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"Sungjoon Lee"

Original Article

Regular Issue

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The Clinical Outcomes of Cervical Spine Chordoma: A Nationwide Multicenter Retrospective Study
Neurospine. 2024;21(3):942-953.   Published online September 30, 2024
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The Clinical Outcomes of Cervical Spine Chordoma: A Nationwide Multicenter Retrospective Study
Neurospine. 2024;21(3):942-953.   Published online September 30, 2024
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Objective
Chordoma, a rare malignant tumor originating from embryonal notochord remnants, exhibits high resistance to conventional treatments, making surgical resection imperative. However, the factors influencing prognosis specifically for cervical spine chordoma have not been clearly identified. We investigate the prognosis of cervical spine chordoma with factors influential in a nationwide multicenter retrospective study.
Methods
This study included all patients diagnosed with cervical spine chordoma at 7 tertiary referral centers from January 1998 to March 2023, excluding those with clivus and thoracic spine chordomas extending into the cervical spine. Local recurrence (LR) was identified through follow-up magnetic resonance imaging, either as reappearance in completely resected tumors or regrowth in residual tumors. The study assessed LR and overall survival, analyzing factors influencing LR and death.
Results
Forty-five patients with cervical spine chordoma had a mean age of 46.4 years. Over a median follow-up of 52 months, LR and distant metastasis were observed in 21 (46.7%) and 4 patients (8.9%), respectively, and 16 patients (36%) were confirmed dead. The 5-year and 10-year cumulative LR rates were 51.3% and 60%, respectively, while the 5-year and 10-year survival rates were 82% and 53%. Age was the only significant factor affecting mortality (hazard ratio, 1.04; 95% confidence interval, 1.04–1.07; p=0.015). Notably, the degree of resection and adjuvant therapy did not statistically significantly impact local tumor control and mortality.
Conclusion
This study, the largest multicenter retrospective analysis of cervical spine chordoma in Korea, identified age as the only factor significantly affecting patient survival.

Citations

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  • Cervical Vertebral Body Implant Modification Accommodating Vertebral Artery Aneurysm Clips: A Case Report
    Robert Rothrock, Vitaly Siomin, Rupesh Kotecha, Starlie C Belnap, Michael McDermott
    Cureus.2026;[Epub]     CrossRef
  • SURGICAL MANAGEMENT OF ANTERIORLY LOCATED TUMORS AT THE CRANIOVERTEBRAL JUNCTION: ADVANCES AND CHALLENGES
    ANTONIO VINICIUS DA SILVA GONÇALVES DA ROCHA, MARIANA CHANTRE-JUSTINO, OCTAVIO AUGUSTO TOMÉ DA SILVA, DAVI SOÉJIMA CORREIA RAMALHO, ALDERICO GIRÃO CAMPOS DE BARROS, ULLYANOV TOSCANO, LUIS E. CARELLI
    Coluna/Columna.2025;[Epub]     CrossRef
  • Comparative Outcomes of Brachyury Vaccine vs. Imatinib in Advanced Chordoma: A Mayo Clinic Experience
    Juan P. Navarro-Garcia de Llano, Harshvardhan G. Iyer, Harry C. Hoffman, Mahesh Seetharam, Steven Attia, Oluwaseun O. Akinduro
    Cancers.2025; 17(21): 3493.     CrossRef
  • 11,369 View
  • 171 Download
  • 2 Web of Science
  • 3 Crossref

Review Article

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Advances in Neural Stem Cell Therapy for Spinal Cord Injury: Safety, Efficacy, and Future Perspectives
Neurospine. 2022;19(4):946-960.   Published online November 10, 2022
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Advances in Neural Stem Cell Therapy for Spinal Cord Injury: Safety, Efficacy, and Future Perspectives
Neurospine. 2022;19(4):946-960.   Published online November 10, 2022
Close
Spinal cord injury (SCI) is a devastating central nervous system injury that leads to severe disabilities in motor and sensory functions, causing significant deterioration in patients’ quality of life. Owing to the complexity of SCI pathophysiology, there has been no effective treatment for reversing neural tissue damage and recovering neurological functions. Several novel therapies targeting different stages of pathophysiological mechanisms of SCI have been developed. Among these, treatments using stem cells have great potential for the regeneration of damaged neural tissues. In this review, we have summarized recent preclinical and clinical studies focusing on neural stem cells (NSCs). NSCs are multipotent cells with specific differentiation capabilities for neural lineage. Several preclinical studies have demonstrated the regenerative effects of transplanted NSCs in SCI animal models through both paracrine effects and direct neuronal differentiation, restoring synaptic connectivity and neural networks. Based on the positive results of several preclinical studies, phase I and II clinical trials using NSCs have been performed. Despite several hurdles and issues that need to be addressed in the clinical use of NSCs in patients with SCI, gradual progress in the technical development and therapeutic efficacy of NSCs treatments has enhanced the prospects for cell-based treatments in SCI.

Citations

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  • Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans
    Ana Milena Silva Olaya, Fernanda Martins Almeida, Ana Maria Blanco Martinez, Suelen Adriani Marques
    Neural Regeneration Research.2025; 20(2): 343.     CrossRef
  • Additive manufacturing in spatial patterning for spinal cord injury treatment
    Christy Kwokdinata, Sing Yian Chew
    Advanced Drug Delivery Reviews.2025; 218: 115523.     CrossRef
  • Enhancing Functional Recovery After Spinal Cord Injury Through Neuroplasticity: A Comprehensive Review
    Yuan-Yuan Wu, Yi-Meng Gao, Ting Feng, Jia-Sheng Rao, Can Zhao
    International Journal of Molecular Sciences.2025; 26(14): 6596.     CrossRef
  • X inactive-specific transcript regulates mitochondrial function and neuronal differentiation of stem cells via IGF2BP2/CPT1A axis in models of spinal cord injury
    Si-Xiang Zeng, Jin-Tao Ye, Si-Hua Huang, Ruo-Xi Liu
    World Journal of Stem Cells.2025;[Epub]     CrossRef
  • LONG-TERM EVALUATION OF THE SAFETY AND EFFECTIVENESS OF NEURAL STEM CELL TRANSPLANTATION FOR CHRONIC THORACIC SPINAL CORD INJURY
    Hanisa Aulia Maharani, Harmin
    Journal of Stem Cell Research and Tissue Engineering.2025; 9(1): 28.     CrossRef
  • THE USE OF STEM CELLS IN THE TREATMENT OF NEURODEGENERATIVE DISEASES - CURRENT STATE OF RESEARCH AND CLINICAL PERSPECTIVES
    Jarosław Baran, Aleksandra Drabik, Elżbieta Bebrysz, Ida Dunder, Magdalena Koss, Mateusz Biszewski, Karolina Dębek-Kalinowska, Piotr Bartnik, Jan Palmi, Weronika Ziomek
    International Journal of Innovative Technologies in Social Science.2025;[Epub]     CrossRef
  • Intramedullary Neural Stem Cell Transplantation in Spinal Cord Injury: Timing, Targets, and Techniques
    Sunghyun Kwon, Suk Hyung Kang, Myeong Jin Ko, Byung-Jou Lee, Woo-Keun Kwon, Sang Ryong Jeon, Kyung Taek Oh, Subum Lee
    Korean Journal of Neurotrauma.2025; 21(4): 265.     CrossRef
  • Advances in Combined Stem Cell and Neurotrophic Factor Therapies for Spinal Cord Injury Repair
    治霖 熊
    Advances in Clinical Medicine.2025; 15(11): 2176.     CrossRef
  • Fat for thought: Lipid regulation of neural stem cell fate
    Joan Cabot, Ain Justin Santillan, Paula Férnandez-García, Victoria Llado, Manuel Torres, Pablo V. Escribá, Enrico Castroflorio
    Biomedicine & Pharmacotherapy.2025; 193: 118785.     CrossRef
  • Stem Cell and Regenerative Therapies for the Treatment of Osteoporotic Vertebral Compression Fractures
    Songzi Zhang, Yunhwan Lee, Yanting Liu, Yerin Yu, Inbo Han
    International Journal of Molecular Sciences.2024; 25(9): 4979.     CrossRef
  • The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury
    Chun Li, Yuping Luo, Siguang Li
    Stem Cell Research & Therapy.2024;[Epub]     CrossRef
  • Morphogenetic Designs, and Disease Models in Central Nervous System Organoids
    Minsung Bock, Sung Jun Hong, Songzi Zhang, Yerin Yu, Somin Lee, Haeeun Shin, Byung Hyune Choi, Inbo Han
    International Journal of Molecular Sciences.2024; 25(14): 7750.     CrossRef
  • Therapeutic Transplantation of Human Central Nervous System Organoids for Neural Reconstruction
    Sung Jun Hong, Minsung Bock, Songzi Zhang, Seong Bae An, Inbo Han
    International Journal of Molecular Sciences.2024; 25(15): 8540.     CrossRef
  • Sbno1 mediates cell–cell communication between neural stem cells and microglia through small extracellular vesicles
    Yifan Zhang, Zhihan Zhu, Zhinuo Li, Jia Feng, Jun Long, Yushu Deng, Waqas Ahmed, Ahsan Ali Khan, Shiying Huang, Qingling Fu, Lukui Chen
    Cell & Bioscience.2024;[Epub]     CrossRef
  • Repeated intrathecal injections of peripheral nerve-derived stem cell spheroids improve outcomes in a rat model of traumatic brain injury
    Hae Eun Shin, Won-Jin Lee, Kwang-Sook Park, Yerin Yu, Gyubin Kim, Eun Ji Roh, Byeong Gwan Song, Joon-Hyuk Jung, Kwangrae Cho, Young-hu Ha, Young-Il Yang, Inbo Han
    Stem Cell Research & Therapy.2024;[Epub]     CrossRef
  • Innovative Strategies in 3D Bioprinting for Spinal Cord Injury Repair
    Daniel Youngsuk Kim, Yanting Liu, Gyubin Kim, Seong Bae An, Inbo Han
    International Journal of Molecular Sciences.2024; 25(17): 9592.     CrossRef
  • Synergistic effects of human umbilical cord mesenchymal stem cells/neural stem cells and epidural electrical stimulation on spinal cord injury rehabilitation
    Zhiping Mu, Jiaodi Qin, Xiaohua Zhou, Kunzheng Wang
    Scientific Reports.2024;[Epub]     CrossRef
  • Spinal cord neural stem cells derived from human embryonic stem cells promote synapse regeneration and remyelination in spinal cord injury model rats
    Xinmeng Wang, Xiangjue Hu, Yuxin Xie, Tianyi Zhao, Lihua Liu, Chao Liu
    European Journal of Neuroscience.2024; 60(11): 6920.     CrossRef
  • Safety and Efficacy of Autologous Bone Marrow Derived Mononuclear Cell Transplant in the Management of Various Neurological Disorders
    Sanjay Kala , Anchal Aggarwal, Bhagat Singh Rajput, Chayanika Kala, Santosh K Barman
    Cureus.2024;[Epub]     CrossRef
  • Induced Neural Stem Cell Transplantation in Spinal Cord Injury: Present Status and Next Steps
    Jae-Woo Jung, Je Hoon Jeong, Myeong Jin Ko, Byung-Jou Lee, Woo-Keun Kwon, Sang Ryong Jeon, Subum Lee
    Korean Journal of Neurotrauma.2024; 20(4): 234.     CrossRef
  • Impact of Endurance Training on Regeneration of Axons, Glial Cells, and Inhibitory Neurons after Spinal Cord Injury: A Link between Functional Outcome and Regeneration Potential within the Lesion Site and in Adjacent Spinal Cord Tissue
    Katarina Kiss Bimbova, Maria Bacova, Alexandra Kisucka, Ján Gálik, Maria Ileninova, Tomas Kuruc, Martina Magurova, Nadezda Lukacova
    International Journal of Molecular Sciences.2023; 24(10): 8616.     CrossRef
  • Co-Administration of Resolvin D1 and Peripheral Nerve-Derived Stem Cell Spheroids as a Therapeutic Strategy in a Rat Model of Spinal Cord Injury
    Seung-Young Jeong, Hye-Lan Lee, SungWon Wee, HyeYeong Lee, GwangYong Hwang, SaeYeon Hwang, SolLip Yoon, Young-Il Yang, Inbo Han, Keung-Nyun Kim
    International Journal of Molecular Sciences.2023; 24(13): 10971.     CrossRef
  • Bibliometric analysis of stem cells for spinal cord injury: current status and emerging frontiers
    Zhizhong Shang, Pingping Wanyan, Mingchuan Wang, Baolin Zhang, Xiaoqian Cui, Xin Wang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Electroacupuncture-Modulated MiR-106b-5p Expression Enhances Autophagy by Targeting Beclin-1 to Promote Motor Function Recovery After Spinal Cord Injury in Rats
    Shuhui Guo, Jianmin Chen, Ye Yang, Xiaolu Li, Yun Tang, Yuchang Gui, Jianquan Chen, jianwen Xu
    Neurospine.2023; 20(3): 1011.     CrossRef
  • 14,787 View
  • 304 Download
  • 21 Web of Science
  • 24 Crossref

Case Reports

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Sudden Paraplegia Caused by Nontraumatic Cervical Disc Rupture: A Case Report
Korean J Spine. 2017;14(4):155-157.   Published online December 31, 2017
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Sudden Paraplegia Caused by Nontraumatic Cervical Disc Rupture: A Case Report
Korean J Spine. 2017;14(4):155-157.   Published online December 31, 2017
Close
A 38-year-old man visited our Emergency Department for sudden onset paraplegia that occurred 1 hour ago. He felt a piercing pain in the posterior neck and became paraplegic while he was watching television, lying down on a sofa. Neurological examination showed motor power grades II-III in both arms and grade 0 in both legs. His cervical magnetic resonance imaging (MRI) showed a large ruptured disc at the C5-6 level, severely compressing the spinal cord. Emergency anterior cervical discectomy and fusion at C5-6 were performed. Because extensive cord swelling was observed on postoperative MRI, laminoplasty from C3 to C6 was performed 3 days after the initial operation. At a postoperative 8-month follow-up, the motor power was improved to grade III-IV- for both hands and grade IV- for both legs. Nontraumatic cervical disc rupture causing acute paraplegia is a very rare but possible event. Immediate neurologic assessment and thorough imaging studies to allow accurate diagnosis are crucial. Emergency surgical decompression is important and may lead to good neurological outcomes.

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  • Non-Traumatic Cervical Disc Herniation Presented as Sudden Paralysis of the Limbs: Two Case Reports
    Jeong-Ju Hong, Cheolsu Jwa, Jae Hoon Kim, Hee In Kang, In-Suk Bae, Hyungjoo Kwon
    The Nerve.2023; 9(2): 184.     CrossRef
  • 10,024 View
  • 163 Download
  • 1 Crossref

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A 20-Year-Old Retained Surgical Gauze Mimicking a Spinal Tumor: A Case Report
Korean J Spine. 2016;13(3):160-163.   Published online September 30, 2016
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A 20-Year-Old Retained Surgical Gauze Mimicking a Spinal Tumor: A Case Report
Korean J Spine. 2016;13(3):160-163.   Published online September 30, 2016
Close

A 79-year-old man visited our clinic complaining of lower back and left leg radiating pain that began 1 month prior to his presentation. He underwent surgery for lumbar disc herniation 20 years ago at another hospital. Magnetic resonance imaging revealed left-sided foraminal stenosis at L4-5. In addition, a paraspinal mass occupying the L4 spinous process and left lamina was observed. We subsequently performed an L4-5 decompression and fusion. During the operation, retained surgical gauze with granulation tissue was found. The term gossypiboma is used to define a mass lesion consisting of retained surgical gauzes and an adjacent foreign body reaction. Gossypibomas are uncommon in the paraspinal area and are mostly asymptomatic in chronic cases. Because there are no specific clinical or radiological signs, they can be confused with other tumorous conditions. Gossypibomas should be included in the differential diagnosis of paraspinal soft-tissue masses detected in patients with a history of prior spinal surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • Retained Surgical Items in Korea: A Systematic Review
    Seong-Hi Park, So-Young Kim, Eun Young Kim
    Quality Improvement in Health Care.2025; 31(1): 75.     CrossRef
  • Paraspinal Gossypiboma (Textiloma) Mimicking a Soft Tissue Tumor
    Prasad Krishnan
    Asian Journal of Neurosurgery.2023; 18(01): 210.     CrossRef
  • MRI of Paraspinal Gossypiboma: Look for the Barium Sulfate Filament
    Julian Kent Seghers, Tom Oyen, Jan Erik Vandevenne
    Journal of the Belgian Society of Radiology.2023; 107(1): 87.     CrossRef
  • Gauze for concern: A Case Report and systematic review of delayed presentation of paraspinal textiloma
    Karthik Shyam, Pushpa Bhari Thippeswamy, Ajoy Prasad Shetty, Raksha Algeri, Shanmuganathan Rajasekaran
    Journal of Clinical Orthopaedics and Trauma.2022; 32: 101967.     CrossRef
  • Intra-abdominal Gossypibomas: Clinical Manifestations, Risk Factors and Prevention
    Geethu Rachel Iype, Inian Samarasam, K. Senthilnathan, Myla Yacob, Vijay Peedicayil Abraham
    Indian Journal of Surgery.2021; 83(4): 885.     CrossRef
  • Spinal Textiloma After Diskectomy: A Case Report and Review of the Literature
    Iraj Lotfinia, Ata Mahdkhah
    World Neurosurgery.2020; 134: 343.     CrossRef
  • Retention of Nonabsorbable Hemostatic Materials (Retained Surgical Sponge, Gossypiboma, Textiloma, Gauzoma, Muslinoma) After Spinal Surgery: A Systematic Review of Cases Reported During the Last Half-Century
    Mehmet Turgut, Ali Akhaddar, Ahmet T. Turgut
    World Neurosurgery.2018; 116: 255.     CrossRef
  • Retained Foreign Body in the Nasal Cavity After Oral Maxillofacial Surgery
    Masanori Tsukamoto, Jun Hirokawa, Takeshi Yokoyama
    Anesthesia Progress.2018; 65(2): 111.     CrossRef
  • Simultaneous Extraction of a Retained Surgical Gauze from Bladder and Uterus 17 Years after Cesarean Section: A Rare Case Report
    Samaneh Rokhgireh, Abolfazl Mehdizadehkashi, Shahla Chaichian, Mansoureh Vahdat, Leila Nazari, Banafsheh Tajbakhsh, Banafsheh Nikfar
    Iranian Red Crescent Medical Journal.2017;[Epub]     CrossRef
  • 10,735 View
  • 107 Download
  • 9 Crossref

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Idiopathic Spontaneous Intramedullary Hemorrhage: A Report of a Rare Case of Repeated Intramedullary Hemorrhage with Unknown Etiology
Korean J Spine. 2015;12(4):279-282.   Published online December 31, 2015
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Idiopathic Spontaneous Intramedullary Hemorrhage: A Report of a Rare Case of Repeated Intramedullary Hemorrhage with Unknown Etiology
Korean J Spine. 2015;12(4):279-282.   Published online December 31, 2015
Close

A 48-year-old woman presented with acute voiding difficulty, numbness and weakness of both lower extremities. Magnetic resonance imaging (MRI) showed an intramedullary hemorrhagic mass that extended from T9 to T10. T8-T10 laminotomy and surgical removal of the hemorrhagic mass was performed. The pathological diagnosis was hematoma. Her neurological status remained the same after the operation. At 5 days post-operation, the patient suddenly became paraplegic, and MRI that was immediately performed revealed a recurrent intramedullary hemorrhage. Emergent surgical evacuation was performed. Again, histological examination showed only hematoma, without any evidence of abnormal vessels or a tumor. A postoperative MRI revealed no abnormal lesions other than those resulting from postoperative changes. At a 9-month follow up, the patient could walk a short distance with the aid of a walker. Because spontaneous intramedullary hemorrhage with unknown etiology is very rare, it is essential to perform a meticulous inspection of the hemorrhagic site to find the underlying cause. Repeated hemorrhage can occur; therefore, close observation of patients after surgery is important in cases without an apparent etiology. Urgent surgical evacuation is important to improve outcomes in these cases.

Citations

Citations to this article as recorded by  Crossref logo
  • Surgical treatment and successful long‐term outcome in a dog with primary haematomyelia
    Rita Melo, Tomas Elvira, Petra Agthe, Edward Ives
    Veterinary Record Case Reports.2026;[Epub]     CrossRef
  • Thoracic myelopathy secondary to spontaneous spinal intramedullary haematoma
    Justin Kian Guan Kwok, Victoria Chua, Gareth Zigui Lim
    Practical Neurology.2025; : pn-2025-004878.     CrossRef
  • Surgical treatment and outcome of haematomyelia with a traumatic cause in a dog and a cat
    Shanshan Guo
    Veterinary Medicine and Science.2024;[Epub]     CrossRef
  • Spontaneous intramedullary hematoma in a patient with COVID‐19 infection: A case report
    Masih Sabouri, Majid Rezvani, Bahram Aminmansour, Arman Sourani, Sadegh Baradaran Mahdavi
    Clinical Case Reports.2022;[Epub]     CrossRef
  • Spontaneous intramedullary hematoma following COVID‐19 vaccination: A case report
    Arman Sourani, Majid Rezvani, Mina Foroughi, Sadegh Baradaran Mahdavi
    Clinical Case Reports.2022;[Epub]     CrossRef
  • Apixaban-associated spontaneous thoracic intramedullary hemorrhage
    Ketan Verma, John Reavey-Cantwell, Brian M. Cameron
    Clinical Neurology and Neurosurgery.2021; 202: 106512.     CrossRef
  • Spontaneous spinal intramedullary hematoma in an infant: A rare entity and a diagnostic challenge
    VibhuShankar Parashar, Priyanka Aswal, TarunKumar Gupta, Gaurav Jaiswal
    Journal of Pediatric Neurosciences.2021; 16(1): 61.     CrossRef
  • “Acute onset tetraplegia associated with immune‐mediated thrombocytopenia and suspected secondary intraspinal hemorrhage in a dog”
    Jasmine S. Lee, Tara Jane Bellis, Adam S. Yoskowitz, Boaz Levitin
    Clinical Case Reports.2019; 7(9): 1673.     CrossRef
  • Surgical intervention for a pediatric isolated intramedullary spinal aneurysm
    Masayoshi Morozumi, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Akiyuki Matsumoto, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Yoshihiro Nishida, Naoki Ishiguro
    European Spine Journal.2018; 27(S3): 342.     CrossRef
  • 9,387 View
  • 114 Download
  • 9 Crossref