Neurospine

Neurospine provides spine clinicians and researchers with peer-reviewed articles on basic and clinical investigation of spine and spinal cord to enhance patient management, education, clinical or experimental research, and professionalism.

The journal will consider submissions in areas on craniocervical to lumbosacral spine including the followings: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, rehabilitation of spine, spinal cord and peripheral nerve diseases.

Review Article

December 31, 2022

Reciprocal Changes Following Cervical Realignment Surgery

Jae-Koo Lee, Seung-Jae Hyun, Seung Heon Yang, Ki-Jeong Kim

Neurospine. 2022;19(4):853-861.

Over the last few decades, the importance of the sagittal plane and its contour has gained significant recognition. Through full-body stereoradiography, the understanding of compensatory mechanisms, and the concept of...

Review Article

December 31, 2022

Classification(s) of Cervical Deformity

Austin C. Kaidi, Han Jo Kim

Neurospine. 2022;19(4):862-867.

Cervical spine deformities (CSD) are complex surgical issues with currently heterogenous management strategies. The classification of CSD is still an evolving field. Rudimentary classification schemas were initially proposed in the...

Review Article

December 31, 2022

Surgical Strategies and Perioperative Considerations for Cervical Deformity With Cerebral Palsy: A Comprehensive Review of the Literature

Hyung Cheol Kim, Sung Han Oh, Jae Keun Oh, Yoon Ha

Neurospine. 2022;19(4):868-875.

The complex nature of the cervical spine makes surgical intervention challenging when treating cervical deformity in patients with cerebral palsy (CDCP). However, few studies have investigated the unique characteristics of...

Original Article

December 31, 2022

Defining Cervical Sagittal Plane Deformity – When Are Sagittal Realignment Procedures Necessary in Patients Presenting Primarily With Radiculopathy or Myelopathy?

Venu M. Nemani, Philip K. Louie, Caroline E. Drolet, John M. Rhee

Neurospine. 2022;19(4):876-882.

Objective: It remains unclear whether cervical sagittal deformity (CSD) should be defined by radiographic parameters alone versus both clinical and radiographic factors, and whether radiographic malalignment by itself warrants a...

Original Article

December 31, 2022

Cervical Inclination Angle: Normative Values in an Adult Multiethnic Asymptomatic Population

Jean Charles Le Huec, Zeeshan M. Sardar, Emanuele Quarto, Meghan Cerpa, Michael P. Kelly, Kazuhiro Hasegawa, Hwee Weng Dennis Hey, Hee-Kit Wong, Hend Riahi, Lawrence G. Lenke, et al.

Neurospine. 2022;19(4):883-888.

Objective: The role of the craniocervical complex in spinal sagittal alignment has rarely been analyzed but it may play a fundamental role in postoperative mechanical complications. The aim of the...

Original Article

December 31, 2022

Measurement of Deformity at the Craniovertebral Junction: Correlation of Triangular Area and Myelopathy

Chih-Chang Chang, Jau-Ching Wu, Chin-Chu Ko, Hsuan-Kan Chang, Yi-Hsuan Kuo, Chao-Hung Kuo, Tsung-Hsi Tu, Wen-Cheng Huang

Neurospine. 2022;19(4):889-895.

Objective: Diseases of the craniovertebral junction (CVJ) are commonly associated with deformity, malalignment, and subsequent myelopathy. The misaligned CVJ might cause compression of neuronal tissues and subsequently clinical symptoms. The...

Original Article

December 31, 2022

Characteristics and Comparisons of Morphometric Measurements and Computed Tomography Hounsfield Unit Values of C2 Laminae for Translaminar Screw Placement Between Patients With and Without Basilar Invagination

Lu-Ping Zhou, Jin Shang, Zhi-Gang Zhang, Zhen-Fei Jiang, Hua-Qing Zhang, Chong-Yu Jia, Ren-Jie Zhang, Cai-Liang Shen

Neurospine. 2022;19(4):899-911.

Objective: Patients with basilar invagination (BI) had high incidences of vertebral variations and high-riding vertebral artery (HRVA) that might restrict the use of pedicle or pars screw and increase the...

Original Article

December 31, 2022

Clinical Impact and Correlations of Odontoid Parameters Following Multilevel Posterior Cervical Fusion Surgery

Jae-Koo Lee, Seung-Jae Hyun, Seung Heon Yang, Ki-Jeong Kim

Neurospine. 2022;19(4):912-920.

Objective: C2 slope (C2S), a cervical parameter mathematically approximated as T1 slope minus cervical lordosis (T1S–CL), predicts functional improvement in cervical deformity patients. Nonetheless, C2S is a positional parameter based...

Original Article

December 31, 2022

The Effect of Subsidence on Segmental and Global Lordosis at Long-term Follow-up After Anterior Cervical Discectomy and Fusion

Akiro H. Duey, Christopher Gonzalez, Eric A. Geng, Pierce J. Ferriter Jr, Ashley M. Rosenberg, Ula N. Isleem, Bashar Zaidat, Paul M. Al-Attar, Jonathan S. Markowitz, Jun S. Kim, et al.

Neurospine. 2022;19(4):927-934.

Objective: Subsidence following anterior cervical discectomy and fusion (ACDF) may lead to disruptions of cervical alignment and lordosis. The purpose of this study was to evaluate the effect of subsidence...

Review Article

December 31, 2022

A Narrative Review of Advances in Neural Precursor Cell Transplantation Therapies for Spinal Cord Injury

Takahiro Kitagawa, Narihito Nagoshi, Hideyuki Okano, Masaya Nakamura

Neurospine. 2022;19(4):935-945.

A spinal cord injury (SCI) is a destructive event that causes a permanent deficit in neurological function because of poor regenerative potential. Transplantation therapies have attracted attention for restoration of...

Review Article

November 10, 2022

Advances in Neural Stem Cell Therapy for Spinal Cord Injury: Safety, Efficacy, and Future Perspectives

Sungjoon Lee, Hyun Nam, Kyeung-Min Joo, Sun-Ho Lee

Neurospine. 2022;19(4):946-960.

Spinal cord injury (SCI) is a devastating central nervous system injury that leads to severe disabilities in motor and sensory functions, causing significant deterioration in patients’ quality of life. Owing...

Review Article

December 31, 2022

Therapeutic Approaches Targeting Vascular Repair After Experimental Spinal Cord Injury: A Systematic Review of the Literature

Laurens Roolfs, Vanessa Hubertus, Jacob Spinnen, Lennard K. Shopperly, Michael G. Fehlings, Peter Vajkoczy

Neurospine. 2022;19(4):961-975.

Traumatic spinal cord injury (SCI) disrupts the spinal cord vasculature resulting in ischemia, amplification of the secondary injury cascade and exacerbation of neural tissue loss. Restoring functional integrity of the...

Review Article

December 31, 2022

Spinal Metastases and the Evolving Role of Molecular Targeted Therapy, Chemotherapy, and Immunotherapy

Elena I. Fomchenko, James C. Bayley, Christopher Alvarez-Breckenridge, Laurence D. Rhines, Claudio E. Tatsui

Neurospine. 2022;19(4):978-993.

Metastatic involvement of the spine is a common complication of systemic cancer progression. Surgery and external beam radiotherapy are palliative treatment modalities aiming to preserve neurological function, control pain and...

Original Article

December 31, 2022

Comparative Effects and Safety of Full-Endoscopic Versus Microscopic Spinal Decompression for Lumbar Spinal Stenosis: A Meta-Analysis and Statistical Power Analysis of 6 Randomized Controlled Trials

Zechuan Yang, Huan Wang, Wenkai Li, Weihua Hu

Neurospine. 2022;19(4):996-1005.

Objective: This meta-analysis with statistical power analysis aimed to evaluate the difference between full-endoscopic and microscopic spinal decompression in treating spinal stenosis. Methods: We searched PubMed, Embase, CENTRAL (Cochrane Central Register...

Original Article

December 31, 2022

Reliability and Diagnostic Accuracy of Standard Dermatomes and Myotomes for Determining the Pathologic Level in Surgically Verified Patients With Cervical Radiculopathy

Chul Gie Hong, Woo Dong Nam

Neurospine. 2022;19(4):1006-1012.

Objective: This study aimed to investigate the reliability and diagnostic accuracy of typical dermatomes and myotomes for determining the pathologic level in surgically verified patients with cervical radiculopathy. Methods: Patients who...

Original Article

October 23, 2022

Surgical Versus Conservative Management for Treating Unstable Atlas Fractures: A Multicenter Study

Jun Jae Shin, Kwang-Ryeol Kim, Joongkyum Shin, Jiin Kang, Ho Jin Lee, Tae Woo Kim, Jae Taek Hong, Sang-Woo Kim, Yoon Ha

Neurospine. 2022;19(4):1013-1025.

Objective: This multicenter study compared radiological parameters and clinical outcomes between surgical and nonsurgical management and investigated treatment characteristics associated with the successful management of unstable atlas fractures. Methods: We retrospectively...

Original Article

December 31, 2022

Full Endoscopic Ligamentum Flavum Sparing Unilateral Laminotomy for Bilateral Recess Decompression: Surgical Technique and Clinical Results

Woo-Keun Kwon, Katherine A. Kelly, Malia McAvoy, Sananthan Sivakanthan, John Ogunlade, Natalie Kai Yi Yap, Sharon Durfy, Christoph P. Hofstetter

Neurospine. 2022;19(4):1028-1038.

Objective: Interlaminar endoscopic spine surgery has been introduced and utilized for lumbar lateral recess decompression. We modified this technique and utilized it for bilateral lateral recess stenoses without significant central...

Original Article

December 31, 2022

Risk Analysis Index and Its Recalibrated Version Predict Postoperative Outcomes Better Than 5-Factor Modified Frailty Index in Traumatic Spinal Injury

Matthew Conlon, Rachel Thommen, Syed Faraz Kazim, Alis J. Dicpinigaitis, Meic H. Schmidt, Rohini G. McKee, Christian A. Bowers

Neurospine. 2022;19(4):1039-1048.

Objective: To assess the discriminative ability of the Risk Analysis Index-administrative (RAI-A) and its recalibrated version (RAI-Rev), compared to the 5-factor modified frailty index (mFI-5), in predicting postoperative outcomes in...

Original Article

December 31, 2022

Impact of Mechanism of Injury on Long-term Neurological Outcomes of Cervical Sensorimotor Complete Acute Traumatic Spinal Cord Injury

Alex B. Bak, Ali Moghaddamjou, Anahita Malvea, Michael G. Fehlings

Neurospine. 2022;19(4):1049-1056.

Objective: Mechanism of injury is a largely understudied descriptor of acute traumatic spinal cord injury (tSCI). This study sought to compare the impact of high-energy and low-energy mechanisms of injury...

Original Article

December 31, 2022

Relationship Between Syrinx Resolution and Cervical Sagittal Realignment Following Decompression Surgery for Chiari I Malformation Related Syringomyelia Based on Configuration Phenotypes

Chunli Lu, Longbing Ma, Jian Guan, Zhenlei Liu, Kai Wang, Wanru Duan, Zan Chen, Hao Wu, Fengzeng Jian

Neurospine. 2022;19(4):1057-1070.

Objective: Combined with different configuration types of syringomyelia, to analyze the correlation between syrinx resolution and changes in cervical sagittal alignment following Foramen magnum and Magendie dredging (FMMD) for syringomyelia...

Original Article

November 18, 2022

Evaluation and Comparation of a Novel Surgical Technique and Hemivertebra Resection to the Correction of Congenital Cervical Scoliosis in Lower Cervical and Cervicothoracic Spine

Shuo Cao, Xin Chen, Shengfa Pan, Yinze Diao, Yanbin Zhao, Tian Xia, Weishi Li, Feifei Zhou, Yu Sun

Neurospine. 2022;19(4):1071-1083.

Objective: To report concave-side distraction technique to treat congenital cervical scoliosis in lower cervical and cervicothoracic spine. To evaluate and compare clinical and radiographic results of this procedure with classic...

Original Article

December 31, 2022

A Nomogram Model for Prediction of Tracheostomy in Patients With Traumatic Cervical Spinal Cord Injury

Yunbo Jian, Dawei Sun, Zhengfeng Zhang

Neurospine. 2022;19(4):1084-1092.

Objective: To develop a nomogram for the prediction of tracheostomy in patients with traumatic cervical spinal cord injury (TCSCI). Methods: A total of 689 TCSCI patients were included in our study....

Original Article

December 31, 2022

Global Trends and Hotspots in Endoscopic Discectomy: A Study Based on Bibliometric Analysis

Boyu Wu, Lei Yang, Chengwei Fu, Yue Zhuo, Xiang Feng, Hui Xiong

Neurospine. 2022;19(4):1093-1107.

Objective: With the advancement of minimally invasive spine surgery, endoscopic discectomy (ED) has become a common technique for degenerative disease of the spine. The present study aimed to explore the...

Original Article

December 31, 2022

Prevalence, Distribution, and Concomitance of Whole-Spine Ossification of the Posterior Longitudinal Ligament and Ossification of the Ligament Flavum in South Koreans: A Whole-Spine-CT-Based Cross-Sectional Study

Yun Hee Choi, Je Hoon Lee, Young Min Kwon

Neurospine. 2022;19(4):1108-1115.

Objective: No studies assessing the prevalence of ossification of the spinal ligament were conducted using whole-spine positron emission tomography and computed tomography (PET-CT) in healthy Koreans. We aimed to determine...

Original Article

December 31, 2022

Freehand Juxtapedicular Screws Placed in the Apical Concavity of Adult Idiopathic Scoliosis Patients: Technique, Computed Tomography Confirmation, and Radiographic Results

Alexander J. Schupper, James D. Lin, Joseph A. Osorio, Nathan J. Lee, Jeremy M Steinberger, Joseph M. Lombardi, Ronald A. Lehman, Lawrence G. Lenke

Neurospine. 2022;19(4):1116-1121.

Objective: The purpose of this study is to highlight our technique for freehand placement of juxtapedicular screws along with intraoperative computed tomography (CT) and radiographic results. Methods: Consecutive patients with adult...

Original Article

December 31, 2022

Description of the Diversity in Surgical Indication and Surgical Strategies for Primary Spinal Cord Tumors: A Nationwide Survey by the Neurospinal Society of Japan

Yasukazu Hijikata, Shigeo Ueda, Takao Yasuhara, Daisuke Umebayashi, Toshiki Endo, Toshihiro Takami, Masaki Mizuno, Kazutoshi Hida, Minoru Hoshimaru

Neurospine. 2022;19(4):1122-1129.

Objective: To assess the current management of primary spinal cord tumors (PSCTs) and determine whether and to what extent there are differences in surgical strategies for PSCTs. Methods: The Neurospinal Society...

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