct and indirect costs. This review evaluates the economic consequences of RLDH and the relative cost-effectiveness of available management strategies. A systematic search of OVID, MEDLINE, and the Cochrane Library was performed through August 2025. Peer-reviewed, English-language studies were included if they examined adults (≥18 years) with RLDH and reported economic data. Exclusion criteria were studies limited to primary, cervical, or thoracic herniations; animal or cadaveric models; and abstracts. Extracted variables included study design, sample size, follow-up duration, and cost components. Of 283 records identified, 220 were screened and 35 underwent full-text review. Six studies met inclusion criteria, with 2 added through citation searching. Reported costs varied considerably: repeat discectomy added $6,907 in one analysis, while fusion increased expenses by more than 350%. Across studies, repeat discectomy remained the most cost-efficient option, providing comparable outcomes with reduced perioperative expenditures. Conservative management had the lowest immediate direct costs (≈$2,300) but likely underestimates the overall burden due to unmeasured productivity losses. Annular closure devices demonstrated potential cost savings of $2,000–5,000 over 2–5 years. RLDH imposes a substantial economic burden. Heterogeneity in costing methods remains a major limitation which hinders evidence-based determinations. Greater transparency, methodological standardization, and incorporation of societal perspectives are essential to accurately assess the socioeconomic impact of RLDH.

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  • Efficacy and safety of unilateral biportal endoscopy for recurrent lumbar disc herniation: A quantitative analysis of 7 cohort studies involving 409 patients
    Mingjiang Luo, Jinkai He, Wei Li, Yingting Tian, Xiao Liu, Weijian Li, Pinyi Liang, Yuxiao Zhou, Zhangchi Liu, Ziliang Zhao, Zhihong Xiao
    Neurosurgical Review.2026;[Epub]     CrossRef
  • 2,479 View
  • 63 Download
  • 1 Web of Science
  • 1 Crossref

Original Article

Regular Issue

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The Clinical Outcomes of Cervical Spine Chordoma: A Nationwide Multicenter Retrospective Study
Neurospine. 2024;21(3):942-953.   Published online September 30, 2024
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The Clinical Outcomes of Cervical Spine Chordoma: A Nationwide Multicenter Retrospective Study
Neurospine. 2024;21(3):942-953.   Published online September 30, 2024
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Objective
Chordoma, a rare malignant tumor originating from embryonal notochord remnants, exhibits high resistance to conventional treatments, making surgical resection imperative. However, the factors influencing prognosis specifically for cervical spine chordoma have not been clearly identified. We investigate the prognosis of cervical spine chordoma with factors influential in a nationwide multicenter retrospective study.
Methods
This study included all patients diagnosed with cervical spine chordoma at 7 tertiary referral centers from January 1998 to March 2023, excluding those with clivus and thoracic spine chordomas extending into the cervical spine. Local recurrence (LR) was identified through follow-up magnetic resonance imaging, either as reappearance in completely resected tumors or regrowth in residual tumors. The study assessed LR and overall survival, analyzing factors influencing LR and death.
Results
Forty-five patients with cervical spine chordoma had a mean age of 46.4 years. Over a median follow-up of 52 months, LR and distant metastasis were observed in 21 (46.7%) and 4 patients (8.9%), respectively, and 16 patients (36%) were confirmed dead. The 5-year and 10-year cumulative LR rates were 51.3% and 60%, respectively, while the 5-year and 10-year survival rates were 82% and 53%. Age was the only significant factor affecting mortality (hazard ratio, 1.04; 95% confidence interval, 1.04–1.07; p=0.015). Notably, the degree of resection and adjuvant therapy did not statistically significantly impact local tumor control and mortality.
Conclusion
This study, the largest multicenter retrospective analysis of cervical spine chordoma in Korea, identified age as the only factor significantly affecting patient survival.

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  • Cervical Vertebral Body Implant Modification Accommodating Vertebral Artery Aneurysm Clips: A Case Report
    Robert Rothrock, Vitaly Siomin, Rupesh Kotecha, Starlie C Belnap, Michael McDermott
    Cureus.2026;[Epub]     CrossRef
  • SURGICAL MANAGEMENT OF ANTERIORLY LOCATED TUMORS AT THE CRANIOVERTEBRAL JUNCTION: ADVANCES AND CHALLENGES
    ANTONIO VINICIUS DA SILVA GONÇALVES DA ROCHA, MARIANA CHANTRE-JUSTINO, OCTAVIO AUGUSTO TOMÉ DA SILVA, DAVI SOÉJIMA CORREIA RAMALHO, ALDERICO GIRÃO CAMPOS DE BARROS, ULLYANOV TOSCANO, LUIS E. CARELLI
    Coluna/Columna.2025;[Epub]     CrossRef
  • Comparative Outcomes of Brachyury Vaccine vs. Imatinib in Advanced Chordoma: A Mayo Clinic Experience
    Juan P. Navarro-Garcia de Llano, Harshvardhan G. Iyer, Harry C. Hoffman, Mahesh Seetharam, Steven Attia, Oluwaseun O. Akinduro
    Cancers.2025; 17(21): 3493.     CrossRef
  • 12,983 View
  • 181 Download
  • 2 Web of Science
  • 3 Crossref

Commentary

Special Issue on AI & Robotics

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Commentary on “Performance of a Large Language Model in the Generation of Clinical Guidelines for Antibiotic Prophylaxis in Spine Surgery”
Neurospine. 2024;21(1):147-148.   Published online March 31, 2024
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Commentary on “Performance of a Large Language Model in the Generation of Clinical Guidelines for Antibiotic Prophylaxis in Spine Surgery”
Neurospine. 2024;21(1):147-148.   Published online March 31, 2024
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  • 4,390 View
  • 104 Download

Original Article

Regular Issue

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Quantitative Analysis of the Effect of Stereotactic Radiosurgery for Postoperative Residual Cervical Dumbbell Tumors: A Multicenter Retrospective Cohort Study
Neurospine. 2024;21(1):293-302.   Published online January 31, 2024
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Quantitative Analysis of the Effect of Stereotactic Radiosurgery for Postoperative Residual Cervical Dumbbell Tumors: A Multicenter Retrospective Cohort Study
Neurospine. 2024;21(1):293-302.   Published online January 31, 2024
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Objective
Stereotactic radiosurgery (SRS) has been performed for spinal tumors. However, the quantitative effect of SRS on postoperative residual cervical dumbbell tumors remains unknown. This study aimed to quantitatively evaluate the efficacy of SRS for treating postoperative residual cervical dumbbell tumors.
Methods
We retrospectively reviewed cases of postoperative residual cervical dumbbell tumors from 1995 to 2020 in 2 tertiary institutions. Residual tumors underwent SRS (SRS group) or were observed with clinical and magnetic resonance imaging (MRI) follow-up (observation group). Tumor regrowth rates were compared between the SRS and observation groups. Additionally, risk factors for tumor regrowth were analyzed.
Results
A total of 28 cervical dumbbell tumors were incompletely resected. Eight patients were in the SRS group, and 20 in the observation group. The mean regrowth rate was not significantly lower (p = 0.784) in the SRS group (0.18 ± 0.29 mm/mo) than in the observation group (0.33 ± 0.40 mm/mo). In the multivariable Cox regression analysis, SRS was not a significant variable (hazard ratio [HR], 0.57; 95% confidence interval [CI], 0.18–1.79; p = 0.336).
Conclusion
SRS did not significantly decrease the tumor regrowth rate in our study. We believe that achieving maximal resection during the initial operation is more important than postoperative adjuvant SRS.

Citations

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  • Preoperative 3D surgical planning using Mimics significantly decreased the rate of internal fixation in cervical dumbbell tumor resection and improved the postoperative outcome: a single-center retrospective study
    Hui Wang, Zhiwen Qin, Hailin Lyu, Lu Gao, Ke Zhang
    European Spine Journal.2026; 35(9): 5525.     CrossRef
  • Preoperative radiotherapy combined with surgery versus surgery alone for primary retroperitoneal sarcoma: a meta-analysis
    Young Rak Kim, Chang-Hyun Lee, Hangeul Park, Jun-Hoe Kim, Chi Heon Kim
    Scientific Reports.2025;[Epub]     CrossRef
  • The utility of intraoperative ultrasonography for spinal cord surgery
    Hangeul Park, Jun-Hoe Kim, Chang-Hyun Lee, Sum Kim, Young-Rak Kim, Kyung-Tae Kim, Ji-hoon Kim, John M. Rhee, Woo-Young Jo, Hyongmin Oh, Hee-Pyoung Park, Chi Heon Kim, Barry Kweh
    PLOS ONE.2024; 19(7): e0305694.     CrossRef
  • A Complete Facet Resection and Cervical Pedicle Screw Placement Enhances Both Gross Total Resection and Motion Preservation for the Cervical Spinal Dumbbell Tumor
    Sungsoo Bae, Dae-Jean Jo, Sun Woo Jang, Danbi Park, Sang Hyub Lee, Jinuk Kim, Chongman Kim, Jin Hoon Park
    World Neurosurgery.2024; 192: e486.     CrossRef
  • 6,180 View
  • 116 Download
  • 4 Web of Science
  • 4 Crossref

Review Article

Regular Issue

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Advances in Neural Stem Cell Therapy for Spinal Cord Injury: Safety, Efficacy, and Future Perspectives
Neurospine. 2022;19(4):946-960.   Published online November 10, 2022
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Advances in Neural Stem Cell Therapy for Spinal Cord Injury: Safety, Efficacy, and Future Perspectives
Neurospine. 2022;19(4):946-960.   Published online November 10, 2022
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Spinal cord injury (SCI) is a devastating central nervous system injury that leads to severe disabilities in motor and sensory functions, causing significant deterioration in patients’ quality of life. Owing to the complexity of SCI pathophysiology, there has been no effective treatment for reversing neural tissue damage and recovering neurological functions. Several novel therapies targeting different stages of pathophysiological mechanisms of SCI have been developed. Among these, treatments using stem cells have great potential for the regeneration of damaged neural tissues. In this review, we have summarized recent preclinical and clinical studies focusing on neural stem cells (NSCs). NSCs are multipotent cells with specific differentiation capabilities for neural lineage. Several preclinical studies have demonstrated the regenerative effects of transplanted NSCs in SCI animal models through both paracrine effects and direct neuronal differentiation, restoring synaptic connectivity and neural networks. Based on the positive results of several preclinical studies, phase I and II clinical trials using NSCs have been performed. Despite several hurdles and issues that need to be addressed in the clinical use of NSCs in patients with SCI, gradual progress in the technical development and therapeutic efficacy of NSCs treatments has enhanced the prospects for cell-based treatments in SCI.

Citations

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  • Stem Cell Therapy: Past, Present, and Future Aspects
    Ece Alim, Angelia Greenwell, Ryan Hess, Nicholas Blanco, Jorge H. Torres, Nurettin Sahiner
    Biomedicines.2026; 14(7): 1443.     CrossRef
  • Treatment with Neuronal-Induced Human Mesenchymal Stem Cells Improves Functional Recovery of Acute Spinal Cord Injury through Attenuating Astrogliosis and Neurotoxic Astrocyte Activation
    Sungjoon Lee, Jinsu Hwang, Han-Seong Jeong, Chi-Heon Kim, Choonghyo Kim, Sujeong Jang
    Journal of Korean Neurosurgical Society.2026; 69(5): 704.     CrossRef
  • Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans
    Ana Milena Silva Olaya, Fernanda Martins Almeida, Ana Maria Blanco Martinez, Suelen Adriani Marques
    Neural Regeneration Research.2025; 20(2): 343.     CrossRef
  • Additive manufacturing in spatial patterning for spinal cord injury treatment
    Christy Kwokdinata, Sing Yian Chew
    Advanced Drug Delivery Reviews.2025; 218: 115523.     CrossRef
  • Enhancing Functional Recovery After Spinal Cord Injury Through Neuroplasticity: A Comprehensive Review
    Yuan-Yuan Wu, Yi-Meng Gao, Ting Feng, Jia-Sheng Rao, Can Zhao
    International Journal of Molecular Sciences.2025; 26(14): 6596.     CrossRef
  • X inactive-specific transcript regulates mitochondrial function and neuronal differentiation of stem cells via IGF2BP2/CPT1A axis in models of spinal cord injury
    Si-Xiang Zeng, Jin-Tao Ye, Si-Hua Huang, Ruo-Xi Liu
    World Journal of Stem Cells.2025;[Epub]     CrossRef
  • LONG-TERM EVALUATION OF THE SAFETY AND EFFECTIVENESS OF NEURAL STEM CELL TRANSPLANTATION FOR CHRONIC THORACIC SPINAL CORD INJURY
    Hanisa Aulia Maharani, Harmin
    Journal of Stem Cell Research and Tissue Engineering.2025; 9(1): 28.     CrossRef
  • THE USE OF STEM CELLS IN THE TREATMENT OF NEURODEGENERATIVE DISEASES - CURRENT STATE OF RESEARCH AND CLINICAL PERSPECTIVES
    Jarosław Baran, Aleksandra Drabik, Elżbieta Bebrysz, Ida Dunder, Magdalena Koss, Mateusz Biszewski, Karolina Dębek-Kalinowska, Piotr Bartnik, Jan Palmi, Weronika Ziomek
    International Journal of Innovative Technologies in Social Science.2025;[Epub]     CrossRef
  • Intramedullary Neural Stem Cell Transplantation in Spinal Cord Injury: Timing, Targets, and Techniques
    Sunghyun Kwon, Suk Hyung Kang, Myeong Jin Ko, Byung-Jou Lee, Woo-Keun Kwon, Sang Ryong Jeon, Kyung Taek Oh, Subum Lee
    Korean Journal of Neurotrauma.2025; 21(4): 265.     CrossRef
  • Advances in Combined Stem Cell and Neurotrophic Factor Therapies for Spinal Cord Injury Repair
    治霖 熊
    Advances in Clinical Medicine.2025; 15(11): 2176.     CrossRef
  • Fat for thought: Lipid regulation of neural stem cell fate
    Joan Cabot, Ain Justin Santillan, Paula Férnandez-García, Victoria Llado, Manuel Torres, Pablo V. Escribá, Enrico Castroflorio
    Biomedicine & Pharmacotherapy.2025; 193: 118785.     CrossRef
  • Stem Cell and Regenerative Therapies for the Treatment of Osteoporotic Vertebral Compression Fractures
    Songzi Zhang, Yunhwan Lee, Yanting Liu, Yerin Yu, Inbo Han
    International Journal of Molecular Sciences.2024; 25(9): 4979.     CrossRef
  • The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury
    Chun Li, Yuping Luo, Siguang Li
    Stem Cell Research & Therapy.2024;[Epub]     CrossRef
  • Morphogenetic Designs, and Disease Models in Central Nervous System Organoids
    Minsung Bock, Sung Jun Hong, Songzi Zhang, Yerin Yu, Somin Lee, Haeeun Shin, Byung Hyune Choi, Inbo Han
    International Journal of Molecular Sciences.2024; 25(14): 7750.     CrossRef
  • Therapeutic Transplantation of Human Central Nervous System Organoids for Neural Reconstruction
    Sung Jun Hong, Minsung Bock, Songzi Zhang, Seong Bae An, Inbo Han
    International Journal of Molecular Sciences.2024; 25(15): 8540.     CrossRef
  • Sbno1 mediates cell–cell communication between neural stem cells and microglia through small extracellular vesicles
    Yifan Zhang, Zhihan Zhu, Zhinuo Li, Jia Feng, Jun Long, Yushu Deng, Waqas Ahmed, Ahsan Ali Khan, Shiying Huang, Qingling Fu, Lukui Chen
    Cell & Bioscience.2024;[Epub]     CrossRef
  • Repeated intrathecal injections of peripheral nerve-derived stem cell spheroids improve outcomes in a rat model of traumatic brain injury
    Hae Eun Shin, Won-Jin Lee, Kwang-Sook Park, Yerin Yu, Gyubin Kim, Eun Ji Roh, Byeong Gwan Song, Joon-Hyuk Jung, Kwangrae Cho, Young-hu Ha, Young-Il Yang, Inbo Han
    Stem Cell Research & Therapy.2024;[Epub]     CrossRef
  • Innovative Strategies in 3D Bioprinting for Spinal Cord Injury Repair
    Daniel Youngsuk Kim, Yanting Liu, Gyubin Kim, Seong Bae An, Inbo Han
    International Journal of Molecular Sciences.2024; 25(17): 9592.     CrossRef
  • Synergistic effects of human umbilical cord mesenchymal stem cells/neural stem cells and epidural electrical stimulation on spinal cord injury rehabilitation
    Zhiping Mu, Jiaodi Qin, Xiaohua Zhou, Kunzheng Wang
    Scientific Reports.2024;[Epub]     CrossRef
  • Spinal cord neural stem cells derived from human embryonic stem cells promote synapse regeneration and remyelination in spinal cord injury model rats
    Xinmeng Wang, Xiangjue Hu, Yuxin Xie, Tianyi Zhao, Lihua Liu, Chao Liu
    European Journal of Neuroscience.2024; 60(11): 6920.     CrossRef
  • Safety and Efficacy of Autologous Bone Marrow Derived Mononuclear Cell Transplant in the Management of Various Neurological Disorders
    Sanjay Kala , Anchal Aggarwal, Bhagat Singh Rajput, Chayanika Kala, Santosh K Barman
    Cureus.2024;[Epub]     CrossRef
  • Induced Neural Stem Cell Transplantation in Spinal Cord Injury: Present Status and Next Steps
    Jae-Woo Jung, Je Hoon Jeong, Myeong Jin Ko, Byung-Jou Lee, Woo-Keun Kwon, Sang Ryong Jeon, Subum Lee
    Korean Journal of Neurotrauma.2024; 20(4): 234.     CrossRef
  • Impact of Endurance Training on Regeneration of Axons, Glial Cells, and Inhibitory Neurons after Spinal Cord Injury: A Link between Functional Outcome and Regeneration Potential within the Lesion Site and in Adjacent Spinal Cord Tissue
    Katarina Kiss Bimbova, Maria Bacova, Alexandra Kisucka, Ján Gálik, Maria Ileninova, Tomas Kuruc, Martina Magurova, Nadezda Lukacova
    International Journal of Molecular Sciences.2023; 24(10): 8616.     CrossRef
  • Co-Administration of Resolvin D1 and Peripheral Nerve-Derived Stem Cell Spheroids as a Therapeutic Strategy in a Rat Model of Spinal Cord Injury
    Seung-Young Jeong, Hye-Lan Lee, SungWon Wee, HyeYeong Lee, GwangYong Hwang, SaeYeon Hwang, SolLip Yoon, Young-Il Yang, Inbo Han, Keung-Nyun Kim
    International Journal of Molecular Sciences.2023; 24(13): 10971.     CrossRef
  • Bibliometric analysis of stem cells for spinal cord injury: current status and emerging frontiers
    Zhizhong Shang, Pingping Wanyan, Mingchuan Wang, Baolin Zhang, Xiaoqian Cui, Xin Wang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Electroacupuncture-Modulated MiR-106b-5p Expression Enhances Autophagy by Targeting Beclin-1 to Promote Motor Function Recovery After Spinal Cord Injury in Rats
    Shuhui Guo, Jianmin Chen, Ye Yang, Xiaolu Li, Yun Tang, Yuchang Gui, Jianquan Chen, jianwen Xu
    Neurospine.2023; 20(3): 1011.     CrossRef
  • 16,062 View
  • 305 Download
  • 22 Web of Science
  • 26 Crossref

Essay

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History of Korean Spinal Neurosurgery Society
Neurospine. 2018;15(3):189-193.   Published online September 21, 2018
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History of Korean Spinal Neurosurgery Society
Neurospine. 2018;15(3):189-193.   Published online September 21, 2018
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Citations

Citations to this article as recorded by  Crossref logo
  • Unprecedented journey to 650 transpedicular screws using freehand technique and intraoperative C-arm imaging with technical nuances
    Mohsin Fayaz, Sarabjit Singh Chibber, Kaushal Deep Singh, Lamkordor Tyngkam, Amir Hela, Bipin Chaurasia
    Journal of Craniovertebral Junction and Spine.2024; 15(3): 326.     CrossRef
  • Arnold Max Meirowsky: champion of the American mobile neurosurgical unit during the Korean War
    Andy Y. Wang, Wenya Linda Bi, Patrick D. Kelly, Paul Klimo, Ron I. Riesenburger
    Neurosurgical Focus.2022; 53(3): E19.     CrossRef
  • History of Spinal Neurosurgery and Spine Societies
    Mehmet Zileli, Salman Sharif, Maurizio Fornari, Premenand Ramani, Fengzeng Jian, Richard Fessler, Se-Hoon Kim, Toshihiro Takami, Nobuyuki Shimokawa, Gilbert Dechambenoit, Mahmood Qureshi, Nikolay Konovalov, Marcos Masini, Enrique Osorio-Fonseca, José Antó
    Neurospine.2020; 17(4): 675.     CrossRef
  • 12,884 View
  • 122 Download
  • 3 Web of Science
  • 3 Crossref

Original Article

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The Impact of Surgical Treatment on Survival in Patients With Cervical Spine Metastases
Neurospine. 2018;15(2):144-153.   Published online June 19, 2018
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The Impact of Surgical Treatment on Survival in Patients With Cervical Spine Metastases
Neurospine. 2018;15(2):144-153.   Published online June 19, 2018
Close
Objective
To compare overall survival (OS) in patients with cervical spine metastases between initial radiotherapy followed by surgery and initial surgery followed by radiotherapy.
Methods
The medical records of 36 patients with cervical spine metastases from January 2007 to December 2015 were retrospectively analyzed. These patients were divided into 2 groups. Group 1 included patients who underwent initial radiotherapy followed by surgery, while group 2 included patients who underwent initial surgery followed by radiotherapy. Clinical outcomes, OS, OS after cervical spine metastasis, and OS after surgery were analyzed in both groups. We evaluated whether primary tumor type, initial treatment modality, the modified Tomita score, Eastern Cooperative Oncology Group performance status, Karnofsky performance status, Japanese Orthopedic Association (JOA) score, Nurick grade, Frankel classification, and preoperative symptoms were associated with OS after cervical spine metastasis.
Results
Both groups exhibited improvement in the postoperative visual analogue scale, but only group 2 showed a significant improvement in postoperative JOA score (p=0.03). OS did not differ significantly between groups. However, OS after cervical spine metastasis was only 7.0 months (95% confidence interval [CI], 4.8–9.3) in group 1 versus 15.8 months (95% CI, 8.8–24.0) in group 2, which represented a significant difference (p<0.05). Factors related to OS after cervical spine metastasis were primary tumor type, initial treatment modality, and preoperative symptoms (p<0.05). Patients who presented with only preoperative pain had approximately 3 fold longer OS after cervical spine metastasis than patients with preoperative motor weakness, even in group 2 (p<0.05).
Conclusion
Surgical treatment prior to the onset of motor weakness or radiotherapy may be a good decision in case of cervical spine metastasis.

Citations

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  • Unplanned Readmission After Surgery for Cervical Spine Metastases
    Hani Chanbour, Lakshmi Suryateja Gangavarapu, Jeffrey W. Chen, Gabriel A. Bendfeldt, Iyan Younus, Mahmoud Ahmed, Steven G. Roth, Leo Y. Luo, Silky Chotai, Amir M. Abtahi, Byron F. Stephens, Scott L. Zuckerman
    World Neurosurgery.2023; 171: e768.     CrossRef
  • Stereotactic Body Radiotherapy for Spine Oligometastases: A Multicentre Retrospective Study From the Italian Association of Radiotherapy and Clinical Oncology (AIRO)
    F. Cuccia, E. Pastorello, C. Franzese, L. Belgioia, M. Bignardi, M. Federico, V. Figlia, N. Giaj Levra, S. Badellino, P. Borghetti, G. Marvaso, G. Montesi, A. Pontoriero, I. Fazio, G. Ferrera, F. Alongi, M. Scorsetti
    Clinical Oncology.2023; 35(12): 794.     CrossRef
  • Mechanical Failure After Total En Bloc Spondylectomy and Salvage Surgery
    Shin Won Kwon, Chun Kee Chung, Young Il Won, Woon Tak Yuh, Sung Bae Park, Seung Heon Yang, Chang Hyun Lee, John M. Rhee, Kyoung-Tae Kim, Chi Heon Kim
    Neurospine.2022; 19(1): 146.     CrossRef
  • Systemic considerations for the surgical treatment of spinal metastatic disease: a scoping literature review
    Mark A MacLean, Charles J Touchette, Miltiadis Georgiopoulos, Tristan Brunette-Clément, Fahad H Abduljabbar, Christopher P Ames, Chetan Bettegowda, Raphaele Charest-Morin, Nicolas Dea, Michael G Fehlings, Ziya L Gokaslan, C Rory Goodwin, Ilya Laufer, Cord
    The Lancet Oncology.2022; 23(7): e321.     CrossRef
  • Is the Spinal Instability Neoplastic Score Accurate and Reliable in Predicting Vertebral Compression Fractures for Spinal Metastasis? A Systematic Review and Qualitative Analysis
    Chang-Hyun Lee, Jae Taek Hong, Sun-Ho Lee, Seong Yi, Moon-Jun Sohn, Sung Hwan Kim, Chun Kee Chung
    Journal of Korean Neurosurgical Society.2021; 64(1): 4.     CrossRef
  • Delayed postoperative radiotherapy increases the incidence of radiographic local tumor progression before radiotherapy and leads to poor prognosis in spinal metastases
    Yining Gong, Hongqing Zhuang, Shan Chong, Qianyu Shi, Feng Wei, Zhongjun Liu, Hanqiang Ouyang, Xiaoguang Liu, Liang Jiang
    Radiation Oncology.2021;[Epub]     CrossRef
  • Surgical outcomes and risk factors for poor outcomes in patients with cervical spine metastasis: a prospective study
    Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Zhongying Zhang, Takashi Yurube, Shingo Miyazaki, Yuji Kakiuchi, Yoshiki Takeoka, Ryu Tsujimoto, Kunihiko Miyazaki, Hiroki Ohnishi, Yuichi Hoshino, Toru Takada, Ryosuke Kuroda
    Journal of Orthopaedic Surgery and Research.2021;[Epub]     CrossRef
  • 14,120 View
  • 200 Download
  • 7 Web of Science
  • 7 Crossref

Case Reports

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Superficial Siderosis of the Central Nervous System Originating from the Thoracic Spine: A Case Report
Korean J Spine. 2016;13(2):83-86.   Published online June 30, 2016
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Superficial Siderosis of the Central Nervous System Originating from the Thoracic Spine: A Case Report
Korean J Spine. 2016;13(2):83-86.   Published online June 30, 2016
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Superficial siderosis of the central nervous system(SSCNS) is a rare disease characterized by hemosiderin deposition on the surface of the central nervous system. We report a case of SSCNS originating from the thoracic spine, presenting with neurological deficits including, sensorineuronal hearing loss, ataxia, and corticospinal and dorsal column tract signs. The patient underwent dural repair with an artificial dural patch. Clinical findings were elicited by neurological examination, imaging studies, and intraoperative findings, and these were addressed through literature review.

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  • Safety and effectiveness of spinal dural defect repair in the management of superficial siderosis: A systematic review and patient-level analysis
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Diffuse Large B-Cell Lymphoma Mimicking Schwannoma of Lumbar Spine
Korean J Spine. 2016;13(2):71-73.   Published online June 30, 2016
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Diffuse Large B-Cell Lymphoma Mimicking Schwannoma of Lumbar Spine
Korean J Spine. 2016;13(2):71-73.   Published online June 30, 2016
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A rare case of solitary diffuse large B-cell lymphoma arising from the lumbar spinal nerve root is reported. A 37-year-old man presented with a 3-month history of progressive numbness and paraparesis in both legs. The initial diagnosis was benign primary intradural extramedullary tumor including schwannoma and meningioma. Histopathological examination revealed diffuse large B-cell lymphoma. While a well-defined T1 isointense mass is common in primary spinal schwannoma, the present case was atypical and had a yellowish neural component. The pathogenesis and radiological findings of spinal diffuse large B-cell lymphoma are discussed and related literature is reviewed.

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    Frontiers in Nuclear Medicine.2024;[Epub]     CrossRef
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Symptomatic Large Spinal Extradural Arachnoid Cyst: A Case Report
Korean J Spine. 2015;12(3):217-220.   Published online September 30, 2015
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Symptomatic Large Spinal Extradural Arachnoid Cyst: A Case Report
Korean J Spine. 2015;12(3):217-220.   Published online September 30, 2015
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Spinal extradural arachnoid cysts (SEACs) are relatively rare cause of compressive myelopathy. SEACs can be either congenital or acquired, but the etiology and the mechanism for their development are still unclear. A number of cases have been reported in the literature, and the one-way valve mechanism is the most widely accepted theory which explains the expansion of cysts and spinal cord compression. We report two cases of SEAC in this article. Patients had intermittent, progressive cord compressing symptoms. MRI image showed large SEAC which caused compression of the spinal cord. Pre-operative cystography and CT myelography were performed to identify the communicating tract. Pre-operative epidural cystography showed a fistulous tract. The patients underwent primary closure of the dural defect which was a communicating tract. The operative finding (nerve root herniation through the tract) suggested that the SEAC developed through a checkvalve mechanism. Postoperatively, the patients had no surgical complications and symptoms were relieved. Based on our experience, preoperative identification of the communicating tract is important in surgical planning. Although surgical excision is the standard surgical treatment, primary closure of the dural defect which was a communicating tract can be an acceptable surgical strategy.

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    Yousuke Kojimahara, Shintaro Tsuge, Keiji Hasegawa, Katsunori Fukutake, Kazumasa Nakamura, Akihito Wada, Hiroshi Takahashi
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    Tomoko Tanaka, Raja S. Boddepalli, Douglas C. Miller, Zongxian Cao, Vivek Sindhwani, Joan R. Coates, Raghav Govindarajan, N. Scott Litofsky
    World Neurosurgery.2018; 109: 298.     CrossRef
  • Spinal Extradural Cyst: Case Report and Review of Literature
    Sean Wy Lee, Aaron Foo, Char Loo Tan, Thomas Tan, Sein Lwin, Tseng Tsai Yeo, Vincent D.W. Nga
    World Neurosurgery.2018; 116: 343.     CrossRef
  • Symptomatic Extra-Dural Arachnoid Cyst
    Habib Abdoul Karim Ouiminga, Magatte Gaye, Cheik Tidiane Hafiz Bougouma, Raphael Marie Kabore, Désiré Harouna Sankara, Oumar Salia, Souleymane Ouattara, Yannick Canton Kessely
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    Arnold H. Menezes, Patrick W. Hitchon, Brian J. Dlouhy
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  • 151 Download
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Clinical Articles

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Spinal Metastasis of Thymic Carcinoma as a Rare Manifestation: A Summary of 7 Consecutive Cases
Korean J Spine. 2014;11(3):157-161.   Published online September 30, 2014
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Spinal Metastasis of Thymic Carcinoma as a Rare Manifestation: A Summary of 7 Consecutive Cases
Korean J Spine. 2014;11(3):157-161.   Published online September 30, 2014
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Backgrounds

Thymic carcinomas are very rare tumors that are often associated with extrathoracic metastasis to other organs. However, it is well known that thymic carcinomas rarely metastasize to the spine, and the prognosis, treatment, and natural course of this disease are not yet standardized.

Methods

We describe seven thymic carcinoma patients with spinal metastasis who were diagnosed and treated in our institute from January 2006 to December 2011. We performed surgical treatment and adjuvant chemotherapy and/or radiation therapy, in consideration of each individual disease's course, and we regularly followed up the patients.

Results

Of the seven patients, five were male and two were female. Six had metastases in the thoracic spine, and one had metastases in the lumbar spine. An extradural lesion was found in five patients, and two patients had both extradural and intradural lesions. The period from the primary diagnosis to spinal metastases varied widely (range, 1.23-14 years). After surgery, all patients showed an improvement of back pain and radicular pain. Two patients were lost to follow-up, but the other five maintained ambulatory function until their final follow-up. Four patients died because of pulmonary complications accompanied with the disease's progression. One patient died from uncontrolled brain metastases. After surgery, the median survival was 204±111.43 days.

Conclusion

Because metastasis to the spine from thymic carcinoma is very rare, there are no treatment guidelines. Nevertheless, we suggest that appropriate surgical management of the metastatic lesion is necessary for the preservation of the patient's quality of life during survival.

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  • Surgical management of spinal intradural metastatic pathologies: a case-based review
    Constantinos Thoma, Zachary K Englander, Georgios Prezerakos
    Journal of Surgical Case Reports.2024;[Epub]     CrossRef
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    Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, Siyuan Yao, Yipeng Wang, Yong Liu
    Clinical Neurology and Neurosurgery.2020; 196: 106056.     CrossRef
  • Spine Metastasis of Thymic Carcinoma in a Pediatric Patient: A Case Report and Comprehensive Literature Review
    Kadir Oktay, Ebru Guzel, Okay Baykara, Mevlana Akbaba, Ibrahim Sari, Aslan Guzel
    Pediatric Neurosurgery.2020; 55(5): 289.     CrossRef
  • Surgical management of spinal metastases of thymic carcinoma
    Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
    Medicine.2019; 98(3): e14198.     CrossRef
  • Treatments and outcomes of spinal metastasis from thymic epithelial tumors: 10-year experience with 15 patients in a single center
    Qi Jia, Jian Yang, Jinbo Hu, Tielong Liu, Cheng Yang, Haifeng Wei, Xinghai Yang, Jianru Xiao
    European Spine Journal.2019; 28(6): 1520.     CrossRef
  • Rare Thymoma Metastases to the Spine: Case Reports and Review of the Literature
    Rebecca L. Achey, Bryan S. Lee, Swetha Sundar, Edward C. Benzel, Ajit A. Krishnaney
    World Neurosurgery.2018; 110: 423.     CrossRef
  • Successful treatment of malignant thymoma with sacrum metastases
    Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
    Medicine.2018; 97(51): e13796.     CrossRef
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Mid-term Clinical Outcomes of Stand-alone Posterior Interbody Fusion with Rectangular Cages: A 4-year-minimum Follow-up
Korean J Spine. 2013;10(3):126-132.   Published online September 30, 2013
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Mid-term Clinical Outcomes of Stand-alone Posterior Interbody Fusion with Rectangular Cages: A 4-year-minimum Follow-up
Korean J Spine. 2013;10(3):126-132.   Published online September 30, 2013
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Objective

We sought to determine minimum 4 years of clinical outcomes including fusion rate, revision rate and complications of patients who underwent placement of rectangular stand-alone cages.

Methods

Thirty-three cases of degenerative spine that had been followed for at least 4-years were reviewed retrospectively. Cages were inserted at L4-L5 level or L5-S1 in 27 or in 6 cases respectively. Visual analogue scale (VAS), Odom's criteria, fusion rate, intervertebral disc height and lumbar lordosis were determined pre- and post-operatively on standing x-rays. Amount of intra- and postoperative blood loss, total volume transfused, duration of surgery and perioperative complications were also evaluated.

Results

The mean VAS score of back pain and sciatica were improved from 8.0 and 7.0 points to 3.4 and 2.4 during 1 years follow-up visit and the scores was raised gradually. Also, during the follow-up, 94% of patients showed excellent or good outcomes by the Odom's criteria. Intervertebral disc height was increased from 8.2±1.4mm to 9.2±1.9mm at the first year of follow-up, however, found to be decreased and stabilized to 8.3±1.8mm after 2 years. The fusion rate was approximately 91% after 4 year postoperative. The segmental angle of lordosis was increased significantly by two years but it was not maintained after four years. A statistically insignificant change in total lumbar lordosis was also observed. Three patients (9%) had experienced perioperative complications.

Conclusion

The use of rectangular stand-alone cages for posterior lumbar interbody fusion (PLIF) resulted in a various degree of subsidence and demonstrate very low complication rate, high functional stability and improved clinical outcomes in patients with degenerative lumbar disc disease.

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  • Posterior self-expanding stand-alone cage: outcomes in degenerative disc disease
    Nia Atanasova Gecheva, Petar Lyubomirov Ilkov, Konstantin Alexandrov Uzunov
    Folia Medica.2026;[Epub]     CrossRef
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    Ming-Hong Chen, Jen-Yuh Chen
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Ten Important Tips in Treating a Patient with Lumbar Disc Herniation
    Farzad Omidi-Kashani, Hamid Hejrati, Shahrara Ariamanesh
    Asian Spine Journal.2016; 10(5): 955.     CrossRef
  • 9,731 View
  • 84 Download
  • 3 Crossref