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Neurospine provides spine clinicians and researchers with peer-reviewed articles on basic and clinical investigation of spine and spinal cord to enhance patient management, education, clinical or experimental research, and professionalism.
The journal will consider submissions in areas on craniocervical to lumbosacral spine including the followings: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, rehabilitation of spine, spinal cord and peripheral nerve diseases.

Review Article

September 30, 2022


History and Evolution of the Minimally Invasive Transforaminal Lumbar Interbody Fusion
Michael C. Prabhu, Kevin C. Jacob, Madhav R. Patel, Hanna Pawlowski, Nisheka N. Vanjani, Kern Singh
Neurospine. 2022;19(3):479-491.

The minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a popular surgical technique for lumbar arthrodesis, widely considered to hold great efficacy while conferring an impressive safety profile through the...

Original Article

May 13, 2022


The Change of Spinal Canal According to Oblique Lumbar Interbody Fusion in Degenerative Spondylolisthesis: A Prospective Observational Study
Young-Seok Lee, Dong-Hyun Lee, Dae-Chul Cho, Inbo Han, Chi Heon Kim, Heum-Dai Kwon, Kyoung-Tae Kim
Neurospine. 2022;19(3):492-500.

Objective: Oblique lumbar interbody fusion (OLIF) involves inserting large cages into the interbody disc space. This expands the spinal canal and neural foramen by stretching the ligament flavum and releasing...

Original Article

September 30, 2022


Safety and Feasibility of Augmented Reality Assistance in Minimally Invasive and Open Resection of Benign Intradural Extramedullary Tumors
Fabian Sommer, Ibrahim Hussain, Sertac Kirnaz, Jacob Goldberg, Lynn McGrath, Rodrigo Navarro-Ramirez, Francois Waterkeyn, Franziska Schmidt, Pravesh Shankar Gadjradj, Roger Härtl
Neurospine. 2022;19(3):501-512.

Objective: Surgical resection of benign intradural extramedullary tumors (BIETs) is effective for appropriately selected patients. Minimally invasive surgical (MIS) techniques have been described for successful resection of BIET while minimizing...

Original Article

May 16, 2022


Comparison of the Clinical Efficacy of Transforaminal Endoscopy and Microtubular Technology for the Treatment of Lumbar Dumbbell-Shaped Tumors
Rui Wang, Ze Yan Liang, Yan Chen, Chun Mei Chen
Neurospine. 2022;19(3):513-523.

Objective: To analyze differences in feasibility and efficacy between the paravertebral approach and microtubular tumorectomy (PAMT) or percutaneous transforaminal endoscopic tumorectomy (PTET) for the treatment of lumbar dumbbell-shaped tumors. Methods: Clinical...

Original Article

September 30, 2022


Comparison Between 3-Dimensional-Printed Titanium and Polyetheretherketone Cages: 1-Year Outcome After Minimally Invasive Transforaminal Interbody Fusion
Do-Yeon Kim, O-Hyuk Kwon, Jeong-Yoon Park
Neurospine. 2022;19(3):524-532.

Objective: Three-dimensional (3D)-printed titanium implants have been developed recently, but the utility is not yet proven. The aim of this study was to compare 3D-printed titanium and polyetheretherketone (PEEK) implants...

Original Article

January 2, 2022


Higher American Society of Anesthesiologists Classification Does Not Limit Safety or Improvement Following Minimally Invasive Transforaminal Lumbar Interbody Fusion
Conor P. Lynch, Elliot D.K. Cha, Cara E. Geoghegan, Caroline N. Jadczak, Shruthi Mohan, Kern Singh
Neurospine. 2022;19(3):533-543.

Objective: The American Society of Anesthesiologists (ASA) physical status classification has been used to risk stratify surgical candidates. Our study compares outcomes of minimally invasive transforaminal lumbar interbody fusion (MIS...

Original Article

September 30, 2022


Indirect Decompression Using Oblique Lumbar Interbody Fusion Revision Surgery Following Previous Posterior Decompression: Comparison of Clinical and Radiologic Outcomes Between Direct and Indirect Decompression Revision Surgery
Sang-Jin Park, Jong-Moon Hwang, Dae-Chul Cho, Subum Lee, Chi Heon Kim, Inbo Han, Dae-Won Park, Heum-Dai Kwon, Kyoung-Tae Kim
Neurospine. 2022;19(3):544-554.

Objective: This study compared the radiological and clinical outcomes with transforaminal lumbar interbody fusion (TLIF) to evaluate the effect of indirect decompression through oblique lumbar interbody fusion (OLIF) as revision...

Original Article

September 30, 2022


Comparative Analysis of Transforaminal Endoscopic Thoracic Discectomy and Microscopic Discectomy for Symptomatic Thoracic Disc Herniation
Junseok Bae, Jisang Kim, Sang-Ho Lee, Jin-Sung Kim
Neurospine. 2022;19(3):555-562.

Objective: To evaluate the clinical outcomes of transforaminal endoscopic thoracic discectomy (TETD) and microscopic discectomy (MD) for the treatment of symptomatic thoracic disc herniation (TDH). Methods: Seventy-seven patients (mean, 55.9 years;...

Original Article

September 30, 2022


Assessing the Learning Process of Transforaminal Endoscopic Discectomy for Sciatica
Pravesh Shankar Gadjradj, Pieter Schutte, Arnold Vreeling, Paul Depauw, Biswadjiet S. Harhangi
Neurospine. 2022;19(3):563-570.

Objective: Percutaneous transforaminal endoscopic discectomy (PTED) is gaining popularity by both surgeons and patients as a less invasive treatment option for sciatica. Concerns, however, exist for its learning curve. No...

Original Article

September 30, 2022


Augmented Reality to Improve Surgical Workflow in Minimally Invasive Transforaminal Lumbar Interbody Fusion – A Feasibility Study With Case Series
Fabian Sommer, Ibrahim Hussain, Sertac Kirnaz, Jacob L. Goldberg, Rodrigo Navarro-Ramirez, Lynn B. McGrath Jr, Franziska A. Schmidt, Branden Medary, Pravesh Shankar Gadjradj, Roger Härtl
Neurospine. 2022;19(3):574-585.

Objective: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a highly reproducible procedure for the fusion of spinal segments. We recently introduced the concept of “total navigation” to improve workflow...

Original Article

September 30, 2022


Posterior Apophyseal Ring Fracture in Adult Lumbar Disc Herniation: An 8-Year Experience in Minimally Invasive Surgical Management of 48 Cases
Shuo Yuan, Qichao Wu, Lei Zang, Ning Fan, Peng Du, Aobo Wang, Tianyi Wang, Fangda Si, Jian Li, Xiaochuan Kong
Neurospine. 2022;19(3):586-593.

Objective: Posterior apophyseal ring fracture (PARF) is an uncommon disorder that is usually accompanied by lumbar disc herniation (LDH). The aim of this study to describe the 8-year experience of...

Original Article

September 30, 2022


Surgeons Learning Curve of Transforaminal Endoscopic Discectomy for Sciatica
Pravesh S. Gadjradj, Arnold Vreeling, Paul R. Depauw, Pieter J. Schutte, Biswadjiet S. Harhangi,
Neurospine. 2022;19(3):594-602.

Objective: Full-endoscopic spine surgery is gaining interest as a less-invasive alternative to treat sciatica caused by a lumbar disc herniation. Concerns, however, exist with the learning curve as percutaneous transforaminal...

Original Article

September 30, 2022


Comparative Analysis With Modified Inclined Technique for Posterior Endoscopic Cervical Foraminotomy in Treating Cervical Osseous Foraminal Stenosis: Radiological and Midterm Clinical Outcomes
Ji Yeon Kim, Dong Hwa Heo, Dong Chan Lee, Tae Hyun Kim, Choon Keun Park
Neurospine. 2022;19(3):603-615.

Objective: We compared the midterm clinical and radiological outcomes between 2 types of full endoscopic posterior cervical foraminotomy, including conventional posterior endoscopic cervical foraminotomy (PECF) and modified inclined technique for...

Review Article

September 30, 2022


Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells
Yuan-huan Ma, Qing-yue Liang, Ying Ding, Inbo Han, Xiang Zeng
Neurospine. 2022;19(3):616-629.

Spinal cord injury (SCI) is a result of a devastating injury to the central nervous system. Currently, there is no effective treatment available for these patients. The possible use of...

Review Article

September 30, 2022


Extra Cellular Matrix Remodeling: An Adjunctive Target for Spinal Cord Injury and Intervertebral Disc Degeneration
Ashish Kumar, Neeraj Kumar, Zarna Pathak, Hemant Kumar
Neurospine. 2022;19(3):632-645.

The extracellular matrix (ECM) is a protein-and-carbohydrate meshwork that supports a variety of biological structures and processes, from tissue development and elasticity to the preservation of organ structures. ECM composition...

Review Article

September 30, 2022


Spinal Cord Injury Provoked Neuropathic Pain and Spasticity, and Their GABAergic Connection
Ankita Bhagwani, Manjeet Chopra, Hemant Kumar
Neurospine. 2022;19(3):646-668.

Traumatic spinal cord injury (SCI) is the devastating neurological damage to the spinal cord that becomes more complicated in the secondary phase. The secondary injury comes with inevitable long-lasting complications,...

Review Article

September 30, 2022


Effect of Acute Physical Interventions on Pathophysiology and Recovery After Spinal Cord Injury: A Comprehensive Review of the Literature
Nicholle E. Lewis, Troy Q. Tabarestani, Brianna R. Cellini, Nina Zhang, Eric J. Marrotte, Haichen Wang, Daniel T. Laskowitz, Muhammad M. Abd-El-Barr, Timothy D. Faw
Neurospine. 2022;19(3):671-686.

Physical rehabilitation is essential for enhancing recovery in individuals with spinal cord injury (SCI); however, aside from early surgical intervention and hemodynamic management, there are no proven interventions for promoting...

Review Article

September 30, 2022


Surgical Considerations to Improve Recovery in Acute Spinal Cord Injury
Troy Q. Tabarestani, Nicholle E. Lewis, Margot Kelly-Hedrick, Nina Zhang, Brianna R. Cellini, Eric J. Marrotte, Theresa Williamson, Haichen Wang, Daniel T. Laskowitz, Timothy D. Faw, et al.
Neurospine. 2022;19(3):689-702.

Acute traumatic spinal cord injury (SCI) can be a devastating and costly event for individuals, their families, and the health system as a whole. Prognosis is heavily dependent on the...

Review Article

September 30, 2022


A Review of Functional Restoration From Spinal Cord Stimulation in Patients With Spinal Cord Injury
Alice Lin, Elias Shaaya, Jonathan S. Calvert, Samuel R. Parker, David A. Borton, Jared S. Fridley
Neurospine. 2022;19(3):703-734.

Traumatic spinal cord injury often leads to loss of sensory, motor, and autonomic function below the level of injury. Recent advancements in spinal cord electrical stimulation (SCS) for spinal cord...

Original Article

September 30, 2022


Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury
Dongwoo Yu, Seul Ah Mun, Sang Woo Kim, Dae-Chul Cho, Chi Heon Kim, Inbo Han, Subum Lee, Sang-Woo Lee, Kyoung-Tae Kim
Neurospine. 2022;19(3):737-747.

Objective: Neuropathic pain is a common secondary complication of spinal cord injury (SCI). N-methyl-D-aspartate (NMDA) receptor activation is critical for hypersensitivity in neuropathic pain. This activation requires the binding of...

Original Article

September 30, 2022


Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord Injury
Hong Kyung Shin, Jin Hoon Park, Sung Woo Roh, Sang Ryong Jeon
Neurospine. 2022;19(3):748-756.

Objective: Acute spinal cord injury (SCI) can result in debilitating motor, sensory, and autonomic dysfunction. As a treatment option, therapeutic hypothermia has been researched to inadequate pharmaceutical treatment, except for...

Original Article

September 30, 2022


Transcription Profiling of a Revealed the Potential Molecular Mechanism of Governor Vessel Electroacupuncture for Spinal Cord Injury in Rats
Xingru Xiao, Qingwen Deng, Xiang Zeng, Bi-Qin Lai, Yuan-Huan Ma, Ge Li, Yuan-Shan Zeng, Ying Ding
Neurospine. 2022;19(3):757-769.

Objective: This study aimed to identify differentially expressed genes (DEGs) by transcriptome analysis to elucidate a potential mechanism by which governor vessel electroacupuncture (GV-EA) promotes neuronal survival, axonal regeneration, and...

Review Article

September 30, 2022


Minimally Invasive Posterior Facet Decortication and Fusion Using Navigated Robotic Guidance: Feasibility and Workflow Optimization
Christopher R. Good, Lindsay D. Orosz, Ronald A. Lehman, Jeffrey L. Gum, Douglas Fox, Isador H. Lieberman
Neurospine. 2022;19(3):773-779.

Minimally invasive spine surgery reduces tissue dissection and retraction, decreasing the morbidity associated with traditional open spine surgery by decreasing blood loss, blood transfusion, complications, and pain. One of the...

Review Article

September 30, 2022


Pathological Classification of the Intramedullary Spinal Cord Tumors According to 2021 World Health Organization Classification of Central Nervous System Tumors, a Single-Institute Experience
Sung-Hye Park, Jae Kyung Won, Chi Heon Kim, Ji Hoon Phi, Seung-Ki Kim, Seung Hong Choi, Chun Kee Chung
Neurospine. 2022;19(3):780-791.

According to the new 2021 World Health Organization (WHO) classification of tumors of the central nervous system (CNS) the classification of the primary intramedullary spinal cord tumors (IM-SCT) follows that...

Original Article

August 15, 2022


Learning Curve and Complications of Unilateral Biportal Endoscopy: Cumulative Sum and Risk-Adjusted Cumulative Sum Analysis
Jinchao Xu, Dong Wang, Jidan Liu, Chengyue Zhu, Jianhang Bao, Wenshuo Gao, Wei Zhang, Hao Pan
Neurospine. 2022;19(3):792-804.

Objective: The purpose of this study was to investigate the learning curve and complications of unilateral biportal endoscopy (UBE) in the treatment of lumbar disc herniation (LDH) and lumbar spinal...

Original Article

August 10, 2022


Successful Criteria for Indirect Decompression With Lateral Lumbar Interbody Fusion
Wicharn Yingsakmongkol, Khanathip Jitpakdee, Stephen Kerr, Worawat Limthongkul, Vit Kotheeranurak, Weerasak Singhatanadgige
Neurospine. 2022;19(3):805-815.

Objective: No consensus criteria have been established regarding ideal candidates for indirect decompression with lateral lumbar interbody fusion (LLIF), and contributing factors of indirect decompression failure were rarely reported. We...

Original Article

September 30, 2022


Phenotypes and Prognostic Factors of Syringomyelia in Single-Center Patients With Chiari I Malformation: Moniliform Type as a Special Configuration
Chunli Lu, Longbing Ma, Chenghua Yuan, Lei Cheng, Xinyu Wang, Wanru Duan, Kai Wang, Zan Chen, Hao Wu, Gao Zeng, et al.
Neurospine. 2022;19(3):816-827.

Objective: The specific association between morphometric characteristics of the syrinx and the prognosis of Chiari malformation type I (CM-I) with syringomyelia following surgical procedure seems to have not been fully...

Original Article

September 30, 2022


Biomechanical Effects of Proximal Polyetheretherketone Rod Extension on the Upper Instrumented and Adjacent Levels in a Human Long-Segment Construct: A Cadaveric Model
Bernardo de Andrada Pereira, Jennifer N. Lehrman, Anna G.U. Sawa, Piyanat Wangsawatwong, Jakub Godzik, David S. Xu, Jay D. Turner, Brian P. Kelly, Juan S. Uribe
Neurospine. 2022;19(3):828-837.

Objective: The high mechanical stress zone at the sudden transition from a rigid to flexible region is involved in proximal junctional kyphosis (PJK) physiopathology. We evaluated the biomechanical performance of...

Original Article

September 30, 2022


Safety and Efficacy of Recombinant Human Bone Morphogenetic Protein-2 in Multilevel Posterolateral Lumbar Fusion in a Prospective, Randomized, Controlled Trial
Ho Yong Choi, Seung-Jae Hyun, Chang Hyun Lee, Ji Hyun Youn, Mi Young Ryu, Ki-Jeong Kim
Neurospine. 2022;19(3):838-846.

Objective: This study is an investigator-initiated, prospective, randomized, controlled study to evaluate the efficacy and safety of the combined use of recombinant human BMP-2 (rhBMP-2) and a hydroxyapatite (HA) carrier...
Current Issue
Volume 19(3); Sep 2022

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Volume 19(3); September

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Korean Journal of Spine
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