This review introduces the current technique of photoacoustic imaging as it is applied in imaging-guided surgery (IGS), which provides the surgeon with image visualization and analysis capabilities during surgery. Numerous imaging techniques have been developed to help surgeons perform complex operations more safely and quickly. Although surgeons typically use these kinds of images to visualize targets hidden by bone and other tissues, it is nonetheless more difficult to perform surgery with static reference images (e.g., computed tomography scans and magnetic resonance images) of internal structures. Photoacoustic imaging could enable real-time visualization of regions of interest during surgery. Several researchers have shown that photoacoustic imaging has potential for the noninvasive diagnosis of various types of tissues, including bone. Previous studies of the surgical application of photoacoustic imaging have focused on cancer surgery, but photoacoustic imaging has also recently attracted interest for spinal surgery, because it could be useful for avoiding pedicle breaches and for choosing an appropriate starting point before drilling or pedicle probe insertion. This review describes the current instruments and clinical applications of photoacoustic imaging. Its primary objective is to provide a comprehensive overview of photoacoustic IGS in spinal surgery.
Citations
Citations to this article as recorded by
Diffusion-based model as a generalizable denoiser for optoacoustic imaging Yuan Xu, Xiang Liu, Xia Li, Sandeep Kumar Kalva, Joachim Buhmann, Daniel Razansky, Xosé Luís Deán-Ben Computers in Biology and Medicine.2026; 200: 111340. CrossRef
Hollow nanoarchitectures: Materials engineering, nanochemistry, and biomedical applications Sandip Ghosh, Chia-Jung Yang, Jui-Yang Lai Progress in Materials Science.2026; 158: 101634. CrossRef
Development of 3D photoacoustic imaging system with 1024-channel transducers for demonstration of carotid artery thrombosis in vivo Moungyoung Lee, Chulgyu Song IEICE Electronics Express.2026; 23(6): 20260011. CrossRef
Advanced Theranostics in a Pancreatic Cancer Model Integrating Dual Optoacoustic‐Photodynamic Performance of Asymmetric Zinc Phthalocyanines Ananya Sharma, Rakesh Kumar Pradhan, Arjun Swamimalai Venkatraman, Sneha Ravanan, Pooja Patkulkar, Ananya Banerjee, Ankita Mandal, Siddharth Jhunjhunwala, Sanhita Sinharay Small.2026;[Epub] CrossRef
Nanostructures for cancer therapeutics and diagnostics: Recent advances and future outlook Seifeldin Elabed, Abdelrahman Sheirf, M. Ali Radiation Physics and Chemistry.2025; 226: 112295. CrossRef
Generative priors-constraint accelerated iterative reconstruction for extremely sparse photoacoustic tomography boosted by mean-reverting diffusion model: Towards 8 projections Teng Lian, Yichen Lv, Kangjun Guo, Zilong Li, Jiahong Li, Guijun Wang, Jiabin Lin, Yiyang Cao, Qiegen Liu, Xianlin Song Photoacoustics.2025; 43: 100709. CrossRef
Multifunctional nanophotonic photoacoustic biosensors: a new era in molecular imaging–guided deep-tissue cancer monitoring Bakr Ahmed Taha, Ghassan M. Sulaiman, Ali J. Addie, Khalil A.A. Khalil, Elsadig M. Ahmed, Vishal Chaudhary, Norhana Arsad Methods.2025; 242: 1. CrossRef
Monitoring angiogenesis in skin autografts using photoacoustic microscopy Dong Zhang, Changjiang Liu, Ying Yuan, Yifeng Yu, Baiwen Qi, Aixi Yu Journal of Biophotonics.2024;[Epub] CrossRef
Advances in imaging modalities for spinal tumors Soichiro Takamiya, Anahita Malvea, Abdullah H Ishaque, Karlo Pedro, Michael G Fehlings Neuro-Oncology Advances.2024; 6(Supplement): iii13. CrossRef
Fast iterative reconstruction for photoacoustic tomography using learned physical model: Theoretical validation Ko-Tsung Hsu, Steven Guan, Parag V. Chitnis Photoacoustics.2023; 29: 100452. CrossRef
Tetrazine-Derived Near-Infrared Dye for Targeted Photoacoustic Imaging of Bone Rowan Swann, Samantha Slikboer, Afaf Genady, Luis Rafael Silva, Nancy Janzen, Amber Faraday, John F. Valliant, Saman Sadeghi Journal of Medicinal Chemistry.2023; 66(9): 6025. CrossRef
Sparse-view reconstruction for photoacoustic tomography combining diffusion model with model-based iteration Xianlin Song, Guijun Wang, Wenhua Zhong, Kangjun Guo, Zilong Li, Xuan Liu, Jiaqing Dong, Qiegen Liu Photoacoustics.2023; 33: 100558. CrossRef
Dicyanoquinodimethane (DCNQ) linked benzothiadiazole and phenothiazine derivatives for photoacoustic imaging Yogajivan Rout, Jean Michel Merkes, Srinivas Banala, Rajneesh Misra Journal of Photochemistry and Photobiology A: Chemistry.2022; 429: 113935. CrossRef
Photoacoustic-MR Image Registration Based on a Co-Sparse Analysis Model to Compensate for Brain Shift Parastoo Farnia, Bahador Makkiabadi, Maysam Alimohamadi, Ebrahim Najafzadeh, Maryam Basij, Yan Yan, Mohammad Mehrmohammadi, Alireza Ahmadian Sensors.2022; 22(6): 2399. CrossRef
Multimodal Imaging and Phototherapy of Cancer and Bacterial Infection by Graphene and Related Nanocomposites Ganesh Gollavelli, Anil V. Ghule, Yong-Chien Ling Molecules.2022; 27(17): 5588. CrossRef
Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion Jiaqi Qian, Lichao Su, Jingjing He, Renjie Ruan, Jun Wang, Ziyi Wang, Peijie Xiao, Changhua Liu, Yang Cao, Weidong Li, Jin Zhang, Jibin Song, Huanghao Yang ACS Nano.2022; 16(10): 16880. CrossRef
Nanotheranostic Strategies for Cancer Immunotherapy Anh Nguyen, Sahana Kumar, Ashish A. Kulkarni Small Methods.2022;[Epub] CrossRef
A Comprehensive Review on Photoacoustic-Based Devices for Biomedical Applications Rita Clarisse Silva Barbosa, Paulo M. Mendes Sensors.2022; 22(23): 9541. CrossRef
Photoacoustic-guided surgery from head to toe [Invited] Alycen Wiacek, Muyinatu A. Lediju Bell Biomedical Optics Express.2021; 12(4): 2079. CrossRef
In Vivo Rodent Cervicothoracic Vasculature Imaging Using Photoacoustic Computed Tomography Junsoo Lee, Hoseong Cho, Sungjo Park, Jaeyul Lee, Daewoon Seong, Ruchire Eranga Wijesinghe, Sangyeob Han, Shinheon Kim, Mansik Jeon, Jeehyun Kim Photonics.2021; 8(8): 312. CrossRef
CuInS2 Quantum Dot and Polydimethylsiloxane Nanocomposites for All‐Optical Ultrasound and Photoacoustic Imaging Semyon Bodian, Richard J. Colchester, Thomas J. Macdonald, Filip Ambroz, Martha Briceno de Gutierrez, Sunish J. Mathews, Yu Man Mandy Fong, Efthymios Maneas, Kathryn A. Welsby, Ross J. Gordon, Paul Collier, Edward Z. Zhang, Paul C. Beard, Ivan P. Parkin, Advanced Materials Interfaces.2021;[Epub] CrossRef
Prospects of Photo- and Thermoacoustic Imaging in Neurosurgery Kristine Ravina, Li Lin, Charles Y Liu, Debi Thomas, Denise Hasson, Lihong V Wang, Jonathan J Russin Neurosurgery.2020; 87(1): 11. CrossRef
Photoacoustic image-guided interventions Madhumithra S Karthikesh, Xinmai Yang Experimental Biology and Medicine.2020; 245(4): 330. CrossRef
Engineering Intelligent Nanosystems for Enhanced Medical Imaging Guido T. van Moolenbroek, Tania Patiño, Jordi Llop, Samuel Sánchez Advanced Intelligent Systems.2020;[Epub] CrossRef
Deep-Learning Image Reconstruction for Real-Time Photoacoustic System MinWoo Kim, Geng-Shi Jeng, Ivan Pelivanov, Matthew O'Donnell IEEE Transactions on Medical Imaging.2020; 39(11): 3379. CrossRef
Photoacoustic imaging of tumor-targeted HSA-modified S-WS2 nanosheet probes Weiqiang Yan, Hongfeng Li, Ting Zhu, Ping Gong, Ruosheng Zeng, Rong Huang, Jiahao Huang, Guanxun Cheng, Xianyue Quan Journal of Nanoparticle Research.2019;[Epub] CrossRef
CARS-imaging guidance for fs-laser ablation precision surgery Tobias Meyer, Roland Ackermann, Robert Kammel, Michael Schmitt, Stefan Nolte, Andreas Tünnermann, Jürgen Popp The Analyst.2019; 144(24): 7310. CrossRef
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