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"Bone mineral density"

Original Articles

Clinical Study/Spinal Imaging

Disuse Bone Loss in Fusion Constructs After Multilevel Lumbar Fusion: A Computed Tomography Hounsfield Unit Analysis
Hyun-Jun Jang, Dongkyu Kim, Bong-Ju Moon, Kyung-Hyun Kim, Jeong-Yoon Park, Sung-Uk Kuh, Keun-Su Kim, Dong-Kyu Chin
Neurospine 2026;23(1):176-186.   Published online January 31, 2026
DOI: https://doi.org/10.14245/ns.2551272.636

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Disuse Bone Loss in Fusion Constructs After Multilevel Lumbar Fusion: A Computed Tomography Hounsfield Unit Analysis
Neurospine. 2026;23(1):176-186.   Published online January 31, 2026
DOI: https://doi.org/10.14245/ns.2551272.636
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Disuse Bone Loss in Fusion Constructs After Multilevel Lumbar Fusion: A Computed Tomography Hounsfield Unit Analysis
Neurospine. 2026;23(1):176-186.   Published online January 31, 2026
DOI: https://doi.org/10.14245/ns.2551272.636
Close
Objective
To evaluate long-term bone quality changes within the fusion construct (FC) after 2- to 3-level lumbar fusion using computed tomography (CT)-derived Hounsfield units (HUs).
Methods
Among 520 screened patients, 222 who underwent 2- to 3-level posterior lumbar interbody fusion met the inclusion criteria. HU values were measured on CT scans preoperatively, at 1-year postoperative, and at final follow-up. The percentage change in HU (HU [final–pre]%) was calculated for each vertebral level.
Results
At the final follow-up, the FC demonstrated a significant decline in HU compared to preoperative values (median [10th–90th percentile], 132.0 [86.5–220.4]; 95% confidence interval [CI], 116.0–142.5 vs. 124.5 [71.0– 210.0]; 109.8–135.1; HU (final–pre)%: -11.0 [-62.0 to 48.5]; -19.9 to -6.1; p<0.001). In contrast, HU increased significantly at the uppermost instrumented vertebra (HU (final–pre)%: median [10th–90th percentile], 28.3 [-19.9 to 102.9]; 95% CI, 21.1–36.4; p<0.001), likely reflecting increased mechanical demands. Subgroup analysis revealed a more pronounced decline in HU in patients with longer follow-up durations, particularly in the FC group (p=0.003).
Conclusion
CT-derived HU revealed progressive trabecular bone loss within FC over time after lumbar fusion. In patients with longer postoperative intervals, clinicians should remain aware of the potential weakening of the FC, which has important implications when considering implant removal or planning revision surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • A Commentary on “Disuse Bone Loss in Fusion Constructs After Multilevel Lumbar Fusion: A Computed Tomography Hounsfield Unit Analysis”
    Jiajun Deng, Hongsheng Lin
    Neurospine.2026; 23(2): 504.     CrossRef
  • Reply Letter: A Commentary on “Disuse Bone Loss in Fusion Constructs After Multilevel Lumbar Fusion: A Computed Tomography Hounsfield Unit Analysis”
    Hyun-Jun Jang, Dongkyu Kim, Bong-Ju Moon, Kyung-Hyun Kim, Jeong-Yoon Park, Sung-Uk Kuh, Keun-Su Kim, Dong-Kyu Chin
    Neurospine.2026; 23(2): 506.     CrossRef
  • 1,465 View
  • 62 Download
  • 2 Crossref

Trauma

Comparative Analysis of Romosozumab Versus Vertebroplasty With Denosumab: Efficacy, Safety, and Secondary Bone Mineral Density Outcomes
Hyun Woong Mun, Jong Joo Lee, Hyun Chul Shin, Tae-Hwan Kim, Seok Woo Kim, Jae Keun Oh
Neurospine 2025;22(1):69-77.   Published online March 31, 2025
DOI: https://doi.org/10.14245/ns.2449228.614

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Comparative Analysis of Romosozumab Versus Vertebroplasty With Denosumab: Efficacy, Safety, and Secondary Bone Mineral Density Outcomes
Neurospine. 2025;22(1):69-77.   Published online March 31, 2025
DOI: https://doi.org/10.14245/ns.2449228.614
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Comparative Analysis of Romosozumab Versus Vertebroplasty With Denosumab: Efficacy, Safety, and Secondary Bone Mineral Density Outcomes
Neurospine. 2025;22(1):69-77.   Published online March 31, 2025
DOI: https://doi.org/10.14245/ns.2449228.614
Close
Objective
This study aimed to compare the efficacy and safety of romosozumab, a bone anabolic agent, versus vertebroplasty, a conventional surgical intervention, in treating osteoporotic vertebral compression fractures (OVCFs).
Methods
A retrospective analysis included 86 thoracic/lumbar compression fracture patients from 2014 to 2022 at a medical center. Forty-two patients received romosozumab (monthly injections for 1 year) followed by 1 year of denosumab, while 44 underwent vertebroplasty followed by denosumab injections biannually for 2 years. Outcomes were assessed using the Numerical Rating Scale (NRS) for pain, bone mineral density (BMD), vertebral compression ratio, and Cobb angle over 12 months.
Results
At 12 months, the romosozumab group showed a greater reduction in NRS scores (4.90 ± 1.01 vs. 4.27 ± 1.34, p = 0.015) and a higher increase in lumbar BMD (0.8 ± 0.5 vs. 0.5 ± 0.3, p = 0.000) compared to the vertebroplasty group. There were no significant differences in changes in hip total BMD and femur neck BMD (p = 0.190, p = 0.167, respectively). Radiographic assessments showed no significant differences in vertebral compression ratio (14.7% vs. 14.8%; p = 0.960) or Cobb angle (4.2° vs. 4.9°; p = 0.302). The incidence of major osteoporotic fractures was lower in the romosozumab group (7.1% vs. 25.0%, p = 0.051), with similar rates of cardiovascular events in both groups (4.8% vs. 9.1%, p = 0.716).
Conclusion
Romosozumab has demonstrated superior pain reduction and lumbar BMD improvement compared to vertebroplasty at 12 months, with no significant differences in radiographic outcomes or adverse events, suggesting it as an alternative to vertebroplasty for OVCF.

Citations

Citations to this article as recorded by  Crossref logo
  • Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis
    Yu‐Chuan Chang, Jian‐Chih Chen, Sung‐Yen Lin, Kun‐Der Lin, Pei‐Shan Ho, Chung‐Hwan Chen, Yin‐Chih Fu, Tien‐Ching Lee
    The Kaohsiung Journal of Medical Sciences.2026;[Epub]     CrossRef
  • Comparative Radiologic Outcomes of Romosozumab and Teriparatide in Osteoporotic Vertebral Fractures
    Jun-Seok Lee, Geon-U Kim, Ho-Young Jung, Young-Hoon Kim, Sang-Il Kim, Sangjun Park, Young-Yul Kim, Hyung-Youl Park
    Journal of Clinical Medicine.2026; 15(6): 2349.     CrossRef
  • Revisiting Cement Augmentation in Osteoporotic Vertebral Fractures: A Narrative Review
    Gilbert Bungay Dimacali, Byung Ho Lee
    Journal of Korean Society of Spine Surgery.2025; 32(4): 144.     CrossRef
  • 11,153 View
  • 220 Download
  • 1 Web of Science
  • 3 Crossref

Bone Biology and Osteoporosis Special Issue

Comparison of the Efficacy of Romosozumab and Teriparatide for the Management of Osteoporotic Vertebral Compression Fractures
Danbi Park, Seo Eun Kim, Hong Kyung Shin, Junghan Seo, Jeong Kyun Joo, Chongman Kim, Sang Hyub Lee, Jin Hoon Park
Neurospine 2023;20(4):1217-1223.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2347030.515

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Comparison of the Efficacy of Romosozumab and Teriparatide for the Management of Osteoporotic Vertebral Compression Fractures
Neurospine. 2023;20(4):1217-1223.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2347030.515
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Comparison of the Efficacy of Romosozumab and Teriparatide for the Management of Osteoporotic Vertebral Compression Fractures
Neurospine. 2023;20(4):1217-1223.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2347030.515
Close
Objective
Romosozumab is increasingly employed to manage osteoporosis. However, no studies have analyzed its effects on recent osteoporotic vertebral compression fractures (OVCFs). Therefore, this study aimed to evaluate the efficacy of romosozumab compared with teriparatide in managing OVCFs.
Methods
The electronic medical records of postmenopausal patients with recent OVCFs who were administered romosozumab or teriparatide for one year from March 2018 to August 2022 were retrospectively reviewed. We compared the 2 groups for demographics, radiological outcomes (compression ratio, Cobb angle, and bone mineral density [BMD]), and clinical outcomes (Numerical Rating Scale [NRS] for back pain).
Results
Fifty-five patients with OVCFs, 32 patients treated with romosozumab and 23 with teriparatide, were included in this study. The change of BMD (g/cm2) values was significantly higher (p = 0.016) in the romosozumab (0.04 ± 0.06) than in the teriparatide group (0.00 ± 0.08) in the femur total. Furthermore, in subgroup analysis, the change of BMD (g/cm2) values in the lumbar spine was significantly higher (p = 0.016) in the romosozumab (0.12 ± 0.06) than in the teriparatide group (0.07 ± 0.06) in the lumbar spine. The decrease in NRS was significantly higher (p = 0.013) in the romosozumab (6.6 ± 2.0) than in the teriparatide group (5.5 ± 2.1). However, there was no significant difference in radiologic outcomes between the 2 groups.
Conclusion
Our findings suggest that romosozumab may be more effective than teriparatide in treating OVCFs in postmenopausal females, particularly in improving BMD and reducing back pain as measured by NRS.

Citations

Citations to this article as recorded by  Crossref logo
  • Romosozumab mitigates progression from radiological to symptomatic adjacent-level fractures compared to teriparatide
    Wei-Han Kao, Yi-Shan Yang, Chen-Ling Lan, Wen-Cheng Lo, Yung-Hsiao Chiang, Jiann-Her Lin
    Osteoporosis International.2026; 37(2): 491.     CrossRef
  • Comparative Radiologic Outcomes of Romosozumab and Teriparatide in Osteoporotic Vertebral Fractures
    Jun-Seok Lee, Geon-U Kim, Ho-Young Jung, Young-Hoon Kim, Sang-Il Kim, Sangjun Park, Young-Yul Kim, Hyung-Youl Park
    Journal of Clinical Medicine.2026; 15(6): 2349.     CrossRef
  • Effectiveness of Posterior Long-Segment Fixation for Thoracolumbar Osteoporotic Compression Fractures: A Retrospective Study
    Jong-Hwan Hong, Jong-Hoon Jung, Ji-Ho Jung, Moon-Soo Han, Jung-Kil Lee
    World Neurosurgery.2025; 194: 123433.     CrossRef
  • Off-label use of teriparatide for the treatment of a vertebral burst fracture in a young patient: A case report and literature review
    Tiziano Villa, Vincenzo Zottola, Carlo Mariani, Alberto Borgonovo, Luciano Redenti
    Trauma Case Reports.2025; 55: 101127.     CrossRef
  • Comparative Analysis of Romosozumab Versus Vertebroplasty With Denosumab: Efficacy, Safety, and Secondary Bone Mineral Density Outcomes
    Hyun Woong Mun, Jong Joo Lee, Hyun Chul Shin, Tae-Hwan Kim, Seok Woo Kim, Jae Keun Oh
    Neurospine.2025; 22(1): 69.     CrossRef
  • A Commentary on “Comparative Analysis of Romosozumab Versus Vertebroplasty With Denosumab: Efficacy, Safety, and Secondary Bone Mineral Density Outcomes”
    Toshihiko Inui
    Neurospine.2025; 22(1): 78.     CrossRef
  • Comparing the Efficacy of Antiosteoporotic Drugs in Preventing Periprosthetic Bone Loss Following Total Hip Arthroplasty: A Systematic Review and Bayesian Network Meta‐Analysis
    Yi Tang, Zhaokai Jin, Yichen Lu, Lei Chen, Shuaijie Lv, Taotao Xu, Peijian Tong, Guoqian Chen
    Orthopaedic Surgery.2024; 16(10): 2344.     CrossRef
  • Commentary on “Deep Learning-Assisted Quantitative Measurement of Thoracolumbar Fracture Features on Lateral Radiographs”
    Chao-Hung Kuo
    Neurospine.2024; 21(1): 44.     CrossRef
  • Comparison of osteoanabolic agents (teriparatide and romosozumab) with bisphosphonates in prevention of subsequent vertebral fractures in patients treated for osteoporotic vertebral fracture for 12 months: An observational cohort study
    Keishi Maruo, Tomoyuki Kusukawa, Masakazu Toi, Tetsuto Yamaura, Masaru Hatano, Hayato Oishi, Kazuma Nagao, Fumihiro Arizumi, Kazuya Kishima, Norichika Yoshie, Toshiya Tachibana
    Bone Reports.2024; 21: 101762.     CrossRef
  • Incidence and Risk Factors of Sacral Fracture Following Lumbosacral Fusion for Degenerative Spinal Stenosis with a Minimum Follow-Up of 2 Years: A Case–Control Study
    Sang Hyub Lee, Dong-Hwan Kim, Jin Hoon Park, Dong-Geun Lee, Choon Keun Park, Dong Ho Kang
    World Neurosurgery.2024; 191: e633.     CrossRef
  • 11,740 View
  • 690 Download
  • 9 Web of Science
  • 10 Crossref

Bone Biology and Osteoporosis Special Issue

Screw Insertional Torque Measurement in Spine Surgery: Correlation With Bone Mineral Density and Hounsfield Unit
Byeong Ho Oh, Jee Yong Kim, Jong Beom Lee, Jae Taek Hong, Jae Hoon Sung, Khoi D. Than, Ho Jin Lee, Il Sup Kim
Neurospine 2023;20(4):1177-1185.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2346830.415

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Screw Insertional Torque Measurement in Spine Surgery: Correlation With Bone Mineral Density and Hounsfield Unit
Neurospine. 2023;20(4):1177-1185.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2346830.415
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Screw Insertional Torque Measurement in Spine Surgery: Correlation With Bone Mineral Density and Hounsfield Unit
Neurospine. 2023;20(4):1177-1185.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2346830.415
Close
Objective
Achieving successful fusion during spine surgery is dependent on rigid pedicle screw fixation. To assess fixation strength, the insertional torque can be measured during intraoperative screw fixation. This study aimed to explore the technical feasibility of measuring the insertional torque of a pedicle screw, while investigating its relationship with bone density.
Methods
Thoraco-lumbar screw fixation fusion surgery was performed on 53 patients (mean age, 65.5 ± 9.8 years). The insertional torque of 284 screws was measured at the point passing through the pedicle using a calibrated torque wrench, with a specially designed connector to the spine screw system. The Hounsfield units (HU) value was determined by assessing the trabecular portion of the index vertebral body on sagittal computed tomography images. We analyzed the relationship between the measured insertional torque and the following bone strength parameters: bone mineral density (BMD) and HU of the vertebral body.
Results
The mean insertion torque was 105.55 ± 58.08 N∙cm and T-score value (BMD) was -1.14 ± 1.49. Mean HU value was 136.37 ± 57.59. Screw insertion torque was positively correlated with BMD and HU in whole patients. However, in cases of osteopenia, all variables showed very weak correlations with insertional torque. In patients with osteoporosis, there was no statistically significant correlation between BMD and torque strength; HU showed a significant correlation.
Conclusion
The insertional torque of screw fixation significantly correlated with bone density (BMD and HU). HU measurements showed greater clinical significance than did BMD values in patients with osteoporosis.

Citations

Citations to this article as recorded by  Crossref logo
  • Femoral Bone Mineral Density Shows Stronger Correlation With Pedicle Screw Insertional Torque than Lumbar Bone Mineral Density or Hounsfield Units: A Retrospective in Vivo Study
    Yoji Ogura, Taisei Kato, Yuichiro Nishiyama, Keisuke Otsuka, Kenta Fujimura, Arya Varthi, Yoshihisa Suzuki
    Global Spine Journal.2026;[Epub]     CrossRef
  • 3D printing enabled biomechanical evaluation of a novel expandable wedge spacer for atlantoaxial reduction
    Chih-Chang Chang, Shao-Fu Huang, Rong-Chen Lin, Chun-Li Lin
    3D Printing in Medicine.2026;[Epub]     CrossRef
  • Pre-Operative Bone Health in Elective Spine Surgery, From Risk Assessment to Optimization Strategies: A Narrative Review
    Mitchell K. Ng, Morgan Hitchner, Jonathan Dalton, Yulia Lee, William A. Green, Gregorio Baek, Joshua Mathew, Yasmine K. Eichbaum, Alan S. Hilibrand, Alexander R. Vaccaro, Gregory D. Schroeder, Christopher K. Kepler
    Global Spine Journal.2026;[Epub]     CrossRef
  • Response to Letter to the Editor for “Femoral Bone Mineral Density Shows Stronger Correlation With Pedicle Screw Insertional Torque than Lumbar Bone Mineral Density or Hounsfield Units: A Retrospective in Vivo Study”
    Yoji Ogura
    Global Spine Journal.2026;[Epub]     CrossRef
  • A clinically applicable energy-based approach for evaluating bone strength
    Qiushi Bai, Jiahao Li, Chi Ma, Gengyu Cao, Yuanyi Wang, Da He, Sheng Lu, Qiang Yang, Yongchang Gao, Jingjing Tian, Kun Cheng, Yu Zhao
    Bone & Joint Research.2026; 15(5): 437.     CrossRef
  • The Correlation Analysis Between the Pedicle Screw Placement Palpation and Torque
    Dongping Wang, Jiamin Yang, Haishan Li, Wei Lin, Shenglin Lei, Yuxian Chen, Yawen You, Chang Liu, Yongxian Li, Yuewei Lin, Huizhi Guo, Guoye Mo, Yongchao Tang, Kai Yuan, Bin Mai, Zhen Zhang, Shuncong Zhang
    World Neurosurgery.2025; 194: 123439.     CrossRef
  • Visuohaptic Feedback in Robotic-Assisted Spine Surgery for Pedicle Screw Placement
    Giuseppe Loggia, Fedan Avrumova, Darren R. Lebl
    Journal of Clinical Medicine.2025; 14(11): 3804.     CrossRef
  • Ageing and BMI in Focus: Rethinking Risk Assessment for Vertebral Fragility and Pedicle Screw Loosening in Older Adults
    Jun Li, André Strahl, Beate Kunze, Stefan Krebs, Martin Stangenberg, Lennart Viezens, Patrick Strube, Marc Dreimann
    Journal of Clinical Medicine.2025; 14(15): 5296.     CrossRef
  • Comparative analysis of 3D CT values for different lumbar pedicle screw trajectories
    Yuanpeng Yue, Ce Dong, Anhang Zhang, Zhenyu Wang
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Long Fiber Type Carbon Fiber Reinforced Plastic Pedicle Screws Exhibit High Strength, Comparable to Titanium-Alloy Screws, and Are Resistant to Loosening
    Kohei Morita, Hiroki Ohashi, Kenji Tsuchida, Yasuhiro Furuta, Satoshi Tani, Kostadin Karagiozov, Yuichi Murayama
    Neurospine.2025; 22(3): 774.     CrossRef
  • Analysis of the performance of different screws in the presence of bone density variability
    Zhirui Lu, Zhongshu Shan, Shuangshuang Ma, Wenxu Xu, Zhibin Liu, Dedong Gao
    Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.2025; 239(11-12): 1121.     CrossRef
  • Does Resistance Indicate Malposition? A Standardized Comparison of Pedicle Screw Placement
    Sascha Kurz, Benjamin Fischer, Janine Schultze, Florian Metzner, Toni Wendler, Christoph-Eckhard Heyde, Stefan Schleifenbaum
    Bioengineering.2025; 12(11): 1254.     CrossRef
  • 7,193 View
  • 338 Download
  • 12 Web of Science
  • 12 Crossref
Predicting Mechanical Complications After Adult Spinal Deformity Operation Using a Machine Learning Based on Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density
Sung Hyun Noh, Hye Sun Lee, Go Eun Park, Yoon Ha, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Sang Hyun Kim, Kyung Hyun Kim
Neurospine 2023;20(1):265-274.   Published online March 31, 2023
DOI: https://doi.org/10.14245/ns.2244854.427

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Predicting Mechanical Complications After Adult Spinal Deformity Operation Using a Machine Learning Based on Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density
Neurospine. 2023;20(1):265-274.   Published online March 31, 2023
DOI: https://doi.org/10.14245/ns.2244854.427
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Predicting Mechanical Complications After Adult Spinal Deformity Operation Using a Machine Learning Based on Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density
Neurospine. 2023;20(1):265-274.   Published online March 31, 2023
DOI: https://doi.org/10.14245/ns.2244854.427
Close
Objective
This study aimed to create an ideal machine learning model to predict mechanical complications in adult spinal deformity (ASD) surgery based on GAPB (modified global alignment and proportion scoring with body mass index and bone mineral density) factors.
Methods
Between January 2009 and December 2018, 238 consecutive patients with ASD, who received at least 4-level fusions and were followed-up for ≥ 2 years, were included in the study. The data were stratified into training (n = 167, 70%) and test (n = 71, 30%) sets and input to machine learning algorithms, including logistic regression, random forest gradient boosting system, and deep neural network.
Results
Body mass index, bone mineral density, the relative pelvic version score, the relative lumbar lordosis score, and the relative sagittal alignment score of the global alignment and proportion score were significantly different in the training and test sets (p < 0.05) between the complication and no complication groups. In the training set, the area under receiver operating characteristics (AUROCs) for logistic regression, gradient boosting, random forest, and deep neural network were 0.871 (0.817–0.925), 0.942 (0.911–0.974), 1.000 (1.000–1.000), and 0.947 (0.915–0.980), respectively, and the accuracies were 0.784 (0.722–0.847), 0.868 (0.817–0.920), 1.000 (1.000–1.000), and 0.856 (0.803–0.909), respectively. In the test set, the AUROCs were 0.785 (0.678–0.893), 0.808 (0.702–0.914), 0.810 (0.710–0.910), and 0.730 (0.610–0.850), respectively, and the accuracies were 0.732 (0.629–0.835), 0.718 (0.614–0.823), 0.732 (0.629–0.835), and 0.620 (0.507–0.733), respectively. The random forest achieved the best predictive performance on the training and test dataset.
Conclusion
This study created a comprehensive model to predict mechanical complications after ASD surgery. The best prediction accuracy was 73.2% for predicting mechanical complications after ASD surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • Determining the risk factors for postoperative mechanical complication in degenerative scoliosis: a machine learning approach based on musculoskeletal metrics
    Jie Li, Zhen Tian, Yinyu Fang, Zhong He, Yanjie Xu, Hui Xu, Zezhang Zhu, Yong Qiu, Zhen Liu
    European Spine Journal.2026; 35(1): 156.     CrossRef
  • Development and validation of a deep learning–powered system for multi-version global alignment and proportion score to predict mechanical complications after adult degenerative scoliosis surgery
    Qifeng Lan, Shanshan Liu, Cheng Zhang, Chenyi Guo, Yiming Shi, Jian He, Xingyu Zhou, Jiaheng Shang, Qiang Qi, Zhaoqing Guo, Zhuoran Sun, Siyu Zhou, Ji Wu, Nanfang Xu, Weishi Li
    European Spine Journal.2026; 35(2): 375.     CrossRef
  • Proximal Junctional Kyphosis Prevention in Adult Spinal Deformity Surgery: A Technical Review of Tethering and Adjunctive Strategies
    Paritash Tahmasebpour, Pawel P. Jankowski, Jason Liang, Joshua Lin, Kyriakos D. Chatzis, Peter S. Tretiakov, Spencer Matthews, Louis Boissiere, John F. Burke, Christopher I. Shaffrey, Aaron Hockley, Peter Passias
    Operative Neurosurgery.2026;[Epub]     CrossRef
  • Predicting postoperative mechanical complications with the ethnicity-adjusted global alignment and proportion score in degenerative scoliosis: does paraspinal muscle degeneration matter?
    Peiyu Li, Jie Li, Abdukahar Kiram, Zhen Tian, Xing Sun, Xiaodong Qin, Benlong Shi, Yong Qiu, Zhen Liu, Zezhang Zhu
    The Spine Journal.2025; 25(2): 347.     CrossRef
  • Uso de inteligencia artificial para predecir complicaciones en cirugías de columna toracolumbar degenerativa: revisión sistemática
    G. Ricciardi, J.I. Cirillo Totera, R. Pons Belmonte, L. Romero Valverde, F. López Muñoz, A. Manríquez Díaz
    Revista Española de Cirugía Ortopédica y Traumatología.2025; 69(5): 446.     CrossRef
  • Risk Factors of 90-Day Unplanned Readmission After Lumbar Spine Surgery for Degenerative Lumbar Disk Disease: A Systematic Review and Meta-Analysis
    Jeong In Seol, Jeong Hoon Yoo, Hyeon Gyu Sung, Hyun Ho Park, Sung Hyeon Noh
    Neurosurgery.2025; 97(4): 908.     CrossRef
  • AI and machine learning in paediatric spine deformity surgery
    Mohsin Khan, Kaustubh Ahuja, Athanasios I Tsirikos
    Bone & Joint Open.2025; 6(5): 569.     CrossRef
  • Novel risk factors and personalized risk calculator for predicting proximal junctional kyphosis after adult spinal deformity surgery
    Qijun Wang, Zheng Wang, Dongfan Wang, Xuan Zhao, Xiaolong Chen, Shibao Lu
    The Bone & Joint Journal.2025; 107-B(8): 829.     CrossRef
  • [Translated article] Use of artificial intelligence to predict complications in degenerative thoracolumbar spine surgery: A systematic review
    G. Ricciardi, J.I. Cirillo Totera, R. Pons Belmonte, L. Romero Valverde, F. López Muñoz, A. Manríquez Díaz
    Revista Española de Cirugía Ortopédica y Traumatología.2025; 69(5): T446.     CrossRef
  • Applications of Artificial Intelligence in the Diagnosis and Treatment of Pediatric Congenital malformations: Recent Advances
    鑫 王
    Advances in Clinical Medicine.2025; 15(09): 91.     CrossRef
  • The predictive value of the global alignment and proportion (GAP) score for mechanical complications following adult spinal deformity surgery: A systematic review and meta-analysis
    Vinicius Ricieri Ferraz, Guilherme Santos Piedade, Carlos R. Goulart, Maria Fernanda Ricieri Ferraz Franco de Souza, Marcelo Ochoa Coelho de Souza Furlan, Philippe A. Mercier, Tobias A. Mattei
    North American Spine Society Journal (NASSJ).2025; 24: 100816.     CrossRef
  • Predicting proximal junctional failure in adult spinal deformity patients using machine learning models based on spinal alignment parameters
    Akihiko Hiyama, Daisuke Sakai, Hiroyuki Katoh, Masato Sato, Masahiko Watanabe
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  • 8,006 View
  • 253 Download
  • 25 Web of Science
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Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density Analysis in Global Alignment and Proportion Score of Each 3 Categories for Predicting Mechanical Complications After Adult Spinal Deformity Surgery
Sung Hyun Noh, Yoon Ha, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Hye Sun Lee, Kyung Hyun Kim
Neurospine 2021;18(3):484-491.   Published online September 30, 2021
DOI: https://doi.org/10.14245/ns.2142470.235

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Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density Analysis in Global Alignment and Proportion Score of Each 3 Categories for Predicting Mechanical Complications After Adult Spinal Deformity Surgery
Neurospine. 2021;18(3):484-491.   Published online September 30, 2021
DOI: https://doi.org/10.14245/ns.2142470.235
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Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density Analysis in Global Alignment and Proportion Score of Each 3 Categories for Predicting Mechanical Complications After Adult Spinal Deformity Surgery
Neurospine. 2021;18(3):484-491.   Published online September 30, 2021
DOI: https://doi.org/10.14245/ns.2142470.235
Close
Objective
This study aimed to analyze the prediction rate of the modified Global Alignment and Proportion (GAP) scoring system with body mass index and bone mineral density (GAPB) in each GAP of the 3 categories.
Methods
Between January 2009 and December 2016, 203 consecutive patients with adult spinal deformity (ASD) underwent corrective fusion of more than 4 levels and were followedup for more than 2 years. As a validation of the GAPB, the GAPB was divided into tertiles (Q1, Q2, Q3) for each section of the GAP score. Each patient’s GAP score and GAPB system complication rate were examined.
Results
Of the 203 patients, 89 patients (44%) developed mechanical complications after ASD surgery. A GAP score analysis of the patients found that 42 patients were proportioned, 85 patients were moderately disproportioned, and 76 patients were severely disproportioned. Mechanical complications occurred with increasing GAPB in the proportioned group, but were not statistically significant (p = 0.0534). However, mechanical complications occurred in a statistically significant manner in the moderately disproportioned and severely disproportioned groups as GAPB increased (p < 0.001).
Conclusion
The GAPB system showed improved predictability for mechanical complications after surgery for ASD in each category of the GAP score.

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Clinical Article

Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats
Seong Jun Ryu, Dal Sung Ryu, Jong Yul Kim, Jeong Yoon Park, Kyung Hyun Kim, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Sung Uk Kuh
Korean J Spine 2015;12(2):55-59.   Published online June 30, 2015
DOI: https://doi.org/10.14245/kjs.2015.12.2.55

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Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats
Korean J Spine. 2015;12(2):55-59.   Published online June 30, 2015
DOI: https://doi.org/10.14245/kjs.2015.12.2.55
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Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats
Korean J Spine. 2015;12(2):55-59.   Published online June 30, 2015
DOI: https://doi.org/10.14245/kjs.2015.12.2.55
Close
Objective

To investigate a suitable animal model for studies of male osteoporosis. Osteoporosis has a particularly high incidence in postmenopausal women, resulting in a substantial amount of research with respect to this disease in women. However, research on osteoporosis in men is still lacking.

Methods

Twenty 10-week-old male Sprague Dawley rats were used in this study, including 4 rats used to establish a baseline bone mineral density (BMD). The other 16 rats were divided into two groups: a sham surgery group (n=8), which underwent a sham operation, and an orchiectomized rat group (OCX) (n=8), which underwent bilateral OCX at 10 weeks of age. Bone mineral density was measured in 4 rats from both the sham surgery group and the OCX group 8 weeks after the surgery, while BMD in the remainder of the rats was measured 10 weeks post-surgery.

Results

Femoral BMD at 8 weeks post-surgery was found to be significantly lower in the OCX group compared to the sham group; a finding that was also similar 10 weeks post-surgery.

Conclusion

8 weeks after undergoing orchiectomy performed via a scrotal, white rats are a suitable model for studies of male osteoporosis.

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    The Aging Male.2021; 24(1): 139.     CrossRef
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    Kyung A Back, Se Hwan Park, Jin Hwan Yoon
    Exercise Science.2020; 29(2): 138.     CrossRef
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    Marina Komrakova, Janek Nagel, Daniel Bernd Hoffmann, Wolfgang Lehmann, Arndt Friedrich Schilling, Stephan Sehmisch
    Calcified Tissue International.2020; 107(6): 593.     CrossRef
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    Hussein F. Sakr, Abdelaziz M. Hussein, Elsayed A. Eid, Ammar Boudaka, Lashin S. Lashin
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    M. Ben Laiba, W. Douki, R. Chemli
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    Seong-Jun Ryu, Dal-Sung Ryu, Jong-Yeol Kim, Jeong-Yoon Park, Kyung-Hyun Kim, Dong-Kyu Chin, Keun-Su Kim, Yong-Eun Cho, Sung-Uk Kuh
    Yonsei Medical Journal.2016; 57(6): 1386.     CrossRef
  • 10,915 View
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