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Tumor

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Clinical Decision Making and Outcomes of Sagittal Vertebral Resection: A Head-to-Head Comparison With Total Vertebral Resection
Neurospine. 2026;23(3):740-753.   Published online July 31, 2026
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Clinical Decision Making and Outcomes of Sagittal Vertebral Resection: A Head-to-Head Comparison With Total Vertebral Resection
Neurospine. 2026;23(3):740-753.   Published online July 31, 2026
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Objective
To compare perioperative burden, hardware outcomes, and oncologic control between sagittal vertebral resection (SVR) and total vertebral resection (TVR) for thoracolumbar tumors, and to propose a practical framework for SVR surgical decision making.
Methods
Clinical data, operative parameters, and follow-up outcomes were retrospectively analyzed. To address baseline imbalances in tumor volume and preoperative embolization, a 1:1 propensity score matching was performed based on 5 critical covariates, resulting in a matched cohort of 78 patients (39 per group). Groups were compared using Student t-test or Mann-Whitney U-test for continuous variables and chi-square/Fisher exact test for categorical variables.
Results
In the total cohort (39 SVR vs. 84 TVR), SVR significantly reduced blood loss (median 1,200 mL vs. 1,500 mL, p=0.016), transfusion (800 mL vs. 1,200 mL, p<0.001), complication rate (51.3% vs. 77.4%, p=0.004), and hospital stay (13.7 days vs. 19.0 days, p=0.012). Bilateral nerve root sacrifice was less frequent in SVR (41.0% vs. 69.0%, p<0.001). Negative surgical margins (71.8% vs. 73.8%, p=0.814) and local recurrence (12.8% vs. 13.1%, p=0.965) were comparable. Postmatching analysis (n=78) confirmed that even after balancing for tumor volume and embolization, the SVR group maintained significant advantages in blood loss (p=0.035) and operation time (p=0.041). Hardware failure occurred in 3 TVR patients (3.6%) but in none after SVR.
Conclusion
SVR significantly reduces perioperative morbidity while maintaining comparable oncologic outcomes relative to TVR. The superiority of SVR remains robust after propensity score adjustment for tumor complexity. By formalizing a type-based surgical decision-making framework, this study provides practical guidance for when and how SVR may be safely adopted as a standardized alternative to TVR in appropriately selected thoracolumbar tumors.
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Transforaminal Endoscopic Thoracic Discectomy Is More Cost-Effective Than Microdiscectomy for Symptomatic Disc Herniations
Neurospine. 2025;22(1):118-127.   Published online March 31, 2025
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Transforaminal Endoscopic Thoracic Discectomy Is More Cost-Effective Than Microdiscectomy for Symptomatic Disc Herniations
Neurospine. 2025;22(1):118-127.   Published online March 31, 2025
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Objective
To analyze costs and cost-effectiveness of transforaminal endoscopic thoracic discectomy (TETD) for the treatment of symptomatic thoracic disc herniation (TDH) and compare it with open microdiscectomy (MD).
Methods
This retrospective cohort study included patients who underwent TETD or MD for symptomatic TDH and had a minimum follow-up of 1 year. Cost analysis included direct costs (primary and secondary hospital costs), indirect costs (lost wages due to work absence), total costs (direct + indirect), and cost-effectiveness (cost per quality-adjusted life year [QALY] and incremental cost-effectiveness ratio [ICER]). Clinical outcomes included patient-reported outcome measures (Oswestry Disability Index [ODI], 36-item Short Form health survey [SF-36]), QALY gained, and reoperation and readmission rates at 1 year. TETD and MD groups were compared for outcome measures.
Results
A total of 111 patients (57 TETD, 54 MD) were included. The direct ($6,270 TETD vs. $7,410 MD, p < 0.01), indirect costs ($1,250 TETD vs. $1,450 MD, p < 0.01), total costs ($7,520 TETD vs. $8,860 MD, p < 0.01), and cost per QALY ($31,333 TETD vs. $44,300 MD, p < 0.01) were significantly lower for TETD compared to MD. ICER of TETD was found to be -$33,500. At 1 year, TETD group showed significantly greater improvement in ODI (46% vs. 36%, p < 0.01) and SF-36 (64% vs. 53%, p < 0.01) and significantly greater QALY gained (0.24 vs. 0.2, p < 0.01) compared to MD group. No significant difference was found in reoperation and readmission rates.
Conclusion
TETD demonstrated significantly better clinical outcomes, lower overall costs, and better cost-effectiveness than MD in appropriately selected patients of symptomatic TDH.

Citations

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  • Editorial: Beyond the Portal Wars—Forging a New Consensus in Endoscopic Spine Surgery
    Jin-Sung Kim, Piya Chavalparit
    Global Spine Journal.2026; 16(1): 9.     CrossRef
  • Uniportal Endoscopic Surgery for Thoracolumbar Junction Disc Herniation in a Patient With Myelopathy: A Technical Note and Surgical Video
    Kang Suk Moon, Michel Gustavo Mondragón-Soto, Pedro Leonardo Villanueva-Solórzano
    Journal of Minimally Invasive Spine Surgery and Technique.2026; 11(1): 155.     CrossRef
  • Measuring Value in Surgery: A Scoping Review of Economic Indices Across Specialties
    Kenneth Nguyen, Emaad Lala, Kento Yamanouchi, Sydney Pattison, Aiyush Bansal, Abhinav Balu, Mir Amaan Ali, Philip K. Louie
    Journal of Surgical Research.2026; 325: 32.     CrossRef
  • Biportal Endoscopic Transforaminal Approach for Midthoracic Calcified Herniated Disc: A Case Report and Technical Note
    Young-Il Ko, Hun-Chul Kim, Jin-Young Lee
    Journal of Minimally Invasive Spine Surgery and Technique.2026; 11(Suppl 2): S343.     CrossRef
  • 7,855 View
  • 202 Download
  • 6 Web of Science
  • 4 Crossref

Review Article

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Clinical Outcomes and Patient Perspectives in Full Endoscopic Cervical Surgery: A Systematic Review
Neurospine. 2025;22(1):81-104.   Published online March 31, 2025
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Clinical Outcomes and Patient Perspectives in Full Endoscopic Cervical Surgery: A Systematic Review
Neurospine. 2025;22(1):81-104.   Published online March 31, 2025
Close
Objective
Full endoscopic cervical surgery (FECS) is an evolving minimally invasive approach for treating cervical spine disorders. This systematic review synthesizes current evidence on the clinical outcomes and patient perspectives associated with FECS, specifically evaluating its safety, efficacy, and overall patient satisfaction.
Methods
A systematic search of the PubMed/MEDLINE, Cochrane Library, Embase, and Web of Science databases was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies published between January 2000 and September 2024 that reported on clinical outcomes or patient perspectives related to FECS were included. Risk of bias was assessed using the ROBINS-I (Risk Of Bias In Non-randomized Studies - of Interventions) tool and the Cochrane Risk of Bias tool. Inclusion criteria encompassed randomized controlled trials, prospective cohort studies, retrospective studies, and observational studies focused on adult populations undergoing FECS for cervical spine surgery.
Results
The final synthesis included 30 studies. FECS was associated with significant reductions in both cervical and radicular pain, as well as meaningful functional improvements, measured by standardized clinical scales such as the Neck Disability Index and visual analogue scale. Patient satisfaction rates were consistently high, with most studies reporting satisfaction exceeding 85%. Complication rates were low, primarily involving transient neurological deficits that were typically resolved without the need for further intervention. Nonrandomized studies generally presented a moderate risk of bias due to confounding and selection, whereas randomized controlled trials exhibited a low risk of bias.
Conclusion
FECS is a safe and effective minimally invasive surgical option for cervical spine disorders associated with substantial pain relief, functional improvement and high levels of patient satisfaction.

Citations

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  • Response to the letter to the editor: Inconsistencies in obesity criteria: implications for systematic reviews on endoscopic spine surgery
    Wongthawat Liawrungrueang, Watcharaporn Cholamjiak, Peem Sarasombath, Yudha Mathan Sakti, Pang Hung Wu, Meng-Huang Wu, Yu-Jen Lu, Lo Cho Yau, Zenya Ito, Sung Tan Cho, Dong-Gune Chang, Kang Taek Lim
    Asian Spine Journal.2026; 20(1): 211.     CrossRef
  • Full-Endoscopic Posterior Cervical Foraminotomy and Discectomy for Cervical Disc Hernia With Unilateral Radiculopathy
    Idris Gurpinar, Mehmet Yigit Akgun, Furkan Almas, Ozkan Ates
    Journal of Minimally Invasive Spine Surgery and Technique.2026; 11(1): 149.     CrossRef
  • Clinical and Functional Outcomes of Posterior Endoscopic Decompression for Symptomatic Cervical Disc Herniation
    Adam Mahendra Teja, Muhammed Anzar, Cheol Wung Park
    Cureus.2026;[Epub]     CrossRef
  • Ultrasound-guided brachial plexus hydrodissection combined with acupotomy release for the treatment of cervical spondylotic radiculopathy: a multicenter retrospective study
    Xiang Shang, Guo-Rui Luan, Yang-Chun Song, Fen Zhang, San-Bing Wu, Kai Geng, Hou-Shan Fang, Wei Wei, Zhen-Ya Wang, Han-Qing Zhao, Yong-Hui Yang, De-Hong Meng
    Frontiers in Aging Neuroscience.2026;[Epub]     CrossRef
  • Current Trends and Future Directions in Lumbar Spine Surgery: A Review of Emerging Techniques and Evolving Management Paradigms
    Gianluca Galieri, Vittorio Orlando, Roberto Altieri, Manlio Barbarisi, Alessandro Olivi, Giovanni Sabatino, Giuseppe La Rocca
    Journal of Clinical Medicine.2025; 14(10): 3390.     CrossRef
  • Navigated Minimally Invasive Cervical and Cervicothoracic Fixation: A Technical Note on Surgical Technique and Proposed Classification
    Spyridon Komaitis, Konstantinos Zygogiannis, Sotirios Karatzoglou, Dimitrios Klitsinikos, Dritan Pasku, Khalid Salem
    Cureus.2025;[Epub]     CrossRef
  • 15,097 View
  • 227 Download
  • 5 Web of Science
  • 6 Crossref

Original Articles

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Preliminary Clinical and Radiological Outcomes of the “No-Punch” Decompression Techniques for Unilateral Biportal Endoscopic Spine Surgery
Neurospine. 2024;21(2):732-741.   Published online June 30, 2024
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Preliminary Clinical and Radiological Outcomes of the “No-Punch” Decompression Techniques for Unilateral Biportal Endoscopic Spine Surgery
Neurospine. 2024;21(2):732-741.   Published online June 30, 2024
Close
Objective
To avoid the most offending surgical instrument for dural tears, we develop a “no-punch” decompression technique for unilateral biportal endoscopic (UBE) spine surgery.
Methods
This retrospective study enrolled 68 consecutive patients with degenerative lumbar spinal stenosis segments. The treatment results were evaluated using the visual analogue scale (VAS) for low back and leg pain, the Japanese Orthopaedic Association (JOA) scores, and the Oswestry Disability Index (ODI). Radiological outcomes were evaluated using the preoperative and postoperative magnetic resonance imaging.
Results
This study included 36 male and 32 female patients who received 109 segments of decompression, with an average age of 68.7 (37–90 years). The average operation time was 52.2 minutes. The average hospital stay was 3.1 days. There were no dural tears but 3 minor surgical complications, all treated conservatively. The VAS for low back and leg pain improved from 4.6 and 7.0 to 0.8 and 1.2. The JOA score improved from 16.2 to 26.8, with an improvement rate of 82.0%. The ODI improved from 50.1 to 18.7. All these improvements were statistically significant. The cross-sectional dural area improved from 61.1 to 151.3 mm2, with an average increase of 90.2 mm2 and 205.3%. 87.1% of the ipsilateral facet joints and 84.7% of the contralateral facet joints were preserved. In 61% of the decompressed segments, the ipsilateral facet joints were preserved better than the contralateral facet joints.
Conclusion
The UBE “no-punch” decompression technique effectively avoids the dural tears. It provides effective neural decompression, excellent facet joint preservation, and good treatment outcomes.

Citations

Citations to this article as recorded by  Crossref logo
  • Clinical outcomes of unilateral biportal endoscopic discectomy vs. microdiscectomy in lumbar disc herniation
    Yi He, Peng-fei Cao, Yin Zhang, Xun-an Xu, Tong-guang Xu
    Frontiers in Medicine.2026;[Epub]     CrossRef
  • Complications and their prevention in unilateral biportal endoscopy: a systematic review with narrative insights and practical management algorithms
    Xavier A. Santander, Martin N. Stienen, Stefan Motov, Héctor U. Quintanilla, Elsa González Pérez
    Acta Neurochirurgica.2026;[Epub]     CrossRef
  • The influence of the positional relationship between the pedicle and the pars interarticularis on unilateral biportal endoscopy: A retrospective cohort study
    Shaoning Shen, Tingyuan Lai, Hao Wei, Wangnan Mao, Lianguo Wu, Hanbing Zeng
    Medicine.2026; 105(12): e47945.     CrossRef
  • Comparison of short-term clinical efficacy between percutaneous endoscopic transforaminal discectomy and unilateral biportal endoscopy in the treatment of upper lumbar disc herniation
    Jing Zhang, Zhinan Ren, Lei Yu, Cheng Peng, Yingjie Hao
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • O‐Arm Navigation Enhances Facet Preservation Without Compromising Clinical Outcomes in UBE Decompression for Radiographically Stable Adult Degenerative Scoliosis: A Single‐Center Comparative Study
    Yi Liu, Yiwei Xie, Zhibao Chen, Ruijun Xu, Haojie Chen, Xiaojian Ye, Jiangming Yu
    Orthopaedic Surgery.2026; 18(6): 1203.     CrossRef
  • Comparison of clinical efficacy and minimal invasiveness between unilateral biportal endoscopic and percutaneous endoscopic lumbar discectomy in the treatment of calcified lumbar disc herniation: a retrospective analysis
    Zhifeng Cheng, Lei Sun, Tao Tang, Qiang Wu, Likan Liang, Haonan Lu, Hao Xu, Bo Hu
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • Comparative efficacy of unilateral biportal endoscopy versus endoscopic foraminoplasty decompression for single-level lumbar spinal stenosis: a retrospective cohort study
    Xu Qiao, Cao Rui, Aikebaierjiang Aisaiti, Li Ning, Shi Lingyun, Sheng Weibin
    Frontiers in Surgery.2026;[Epub]     CrossRef
  • Cost-effectiveness analysis of the early transition from microscopic to biportal endoscopic unilateral laminectomy bilateral decompression
    Sung-Eun Kwon, Hangeul Park, Noah Hong, Woojin Kim, Jungbo Sim, Ho Sung Myeong, Seunghoon Lee, Jun-Hoe Kim, Chang-Hyun Lee, Fon-Yih Tsuang, Chi Heon Kim
    Medicine.2026; 105(34): e50400.     CrossRef
  • Clinical Outcomes of Unilateral Biportal Endoscopy in Lumbar Disc Herniation and Degenerative Lumbar Canal Stenosis
    Chandrashekhar Vijay Gaike, Shraddha Dattatraya Kardile, Girish Namdevrao Gadekar, Saurabh Shrikant Kulkarni
    International Journal of Recent Surgical and Medical Sciences.2025; 11: e004.     CrossRef
  • A Comparative Study of the No-Punch Technique in Reducing Surgical Complications Associated with Unilateral Biportal Endoscopic Spine Surgery
    Jwo-Luen Pao, Chun-Chien Chang
    Journal of Clinical Medicine.2025; 14(20): 7295.     CrossRef
  • Unilateral biportal endoscopy for the treatment of adjacent segment disease after lumbar fusion in elderly patients: a matched comparison study
    Hongwei Duan, Minghui Liang, Yu Xi, Ruiyuan Chen, Ning Fan, Tianyi Wang, Aobo Wang, Ziqian Ma, Lei Zang, Shuo Yuan
    Frontiers in Surgery.2025;[Epub]     CrossRef
  • Biportal Endoscopic Transforaminal Lumbar Interbody Fusion: The Double-Cage Technique
    Jwo-Luen Pao
    Journal of Minimally Invasive Spine Surgery and Technique.2024; 9(2): 203.     CrossRef
  • 9,024 View
  • 496 Download
  • 12 Web of Science
  • 12 Crossref

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Severe Preoperative Disability Is Associated With Greater Mental Health Improvements Following Surgery for Degenerative Spondylolisthesis: A Cohort Matched Analysis
Neurospine. 2024;21(1):253-260.   Published online January 31, 2024
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Severe Preoperative Disability Is Associated With Greater Mental Health Improvements Following Surgery for Degenerative Spondylolisthesis: A Cohort Matched Analysis
Neurospine. 2024;21(1):253-260.   Published online January 31, 2024
Close
Objective
To evaluate preoperative disability’s influence on patient-reported outcomes (PROs) following surgery for degenerative spondylolisthesis (DS).
Methods
DS patients who underwent surgical intervention were retrospectively identified from a single-surgeon spine registry. Cohorts based on Oswestry Disability Index (ODI) < 41 (milder disability) and ≥ 41 (severe disability) were created. Demographic differences were accounted for with 1:1 propensity score matching. For the matched sample, perioperative and PRO data were additionally collected. PROs assessed included mental health, physical function, pain, and disability. Pre- and up to 2-year postoperative PROs were utilized. Average time to final follow-up was 15.7 ± 8.8 months. Improvements in PROs and minimal clinically important difference (MCID) rates were calculated. Continuous variables were compared through Student t-test and categorical variables were compared through chi-square tests.
Results
Altogether, 214 patients were included with 77 in the milder disability group. The severe disability group had worse postoperative day (POD) 1 pain scores and longer hospital stays (p ≤ 0.038, both). The severe disability group reported worse outcomes pre- and postoperatively (p < 0.011, all), but had greater average improvement in 12-item Short Form health survey mental composite score (SF-12 MCS), 9-Item Patient Health Questionnaire (PHQ-9), visual analogue scale (VAS)-back, and ODI by 6 weeks (p ≤ 0.037, all) and PHQ-9, VAS-back and ODI by final follow-up (p ≤ 0.015, all). The severe disability cohort was more likely to achieve MCID for SF-12 MCS, PHQ-9, and ODI (p ≤ 0.003, all).
Conclusion
Patients with greater baseline disability report higher POD 1 pain and discharge later than patients with milder disability. While these patients report inferior physical/mental health before and after surgery, they report greater improvements in mental health and disability postoperatively.

Citations

Citations to this article as recorded by  Crossref logo
  • Surgical Site Infection After Primary Posterior Lumbar Fusion Increases the Risk of New-Onset Mental Health Disorders:
    Matthew H. Meade, Omar Sbaih, Hunter Smith, Nithin Gupta, Mark Miller, Ruchir Nanavati, William DiCiurcio, Hikmat Chmait, Mitchell Ng, Gregory Schroeder, Christopher Kepler, Barrett Woods, Andrew P. White
    Spine Open.2026;[Epub]     CrossRef
  • Passive recharge burst spinal cord stimulation for the treatment of refractory nonsurgical low back pain: 24-month results from a prospective randomized controlled trial and predictors of success
    James J Yue, Steven Falowski, Edward Tavel, Robert Heros, Anne Christopher, Denis Patterson, Robert Funk, Ibrahim Mohab, Sayed Wahezi, Jacqueline Weisbein, Christopher J Gilligan, Ajay Antony, Michael Fishell, Jessica Jameson, Chi Lim, Nathan Miller, Derr
    North American Spine Society Journal (NASSJ).2026; 27: 100911.     CrossRef
  • Analysis of preoperative and postoperative depression and anxiety in patients with lumbar disc herniation with radiculopathy treated with percutaneous transforaminal endoscopic discectomy
    Yatao Wei, Hailun Huang, Kui Sun, Heng Gao, Zhenwen Cao, Bin Zhang, Junzhe Wu, Yongai Liu
    Frontiers in Psychiatry.2024;[Epub]     CrossRef
  • 5,307 View
  • 89 Download
  • 2 Web of Science
  • 3 Crossref

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Comparing Outcomes of Banana-Shaped and Straight Cages in Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Diseases: A Systematic Review and Meta-Analysis
Neurospine. 2024;21(1):261-272.   Published online January 31, 2024
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Comparing Outcomes of Banana-Shaped and Straight Cages in Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Diseases: A Systematic Review and Meta-Analysis
Neurospine. 2024;21(1):261-272.   Published online January 31, 2024
Close
Objective
This meta-analysis aims to refine the understanding of the optimal choice between different cage shapes in transforaminal lumbar interbody fusion (TLIF) by systematically comparing perioperative data, radiological outcomes, clinical results, and complications associated with banana-shaped and straight bullet cages.
Methods
A meticulous literature search encompassing PubMed, Embase, Scopus, Web of Science, China Knowledge Network, and Wanfang Data was executed up to October 5, 2023. Inclusion criteria focused on studies comparing banana-shaped and straight bullet cages in TLIF. The quality of included studies was assessed using appropriate tools such as the Newcastle-Ottawa Scale (NOS) for nonrandomized studies. Rigorous evaluations were performed for radiographic outcomes, including disc height (DH), segmental lordosis (SL), lumbar lordosis (LL), subsidence, and fusion rates. Clinical outcomes were meticulously evaluated using visual analogue scale (VAS), Oswestry Disability Index (ODI), and complications.
Results
The analysis incorporated 7 studies, involving 573 patients (297 with banana-shaped cages, 276 with straight cages), all with NOS ratings exceeding 5 stars. No statistically significant differences were observed in operative time, blood loss, or hospitalization between the 2 cage shapes. Banana-shaped cages exhibited greater changes in DH (p = 0.001), SL (p = 0.02), and LL (p = 0.01). Despite statistically higher changes in ODI for straight cages (26.33, p < 0.0001), the actual value remained similar to banana-shaped cages (26.15). Both cage types demonstrated similar efficacy in VAS, complication rates, subsidence, and fusion rates.
Conclusion
Although banana-shaped cages can excel in restoring DH, SL, and LL, straight bullet cages can provide comparable functional improvements, pain relief, and complication rates.

Citations

Citations to this article as recorded by  Crossref logo
  • Cage design-centric glider approach to full-endoscopic lumbar fusion: optimizing nerve root protection in facet-sparing and facet-resecting techniques
    Yu-Chia Hsu, Hao-Chun Chuang, Yuan-Fu Liu, Chao-Jui Chang, Yu-Meng Hsiao, Yi-Hung Huang, Keng-Chang Liu, Chien-Min Chen, Hyeun-Sung Kim, Cheng-Li Lin
    Asian Spine Journal.2026; 20(2): 343.     CrossRef
  • Recovery outcomes for military personnel undergoing surgery for lumbar spinal stenosis induced by physical overload: a retrospective study
    Vasyl Melenko, Lyudmila Kravchuk, Dmytro Nozdrenko, Andriy Maznychenko, Tetiana Abramovych, Inna Sokolowska, Iakіv Fishchenko
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • A Review of Synthetic Bone Grafts in Lumbar Interbody Fusion
    Jaden Wise, Isabella Merem, Dahlia Wrubluski, Xuanzong Zhang, Ridge Weston, Min Shi, Maohua Lin, Frank D. Vrionis
    Bioengineering.2026; 13(3): 262.     CrossRef
  • IMPACT OF INTERBODY CAGE GEOMETRY ON OUTCOMES OF MICRODISCECTOMY WITH INTERBODY FUSION
    Yevgenii Slynko, Roman Chamata, Olexander Potapov
    Eastern Ukrainian Medical Journal.2026; 14(1): 268.     CrossRef
  • 3D printed titanium banana interbody cages versus titanium-coated PEEK bullet cages for TLIF
    Connor C. Jacob, Ryan Eaton, Jacob Ward, Katelyn Sette, Seth Wilson, Matthieu D. Weber, Olivia Duru, Alexander Keister, Markus E. Harrigan, Andrew J. Grossbach, Stephanus Viljoen
    Clinical Neurology and Neurosurgery.2025; 249: 108731.     CrossRef
  • Comparison of Sagittal Plane Correction With “Bullet” Versus “Banana” Type Transforaminal Lumbar Interbody Fusion Devices
    Zach Pennington, Abdelrahman Hamouda, Michael Martini, Rahul Kumar, Anthony L. Mikula, Maria Astudillo Potes, Mohamad Bydon, Michelle J. Clarke, William E. Krauss, Ahmad N. Nassr, Brett A. Freedman, Arjun S. Sebastian, Jeremy L. Fogelson, Benjamin D. Elde
    Operative Neurosurgery.2025; 29(5): 624.     CrossRef
  • Expandable cage technology in minimally invasive transforaminal interbody fusion: where are we and what does the future hold?
    Chibuikem A. Ikwuegbuenyi, Noah Willett, Evan Wang, Sean Inzerillo, Ibrahim Hussain
    Expert Review of Medical Devices.2025; 22(4): 349.     CrossRef
  • ‘Rebound Phenomenon’ – a Cause of Early Cage Back-out in Transforaminal Lumbar Interbody Fusion Surgery: Insights from Case Series of 1545 Patients
    Jvahar Jill, Sathish Muthu, Guna Pratheep Kalanchiam, Nalli Ramanathan Uvaraj
    Indian Journal of Orthopaedics.2025; 59(12): 2126.     CrossRef
  • Transforaminal Lumbar Interbody Fusion (TLIF) with Expandable Banana-Shaped Interbody Spacers—Institutional 5-Year Experience
    Martin N. Stienen, Lorenzo Bertulli, Gregor Fischer, Linda Bättig, Yesim Yildiz, Laurin Feuerstein, Francis Kissling, Thomas Schöfl, Felix C. Stengel, Daniele Gianoli, Stefan Motov, Ethan Schonfeld, Anand Veeravagu, Benjamin Martens, Nader Hejrati
    Journal of Clinical Medicine.2025; 14(15): 5402.     CrossRef
  • Segmental lordosis in lumbar stabilization in patients with degenerative pathology: a non-systematic literature review
    O. N. Leonova, N. S. Kuzmin, E. S. Baykov, A. V. Krutko
    Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika).2025; 22(3): 67.     CrossRef
  • Comparison of full endoscopic lumbar discectomy combined with and without platelet-rich plasma injections for lumbar disc herniation: a meta-analysis
    Liangjie Lu, Keyi Xiao, Li-Ru He, Rui-Song Chen, Teng-Hui Zeng, Guang-Xun Lin
    Asian Spine Journal.2025; 19(5): 728.     CrossRef
  • Radiographic Analysis of Endplate Coverage of a 3-Dimensional-Expandable Transforaminal Lumbar Interbody Fusion (TLIF) Implant Compared to Static TLIF and Anterior Lumbar Interbody Fusion Implants
    Jacob Mazza, Manhal Siddiqi, John Paul G. Kolcun, Dominick Richards, Richard G. Fessler
    Neurospine.2025; 22(4): 891.     CrossRef
  • 7,947 View
  • 201 Download
  • 15 Web of Science
  • 12 Crossref

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Prognostic Value in Preoperative Veterans RAND-12 Mental Component Score on Clinical Outcomes for Patients Undergoing Minimally Invasive Lateral Lumbar Interbody Fusion
Neurospine. 2024;21(1):361-371.   Published online January 29, 2024
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Prognostic Value in Preoperative Veterans RAND-12 Mental Component Score on Clinical Outcomes for Patients Undergoing Minimally Invasive Lateral Lumbar Interbody Fusion
Neurospine. 2024;21(1):361-371.   Published online January 29, 2024
Close
Objective
To evaluate the effect of Veterans RAND 12-item health survey mental composite score (VR-12 MCS) on postoperative patient-reported outcome measures (PROMs) after undergoing lateral lumbar interbody fusion.
Methods
Retrospective data from a single-surgeon database created 2 cohorts: patients with VR-12 MCS ≥ 50 or VR-12 MCS < 50. Preoperative, 6-week, and final follow-up (FF)- PROMs including VR-12 MCS/physical composite score (PCS), 12-item Short Form health survey (SF-12) MCS/PCS, Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS-PF), Patient Health Questionnaire-9 (PHQ-9), visual analogue scale (VAS)-back/leg pain (VAS-BP/LP), and Oswestry Disability Index (ODI) were collected. ∆6-week and ∆FF-PROMs were calculated. Minimal clinically important difference (MCID) achievement rates were determined from established cutoffs from the literature. For intercohort comparison, chi-square analysis was used for categorical variables, and Student t-test for continuous variables.
Results
Seventy-nine patients were included; 25 were in VR-12 MCS < 50. Mean postoperative follow-up time was 17.12 ± 8.43 months. The VR-12 MCS < 50 cohort had worse VR-12 PCS, SF-12 MCS, PROMIS-PF, PHQ-9, VAS-BP, and ODI scores preoperatively (p ≤ 0.014, all), worse VR-12 MCS/PCS, SF-12 MCS, PROMIS-PF, PHQ-9, and ODI scores at 6-week postoperatively (p ≤ 0.039, all), and worse VR-12 MCS, SF-12 MCS, PROMIS-PF, PHQ-9, VAS-BP, VAS-LP, and ODI scores at FF (p ≤ 0.046, all). The VR-12 MCS < 50 cohort showed greater improvement in VR-12 MCS and SF-12 MCS scores at 6 weeks and FF (p ≤ 0.005, all). The VR-12 MCS < 50 cohort experienced greater MCID achievement for VR-12 MCS, SF-12 MCS, and PHQ-9 (p ≤ 0.006, all).
Conclusion
VR-12 MCS < 50 yielded worse mental health, physical function, pain and disability postoperatively, yet reported greater improvements in magnitude and MCID achievement for mental health.

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  • Preoperative mental health status measured by the SF12 questionnaire correlates with patient reported outcomes one year after total knee arthroplasty
    Jordi Faig-Martí, Robert Ferrer-Rivero, Adriana Martínez-Catasús
    Journal of Orthopaedic Reports.2026; 5(4): 100852.     CrossRef
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A Predictive Model of Failure to Rescue After Thoracolumbar Fusion
Neurospine. 2023;20(4):1337-1345.   Published online December 31, 2023
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A Predictive Model of Failure to Rescue After Thoracolumbar Fusion
Neurospine. 2023;20(4):1337-1345.   Published online December 31, 2023
Close
Objective
Although failure to rescue (FTR) has been utilized as a quality-improvement metric in several surgical specialties, its current utilization in spine surgery is limited. Our study aims to identify the patient characteristics that are independent predictors of FTR among thoracolumbar fusion (TLF) patients.
Methods
Patients who underwent TLF were identified using relevant diagnostic and procedural codes from the National Surgical Quality Improvement Program (NSQIP) database from 2011–2020. Frailty was assessed using the risk analysis index (RAI). FTR was defined as death, within 30 days, following a major complication. Univariate and multivariable analyses were used to compare baseline characteristics and early postoperative sequelae across FTR and non-FTR cohorts. Receiver operating characteristic (ROC) curve analysis was used to assess the discriminatory accuracy of the frailty-driven predictive model for FTR.
Results
The study cohort (N = 15,749) had a median age of 66 years (interquartile range, 15 years). Increasing frailty, as measured by the RAI, was associated with an increased likelihood of FTR: odds ratio (95% confidence interval [CI]) is RAI 21–25, 1.3 [0.8–2.2]; RAI 26–30, 4.0 [2.4–6.6]; RAI 31–35, 7.0 [3.8–12.7]; RAI 36–40, 10.0 [4.9–20.2]; RAI 41– 45, 21.5 [9.1–50.6]; RAI ≥ 46, 45.8 [14.8–141.5]. The frailty-driven predictive model for FTR demonstrated outstanding discriminatory accuracy (C-statistic = 0.92; CI, 0.89–0.95).
Conclusion
Baseline frailty, as stratified by type of postoperative complication, predicts FTR with outstanding discriminatory accuracy in TLF patients. This frailty-driven model may inform patients and clinicians of FTR risk following TLF and help guide postoperative care after a major complication.

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  • Predictive value of the risk analysis index for 30-day mortality following surgical management of thoracolumbar vertebral body fractures
    Stefan Prvulovic, Nithin Gupta, Sina Zhogi, Charles Bowers, Kishan Shah, Alfred Marcinkowski, Anjali Gupta, Christian Bowers
    European Spine Journal.2026; 35(4): 1964.     CrossRef
  • Is the “Fix-and-Replace” Method Associated With Higher Early Perioperative Risk Than Isolated Internal Fixation for Acetabular Fractures in Frail Patients?
    Tyler K. Williamson, Luke Verlinsky, Loc-Uyen Vo, Ravi Karia, Case Martin
    Journal of Orthopaedic Trauma.2026; 40(4): 196.     CrossRef
  • Frailty and the Older Neurosurgical Patient: Assessment, Outcomes and Management
    Adele S. Budiansky, Dan Budiansky, Daniel I. McIsaac
    Current Anesthesiology Reports.2025;[Epub]     CrossRef
  • Frailty Predicts Failure to Rescue Following Malignant Brain Tumor Resection: A National Surgical Quality Improvement Program Analysis of 14,721 Patients/ (2012–2020)
    Stefan T. Prvulovic, Joanna M. Roy, Akshay Warrier, Pemla Jagtiani, Joe Hirsch, Michael M. Covell, Christian A. Bowers
    World Neurosurgery.2025; 195: 123671.     CrossRef
  • Failure to Rescue After Brain Tumor Resection: A National Surgical Quality Improvement Program Analysis (2012-2020)
    Joanna M. Roy, Stefan T. Prvulovic, Akshay Warrier, Arash K. Mousavi, Shubhang Bhalla, Damian Sanchez, Pemla Jagtiani, Vinay Verma, Jonathan Roy Varghese, Praveen Sanmuganthan, Johnny Delashaw, Christian A. Bowers
    Neurosurgery.2025; 97(5): 1170.     CrossRef
  • Clinical Utility and Actionability of Failure to Rescue Prediction Model for Thoracolumbar Fusion: A Focus on Variable Relevance – A Commentary on “A Predictive Model of Failure to Rescue After Thoracolumbar Fusion”
    Seyed Amirhossein Tabatabaei, Mohammad Reza Cheraghi
    Neurospine.2025; 22(2): 615.     CrossRef
  • Reply Letter: A Commentary on “A Predictive Model of Failure to Rescue After Thoracolumbar Fusion”
    Joanna M. Roy, Aaron C. Segura, Michael M. Covell, Christian A. Bowers
    Neurospine.2025; 22(2): 617.     CrossRef
  • Frailty assessment in acute spinal cord injury surgery: Insights from the risk analysis index and broader neurosurgical context
    Omar Sbaih, Stefan Prvulovic, Shubhang Bhalla, Michael Covell, Christian A. Bowers
    The Journal of Spinal Cord Medicine.2025; : 1.     CrossRef
  • Serum Albumin Level as a Predictor of Failure to Rescue in Patients Undergoing Surgery for Spinal Metastases
    Esli Nájera Samaniego, Rose Fluss, Ali Haider Bangash, Sertac Kirnaz, Saikiran Murthy, Yaroslav Gelfand, Reza Yassari, Rafael De La Garza Ramos
    Cancers.2025; 17(21): 3477.     CrossRef
  • 5,141 View
  • 149 Download
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Lowest Instrumented Vertebra at L3 Versus L4 in Posterior Fusion for Moderate Lenke 5C Type Adolescent Idiopathic Scoliosis: A Case-Match Radiological Study
Neurospine. 2023;20(4):1380-1388.   Published online December 31, 2023
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Lowest Instrumented Vertebra at L3 Versus L4 in Posterior Fusion for Moderate Lenke 5C Type Adolescent Idiopathic Scoliosis: A Case-Match Radiological Study
Neurospine. 2023;20(4):1380-1388.   Published online December 31, 2023
Close
Objective
To compare the radiological outcomes in Lenke 5C type patients whose lowest instrumented vertebra (LIV) was L3 or L4 in a case-match study.
Methods
We conducted a retrospective case-match study and included 82 patients in the study. Radiological results before surgery, after surgery, and at last follow-up were recorded and analyzed in the L3 and L4 groups.
Results
After matching the age, Risser’s sign, sex, and main Cobb, 41 pairs of patients were enrolled in our study. The total fusion segments in the L3 group (median [interquartile range]: 5.0 [6.0–5.0]) were shorter than those in the L4 group (6.0 [6.5–6.0]). The main curve was significantly corrected after surgery in both groups, and was comparable at the last followup between groups. In addition, according to the results of Fisher precision probability test, there was no significant difference of coronal or sagittal imbalance between the 2 groups at the 2-year follow-up.
Conclusion
The correction in coronal and sagittal planes in L3 group and L4 group remains similar. On account of more motion segments, L3 could be an ideal choice as LIV in moderate Lenke 5C type AIS. Long-term follow-up is needed to evaluate the effect of larger compensatory lumbar-sacral curve when stopping at L3.

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  • Does the prone uninstrumented intraoperative frontal radiograph influence distal fusion level selection in adolescent idiopathic scoliosis surgery?
    François Luc, Simon Arvati, Nicolas Mainard, Anne-Laure Simon, Mourad Ould-Slimane, Brice Ilharreborde
    Orthopaedics & Traumatology: Surgery & Research.2026; 112(4): 104429.     CrossRef
  • Lowest Instrumented Vertebra Selection in Adolescent Idiopathic Scoliosis With Concomitant Spondylolysis
    Mutaleeb A. Shobode, Josiah J. Wolf, Asahi Murata, Anirejuoritse Bafor, Kirsten Tulchin-Francis, Walter P. Samora, Reid C. Chambers, Allen Kadado
    Global Spine Journal.2026; 16(6): 2630.     CrossRef
  • Advances in fusion level selection and surgical approaches for adolescent idiopathic scoliosis based on the Lenke classification system: a narrative review
    Ruiyuan Chen, Yu Xi, Tianyi Wang, Aobo Wang, Ziqian Ma, Minghui Liang, Shuo Yuan, Lei Zang, Ning Fan
    BMC Surgery.2026;[Epub]     CrossRef
  • Research Progress in the Diagnosis and Treatment of Idiopathic Scoliosis
    青山 刘
    Advances in Clinical Medicine.2026; 16(04): 248.     CrossRef
  • Distal Adding‐On After Selective Thoracolumbar/Lumbar Fusion for Lenke 5C AIS: The Role of Proximal Coronal Construct Position and Postoperative UIV Translation
    Xiaohan Ye, You Du, Yiwei Zhao, Ziquan Li, Yang Yang, Chenkai Li, Guanfeng Lin, Shengru Wang, Jianguo Zhang
    Orthopaedic Surgery.2026; 18(6): 1191.     CrossRef
  • Postoperative Coronal Imbalance in Dystrophic Lumbar Scoliosis Secondary to Neurofibromatosis Type 1: Incidence and Outcomes
    广澳 阚
    Advances in Clinical Medicine.2026; 16(05): 2650.     CrossRef
  • Is It Enough to Stop Distal Fusion at L3 in Mild to Moderate Lenke 5C Adolescent Idiopathic Scoliosis Patients?
    Chenkai Li, Xiaohan Ye, Haoran Zhang, Yang Yang, You Du, Yiwei Zhao, Shengru Wang, Jianguo Zhang
    Orthopaedic Surgery.2025; 17(1): 105.     CrossRef
  • Variations of Radiographic Parameters Relevant to the Presumed Lower Instrumented Vertebrae During Intraoperative Fluoroscopic Positioning for Lenke 5/6 Adolescent Idiopathic Scoliosis
    Tianyuan Zhang, Yuheng Zhang, Weijia Li, Yaolong Deng, Jingfan Yang, Wenyuan Sui, Zifang Huang, Junlin Yang
    World Neurosurgery.2025; 194: 123543.     CrossRef
  • Direct vertebral rotation (DVR) spinal instrumentation for the correction of adolescent idiopathic scoliosis Lenke 5 C
    Emmanuel Alonge, Gengming Zhang, HongQi Zhang, Chaofeng Guo
    European Spine Journal.2025; 34(7): 2739.     CrossRef
  • Principles of Level Selection for Instrumentation in Adult Thoracolumbar Spinal Deformity Surgery
    Zeeshan M. Sardar, Josephine R. Coury, Katherine Dong, Anson G. Bautista, Lawrence G. Lenke, Justin L. Reyes
    Journal of Bone and Joint Surgery.2025; 107(20): 2322.     CrossRef
  • Hyper‐Selective Posterior Fusion is Recommended When the Modified S‐Line is Positive in Lenke 5C Adolescent Idiopathic Scoliosis
    Qi Gu, Hongda Bao, Shibin Shu, Xin Zhang, Yong Qiu, Zezhang Zhu
    Orthopaedic Surgery.2024; 16(6): 1390.     CrossRef
  • Postoperative Coronal Imbalance in Lenke 5C Adolescent Idiopathic Scoliosis: Evolution, Risk Factors, and Clinical Implications
    Yinyu Fang, Jie Li, Zongshan Hu, Zezhang Zhu, Yong Qiu, Zhen Liu
    Neurospine.2024; 21(3): 903.     CrossRef
  • 6,472 View
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Outcomes of Surgical Treatment for Patients With Mild Scoliosis and Age-Appropriate Sagittal Alignment With Minimum 2-Year Follow-up
Neurospine. 2023;20(3):837-848.   Published online September 30, 2023
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Outcomes of Surgical Treatment for Patients With Mild Scoliosis and Age-Appropriate Sagittal Alignment With Minimum 2-Year Follow-up
Neurospine. 2023;20(3):837-848.   Published online September 30, 2023
Close
Objective
The goal of this study was to determine if patients with mild scoliosis and age-appropriate sagittal alignment have favorable outcomes following surgical correction.
Methods
Retrospective review of a prospective, multicenter adult spinal deformity database. Inclusion criteria: operative patients age ≥18 years, and preoperative pelvic tilt, mismatch between pelvic incidence and lumbar lordosis (PI–LL), and C7 sagittal vertical axis all within established age-adjusted thresholds with minimum 2-year follow-up. Health-related quality of life (HRQoL) scores: Oswestry Disability Index (ODI), 36-item Short Form health survey (SF-36), Scoliosis Research Society-22R (SRS22R), back/leg pain Numerical Rating Scale and minimum clinically important difference (MCID)/substantial clinical benefit (SCB). Two-year and preoperative HRQoL radiographic data were compared. Patients with mild scoliosis (Mild Scoli, Max coronal Cobb 10°–30°) were compared to those with larger curves (Scoli).
Results
One hundred fifty-one patients included from 667 operative patients (82.8% women; average age, 56.4 ± 16.2 years). Forty-two patients (27.8%) included in Mild Scoli group. Mild Scoli group had significantly worse baseline leg pain, ODI, and physical composite scores (p < 0.02). Mean 2-year maximum coronal Cobb angle was significantly improved compared to baseline (p < 0.001). All 2-year HRQoL measures were significantly improved compared to (p < 0.001) except mental composite score, SRS activity and SRS mental for the Mild Scoli group (p > 0.05). From the mild Scoli group, 36%–74% met either MCID or SCB for the HRQoL measures. Sixty-four point three percent had minimum 1 complication, 28.6% had a major complication, 35.7% had reoperation.
Conclusion
Mild scoliosis patients with age-appropriate sagittal alignment benefit from surgical correction, decompression, and stabilization at 2 years postoperative despite having a high complication rate.

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  • Subject‐Specific Musculoskeletal Modeling: The Future of Predicting and Preventing Proximal Junctional Failure in Adult Spinal Deformity
    Nima Ashjaee, Alexa Semonche, Anthony L. Mikula, Laszlo Kiss, Dennis E. Anderson, Dominika Ignasiak, Stephen H. M. Brown, John Street, Sidney Fels, Samuel R. Ward, Christopher Ames, Thomas R. Oxland
    JOR SPINE.2025;[Epub]     CrossRef
  • 5,375 View
  • 158 Download
  • 3 Web of Science
  • 1 Crossref

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Early Experience With Uniplanar Versus Biplanar Expandable Interbody Fusion Devices in Single-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion
Neurospine. 2023;20(2):487-497.   Published online June 30, 2023
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Early Experience With Uniplanar Versus Biplanar Expandable Interbody Fusion Devices in Single-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion
Neurospine. 2023;20(2):487-497.   Published online June 30, 2023
Close
Objective
To compare the early radiographic and clinical outcomes of expandable uniplanar versus biplanar interbody cages used for single-level minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).
Methods
A retrospective review of 1-level MIS-TLIFs performed with uniplanar and biplanar polyetheretherketone cages was performed. Radiographic measurements were performed on radiographs taken preoperatively, at 6-week follow-up, and 1-year follow-up. Oswestry Disability Index (ODI) and visual analogue scale (VAS) for back and leg at 3-month and 1-year follow-up.
Results
A total of 93 patients (41 uniplanar, 52 biplanar) were included. Both cage types provided significant postoperative improvements in anterior disc height, posterior disc height, and segmental lordosis at 1 year. No significant differences in cage subsidence rates were found between uniplanar (21.9%) and biplanar devices (32.7%) at 6 weeks (odds ratio, 2.015; 95% confidence interval, 0.651–6.235; p = 0.249) with no additional instances of subsidence at 1 year. No significant differences in the magnitude of improvements based on ODI, VAS back, or VAS leg at 3-month or 1-year follow-up between groups and the proportion of patients achieving the minimal clinically important difference in ODI, VAS back, or VAS leg at 1 year were not statistically significantly different (p > 0.05). Finally, there were no significant differences in complication rates (p = 0.283), 90-day readmission rates (p = 1.00), revision surgical procedures (p = 0.423), or fusion rates at 1 year (p = 0.457) between groups.
Conclusion
Biplanar and uniplanar expandable cages offer a safe and effective means of improving anterior disc height, posterior disc height, segmental lordosis, and patient-reported outcome measures at 1 year postoperatively. No significant differences in radiographic outcomes, subsidence rates, mean subsidence distance, 1-year patient-reported outcomes, and postoperative complications were noted between groups.

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  • Radiographic Changes and Cage Subsidence following Vertically Expandable Interbody Cage Use in Single-level Lumbar Fusion for Nonosteoporotic Patients: A Retrospective Study
    Shih-Hao Cheng, Hsiang-Lin Huang, Yu-Chuan Tsuei, William Chu, Man-Kuan Au, Ya-Chin Chen, Wen-Hsiang Chou
    Formosan Journal of Musculoskeletal Disorders.2026; 17(3): 122.     CrossRef
  • Comparison of clinical and radiographic outcomes in unilateral transforaminal lumbar interbody fusion: a retrospective analysis of three surgical approaches
    Guanyi Liu, Xuan Wang, Jiawei Zhang, Nanjian Xu, Lu Mao, Jun Qian, Xuyu Liao, Leijie Zhou, Yadan Niu
    European Spine Journal.2025; 34(1): 204.     CrossRef
  • Expandable interbody cages for lumbar spinal fusion: a systematic review
    Daniel Orr, Ron Anderson, Anna Jensen, Tyler Peterson, John Edwards, Anton E. Bowden
    The Spine Journal.2025; 25(8): 1773.     CrossRef
  • Clinical outcome and complications comparison between expandable and static cages in open TLIF surgery: A 2-year retrospective study
    Ta-Wei Lai, Po-Ming Chen, Chi-Huan Li, Cheng-Jung Chan, Po-Cheng Cheng, Chun-Hsien Huang, Li-Ching Kuo, Ming-Chou Ku
    Medicine.2025; 104(34): e44042.     CrossRef
  • Comparative Outcomes of Biportal Endoscopic Decompression, Conventional Subtotal Laminectomy, and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Central Stenosis
    Mu Ha Lee, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Dong Kyu Chin, Keun Su Kim, Jeong-Yoon Park
    Neurospine.2024; 21(4): 1178.     CrossRef
  • Unilateral transforaminal lumbar interbody fusion through a modified hemilateral spinous process-splitting approach
    Guanyi Liu, Xiaodi Zou, Yanzhao Dong, Ahmad Alhaskawi, Lihua Hu, Lu Mao, Jun Qian, Jichong Ying, Sahar Ahmed Abdalbary, Olga Alenikova, Yizhong Ma, Hui Lu
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • 6,474 View
  • 174 Download
  • 5 Web of Science
  • 6 Crossref

NASS/Neurospine Endoscopic Spine Surgery Special Issue

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Biportal Endoscopic Transforaminal Lumbar Interbody Fusion Using Double Cages: Surgical Techniques and Treatment Outcomes
Neurospine. 2023;20(1):80-91.   Published online March 31, 2023
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Biportal Endoscopic Transforaminal Lumbar Interbody Fusion Using Double Cages: Surgical Techniques and Treatment Outcomes
Neurospine. 2023;20(1):80-91.   Published online March 31, 2023
Close
Objective
To describe the surgical techniques and the treatment outcomes of biportal endoscopic transforaminal lumbar interbody fusion (BETLIF) using double cages.
Methods
This study included 89 patients with 114 fusion segments between July 2019 and May 2021. One pure polyetheretherketone (PEEK) cage and 1 composite titanium-PEEK cage were used for interbody fusion. Clinical outcomes measures included visual analogue scale (VAS) scores for lower back pain and leg pain, Oswestry Disability Index (ODI), and Japanese Orthopedic Association (JOA) scores. Computed tomography (CT) of the lumbar spine 1 year postoperatively was used to evaluate the Bridwell interbody fusion grades.
Results
There were significant improvement in VAS for lower back pain from 5.2 ± 3.1 to 1.7 ± 2.1, VAS for leg pain from 6.3 ± 2.5 to 1.7 ± 2.0, ODI from 46.7 ± 17.0 to 12.7 ± 16.1, and JOA score from 15.6 ± 6.3 to 26.4 ± 3.2. The p-values were all < 0.001. The average hospital stay was 5.7 ± 1.1 days. The CT studies available for 60 fusion segments showed successful fusion (Bridwell grade I or grade II) in 56 segments (93.3%). Significant cage subsidence of more than 2 mm was only noted in 3 segments (5.0%). Complications included 1 dural tear, 2 pedicle screws malposition, and 2 epidural hematomas, in which 2 patients required reoperations.
Conclusion
BETLIF with double cages provided good neural decompression and a sound environment for interbody fusion with a big cage footprint, a large amount of bone graft, endplate preservation, and segmental stability.

Citations

Citations to this article as recorded by  Crossref logo
  • Sagittal Alignment and Clinical Outcomes After Biportal Endoscopic Transforaminal Lumbar Interbody Fusion Using a Single Expandable Cage: One Year Follow-up
    Sub-Ri Park, Namhoo Kim, Ji-Won Kwon, Kyung-Soo Suk, Hak-Sun Kim, Seong-Hwan Moon, Si-Young Park, Byung Ho Lee, Jae-Won Shin, Jin-Oh Park
    World Neurosurgery.2026; 205: 124698.     CrossRef
  • Meta-Analysis of Complications in Minimally Invasive Spine Surgery (2013–2024)
    Sean Inzerillo, Eesha Gurav, Chibuikem A. Ikwuegbuenyi, Noah Willett, Mousa Hamad, Ibrahim Hussain, Alan Hernández-Hernández, Galal Elsayed, Roger Härtl, Osama Kashlan
    Spine.2026; 51(3): E47.     CrossRef
  • Long-term comparative study of Open-TLIF, MIS-TLIF, and UBE-TLIF in single-level degenerative lumbar spondylolisthesis
    Jian Luo, Lihua Shen, Changshen Bao, Zhichao Gao
    European Journal of Medical Research.2026;[Epub]     CrossRef
  • Comparative analysis of single vs. double cage insertion in unilateral biportal endoscopic lumbar interbody fusion: clinical and radiological outcomes
    Guisi Xie, Yanli Pan, Zhongshu Shan, Chan Wang Lei, Lek Hang Cheang, Jiaming Liang, Junfeng Shen, Wei Zhang, Chengyue Zhu
    Frontiers in Surgery.2026;[Epub]     CrossRef
  • Clinical and Radiological Outcomes of Double-Cage Full Endoscopic Transforaminal Lumbar Interbody Fusion Compared with Posterior Lumbar Interbody Fusion : A Retrospective Cohort Study
    Chi Ho Kim, Pius Kim, Chang Il Ju, Jong Hun Seo
    Journal of Korean Neurosurgical Society.2026; 69(4): 596.     CrossRef
  • Direct endoscopic visualization improves endplate preparation in lumbar interbody fusion: a comparative study of biportal endoscopic and conventional techniques
    Hyun-Jin Park, Samuel K. Cho, Sang-Min Park, Min-Seok Kang, Ho-Joong Kim, Jin S. Yeom
    European Spine Journal.2026;[Epub]     CrossRef
  • Fusion cage with ipsilateral-impaction bone grafting in treating lumbar spinal stenosis combined with segmental instability
    Wenbo Wu, Hanmo Fang, Kun Wang, Xiaobo Feng, Xianlin Zeng, Cao Yang, Lin Xie
    Spine Research.2026;[Epub]     CrossRef
  • Biportal Endoscopic Transforaminal Interbody Fusion: Comparing Primary Versus Revision Cases
    Ju-Eun Kim, Eugene J. Park, Daniel K. Park
    Journal of the American Academy of Orthopaedic Surgeons.2025; 33(18): e1081.     CrossRef
  • What is the learning curve for endoscopic spine surgery? A comprehensive systematic review
    Justin P. Chan, Thomas Olson, Beshoy Gabriel, Sohaib Hashmi, Hao-Hua Wu, Hansen Bow, Yu-Po Lee, Nitin Bhatia, Michael Oh, Don Y Park
    The Spine Journal.2025;[Epub]     CrossRef
  • A Muscle-Driven Spine Model for Predictive Simulations in the Design of Spinal Implants and Lumbar Orthoses
    Robin Remus, Andreas Lipphaus, Marisa Ritter, Marc Neumann, Beate Bender
    Bioengineering.2025; 12(3): 263.     CrossRef
  • Clinical Application and Research of Robot-Assisted Endoscopic Lumbar Spinal Canal Decompression Fusion Internal Fixation Technique
    佳文 孙
    Journal of Clinical Personalized Medicine.2025; 04(02): 609.     CrossRef
  • Effectiveness of biportal endoscopic lumbar interbody fusion using the multi-layer bone grafting technique: a retrospective study from Vietnam
    Tran Vu Hoang Duong, Pham Anh Tuan, Huynh Van Vu, Chu Van Lam, Le Tan Linh, Phan Duy, Wongthawat Liawrungrueang
    Asian Spine Journal.2025; 19(2): 228.     CrossRef
  • Biportal endoscopic lumbar interbody fusion using a large polyetheretherketone cage: preliminary results
    Sang-Min Park, Hyun-Jin Park, Ki-Han You, Ho-Joong Kim, Jin S. Yeom
    Asian Spine Journal.2025; 19(2): 252.     CrossRef
  • Comparison of mid-term outcomes between unilateral biportal endoscopic and minimally invasive transforaminal lumbar interbody fusion in the treatment of single-level lumbar degenerative disease
    Xuelei Zhang, Qiumei Yuan, Yu Zhang, Zuchao Gu, Guo Li, Koji Akeda
    PLOS One.2025; 20(4): e0321569.     CrossRef
  • Optimizing Lumbar Interbody Fusion: A Technical Note on Biportal Endoscopic Transforaminal Lumbar Interbody Fusion with Dual Cage Strategy
    Atmaranjan Dash, Karansinh Raosaheb Parve Patil, Anurag Reddy Kancharla, Bhushan P. Meshram, Rajesh R. Jamoria, Amaresh Cadapa Prahallad, Mandar P. Patil, Vaibhav S. Dhawali
    Journal of Spinal Surgery.2025; 12(2): 37.     CrossRef
  • The Surgical and Functional Outcomes of Biportal Posterolateral Endoscopic Lumbar Interbody Fusion via Percutaneous Pedicle Screw Incisional Wounds: A Case Series
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    Journal of Minimally Invasive Spine Surgery and Technique.2025; 10(Suppl 2): S235.     CrossRef
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Weekend Admission Increases Risk of Readmissions Following Elective Cervical Spinal Fusion
Neurospine. 2023;20(1):290-300.   Published online March 31, 2023
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Weekend Admission Increases Risk of Readmissions Following Elective Cervical Spinal Fusion
Neurospine. 2023;20(1):290-300.   Published online March 31, 2023
Close
Objective
The “weekend effect” occurs when patients cared for during weekends versus weekdays experience worse outcomes. But reasons for this effect are unclear, especially amongst patients undergoing elective cervical spinal fusion (ECSF). Our aim was to analyze whether index weekend admission affects 30- and 90-day readmission rates post-ECSF.
Methods
All ECSF patients > 18 years were retrospectively identified from the 2016–2018 Healthcare Cost and Utilization Project Nationwide Readmissions Database (NRD), using unique patient linkage codes and International Classification of Diseases, Tenth Revision codes. Patient demographics, comorbidities, and outcomes were analyzed. Univariate logistic regression analyzed primary outcomes of 30- and 90-day readmission rates in weekday or weekend groups. Multivariate regression determined the impact of complications on readmission rates.
Results
Compared to the weekday group (n = 125,590), the weekend group (n = 1,026) held a higher percentage of Medicare/Medicaid insurance, incurred higher costs, had longer length of stay, and fewer routine home discharge (all p < 0.001). There was no difference in comorbidity burden between weekend versus weekday admissions, as measured by the Elixhauser Comorbidity Index (p = 0.527). Weekend admissions had higher 30-day (4.30% vs. 7.60%, p < 0.001) and 90-day (7.80% vs. 16.10%, p < 0.001) readmission rates, even after adjusting for sex, age, insurance status, and comorbidities. All-cause complication rates were higher for weekend admissions (8.62% vs. 12.7%, p < 0.001), specifically deep vein thrombosis, infection, neurological conditions, and pulmonary embolism.
Conclusion
Index weekend admission increases 30- and 90-day readmission rates after ECSF. In patients undergoing ECSF on weekends, postoperative care for patients at risk for specific complications will allow for improved outcomes and health care utilization.

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    The Journal of Knee Surgery.2025; 38(09): 477.     CrossRef
  • Incidence and predictors of acute kidney injury after elective surgery for lumbar degenerative disease: A 13-year analysis of the US Nationwide Inpatient Sample
    Yueh-Ying Hsieh, Lien-Chen Wu, I-Chun Chen, Chang-Jung Chiang
    Journal of the Chinese Medical Association.2024; 87(4): 400.     CrossRef
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Impact of Mechanism of Injury on Long-term Neurological Outcomes of Cervical Sensorimotor Complete Acute Traumatic Spinal Cord Injury
Neurospine. 2022;19(4):1049-1056.   Published online December 31, 2022
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Impact of Mechanism of Injury on Long-term Neurological Outcomes of Cervical Sensorimotor Complete Acute Traumatic Spinal Cord Injury
Neurospine. 2022;19(4):1049-1056.   Published online December 31, 2022
Close
Objective
Mechanism of injury is a largely understudied descriptor of acute traumatic spinal cord injury (tSCI). This study sought to compare the impact of high-energy and low-energy mechanisms of injury in neurological outcomes of cervical sensorimotor complete tSCI.
Methods
Patients with tSCI were identified in 4 prospective, multicenter clinical trials and registries. American Spinal Injury Association Impairment Scale (AIS) grade was assessed ≤ 72 hours postinjury and followed up between 12 to 52 weeks. Patients were included if they had a cervical and sensorimotor complete (AIS–A) injury at baseline. Study outcomes were change in AIS grade and lower extremity motor, upper extremity motor, and total motor scores. Propensity score matching between high-energy mechanisms of injury (HEMI; e.g. , motor vehicle collisions) and low-energy mechanisms of injury (LEMI; e.g. , falls) groups was performed. Adjusted groups were compared with paired t-tests and McNemar test.
Results
Of 667 patients eligible for inclusion, 523 experienced HEMI (78.4%). HEMI patients were younger, had lower body mass index, more associated fractures or dislocations, and lower baseline lower extremity motor scores. After propensity score matching of these baseline variables, 118 pairs were matched. HEMI patients had a significantly worse motor recovery from baseline to follow-up based on their diminished change in upper extremity motor scores and total motor scores.
Conclusion
Cervical sensorimotor complete tSCIs from HEMI were associated with significantly lower motor recovery compared to LEMI patients. Our findings suggest that mechanism of injury should be considered in modelling prognosis and in understanding the heterogeneity of outcomes after acute tSCI.

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  • The burden of acute care of patients with traumatic vs. non-traumatic SCI: A comparative study
    Antoine Dionne, Andréane Richard-Denis, Émile Brouillard, Ismael Lassassy, Étienne Bourassa-Moreau, Paul Khoueir, Zhi Wang, Jean-Marc Mac-Thiong
    The Journal of Spinal Cord Medicine.2026; 49(3): 611.     CrossRef
  • The Burden of Concomitant Spinal Injury in the Setting of Traumatic Brain Injury that Required Admission to ICU—Lessons from a Tertiary Neurosurgery Center
    Andreas K. Demetriades, Imran Shah, Ali R. Syed, Charles Wallis, Wilco Peul
    Neurocritical Care.2026; 44(3): 922.     CrossRef
  • Development and validation of a multilevel scale for quantitative assessment of mechanical exposure in traumatic spinal injuries
    Oleksii S. Nekhlopochyn, Vadym V. Verbov, Ievgen V. Cheshuk, Milan V. Vorodi
    Ukrainian Neurosurgical Journal.2026; 32(1): 69.     CrossRef
  • Ultra-early decompression and prevention of secondary injury in traumatic spinal cord injury: A single-center study
    Hong Kai Wang, Sheng-Han Huang, Cheng-Yu Li, Kuan-Hung Chen, Yan-Po Kang, Ying-Ching Li, Yu-Jen Lu
    The Journal of Spinal Cord Medicine.2026; : 1.     CrossRef
  • Serum C-Reactive Protein-to-Albumin Ratio as a Clinical Risk Factor for Traumatic Spinal Cord Injury
    Erxing Tao, Zhixin Liu, Yihao Liu, Chengyun Wang, Genbo Huang, Chunhua Xu, Zihan Ding
    World Neurosurgery.2025; 194: 123546.     CrossRef
  • International Spinal Cord Injury Community Survey: Socioeconomic and Healthcare Satisfaction in Spain
    Miguel Angel González-Viejo, Merce Avellanet, Anna Boada-Pladellorens, Lluïsa Montesinos-Magraner, María Luisa Jaúregui-Abrisqueta, Enrique Bárbara-Bataller, Bosco Méndez-Ferrer, Judith Sánchez-Raya, Nora Cívicos, José Luis Méndez-Suarez, Juana María Barr
    Global Spine Journal.2024; 14(8): 2381.     CrossRef
  • Traumatic spinal cord injury in South Korea for 13 years (2008–2020)
    Sung Hyun Noh, Eunyoung Lee, Kyoung-Tae Kim, Sang Hyun Kim, Pyung Goo Cho
    Scientific Reports.2024;[Epub]     CrossRef
  • MRI variables and peripheral inflammatory response biomarkers predict severity and prognosis in patients with acute cervical traumatic spinal cord injury
    Zihan Ding, Wu Zhou, Deliang Wang, Lin Li, Chengyun Wang, Chunliang Wang
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • Co-Administration of Resolvin D1 and Peripheral Nerve-Derived Stem Cell Spheroids as a Therapeutic Strategy in a Rat Model of Spinal Cord Injury
    Seung-Young Jeong, Hye-Lan Lee, SungWon Wee, HyeYeong Lee, GwangYong Hwang, SaeYeon Hwang, SolLip Yoon, Young-Il Yang, Inbo Han, Keung-Nyun Kim
    International Journal of Molecular Sciences.2023; 24(13): 10971.     CrossRef
  • 8,229 View
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Psychometric Properties of the Scoliosis Research Society Questionnaire (Version 22r) Domains Among Adults With Spinal Deformity: A Rasch Measurement Theory Analysis
Neurospine. 2022;19(2):422-433.   Published online May 15, 2022
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Psychometric Properties of the Scoliosis Research Society Questionnaire (Version 22r) Domains Among Adults With Spinal Deformity: A Rasch Measurement Theory Analysis
Neurospine. 2022;19(2):422-433.   Published online May 15, 2022
Close
Objective
Adult spinal deformity (ASD) have lower health-related quality of life (HRQoL) compared to the general population. Applying Rasch measurement theory (RMT), this study tested the revised Scoliosis Research Society-22 (SRS-22r) HRQoL instrument among symptomatic adult patients with degenerative spinal disorders and varying degrees of ASD.
Methods
SRS-22r data from 637 outpatient spine clinic patients with degenerative spine conditions were investigated for unidimensionality, item/scale fit, differential item functioning (DIF), scale coverage/targeting, and person separation index (PSI) using RMT.
Results
Unidimensionality of the SRS-22r was not supported for either the total score or for 3 of its 5 domains. Item fit was acceptable for 11/22 items. The individual domains showed good coverage despite the degree of structural disorders. Ordered thresholds were achieved by merging response categories in some of the items. DIF towards age or sex was found in 11/22 items and in some domain items. The PSI exceeded 0.7 for the SRS-22r total score.
Conclusion
The individual domain scores of the SRS-22r perform better than the total score providing good coverage and targeting among patients with ASD. Refinements of items and domains may improve the structural validity of the instrument to meet the criteria for measuring ASD patients, even when multidimensionality persists.

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    A. Shiju Majeed, B.P. Vinodkumar, N. Ajina
    Journal of Orthopaedic Reports.2026; 5(4): 100897.     CrossRef
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    Heidi Mannström, Juhani Multanen, Jari Ylinen, Arto Hautala, Arttu Peuna, Lauri Karttunen, Liisa Pekkanen, Kati Kyrölä
    Spine.2025; 50(8): 522.     CrossRef
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    Omid Jalali, Justin S. Smith, Shay Bess, Richard Hostin, Renaud Lafage, Virginie Lafage, Christopher I. Shaffrey, Christopher P. Ames, Lawrence G. Lenke, Michael P. Kelly
    Spine.2024; 49(10): 682.     CrossRef
  • Development and Preliminary Testing of the Staffordshire Questionnaire for Adolescent Idiopathic Scoliosis (SQ‐AIS): Content and Face Validity
    Enza Leone, Nachiappan Chockalingam, Robert Needham, Aoife Healy, Nicola Eddison, Nikola Jevtic, Vinay Jasani
    Health Science Reports.2024;[Epub]     CrossRef
  • 10,105 View
  • 209 Download
  • 4 Web of Science
  • 4 Crossref