Neurospine

Neurospine provides spine clinicians and researchers with peer-reviewed articles on basic and clinical investigation of spine and spinal cord to enhance patient management, education, clinical or experimental research, and professionalism.

The journal will consider submissions in areas on craniocervical to lumbosacral spine including the followings: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, rehabilitation of spine, spinal cord and peripheral nerve diseases.

Review Article

June 30, 2024

Pharmacological Treatment of Degenerative Cervical Myelopathy: A Critical Review of Current Evidence

Jordan J Levett, Miltiadis Georgiopoulos, Simon Martel, Wissam Al Mugheiry, Nikolaos A. Stavropoulos, Miguel Vega-Arroyo, Carlo Santaguida, Michael H. Weber, Jeff D. Golan, Peter Jarzem, et al.

Neurospine. 2024;21(2):375-400.

Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction in adults, representing substantial morbidity and significant financial and resource burdens. Typically, patients with progressive DCM will eventually...

Original Article

June 30, 2024

Baseline Frailty Measured by the Risk Analysis Index and 30-Day Mortality After Surgery for Spinal Malignancy: Analysis of a Prospective Registry (2011–2020)

Rachel Thommen, Christian A. Bowers, Aaron C. Segura, Joanna M. Roy, Meic H. Schmidt

Neurospine. 2024;21(2):404-413.

Objective: To evaluate the prognostic utility of baseline frailty, measured by the Risk Analysis Index (RAI), for prediction of postoperative mortality among patients with spinal malignancy (SM) undergoing resection. Methods: SM...

Original Article

May 2, 2024

Comparison of the Clinical Efficacy of Anabolic Agents and Bisphosphonates in the Patients With Osteoporotic Vertebral Fracture: Systematic Review and Meta-analysis of Randomized Controlled Trials

Ikchan Jeon, Sung Bae Park, Bong Ju Moon, Miyoung Choi, Sung Uk Kuh, Jongtae Kim

Neurospine. 2024;21(2):416-429.

Objective: We investigated the clinical efficacy of anabolic agents compared with bisphosphonates (BPs) for the incidence of new osteoporotic vertebral fracture (OVF) and fracture healing of OVF in the patients...

Original Article

June 30, 2024

The Utility and Feasibility of Smart Glasses in Spine Surgery: Minimizing Radiation Exposure During Percutaneous Pedicle Screw Insertion

Yoshiaki Hiranaka, Yoshiki Takeoka, Takashi Yurube, Takeru Tsujimoto, Yutaro Kanda, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Naotoshi Kumagai, et al.

Neurospine. 2024;21(2):432-439.

Objective: Spine surgeons are often at risk of radiation exposure due to intraoperative fluoroscopy, leading to health concerns such as carcinogenesis. This is due to the increasing use of percutaneous...

Original Article

June 30, 2024

Radiological and Clinical Significance of Cervical Dynamic Magnetic Resonance Imaging for Cervical Spondylotic Myelopathy

Jun Jae Shin, Sun Joon Yoo, Tae Woo Kim, Jae-Young So, Won Joo Jeong, Mu Ha Lee, Joongkyum Shin, Yoon Ha

Neurospine. 2024;21(2):443-454.

Objective: The study compared the morphometric changes of the cervical spinal cord using dynamic magnetic resonance imaging (MRI) in patients with cervical spondylotic myelopathy (CSM) and assessed the correlation with...

Review Article

June 30, 2024

Assessing the Fractional Curve for Proper Management of Adult Degenerative Scoliosis

Seth C. Ransom, Zach Pennington, Nolan J. Brown, Shane Shahrestani, Jessica Ryvlin, Ali Shoustari, John C. Hagen, Anthony L. Mikula, Nikita Lakomkin, Luis D. Diaz-Aguilar, et al.

Neurospine. 2024;21(2):458-473.

Adult degenerative scoliosis (ADS) is a coronal plane deformity often accompanied by sagittal plane malalignment. Surgical correction may involve the major and/or distally-located fractional curves (FCs). Correction of the FC...

Review Article

June 30, 2024

Artificial Intelligence in Spinal Imaging and Patient Care: A Review of Recent Advances

Sungwon Lee, Joon-Yong Jung, Akaworn Mahatthanatrakul, Jin-Sung Kim

Neurospine. 2024;21(2):474-486.

Artificial intelligence (AI) is transforming spinal imaging and patient care through automated analysis and enhanced decision-making. This review presents a clinical task-based evaluation, highlighting the specific impact of AI techniques...

Review Article

June 30, 2024

Comparative Review of the Socioeconomic Burden of Lower Back Pain in the United States and Globally

Diana Chang, Austin Lui, Alisa Matsoyan, Michael M. Safaee, Henry Aryan, Christopher Ames

Neurospine. 2024;21(2):487-501.

Internationally, the United States (U.S.) cites the highest cost burden of low back pain (LBP). The cost continues to rise, faster than the rate of inflation and overall growth of...

Original Article

June 30, 2024

Radiographic and Clinical Outcomes of Transverse Process Hook Placement at the Proximal Thoracic Upper Instrumented Vertebra in Adult Spinal Deformity Surgery

Sang Hun Lee, Micheal Raad, Andrew H. Kim, David B. Cohen, Khaled M. Kebaish

Neurospine. 2024;21(2):502-509.

Objective: Few studies have reported radiographic and clinical outcomes of transverse process hook (TPH) placement at the proximal thoracic upper instrumented vertebra (UIV) in adult spinal deformity (ASD) surgery. This...

Original Article

June 30, 2024

Magnetic Resonance Imaging-Related Anatomic and Functional Parameters for the Diagnosis and Prognosis of Chiari Malformation Type I: A Systematic Review and Meta-analysis

Zairan Wang, Zhimin Li, Shiyuan Han, Xianghui Hu, Siyuan Pang, Yongning Li, Jun Gao

Neurospine. 2024;21(2):510-524.

Objective: Imaging parameters of Chiari malformation type I (CMI) development are not well established. This study aimed to collect evidence of general or specific imaging measurements in patients with CMI,...

Original Article

February 1, 2024

Are There Advantages in Cervical Intrafacetal Fusion With Minimal Posterolateral Fusion (PLF) Compared to Conventional PLF in Posterior Cervical Fusion?

Sun Woo Jang, Sang Hyub Lee, Jeong Kyun Joo, Hong Kyung Shin, Jin Hoon Park, Sung Woo Roh, Sang Ryong Jeon

Neurospine. 2024;21(2):525-535.

Objective: We propose that cervical intrafacetal fusion (cIFF) using bone chip insertion into the facetal joint space additional to minimal PLF is a supplementary fusion method to conventional posterolateral fusion...

Original Article

February 1, 2024

Finite Element Analysis of Stress Distribution and Range of Motion in Discogenic Back Pain

Pyung-Goo Cho, Seon-Jin Yoon, Dong Ah Shin, Min Cheol Chang

Neurospine. 2024;21(2):536-543.

Objective: Precise knowledge regarding the mechanical stress applied to the intervertebral disc following each individual spine motion enables physicians and patients to understand how people with discogenic back pain should...

Original Article

February 1, 2024

Comparison of Transoral Anterior Jefferson-Fracture Reduction Plate and Posterior Screw-Rod Fixation in C1-Ring Osteosynthesis for Unstable Atlas Fractures

Mandi Cai, Yifeng Wu, Rencai Ma, Junlin Chen, Zexing Chen, Chenfu Deng, Xinzhao Huang, Xiangyang Ma, Xiaobao Zou

Neurospine. 2024;21(2):544-554.

Objective: To compare the clinical outcomes of transoral anterior Jefferson-fracture reduction plate (JeRP) and posterior screw rod (PSR) surgery for unstable atlas fractures via C1-ring osteosynthesis. Methods: From June 2009 to...

Original Article

February 1, 2024

Knockdown of best1 Gene in Zebrafish Caused Abnormal Neuronal and Skeletal Development - A Subtype of Craniovertebral Junction Malformation?

Zhenlei Liu, Kang Li, Kai Wang, Lei Zhang, Shanhang Jia, He Wang, Fengzeng Jian, Hao Wu

Neurospine. 2024;21(2):555-564.

Objective: To investigate the developmental defects caused by knockdown of best1 gene in zebrafish as a model for a subtype of craniovertebral junction (CVJ) malformation. Methods: Two antisense morpholinos (MOs) were...

Original Article

June 30, 2024

Clinical and Radiological Outcomes in C2 Recapping Laminoplasty for the Pathologies in the Upper Cervical Spine

Dong Hun Kim, Jae Taek Hong, Jung Woo Hur, Il Sup Kim, Ho Jin Lee, Jong Beom Lee

Neurospine. 2024;21(2):565-574.

Objective: To evaluate C2 muscle preservation effect and the radiological and clinical outcomes after C2 recapping laminoplasty. Methods: Fourteen consecutive patients who underwent C2 recapping laminoplasty around C1–2 level were enrolled....

Original Article

May 18, 2024

A Comparative Study of 2 Techniques to Avoid Bone Cement Loosening and Displacement After Percutaneous Vertebroplasty Treating Unstable Kummell Disease

Jie Guo, Yesheng Bai, Liang Li, Jiangtao Wang, Yuhang Wang, Dinghun Hao, Biao Wang

Neurospine. 2024;21(2):575-587.

Objective: Percutaneous vertebroplasty (PVP) is currently the most common surgical procedure for unstable Kummell disease (KD), but cement loosening or displacement often occurs after PVP. We had been using percutaneous...

Original Article

June 30, 2024

Incidence and Survival of Patients With Malignant Primary Spinal Cord Tumors: A Population-Based Analysis

Huanbing Liu, Linnan Duan, Zhibin Li, Yuanhao Liu, Yubo Wang

Neurospine. 2024;21(2):588-595.

Objective: Epidemiological studies on spinal cord tumors are rare, and studies on primary intramedullary tumors are even rarer. The incidence and survival of patients with primary intramedullary spinal cord tumors...

Original Article

June 30, 2024

Predictors of Persistent Postoperative Numbness Following Lumbar Fusion in Patients Older Than 75 Years: A Minimum 2-Year Follow-up

Takeru Tsujimoto, Masahiro Kanayama, Shotaro Fukada, Fumihiro Oha, Yukitoshi Shimamura, Yuichi Hasegawa, Tomoyuki Hashimoto, Kenichiro Kakutani, Takashi Yurube, Yoshiki Takeoka, et al.

Neurospine. 2024;21(2):596-605.

Objective: To evaluate the preoperative and perioperative predictors of persistent leg numbness following lumbar fusion in patients aged ≥ 75 years. Methods: This single-center retrospective study examined 304 patients aged ≥...

Original Article

June 30, 2024

Biomechanical Analysis of Hybrid Artificial Discs or Zero-Profile Devices for Treating 1-Level Adjacent Segment Degeneration in ACDF Revision Surgery

Weishi Liang, Yihan Yang, Bo Han, Duan Sun, Peng Yin, Yong Hai

Neurospine. 2024;21(2):606-619.

Objective: Cervical hybrid surgery optimizes the use of cervical disc arthroplasty (CDA) and zero-profile (ZOP) devices in anterior cervical discectomy and fusion (ACDF) but lacks uniform combination and biomechanical standards,...

Original Article

May 20, 2024

Using Machine Learning Models to Identify Factors Associated With 30-Day Readmissions After Posterior Cervical Fusions: A Longitudinal Cohort Study

Aneysis D. Gonzalez-Suarez, Paymon G. Rezaii, Daniel Herrick, Seth Stravers Tigchelaar, John K. Ratliff, Mirabela Rusu, David Scheinker, Ikchan Jeon, Atman M. Desai

Neurospine. 2024;21(2):620-632.

Objective: Readmission rates after posterior cervical fusion (PCF) significantly impact patients and healthcare, with complication rates at 15%–25% and up to 12% 90-day readmission rates. In this study, we aim...

Original Article

June 30, 2024

Analyzing Large Language Models’ Responses to Common Lumbar Spine Fusion Surgery Questions: A Comparison Between ChatGPT and Bard

Siegmund Philipp Lang, Ezra Tilahun Yoseph, Aneysis D. Gonzalez-Suarez, Robert Kim, Parastou Fatemi, Katherine Wagner, Nicolai Maldaner, Martin N. Stienen, Corinna Clio Zygourakis

Neurospine. 2024;21(2):633-641.

Objective: In the digital age, patients turn to online sources for lumbar spine fusion information, necessitating a careful study of large language models (LLMs) like chat generative pre-trained transformer (ChatGPT)...

Original Article

June 30, 2024

Inhibition of Ferroptosis by Mesenchymal Stem Cell-Derived Exosomes in Acute Spinal Cord Injury: Role of Nrf2/GCH1/BH4 Axis

Yixin Chen, Bingfa Li, Jing Quan, Zhe Li, Yan Li, Yinbo Tang

Neurospine. 2024;21(2):642-655.

Objective: The therapeutic benefits of exosomes obtained from mesenchymal stem cells (MSCs) in acute spinal cord injury (SCI) have been demonstrated in recent years, but the precise mechanisms remain unknown....

Original Article

June 30, 2024

Comparison of Single or Double Titanium Mesh Cage for Anterior Reconstruction After Total En Bloc Spondylectomy for Thoracic and Lumbar Spinal Tumors

Ao Leng, Qi Wang, Jiacheng Li, Yu Long, Song Shi, Lingzhi Meng, Mingming Guo, Hailong Yu, Liangbi Xiang

Neurospine. 2024;21(2):656-664.

Objective: To compare the clinical efficacy of anterior column reconstruction using single or double titanium mesh cage (TMC) after total en bloc spondylectomy (TES) of thoracic and lumbar spinal tumors. Methods:...

Original Article

June 30, 2024

The Quantitative Evaluation of Automatic Segmentation in Lumbar Magnetic Resonance Images

Yao-Wen Liang, Yu-Ting Fang, Ting-Chun Lin, Cheng-Ru Yang, Chih-Chang Chang, Hsuan-Kan Chang, Chin-Chu Ko, Tsung-Hsi Tu, Li-Yu Fay, Jau-Ching Wu, et al.

Neurospine. 2024;21(2):665-675.

Objective: This study aims to overcome challenges in lumbar spine imaging, particularly lumbar spinal stenosis, by developing an automated segmentation model using advanced techniques. Traditional manual measurement and lesion detection...

Original Article

June 30, 2024

A Nomogram for Predicting Overall Survival of Patients With Primary Spinal Cord Glioblastoma

Yao Wang, Qingchun Mu, Minfeng Sheng, Yanming Chen, Fengzeng Jian, Rujun Li

Neurospine. 2024;21(2):676-689.

Objective: Primary spinal cord glioblastoma (PSCGBM) is a rare malignancy with a poor prognosis. To date, no prognostic nomogram for this rare disease was established. Hence, we aimed to develop...

Original Article

June 30, 2024

A Comparative Factor Analysis and New Magnetic Resonance Imaging Scoring System for Differentiating Pyogenic Versus Tuberculous Spondylodiscitis

Terdpong Tanaviriyachai, Patchara Pornsopanakorn, Kongtush Choovongkomol, Tada Virathepsuporn, Urawit Piyapromdee, Sarut Jongkittanakul, Weera Sudprasert, Sirichai Wiwatrojanagul

Neurospine. 2024;21(2):690-700.