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"Vertebroplasty"

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Trauma

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Development and Validation of a Nomogram for Predicting Adjacent Vertebral Fracture After Osteoporotic Vertebral Compression Fracture Surgery: A Multicenter Retrospective Cohort Study
Neurospine. 2025;22(2):592-602.   Published online April 16, 2025
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Development and Validation of a Nomogram for Predicting Adjacent Vertebral Fracture After Osteoporotic Vertebral Compression Fracture Surgery: A Multicenter Retrospective Cohort Study
Neurospine. 2025;22(2):592-602.   Published online April 16, 2025
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Objective
Osteoporotic vertebral compression fractures (OVCFs) are a major public health concern. While percutaneous vertebral augmentation (PVA) is an effective treatment for OVCF, adjacent vertebral fractures (AVF) often occur post-PVA, adversely affecting treatment outcomes. This study aims to develop a nomogram for predicting AVF risk using multicenter data to aid clinical decision-making for OVCF patients.
Methods
We retrospectively analyzed patients who underwent PVA at 3 hospitals between 2017 and 2022. The cohort was divided into a training set (80%) and a validation set (20%). Independent risk factors for AVF were identified using LASSO (least absolute shrinkage and selection operator) and logistic regression. Seven significant factors were: bone mineral density, diabetes, total fractured vertebrae, intravertebral vacuum cleft sign, recovery of local kyphosis angle, regular aerobic exercise, and lumbar brace use.
Results
Among the 483 patients, 52 (10.76%) developed adjacent vertebral refractures within 2 years. The nomogram demonstrated high predictive accuracy, with area under the curves of 89.21% in the training set and 98.33% in the validation set.
Conclusion
This pioneering nomogram, incorporating baseline, surgical, and postoperative factors, provides valuable guidance for spine surgeons in preoperative planning and postoperative management, enabling personalized prognosis and rehabilitation for OVCF patients.

Citations

Citations to this article as recorded by  Crossref logo
  • Risk Factors for Osteoporotic Vertebral Compression Fracture and Evaluation of Clinical Outcomes of Minimally Invasive Vertebral Augmentation
    Zhuang Zhu, Ying Li, Jixiang Chen, Shuang Su, Ru Tao, Defeng Wang
    Global Spine Journal.2026;[Epub]     CrossRef
  • Prediction models for subsequent vertebral fractures after percutaneous vertebroplasty or kyphoplasty: a systematic review and critical appraisal
    Linlin Zhang, Shuqiu Lin, Wenping Xue, Wei Wang, Yanling Zhou
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • Functional recovery and pain reduction following surgical and non-surgical management of osteoporosis-related bone, joint, and spine disorders
    Dr. Utkarsh Mahera, Dr. Saurabh Sahu, Mahesh Kumar Navadaya, Dr. Longjam Darendrajit Singh, Dr. Bhagyesh Darji, Dr. Veenakirthika.S
    PAIN, JOINTS, SPINE.2026; : 106.     CrossRef
  • The osteoporosis-fracture cascade: new insights into vertebral fracture prevalence and financial costs in China
    Guoliang Ma, He Yin, Liguo Zhu
    International Journal of Surgery.2025; 111(7): 4921.     CrossRef
  • 6,800 View
  • 140 Download
  • 3 Web of Science
  • 4 Crossref

Original Articles

Deformity

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Does Vertebral Cement Augmentation Reduce Postoperative Proximal Junction Complications in Spinal Deformity Corrective Surgery: A Systematic Review and Meta-analysis
Neurospine. 2025;22(1):51-66.   Published online March 31, 2025
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Does Vertebral Cement Augmentation Reduce Postoperative Proximal Junction Complications in Spinal Deformity Corrective Surgery: A Systematic Review and Meta-analysis
Neurospine. 2025;22(1):51-66.   Published online March 31, 2025
Close
Objective
To assess the effectiveness of vertebral cement augmentation (VCA) at upper instrumented vertebra (UIV) and UIV+1 in preventing proximal junction complications in correction surgery for adult spinal deformity patients.
Methods
A literature search was conducted on Web of Science, PubMed, and Cochrane Library databases for comparative studies published before December 30th, 2024. Two reviewers independently screened eligible articles based on the inclusion and exclusion criteria, assessed study quality with Newcastle-Ottawa scale, and extracted data like study characteristics, surgical details, primary and secondary outcomes. Data analysis was performed using Review Manager 5.4 and Stata software.
Results
Of all 513 papers screened, a meta-analysis was conducted on 7 articles, which included 333 cases in the VCA group and 827 cases in the control group. Patients in the VCA group had significantly older age and lower T score than patients in the control group. Although there was no statistically significant difference in the incidence of proximal junctional failure between the 2 groups, the results of the meta-analysis showed that the incidence of proximal junctional failure and the need for revision surgery were reduced by 36% and 71%, respectively, in the VCA group. One study reported 2 clinically silent pulmonary cement embolism and 1 patient requiring surgical decompression for cement leak into the spinal canal.
Conclusion
This meta-analysis supported the use of VCA in corrective surgery for spinal deformities patients, especially in patients with advanced age and osteoporosis.

Citations

Citations to this article as recorded by  Crossref logo
  • Proximal Junctional Kyphosis Prevention in Adult Spinal Deformity Surgery: A Technical Review of Tethering and Adjunctive Strategies
    Paritash Tahmasebpour, Pawel P. Jankowski, Jason Liang, Joshua Lin, Kyriakos D. Chatzis, Peter S. Tretiakov, Spencer Matthews, Louis Boissiere, John F. Burke, Christopher I. Shaffrey, Aaron Hockley, Peter Passias
    Operative Neurosurgery.2026;[Epub]     CrossRef
  • Machine learning–based identification of distinct risk factors for moderate versus severe proximal junctional kyphosis after adult spinal deformity surgery
    Dong-Ho Kang, Jin-Sung Park, Chong-Suh Lee, Se-Jun Park
    The Spine Journal.2026;[Epub]     CrossRef
  • The use of hooks in upper instrumented vertebra to prevent proximal junctional complications: a systematic review and meta-analysis
    Hifza Babar, Dong Li, Jie Li, Zhen Liu, Zezhang Zhu, Yong Qiu
    BMC Surgery.2026;[Epub]     CrossRef
  • Vertebral Cement Augmentation is Associated With Reduced Rates of Proximal Junctional Failure in Adult Spinal Deformity Surgery: A Systematic Review and Meta-Analysis of 1211 Patients
    Stavros Matsoukas, Shaan Patel, Pavlos Texakalidis, Teleale F. Gebeyehu, Joshua E. Heller, Jack Jallo, James S. Harrop, Srinivas K. Prasad
    Operative Neurosurgery.2025;[Epub]     CrossRef
  • Revisiting Cement Augmentation in Osteoporotic Vertebral Fractures: A Narrative Review
    Gilbert Bungay Dimacali, Byung Ho Lee
    Journal of Korean Society of Spine Surgery.2025; 32(4): 144.     CrossRef
  • 8,298 View
  • 116 Download
  • 5 Crossref

Trauma

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Comparative Analysis of Romosozumab Versus Vertebroplasty With Denosumab: Efficacy, Safety, and Secondary Bone Mineral Density Outcomes
Neurospine. 2025;22(1):69-77.   Published online March 31, 2025
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Comparative Analysis of Romosozumab Versus Vertebroplasty With Denosumab: Efficacy, Safety, and Secondary Bone Mineral Density Outcomes
Neurospine. 2025;22(1):69-77.   Published online March 31, 2025
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Objective
This study aimed to compare the efficacy and safety of romosozumab, a bone anabolic agent, versus vertebroplasty, a conventional surgical intervention, in treating osteoporotic vertebral compression fractures (OVCFs).
Methods
A retrospective analysis included 86 thoracic/lumbar compression fracture patients from 2014 to 2022 at a medical center. Forty-two patients received romosozumab (monthly injections for 1 year) followed by 1 year of denosumab, while 44 underwent vertebroplasty followed by denosumab injections biannually for 2 years. Outcomes were assessed using the Numerical Rating Scale (NRS) for pain, bone mineral density (BMD), vertebral compression ratio, and Cobb angle over 12 months.
Results
At 12 months, the romosozumab group showed a greater reduction in NRS scores (4.90 ± 1.01 vs. 4.27 ± 1.34, p = 0.015) and a higher increase in lumbar BMD (0.8 ± 0.5 vs. 0.5 ± 0.3, p = 0.000) compared to the vertebroplasty group. There were no significant differences in changes in hip total BMD and femur neck BMD (p = 0.190, p = 0.167, respectively). Radiographic assessments showed no significant differences in vertebral compression ratio (14.7% vs. 14.8%; p = 0.960) or Cobb angle (4.2° vs. 4.9°; p = 0.302). The incidence of major osteoporotic fractures was lower in the romosozumab group (7.1% vs. 25.0%, p = 0.051), with similar rates of cardiovascular events in both groups (4.8% vs. 9.1%, p = 0.716).
Conclusion
Romosozumab has demonstrated superior pain reduction and lumbar BMD improvement compared to vertebroplasty at 12 months, with no significant differences in radiographic outcomes or adverse events, suggesting it as an alternative to vertebroplasty for OVCF.

Citations

Citations to this article as recorded by  Crossref logo
  • Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis
    Yu‐Chuan Chang, Jian‐Chih Chen, Sung‐Yen Lin, Kun‐Der Lin, Pei‐Shan Ho, Chung‐Hwan Chen, Yin‐Chih Fu, Tien‐Ching Lee
    The Kaohsiung Journal of Medical Sciences.2026;[Epub]     CrossRef
  • Comparative Radiologic Outcomes of Romosozumab and Teriparatide in Osteoporotic Vertebral Fractures
    Jun-Seok Lee, Geon-U Kim, Ho-Young Jung, Young-Hoon Kim, Sang-Il Kim, Sangjun Park, Young-Yul Kim, Hyung-Youl Park
    Journal of Clinical Medicine.2026; 15(6): 2349.     CrossRef
  • Revisiting Cement Augmentation in Osteoporotic Vertebral Fractures: A Narrative Review
    Gilbert Bungay Dimacali, Byung Ho Lee
    Journal of Korean Society of Spine Surgery.2025; 32(4): 144.     CrossRef
  • 11,588 View
  • 226 Download
  • 1 Web of Science
  • 3 Crossref

Video Article

Video Articles: Special Issue With JMISST

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Transforaminal Endoscopic Lumbar Foraminotomy for Iatrogenic Foraminal Stenosis Following Vertebroplasty
Neurospine. 2024;21(4):1137-1140.   Published online December 31, 2024
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Transforaminal Endoscopic Lumbar Foraminotomy for Iatrogenic Foraminal Stenosis Following Vertebroplasty
Neurospine. 2024;21(4):1137-1140.   Published online December 31, 2024
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We present a case of iatrogenic lumbar foraminal stenosis caused by bone-cement leakage during vertebroplasty, successfully managed using transforaminal endoscopic lumbar foraminotomy (TELF). Vertebroplasty is an effective treatment for osteoporotic vertebral compression fractures (VCFs); however, complications such as bone-cement leakage can lead to vascular or neurological issues, including lumbar radiculopathy. TELF is a minimally invasive surgical option for addressing various forms of lumbar foraminal stenosis. An 82-year-old female patient presented to Gachon University Gil Medical Center with severe right inguinal pain radiating to the anterior thigh and knee. Six months prior, she had undergone vertebroplasty at the L3 level for an osteoporotic VCF at another hospital. Following the procedure, she developed radicular leg pain with a diminished knee jerk reflex, which progressively worsened despite extensive conservative treatment. Magnetic resonance imaging and computed tomography revealed right-sided L3–4 foraminal stenosis caused by bone-cement leakage from the prior vertebroplasty. TELF was performed under local anesthesia to decompress the affected area. Bone-cement fragments, along with hypertrophic bone and ligaments, were successfully removed, achieving sufficient decompression of the exiting nerve root. The patient experienced immediate postoperative pain relief. This case represents the first documented instance of endoscopic decompression for iatrogenic foraminal stenosis following vertebroplasty. TELF, performed safely under local anesthesia, demonstrates its effectiveness as a minimally invasive solution for this rare complication.

Citations

Citations to this article as recorded by  Crossref logo
  • Cement leakage into adjacent vertebra during percutaneous vertebroplasty: “Gild the Lily” or “Kill two birds with one stone”?
    Rui-Feng Ji, De-an Qin
    International Journal of Surgery.2026; 112(6): 12975.     CrossRef
  • Current Evidence and Clinical Implications of Full-Endoscopic Spine Surgery for Post-Vertebroplasty Lumbar Radiculopathy: A Comprehensive Review
    Yong Ahn, Sol Lee, Chang Won Lee
    Journal of Pain Research.2026; Volume 19: 1.     CrossRef
  • O-arm navigation-based transforaminal unilateral biportal endoscopic discectomy for upper lumbar disc herniation: an innovative preliminary study
    Dong Hyun Lee, Choon Keun Park, Jin-Sung Kim, Jin Sub Hwang, Jin Young Lee, Dong-Geun Lee, Jae-Won Jang, Jun Yong Kim, Yong-Eun Cho, Dong Chan Lee
    Asian Spine Journal.2025; 19(2): 194.     CrossRef
  • Risk factors analysis of recurrent vertebral fractures after vertebroplasty
    Wei Wu, Kai Zhou, Bo Yang, Xianjin Luo
    Current Problems in Surgery.2025; 70: 101836.     CrossRef
  • 3,536 View
  • 85 Download
  • 3 Web of Science
  • 4 Crossref

Original Articles

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A Comparative Study of 2 Techniques to Avoid Bone Cement Loosening and Displacement After Percutaneous Vertebroplasty Treating Unstable Kummell Disease
Neurospine. 2024;21(2):575-587.   Published online May 18, 2024
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A Comparative Study of 2 Techniques to Avoid Bone Cement Loosening and Displacement After Percutaneous Vertebroplasty Treating Unstable Kummell Disease
Neurospine. 2024;21(2):575-587.   Published online May 18, 2024
Close
Objective
Percutaneous vertebroplasty (PVP) is currently the most common surgical procedure for unstable Kummell disease (KD), but cement loosening or displacement often occurs after PVP. We had been using percutaneous pediculoplasty (PPP) or a self-developed bone cement bridging screw system to avoid this severe complication. This study intends to compare these novel surgical procedures through a 2-year follow-up evaluation.
Methods
From May 2017 to May 2021, 77 patients with single-level unstable KD were included in the PPP group, and 42 patients received the PVP-bone cement bridging screw system were included in the screw group. The changes in the vertebral body index (VBI), bisegmental Cobb angle, visual analogue scale (VAS) and Oswestry Disability Index (ODI) and the cement loosening rate and displacement rate at different follow-up time points were used to evaluate the clinical efficacy.
Results
There was no significant difference in VBI or bisegmental Cobb angle between the 2 groups (p > 0.05) before operation, immediately after operation and at 6-month followup, while at 1-year and 2-year postoperative evaluations, the screw group had higher VBI and bisegmental Cobb angle than the PPP group (p < 0.05). Before operation, immediately after operation, at 6-month and 1-year follow-up, there was no significant difference in VAS or ODI score between the 2 groups (p > 0.05), while at 2-year follow-up, the screw group still had higher VAS and ODI scores than the PPP group (p < 0.05). No bone cement displacement occurred in both groups, but the rate of bone cement loosening was 14.29% in group PPP, and 0 in screw group (p < 0.05).
Conclusion
This 2-year follow-up study shows that the PVP-bone cement bridging screw system combined therapy had better midterm treatment efficacy than the PVP-PPP combined therapy in patients with unstable KD, and the bone cement bridging screw system is a preferred therapy with better anti cement loosening ability.

Citations

Citations to this article as recorded by  Crossref logo
  • Bone cement displacement after percutaneous vertebroplasty for a three-column fracture: a case report
    Yuhang Qin, Shuai Zhang
    BMC Surgery.2026;[Epub]     CrossRef
  • Biomechanical study of robot-navigated targeted cross-puncture percutaneous vertebroplasty for Kümmell's disease: finite element analysis
    Haibin Zhou, Chunjiu Gao, Xiaoyuan Zhang, Bao Chen, Xiao Meng, Yifeng Liao, Xuebin Tang, Hua Li, Yunqing Wang
    Frontiers in Rehabilitation Sciences.2026;[Epub]     CrossRef
  • Combine Short‐Segment Fixation and Leverage Reduction Technique to Correct Kyphotic Angle in Kümmell's Disease
    Yunwei Long, Guangzi Chen, Delu Zeng, Xiangyu Tang, Chaoxu Liu
    Orthopaedic Surgery.2026; 18(7): 1518.     CrossRef
  • Clinical effectiveness of percutaneous vertebroplasty in elderly patients with osteoporotic lumbar vertebral fractures: A retrospective study
    Ruo-Yi Deng, Peng Zhan
    Current Problems in Surgery.2025; 69: 101820.     CrossRef
  • Short-Segment Fixation With Bone Cement Augmentation for Unstable Kümmell Disease
    Yu-liang Sun, Wan Dun, Tao Gu, Hua-gang Shi, Wei Cui, Xuan-geng Deng
    Clinical Spine Surgery.2025;[Epub]     CrossRef
  • 6,097 View
  • 145 Download
  • 8 Web of Science
  • 5 Crossref

Bone Biology and Osteoporosis Special Issue

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Comparative Efficacy of Surgical Interventions for Osteoporotic Vertebral Compression Fractures: A Systematic Review and Network Meta-analysis
Neurospine. 2023;20(4):1142-1158.   Published online December 31, 2023
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Comparative Efficacy of Surgical Interventions for Osteoporotic Vertebral Compression Fractures: A Systematic Review and Network Meta-analysis
Neurospine. 2023;20(4):1142-1158.   Published online December 31, 2023
Close
Objective
We aimed to comprehensively compare surgical methods for osteoporotic vertebral compression fracture (OVCF) using systematic review and network meta-analysis to understand their effectiveness and outcomes, as current research provides limited overviews.
Methods
We followed PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines, preregistering our protocol with PROSPERO. We analyzed Englishpublished randomized controlled trials (RCTs) on adults with OVCFs that evaluated pain intensity or functionality using tools like visual analogue scale (VAS) or Oswestry Disability Index (ODI). Exclusions included non-RCTs, malignancy-related fractures, and certain interventions. Using the RoB 2 tool, we assessed bias and visualized results with Robvis. Our primary outcome was pain intensity, with secondary outcomes including disability, new fractures, and cement leakage. Results were synthesized using Stata/MP.
Results
Thirty-four RCTs from 10 countries, totaling 4,384 patients, were analyzed. Shortterm VAS indicated kyphoplasty with facet joint injection (KIJ) as the top treatment at 87.7%, while unipedicular kyphoplasty (UKP) led to long-term at 74.9%. Short-term ODI favored vertebroplasty with facet joint injection (VIJ) at 98.4%, with kyphoplasty (KP) leading longterm at 66.0%. All surgical techniques were superior to conservative treatment. Vertebral augmentation devices reported the fewest new fractures and curved vertebroplasty had the least cement leakage. SUCRA (surface under the cumulative ranking) analyses suggested UKP and VIJ as top choices for postoperative pain relief, with VIJ excelling in postoperative disability improvement.
Conclusion
Our analysis evaluates 12 OVCF interventions, underscoring KIJ for short-term pain relief and VIJ and UKP for long-term efficacy. Notably, VIJ stands out in disability outcomes, emphasizing the need for comprehensive OVCF management.

Citations

Citations to this article as recorded by  Crossref logo
  • Diagnosis and treatment of osteoporotic vertebral fractures
    Martin Bibza, Michal Božík, Mário Malina, Boris Šteňo
    Clinical Osteology.2026; 31(1): 55.     CrossRef
  • Predicting long-term clinical mortality of elderly patients with vertebral compression fractures
    Shuofan Wang, Kaiwen Peng, Kaili Peng, Zhichao Gao
    Frontiers in Medicine.2026;[Epub]     CrossRef
  • The bisegmental Cobb angle in osteoporotic spine fractures: Does it influence treatment decision or functional outcome?
    Philipp Schenk, Bernhard W. Ullrich, Felix C. Kohler, Falko Schwarz, Klaus J. Schnake, Michael A. Scherer, Gregor Schmeiser, Katja Liepold, Marion Riehle, Michael Müller, Martin Bäumlein, Sebastian Katscher, Max J. Scheyerer, Georg Osterhoff, Kai Sprengel
    Brain and Spine.2026; 6: 106099.     CrossRef
  • Vertebral augmentation procedures for osteoporotic vertebral compression fractures: a network meta-analysis of randomized controlled trials
    Basel Musmar, Hammam Abdalrazeq, Arbaz Momin, Michael Baldassari, Pious Patel, Matthews Lan, Stephanie Serva, Joseph Schaefer, Jenna Langbein, Karim Hafazalla, D. Mitchell Self, Steven Glener, Hassan Saad, Daniel Franco, James S. Harrop
    Neurosurgical Review.2026;[Epub]     CrossRef
  • Restoration of Sagittal Alignment and Pulmonary Function With Percutaneous Vertebral Body Augmentation for Painful Osteoporotic Vertebral Compression Fractures: A Systematic Review
    Hanne H Jørgensen, Mikkel Ø Andersen, Tove F Frandsen, Line A Wickstrøm, Benjamin Kostic, Leah Y Carreon
    Cureus.2025;[Epub]     CrossRef
  • Prophylactic Antibiotics in Vertebroplasty and Kyphoplasty: A Nationwide Analysis of Infection Rates and Antibiotic Use in South Korea
    Youngjin Kim, Young-Hoon Kim, Sukil Kim, Jun-Seok Lee, Sang-Il Kim, Joonghyun Ahn, So-Young Han, Hyung-Youl Park
    Antibiotics.2025; 14(9): 901.     CrossRef
  • Spinal Subdural Hematoma After Kyphoplasty in a Patient on Warfarin: A Case Report and Literature Review
    Ho-Young Jung, Jun-Seok Lee, Geon-U Kim, Hyung-Youl Park
    Journal of Advanced Spine Surgery.2025; 15(1): 38.     CrossRef
  • SPINAL DISORDER DIAGNOSIS BASED ON DEEP LEARNING INTEGRATING BIOMECHANICAL DATA
    HUI-JUAN WAN, TENG-TENG ZHANG, JIN-XIN ZHENG, BING-BING WANG, YONG-JUN CHEN
    Journal of Mechanics in Medicine and Biology.2025;[Epub]     CrossRef
  • Minimally Invasive Treatment Using Biportal Endoscopic Decompression with Vertebroplasty for Osteoporotic Vertebral Compression Fractures in Older Adult Patients
    Sang-Min Park, Sang-Soo Na, Ho-Joong Kim, Jin S. Yeom
    Clinics in Orthopedic Surgery.2025; 17(5): 836.     CrossRef
  • Interleukin Concentrations in Bone Marrow Fluid and MRI Prognostic Findings in Osteoporotic Vertebral Fractures
    Yasuhiro Nakajima, Akinori Kageyama, Yasukazu Hijikata, Ayako Motomura, Takashi Tsujiuchi, Koji Osuka
    Cureus.2025;[Epub]     CrossRef
  • Osteoporosis en columna vertebral
    Barón Zárate Kalfópulos, Irving Omar Estévez-García
    Investigación en Discapacidad.2025; 11(2): 41.     CrossRef
  • A retrospective study identifying the primary source of hidden blood loss during vertebroplasty
    Yuanhao Wang, Ting Zhao, Cong Chen, Baoshan Xu
    Medicine.2025; 104(42): e45213.     CrossRef
  • The Use of Polymethylmethacrylate Cement in Percutaneous Vertebroplasty Versus Conservative Management: How to Treat Osteoporotic Vertebral Compression Fractures
    Corrado Ciatti, Chiara Asti, Pietro Maniscalco, Michelangelo Rinaldi, Gianfranco Pirellas, Gianfilippo Caggiari, Francesco Pisanu, Angelino Sanna, Carlo Doria
    Medicina.2025; 61(11): 2004.     CrossRef
  • Influence of thoracolumbar kyphotic Cobb angle on prognosis after PKP surgery
    Peng Yuan, Xiang Ge, Qiang Shi, Yifan Wu, Zhen Yu
    Scientific Reports.2025;[Epub]     CrossRef
  • Commentary on “Deep Learning-Assisted Quantitative Measurement of Thoracolumbar Fracture Features on Lateral Radiographs”
    Chao-Hung Kuo
    Neurospine.2024; 21(1): 44.     CrossRef
  • Clinical Oversight and Delayed Diagnosis of a Pathological Compression Fracture Causing Paraplegia
    Yin-Sheng Chen, Ping-Chuan Liu, Chih-Chang Chang, Tsung-Hsi Tu, Chao-Hung Kuo
    Cureus.2024;[Epub]     CrossRef
  • Clinical significance of modified unilateral puncture percutaneous vertebroplasty guided by 3D- printed guides in the treatment of osteoporotic vertebral compression fractures: a retrospective study
    Tao Gao, Sheng-Yu Wan, Zhi-Yu Chen, Tao Li, Xu Lin, Hai-Gang Hu, Jian-Dong Tang, Chao Wu
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • Validity and reliability of the osteoporotic fracture treatment score (OF score) and outcomes across various treatments in osteoporosis vertebral compression fracture patients
    Korawish Mekariya, Borriwat Santipas, Harit Khamnurak, Wilasinee Sirichativapee, Ekkapoj Korwutthikulrangsri, Monchai Ruangchainikom, Werasak Sutipornpalangkul
    Journal of Orthopaedic Surgery and Research.2024;[Epub]     CrossRef
  • 15,191 View
  • 254 Download
  • 13 Web of Science
  • 18 Crossref

Review Article

Bone Biology and Osteoporosis Special Issue

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Treatment for Osteoporotic Vertebral Fracture - A Short Review of Orthosis and Percutaneous Vertebroplasty and Balloon Kyphoplasty
Neurospine. 2023;20(4):1124-1131.   Published online December 31, 2023
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Treatment for Osteoporotic Vertebral Fracture - A Short Review of Orthosis and Percutaneous Vertebroplasty and Balloon Kyphoplasty
Neurospine. 2023;20(4):1124-1131.   Published online December 31, 2023
Close
The management of osteoporotic vertebral fractures (OVFs) in the elderly includes nonoperative treatment and vertebroplasty, but has not been established due to the diversity of patient backgrounds. The purpose of this study was to compare the impact of 3 treatment modalities for the management of OVF: orthotic treatment, percutaneous vertebroplasty (PVP), and balloon kyphoplasty (BKP). The method was based on an analysis of the latest RCTs, meta-analyses, and systematic reviews on these topics. No study showed a benefit of bracing with high level of evidence. Trials were found that showed comparable outcomes without orthotic treatment. Only 1 randomized controlled trial (RCT) showed an improvement in pain relief up to 6 months compared with no orthosis. Rigid and nonrigid orthoses were equally effective. Four of 5 RCTs comparing vertebroplasty and sham surgery were equally effective, and one RCT showed superior pain relief with vertebroplasty within 3 weeks of onset. In open trials comparing vertebroplasty with nonoperative management, vertebroplasty was superior. PVP and BKP were comparable in terms of pain relief, improvement in quality of life, and adjacent vertebral fractures. BKP does not affect global sagittal alignment, although BKP may restore vertebral body height. An RCT was published showing that PVP was effective in chronic cases without pain relief. Vertebroplasty improved life expectancy by 22% at 10 years. The superiority of orthotic therapy for OVF was seen only in short-term pain relief. Soft orthoses proved to be a viable alternative to rigid orthoses. Vertebroplasty within 3 weeks may be useful. There is no significant difference in clinical efficacy between PVP and BKP. Vertebroplasty improves life expectancy.

Citations

Citations to this article as recorded by  Crossref logo
  • The innovative application of 3D-printed spinal braces in post-percutaneous vertebroplasty care for osteoporotic vertebral compression fractures: A retrospective study
    Ya-Ping Xiao, Jie Liu, Ling Li, Hai-Jia Xu, Wen Liao, Jia-Tao Huang, Zhang-Hua Li
    Journal of Clinical Neuroscience.2026; 143: 111723.     CrossRef
  • Multidisciplinary management of acute osteoporotic vertebral fracture: results of a national Delphi consensus
    Luis Alvarez-Galovich, Estanislao Arana, Juan Francisco Blanco Blanco, José Manuel Cancio Trujillo, Santos Castañeda, Carolina de Miguel Benadiba, Alfonso González Ramírez, Guillermo Martínez Díaz-Guerra
    Archives of Osteoporosis.2026;[Epub]     CrossRef
  • Relationship of Preexisting Vertebral Fractures and Endplate Injury to Intervertebral Bridging Ossification After Balloon Kyphoplasty for Osteoporotic Vertebral Fractures
    Toshiaki Maruyama, Naosuke Kamei, Toshio Nakamae, Yoshinori Fujimoto, Kiyotaka Yamada, Kazuto Nakao, Fadlyansyah Farid, Hiroki Fukui, Nobuo Adachi, Shashank Kaushik
    Journal of Osteoporosis.2026;[Epub]     CrossRef
  • Postoperative bracing after vertebroplasty: a prospective randomized controlled study
    Haimiti Abudouaini, Guang Yang, Jianbin Guan
    Annals of Physical and Rehabilitation Medicine.2026; 69(5): 102094.     CrossRef
  • Health-related Quality of Life After Vertebral Augmentation for Osteoporotic Vertebral Compression Fractures
    Si Wei, Zhenjin Cai, Hao Zheng, Hongjie Zhang, Xiaoli Quan, Yaoyue Luo, Guangwei Wang
    Current Osteoporosis Reports.2026;[Epub]     CrossRef
  • Comparative Accuracy Assessment of Thoraco-Lumbo-Sacral Orthosis Fabrication: Conventional Contact Casting Versus Noncontact 3-Dimensional Digital Scanning
    Naotoshi Kumagai, Takashi Yurube, Masao Ryu, Yoshiki Takeoka, Yutaro Kanda, Kohei Kuroshima, Yoshiaki Hiranaka, Masahiko Furuya, Daisuke Nakagawa, Yu Inoue, Ryosuke Kuroda, Kenichiro Kakutani
    Neurospine.2026; 23(2): 335.     CrossRef
  • Impact of Percutaneous Vertebroplasty on Vertebral Height and Sagittal Alignment in Thoracolumbar Osteoporotic Compression Fractures: A Retrospective Observational Study
    Junho Oh, Gi Jeong Park, Kwang-Ryeol Kim
    Journal of Advanced Spine Surgery.2026; 16(1): 1.     CrossRef
  • Percutaneous vertebroplasty by two-step fluoroscopy: a treatment for osteoporotic compression fractures of thoracic vertebrae in older adults
    Jianzhong Ge, Kuisheng Chen, Peng Xu, Zhiling Zhang, Kai Wang, Tao Zhang, Xin Dong, Zhigang Kang, Yizhou Ge, Feng Chang
    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
  • Incidence of new osteoporotic adjacent vertebral body fractures. A comparison between conservative treatment and vertebral body augmentation (vertebroplasty, kyphoplasty): a systematic review and meta-analysis
    Panagiotis Korovessis, Vasileios Syrimpeis, Alkis Korovesis, Georgios Dimakopoulos
    Frontiers in Surgery.2025;[Epub]     CrossRef
  • Assessing the Role of Expandable Vertebral Augmentation versus High-Viscosity Cement Vertebroplasty in Severe Osteoporotic Vertebral Fracture Management: A Prospective Cohort Study
    Yi-Chen Liu, You-Rui Lin, Sung Huang Laurent Tsai, Ying-Chih Wang, Chia-Wei Chang, Tung-Yi Lin, Tsai-Sheng Fu, Wen-Jer Chen
    World Neurosurgery.2025; 200: 124166.     CrossRef
  • Vertebral Augmentation for Osteoporotic Vertebral Fractures
    Masahiro Kawanishi, Yutaka Ito, Hidekazu Tanaka, Naokado Ikeda, Kunio Yokoyama, Makoto Yamada, Akira Sugie, Daiji Ichihashi
    Spinal Surgery.2025; 39(3): 228.     CrossRef
  • Stem Cell and Regenerative Therapies for the Treatment of Osteoporotic Vertebral Compression Fractures
    Songzi Zhang, Yunhwan Lee, Yanting Liu, Yerin Yu, Inbo Han
    International Journal of Molecular Sciences.2024; 25(9): 4979.     CrossRef
  • Promotion of Bone Formation in a Rat Osteoporotic Vertebral Body Defect Model via Suppression of Osteoclastogenesis by Ectopic Embryonic Calvaria Derived Mesenchymal Stem Cells
    Yerin Yu, Somin Lee, Minsung Bock, Seong Bae An, Hae Eun Shin, Jong Seop Rim, Jun-oh Kwon, Kwang-Sook Park, Inbo Han
    International Journal of Molecular Sciences.2024; 25(15): 8174.     CrossRef
  • Different polymethylmethacrylate (PMMA) reinforcement strategies for long bone osteoplasty procedures: a controlled laboratory comparison using the 4-point bending test
    David Putzer, Valentina Egger, Johannes Pallua, Martin Thaler, Werner Schmölz, Michael Nogler
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • 11,378 View
  • 256 Download
  • 12 Web of Science
  • 14 Crossref

Original Articles

Bone Biology and Osteoporosis Special Issue

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Utilization of Vertebroplasty/Kyphoplasty in the Management of Compression Fractures: National Trends and Predictors of Vertebroplasty/Kyphoplasty
Neurospine. 2023;20(4):1132-1139.   Published online December 31, 2023
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Utilization of Vertebroplasty/Kyphoplasty in the Management of Compression Fractures: National Trends and Predictors of Vertebroplasty/Kyphoplasty
Neurospine. 2023;20(4):1132-1139.   Published online December 31, 2023
Close
Objective
The purpose of this study is to examine the utilization of kyphoplasty/vertebroplasty procedures in the management of compression fractures. With the growing elderly population and the associated increase in rates of osteoporosis, vertebral compression fractures have become a daily encounter for spine surgeons. However, there remains a lack of consensus on the optimal management of this patient population.
Methods
A retrospective analysis of 91 million longitudinally followed patients from 2016 to 2019 was performed using the PearlDiver Patient Claims Database. Patients with compression fractures were identified using International Classification of Disease, 10th Revision codes, and a subset of patients who received kyphoplasty/vertebroplasty were identified using Common Procedural Terminology codes. Baseline demographic and clinical data between groups were acquired. Multivariable regression analysis was performed to determine predictors of receiving kyphoplasty/vertebroplasty.
Results
A total of 348,457 patients with compression fractures were identified with 9.2% of patients receiving kyphoplasty/vertebroplasty as their initial treatment. Of these patients, 43.5% underwent additional kyphoplasty/vertebroplasty 30 days after initial intervention. Patients receiving kyphoplasty/vertebroplasty were significantly older (72.2 vs. 67.9, p < 0.05), female, obese, had active smoking status and had higher Elixhauser Comorbidity Index scores. Multivariable analysis demonstrated that female sex, smoking status, and obesity were the 3 strongest predictors of receiving kyphoplasty/vertebroplasty (odds ratio, 1.27, 1.24, and 1.14, respectively). The annual rate of kyphoplasty/vertebroplasty did not change significantly (range, 8%–11%).
Conclusion
The majority of vertebral compression fractures are managed nonoperatively. However, certain patient factors such as smoking status, obesity, female sex, older age, osteoporosis, and greater comorbidities are predictors of undergoing kyphoplasty/vertebroplasty.

Citations

Citations to this article as recorded by  Crossref logo
  • The Effectiveness of Fu’s Subcutaneous Needling for Residual Pain After Percutaneous Vertebral Augmentation in Osteoporotic Vertebral Compression Fractures: A Randomized Clinical Trial Protocol
    Qiong Wang, Zhengqiang Ren, Binru Wang, Juan Du, Xinming Li, Jianjiao Mou
    Journal of Pain Research.2026; Volume 19: 1.     CrossRef
  • Minimally Invasive Treatment Using Biportal Endoscopic Decompression with Vertebroplasty for Osteoporotic Vertebral Compression Fractures in Older Adult Patients
    Sang-Min Park, Sang-Soo Na, Ho-Joong Kim, Jin S. Yeom
    Clinics in Orthopedic Surgery.2025; 17(5): 836.     CrossRef
  • Single-Level Vertebral Augmentation Procedures
    Rahul H. Jayaram, Rohil Malpani, Albert L. Rancu, Philip P. Ratnasamy, Anshu Jonnalagadda, Jonathan N. Grauer
    Clinical Spine Surgery.2025;[Epub]     CrossRef
  • Commentary on “Utilization of Vertebroplasty/Kyphoplasty in the Management of Compression Fractures: National Trends and Predictors of Vertebroplasty/Kyphoplasty”
    Sahir S. Jabbouri, Peter G. Whang
    Neurospine.2023; 20(4): 1140.     CrossRef
  • From the Editor-in-Chief: Featured Articles in the December 2023 Issue
    Inbo Han
    Neurospine.2023; 20(4): 1093.     CrossRef
  • 10,993 View
  • 234 Download
  • 5 Web of Science
  • 5 Crossref

Bone Biology and Osteoporosis Special Issue

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The Effectiveness of Vertebral Height Restoration Based on the Vertebroplasty Procedure Used to Treat Osteoporotic Vertebral Fractures
Neurospine. 2023;20(4):1159-1165.   Published online December 31, 2023
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The Effectiveness of Vertebral Height Restoration Based on the Vertebroplasty Procedure Used to Treat Osteoporotic Vertebral Fractures
Neurospine. 2023;20(4):1159-1165.   Published online December 31, 2023
Close
Objective
Whether the use of a balloon or stent in vertebroplasty for vertebral fractures, such as balloon kyphoplasty (BKP) or vertebral body stenting (VBS), actually contributes to the restoration of postoperative vertebral height is unclear. The aim of the current study was to compare the effectiveness of percutaneous vertebroplasty (PVP), BKP, and VBS in the correction of collapsed vertebrae in patients with painful vertebral fractures.
Methods
The cases studied involved 34 vertebrae in 28 patients treated with PVP, 43 vertebrae in 38 patients treated with BKP, and 20 vertebrae in 20 patients treated with VBS at Izinkai Takeda General Hospital. Changes in the vertebral height and local kyphosis angle were measured based on standing lumbar radiographs before and after surgery and were compared among the treatment groups.
Results
There were no differences in changes in the height of the anterior wall, middle body, or posterior wall of the treated vertebrae among the 3 treatment groups. The same was true for changes in the local kyphosis angle. The effectiveness of vertebral height restoration depended heavily upon preoperative vertebral instability in all the treatment groups. Correction loss due to balloon deflation effect or balloon sinking was noted with VBS or BKP.
Conclusion
BKP and VBS have the advantage of reducing the risk of extravertebral leakage of injected bone cement, but they have a disadvantage in that they are no more effective than PVP in restoring collapsed vertebrae despite the use of a balloon or metal stent.

Citations

Citations to this article as recorded by  Crossref logo
  • Clinical Outcomes of Vertebral Body Stenting for Osteoporotic Vertebral Fractures: Focus on Collapse Prevention and Magnetic Resonance Imaging-Based Indication
    Kenji Uda, Takayuki Awaya, Toshiki Fukuoka, Tomotaka Iwakoshi, Hinako Nagamatsu, Kazuki Ishii, Takashi Abe, Osamu Suzuki, Yoshitaka Nagashima, Takafumi Tanei, Yusuke Nishimura, Ryuta Saito
    Global Spine Journal.2026; 16(2): 992.     CrossRef
  • Comparison of Surgical Outcomes Between Vertebral Body Stenting (VBS) and Balloon Kyphoplasty (BKP)—Multicenter Cohort Study
    Akiyoshi Miyamoto, Ingrid Ignacio, Masato Tanaka, Shinya Arataki, Tadashi Komatsubara, Ryo Ugawa, Nitin Jaiswal, Pankaj Kumar Sharma, Yoshiaki Oda, Koji Uotani
    Journal of Clinical Medicine.2026; 15(9): 3371.     CrossRef
  • Impact of Percutaneous Vertebroplasty on Vertebral Height and Sagittal Alignment in Thoracolumbar Osteoporotic Compression Fractures: A Retrospective Observational Study
    Junho Oh, Gi Jeong Park, Kwang-Ryeol Kim
    Journal of Advanced Spine Surgery.2026; 16(1): 1.     CrossRef
  • Minimally Invasive Treatment Using Biportal Endoscopic Decompression with Vertebroplasty for Osteoporotic Vertebral Compression Fractures in Older Adult Patients
    Sang-Min Park, Sang-Soo Na, Ho-Joong Kim, Jin S. Yeom
    Clinics in Orthopedic Surgery.2025; 17(5): 836.     CrossRef
  • Comparative Radiologic and Morphologic Analysis of Posterolateral Fusion and Percutaneous Pedicle Screw Fixation for Thoracolumbar Junction Burst Fractures
    Hyung-Rae Lee, Minseung Kang, Jae Min Park, Jae-Hyuk Yang
    Journal of Clinical Medicine.2025; 14(18): 6379.     CrossRef
  • Stem Cell and Regenerative Therapies for the Treatment of Osteoporotic Vertebral Compression Fractures
    Songzi Zhang, Yunhwan Lee, Yanting Liu, Yerin Yu, Inbo Han
    International Journal of Molecular Sciences.2024; 25(9): 4979.     CrossRef
  • Promotion of Bone Formation in a Rat Osteoporotic Vertebral Body Defect Model via Suppression of Osteoclastogenesis by Ectopic Embryonic Calvaria Derived Mesenchymal Stem Cells
    Yerin Yu, Somin Lee, Minsung Bock, Seong Bae An, Hae Eun Shin, Jong Seop Rim, Jun-oh Kwon, Kwang-Sook Park, Inbo Han
    International Journal of Molecular Sciences.2024; 25(15): 8174.     CrossRef
  • 5,957 View
  • 225 Download
  • 6 Web of Science
  • 7 Crossref

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Quantitative Comparison of Vertebral Structural Changes After Percutaneous Vertebroplasty Between Unilateral Extrapedicular Approach and Bilateral Transpedicular Approach Using Voxel-Based Morphometry
Neurospine. 2023;20(4):1287-1302.   Published online September 25, 2023
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Quantitative Comparison of Vertebral Structural Changes After Percutaneous Vertebroplasty Between Unilateral Extrapedicular Approach and Bilateral Transpedicular Approach Using Voxel-Based Morphometry
Neurospine. 2023;20(4):1287-1302.   Published online September 25, 2023
Close
Objective
To compare unilateral extrapedicular vertebroplasty (UEV) and bilateral transpedicular vertebroplasty (BTV) by quantitatively calculating the structural changes of fractured vertebral body after percutaneous vertebroplasty (PVP) using 3-dimensional voxel-based morphometry (VBM).
Methods
We calculated bone cement volume (BCV); vertebral body volume (VBV); leaked intradiscal BCV; and spatial, symmetric, and even bone cement distribution (BCD) in and out of 222 vertebral bodies treated with 2 different PVPs using VBM and evaluated the incidence of subsequent vertebral compression fracture (SVCF). Statistical analyses were conducted to compare values between the 2 different PVPs.
Results
Relative BCV, which is a potential risk factor for SVCF, was higher in the BTV group based on the data using VBM (0.22±0.03 vs. 0.29±0.03; p<0.001, t-test); however, the SVCF incidence between the 2 surgeries was not significantly different (UEV, 24.7%; BTV, 31%; p=0.046, chi-square test). Spatial, even, and symmetric BCD along the 3 axes was not significantly different between UEV and BTV using VBM (x, y, z-axis, p=0.893, p= 0.590, p=0.908 respectively, chi-square test).
Conclusion
Contrary to intuitive concerns, UEV can inject a sufficient and more optimal BCV than BTV. Additionally, it can inject bone cement spatially, symmetrically, and evenly well-distributed without an increased rate of intradiscal leakage and SVCF compared with BTV based on VBM. Therefore, UEV could be a superior alternative surgical method with similar clinical effectiveness and safety, considering the above results and the consensus that UEV is less invasive.

Citations

Citations to this article as recorded by  Crossref logo
  • Clinical outcomes of unilateral versus bilateral percutaneous vertebroplasty under local anaesthesia: a prospective randomised study
    Igor Movrin
    Frontiers in Surgery.2026;[Epub]     CrossRef
  • Clinical and radiological outcome comparison of unilateral vs. bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures
    Levent Aydın, Buse Sarıgül, Tufan Agah Kartum, Gonca Gül Öndüç, Saime Ayça Şahin, Ali Fatih Ramazanoğlu
    Medical Journal of Western Black Sea.2026; 10(1): 157.     CrossRef
  • Surgical robot-guided unilateral percutaneous kyphoplasty: anatomical features and clinical efficacy of a modified transverse process-pedicle approach
    Zhuanghui Wang, Yuanfeng Wang, Hao Chen, Run Zhang, Jue Zhang, Qinghong Ma, Chao Sun
    Journal of Robotic Surgery.2025;[Epub]     CrossRef
  • Factors influencing acute pain after percutaneous vertebroplasty in patients with thoracolumbar fractures and its predictive model creation and validation
    Ren-Lin Huang, Yong Zhou, Yi Liu, Chen Feng
    Medicine.2025; 104(44): e45409.     CrossRef
  • From the Editor-in-Chief: Featured Articles in the December 2023 Issue
    Inbo Han
    Neurospine.2023; 20(4): 1093.     CrossRef
  • Commentary on “Quantitative Comparison of Vertebral Structural Changes After Percutaneous Vertebroplasty Between Unilateral Extrapedicular Approach and Bilateral Transpedicular Approach Using Voxel-Based Morphometry”
    Toshihiko Inui
    Neurospine.2023; 20(4): 1303.     CrossRef
  • 10,058 View
  • 543 Download
  • 8 Web of Science
  • 6 Crossref

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Cement Augmentation of Vertebral Compression Fractures May Be Safely Considered in the Very Elderly
Neurospine. 2021;18(1):226-233.   Published online March 31, 2021
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Cement Augmentation of Vertebral Compression Fractures May Be Safely Considered in the Very Elderly
Neurospine. 2021;18(1):226-233.   Published online March 31, 2021
Close
Objective
The objective of the current study was to perform a retrospective review of a national database to assess the safety of cement augmentation for vertebral compression fractures in geriatric populations in varying age categories.
Methods
The 2005–2016 National Surgical Quality Improvement Program databases were queried to identify patients undergoing kyphoplasty or vertebroplasty in the following age categories: 60–69, 70–79, 80–89, and 90+ years old. Demographic variables, comorbidity status, procedure type, provider specialty, inpatient/outpatient status, number of procedure levels, and periprocedure complications were compared between age categories using chi-square analysis. Multivariate logistic regressions controlling for patient and procedural variables were then performed to assess the relative periprocedure risks of adverse outcomes of patients in the different age categories relative to those who were 60–69 years old.
Results
For the 60–69, 70–79, 80–89, and 90+ years old cohorts, 486, 822, 937, and 215 patients were identified, respectively. After controlling for patient and procedural variables, 30-day any adverse events, serious adverse events, reoperation, readmission, and mortality were not different for the respective age categories. Cases in the 80- to 89-year-old cohort were at increased risk of minor adverse events compared to cases in the 60- to 69-year-old cohort.
Conclusion
As the population ages, cement augmentation is being considered as a treatment for vertebral compression fractures in increasingly older patients. These results suggest that even the very elderly may be appropriately considered for these procedures (level of evidence: 3).

Citations

Citations to this article as recorded by  Crossref logo
  • Surgical management of spinal metastases from primary lung carcinoma: demographics, clinical characteristics, and outcomes—A retrospective analysis
    Jun Li, Yuhan Zheng, Xiaohua Lv, Rong Zeng, Yating Zhao, Yucheng Xiang, Ke Zhan, Congcong Liu, Houqing Long, Ke Chen
    Frontiers in Surgery.2026;[Epub]     CrossRef
  • Advantages of TiRobot-assisted surgery in the treatment of osteoporotic thoracolumbar compression fractures: a meta-analysis based on multiple clinical indicators
    Yu Liu, Zidong Xia, Huiling Chen, Jian Wang, Mengtian Cao, Guohang Shen, Mingyuan Fan, Kaiyong Wang, Yang Chen, Yupei Dai
    Journal of Robotic Surgery.2025;[Epub]     CrossRef
  • Spinal augmentation for vertebral body fractures in the elderly population
    Alexander R. Evans, Taylor Niznik, Chao Li, Zachary A. Smith
    GeroScience.2025;[Epub]     CrossRef
  • The future of ambulatory surgery for geriatric patients
    Mary Ann Vann
    Best Practice & Research Clinical Anaesthesiology.2023; 37(3): 343.     CrossRef
  • What are the risk factors for a second osteoporotic vertebral compression fracture?
    Sang Hoon Hwang, Pyung Goo Cho, Kyoung-Tae Kim, Keung Nyun Kim, Sang Hyun Kim, Sung Hyun Noh
    The Spine Journal.2023; 23(11): 1586.     CrossRef
  • Beyond Pain Relief: An In-Depth Review of Vertebral Height Restoration After Balloon Kyphoplasty in Vertebral Compression Fractures
    Siddharth K Patel, Sohael Khan, Ventaktesh Dasari, Suvarn Gupta
    Cureus.2023;[Epub]     CrossRef
  • Risk of Revision After Vertebral Augmentation for Osteoporotic Vertebral Fracture: A Narrative Review
    Shinji Takahashi, Hiroyuki Inose, Koji Tamai, Masayoshi Iwamae, Hidetomi Terai, Hiroaki Nakamura
    Neurospine.2023; 20(3): 852.     CrossRef
  • The Effectiveness of Vertebral Height Restoration Based on the Vertebroplasty Procedure Used to Treat Osteoporotic Vertebral Fractures
    Kunio Yokoyama, Naokado Ikeda, Hidekazu Tanaka, Yutaka Ito, Akira Sugie, Makoto Yamada, Masahiko Wanibuchi, Masahiro Kawanishi
    Neurospine.2023; 20(4): 1159.     CrossRef
  • Treatment for Osteoporotic Vertebral Fracture - A Short Review of Orthosis and Percutaneous Vertebroplasty and Balloon Kyphoplasty
    Masahiro Kawanishi, Hidekazu Tanaka, Yutaka Ito, Makoto Yamada, Kunio Yokoyama, Akira Sugie, Naokado Ikeda
    Neurospine.2023; 20(4): 1124.     CrossRef
  • Commentary on “Utilization of Vertebroplasty/Kyphoplasty in the Management of Compression Fractures: National Trends and Predictors of Vertebroplasty/Kyphoplasty”
    Sahir S. Jabbouri, Peter G. Whang
    Neurospine.2023; 20(4): 1140.     CrossRef
  • Difference in the Cobb Angle Between Standing and Supine Position as a Prognostic Factor After Vertebral Augmentation in Osteoporotic Vertebral Compression Fractures
    In-Suk Bae, Byung Gwan Moon, Hee In Kang, Jae Hoon Kim, Cheolsu Jwa, Deok Ryeong Kim
    Neurospine.2022; 19(2): 357.     CrossRef
  • Kyphoplasty: why, when and how?
    Umile Giuseppe Longo, Rocco Papalia, Sergio De Salvatore, Valentina Piccioni, Vincenzo Denaro
    International Journal of Bone Fragility.2022; 2(1): 41.     CrossRef
  • 11,311 View
  • 222 Download
  • 11 Web of Science
  • 12 Crossref

Case Report

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Cement Leakage into Adjacent Vertebral Body Following Percutaneous Vertebroplasty
Korean J Spine. 2016;13(2):74-76.   Published online June 30, 2016
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Cement Leakage into Adjacent Vertebral Body Following Percutaneous Vertebroplasty
Korean J Spine. 2016;13(2):74-76.   Published online June 30, 2016
Close

Percutaneous vertebroplasty (PV) is a minimally invasive procedure for osteoporotic vertebral compression fractures that fail to respond to conventional conservative treatment. It significantly improves intolerable back pain within hours, and has a low complication rate. Although rare, PV is not free of complications, most of which are directly related to cement leakage. Because of its association with new adjacent fracture, the importance of cement leakage into the adjacent disc space is paramount. Here, we report an interesting case of cement leakage into the adjacent upper vertebral body as well as disc space following PV. To the best of our knowledge, there has been no report of cement leakage into the adjacent vertebral body following PV. This rare case is presented along with a review of the literature.

Citations

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  • Cement leakage into adjacent vertebra during percutaneous vertebroplasty: “Gild the Lily” or “Kill two birds with one stone”?
    Rui-Feng Ji, De-an Qin
    International Journal of Surgery.2026; 112(6): 12975.     CrossRef
  • Current Evidence and Clinical Implications of Full-Endoscopic Spine Surgery for Post-Vertebroplasty Lumbar Radiculopathy: A Comprehensive Review
    Yong Ahn, Sol Lee, Chang Won Lee
    Journal of Pain Research.2026; Volume 19: 1.     CrossRef
  • Bone Bridge Effect for the Treatment of Acute Osteoporotic Vertebral Compression Fractures: A Multistrategic Approach Using an Anabolic Agent
    Ja-Yeong Yoon, Sung-Min Kim, Seong-Hwan Moon, Hak-Sun Kim, Kyung-Soo Suk, Si-Young Park, Ji-Won Kwon, Byung Ho Lee
    Yonsei Medical Journal.2026; 67(6): 492.     CrossRef
  • Therapeutic Efficacy and Safety of Percutaneous Curved Vertebroplasty in Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta‐Analysis
    Yan Sun, Yong Zhang, Haoning Ma, Mingsheng Tan, Zhihai Zhang
    Orthopaedic Surgery.2023; 15(10): 2492.     CrossRef
  • Adjacent Intravertebral Cement Leakage During Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures
    De-an Qin, Jie-fu Song, Qing-yuan Liang
    Pain Medicine.2021; 22(6): 1453.     CrossRef
  • Percutaneous curved vertebroplasty in the treatment of thoracolumbar osteoporotic vertebral compression fractures
    Yonghong Cheng, Yiming Liu
    Journal of International Medical Research.2019; 47(6): 2424.     CrossRef
  • 12,178 View
  • 123 Download
  • 6 Crossref

Clinical Articles

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The Effectiveness of Gelfoam Technique before Percutaneous Vertebroplasy: Is It Helpful for Prevention of Cement Leakage? A Prospective Randomized Control Study
Korean J Spine. 2016;13(2):63-66.   Published online June 30, 2016
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The Effectiveness of Gelfoam Technique before Percutaneous Vertebroplasy: Is It Helpful for Prevention of Cement Leakage? A Prospective Randomized Control Study
Korean J Spine. 2016;13(2):63-66.   Published online June 30, 2016
Close
Objective

Preinjection gelfoam embolization during percutaneous vertebroplasty (PVP) has been thought alternative technique to prevent the leakage of bone cement. The goal of this study was to evaluate whether the gelfoam techniques are useful to reduce bone cement leakage.

Methods

Total 100 PVPs of osteoporotic spine compression fractures were performed by 1 spine surgeon who experienced more than 500 PVP cases under prospective control study. Operation was done in T-L junction (T10-L2) fractures with bi-transpedicular approach. Preinjection gelfoam PVP was done in the 50 levels. As control group, PVP without gelfoam was done in the 50 levels. We did not perform preoperative venography. We inserted normal saline-mixed gelfoam to the anterior third of vertebral body via PVP needle, and then 3mL of polymethylmetacrylate (PMMA) was injected. We prospectively evaluated the incidence and leakage pattern of PMMA by postoperative computed tomography.

Results

Between gelfoam and control groups, there were 11 leaks (22%) versus 12 leaks (26%). The mean operation time was 7.00 minutes versus 6.30 minutes. In gelfoam group, there were 6 spinal canal leaks, 4 paravertebral venous leaks, and 1 soft tissue leaks. In control group, there were 4 spinal canal leaks, 8 paravertebral venous leaks, and 1 disc space leak. In spite of cement leakage, there was no symptomatic case in both groups. Statistically, gelfoam technique was not related to decrease the incidence of leakage (p=0.64).

Conclusion

Our prospective study showed that it did not significantly decrease cement leakage when vertebroplasty is performed by experienced spine surgeon.

Citations

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  • Feasibility Analysis of the Bone Cement‐Gelatine Sponge Composite Intravertebral Prefilling Technique for Reducing Bone Cement Leakage in Stage I and II Kümmell's Disease: A Prospective Randomized Controlled Trial
    Chengqiang Zhou, Shaolong Huang, Yifeng Liao, Feng Zhang, Xiao Meng, Zhongjian Tang, Xu Zhang, Hua Li, Yao Zhang, Shuai Zhao, Yunqing Wang
    Orthopaedic Surgery.2023; 15(7): 1763.     CrossRef
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Influence of Compression Ratio Differences between Magnetic Resonance Images and Simple Radiographs on Osteoporotic Vertebral Compression Fracture Prognosis after Vertebroplasty
Korean J Spine. 2014;11(2):62-67.   Published online June 30, 2014
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Influence of Compression Ratio Differences between Magnetic Resonance Images and Simple Radiographs on Osteoporotic Vertebral Compression Fracture Prognosis after Vertebroplasty
Korean J Spine. 2014;11(2):62-67.   Published online June 30, 2014
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Objective

The extent of collapse progression after vertebroplasty in osteoporotic vertebral compression fractures (OVCF) has known to be various. In this study, we investigated that how much difference of compression ratio between standing simple radiograph and supine magnetic resonance imaging (MRI) affects the collapse progression after vertebroplasty.

Methods

This retrospective cohort study was carried out based on 27 patients with 31 OVCFs undergone vertebrplastyin the thoracolumbar junction (T12-L2), from January to December 2009. The OVCFs were divided to two groups, the smaller group A and larger group B, by mean compression ratio difference (8.1%) between standing simple radiograph and supine MRI.

Results

There were no significant differences in the baseline characteristics of the two groups except age. There were also no significant differences between the periodic compression ratio, back pain, Cobb's angle during follow-up period. However, Group B seemed to show improvements from the initial state to the point just after the operation, but eventually took a much worse course than group A. In the end, judging from the compression ratios of the two groups at the last follow up, group A showed less progression.

Conclusion

Although the clinical outcome was not different significantly, a greater compression ratio difference in the initial study resulted in a greater collapse progression at last follow-up. Therefore, we suggest that it is important to check the initial standing simple radiograph, as well as supine MRI, for predicting collapse progression after vertebroplasty.

Citations

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The Clinical Characteristics of Lower Lumbar Osteoporotic Compression Fractures Treated by Percutaneous Vertebroplasty : A Comparative Analysis of 120 Cases
Korean J Spine. 2013;10(4):221-226.   Published online December 31, 2013
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The Clinical Characteristics of Lower Lumbar Osteoporotic Compression Fractures Treated by Percutaneous Vertebroplasty : A Comparative Analysis of 120 Cases
Korean J Spine. 2013;10(4):221-226.   Published online December 31, 2013
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Objective

The purpose of this study is to provide accurate understanding of clinical presentations and surgical outcomes as well as to identify the unique characteristics of lower lumbar osteoporotic compression fracture (OCF).

Methods

Clinical data were collected from 120 patients who had L3, L4 or L5 percutaneous vertebroplasty (PVP) performed from 2008 to 2012 at the single institute. L4 or L5 PVP patients were classified into group 1 and group 2 was for L3 PVP patients. Medical records were retrospectively investigated at 1 month after PVP. Long term follow-up results were obtained at a median value of 22 months after PVP.

Results

75% of the patients in group 1 were not associated with traumatic events, 71% presenting with leg radiating symptoms and 46% requiring an additional decompressive surgery, more often than those in group 2. These differences are statistically significant (p<0.05). The short term medical record review demonstrated that only 73% of patients in group 1 were ameliorated with regard to back motion pain, whereas those in group 2 reported 87.7% rates of amelioration in identical category (p<0.05). The long term follow up confirmed a significantly worse outcome in group 1, with only 55.7% of patients reporting amelioration in their pain or functional status, but 71.7% rate of amelioration in group 2.

Conclusion

The OCFs at the L4 or L5 level have different clinical characteristics from those at upper levels of the lumbar spine.

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  • 84 Download
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