Neurospine

Neurospine provides spine clinicians and researchers with peer-reviewed articles on basic and clinical investigation of spine and spinal cord to enhance patient management, education, clinical or experimental research, and professionalism.

The journal will consider submissions in areas on craniocervical to lumbosacral spine including the followings: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, rehabilitation of spine, spinal cord and peripheral nerve diseases.

Review Article

June 30, 2022

Curcumin as a Promising Neuroprotective Agent for the Treatment of Spinal Cord Injury: A Review of the Literature

Subum Lee, Dae-Chul Cho, Inbo Han, Kyoung-Tae Kim

Neurospine. 2022;19(2):249-261.

Curcumin is a polyphenolic chemical derived from the rhizomes of Curcuma longa. It has been used throughout the Indian subcontinent for medicinal purposes, religious events, and regional cuisine. It has...

Review Article

May 16, 2022

Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors

Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Junya Yamaguchi, Shoichi Haimoto, Fumiharu Ohka, Masakazu Takayasu, Ryuta Saito

Neurospine. 2022;19(2):262-271.

The study of genetic alterations and molecular biology in central nervous system (CNS) tumors has improved the accuracy of estimations of patient prognosis and tumor categorization. Therefore, the updated 2021...

Review Article

June 30, 2022

The Role of Alginate Hydrogels as a Potential Treatment Modality for Spinal Cord Injury: A Comprehensive Review of the Literature

Ryan Jarrah, Sally El Sammak, Chiduziem Onyedimma, Abdul Karim Ghaith, F.M. Moinuddin, Archis R. Bhandarkar, Ahad Siddiqui, Nicolas Madigan, Mohamad Bydon

Neurospine. 2022;19(2):272-280.

Objective: To comprehensively characterize the utilization of alginate hydrogels as an alternative treatment modality for spinal cord injury (SCI). Methods: An extensive review of the published literature on studies using alginate...

Review Article

June 30, 2022

Established and Emerging Therapies in Acute Spinal Cord Injury

Ron Gadot, David N. Smith, Marc Prablek, Joey K. Grochmal, Alfonso Fuentes, Alexander E. Ropper

Neurospine. 2022;19(2):283-296.

Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an annual incidence of 20–50 per million people. Following initial assessment with appropriate physical examination and...

Review Article

June 30, 2022

Genetic Odyssey to Ossification of the Posterior Longitudinal Ligament in the Cervical Spine: A Systematic Review

Young Il Won, Chang-Hyun Lee, Woon Tak Yuh, Shin Won Kwon, Chi Heon Kim, Chun Kee Chung

Neurospine. 2022;19(2):299-306.

Despite numerous studies, the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) is still unclear. Previous genetic studies proposed variations in genes related to bone and collagen as a...

Original Article

January 2, 2022

What Can Legacy Patient-Reported Outcome Measures Tell Us About Participation Bias in Patient-Reported Outcomes Measurement Information System Scores Among Lumbar Spine Patients?

Conor P. Lynch, Elliot D.K. Cha, Caroline N. Jadczak, Shruthi Mohan, Cara E. Geoghegan, Kern Singh

Neurospine. 2022;19(2):307-314.

Objective: Patient-Reported Outcomes Measurement Information System (PROMIS) is a validated tool for assessing patient-reported outcomes in spine surgery. However, PROMIS is vulnerable to nonresponse bias. The purpose of this study...

Original Article

January 2, 2022

Effects of Anterior Plating on Achieving Clinically Meaningful Improvement Following Single-Level Anterior Cervical Discectomy and Fusion

Conor P. Lynch, Elliot D.K. Cha, Madhav R. Patel, Caroline N. Jadczak, Shruthi Mohan, Cara E. Geoghegan, Kern Singh

Neurospine. 2022;19(2):315-322.

Objective: The clinical utility of anterior cervical plating for anterior cervical discectomy and fusion (ACDF) procedures remains controversial. This study aims to compare the impact of cervical plating on achievement...

Original Article

May 12, 2022

Analysis of the Incidence and Risk Factors of Postoperative Delirium in Patients With Degenerative Cervical Myelopathy

Namhoo Kim, Tae-Hwan Kim, Jae Keun Oh, Jeongsup Lim, Kang Uk Lee, Seok Woo Kim

Neurospine. 2022;19(2):323-333.

Objective: The purpose of this study is to analyze various risk factors that can cause postoperative delirium (POD) in degenerative cervical myelopathy (DCM) patients, which may affect normal recovery and...

Original Article

May 12, 2022

Cost-Utility Analysis Compared Between Radiotherapy Alone and Combined Surgery and Radiotherapy for Symptomatic Spinal Metastases in Thailand

Pasawat Taechalertpaisarn, Sirichai Wilartratsami, Pochamana Phisalprapa, Chayanis Kositamongkol, Achiraya Teyateeti, Panya Luksanapruksa

Neurospine. 2022;19(2):334-347.

Objective: To investigate the patient quality of life and cost-utility compared between radiotherapy alone and combined surgery and radiotherapy for spinal metastasis (SM) in Thailand. Methods: Patients with SM with an...

Original Article

May 12, 2022

Conversational Artificial Intelligence for Spinal Pain Questionnaire: Validation and User Satisfaction

Kyoung Hyup Nam, Da Young Kim, Dong Hwan Kim, Jung Hwan Lee, Jae Il Lee, Mi Jeong Kim, Joo Young Park, Jae Hyun Hwang, Sang Seok Yun, Byung Kwan Choi, et al.

Neurospine. 2022;19(2):348-356.

Objective: The purpose of our study is to develop a spoken dialogue system (SDS) for pain questionnaire in patients with spinal disease. We evaluate user satisfaction and validated the performance...

Original Article

May 17, 2022

Difference in the Cobb Angle Between Standing and Supine Position as a Prognostic Factor After Vertebral Augmentation in Osteoporotic Vertebral Compression Fractures

In-Suk Bae, Byung Gwan Moon, Hee In Kang, Jae Hoon Kim, Cheolsu Jwa, Deok Ryeong Kim

Neurospine. 2022;19(2):357-366.

Objective: We retrospectively analyzed patients with osteoporotic vertebral compression fracture (OVCF) undergoing vertebral augmentation to compare the Cobb angle changes in the supine and standing positions and the clinical outcomes. Methods:...

Original Article

May 12, 2022

Learning Curve of ROSA ONE Spine System for Transpedicular Screw Placement

Bing-Hung Hsu, Heng-Wei Liu, Kha-Liang Lee, Ming-Chin Lin, Gao Chen, Jang Yu, Chiao-Ling Chen, I-Chang Su, Chien-Min Lin

Neurospine. 2022;19(2):367-375.

Objective: The study investigated our institutional learning curve for the ROSA ONE spine system (ROSA) based on ROSA usage time. Methods: ROSA was designed to provide high accuracy for spinal pedicle...

Original Article

June 30, 2022

Radiation Dose Reduction and Surgical Efficiency Improvement in Endoscopic Transforaminal Lumbar Interbody Fusion Assisted by Intraoperative O-arm Navigation: A Retrospective Observational Study

Junfeng Gong, Xinle Huang, Liwen Luo, Huan Liu, Hao Wu, Ying Tan, Changqing Li, Yu Tang, Yue Zhou

Neurospine. 2022;19(2):376-384.

Objective: Endoscopic transforaminal lumbar interbody fusion (Endo-TLIF) has gained increasing popularity among spine surgeons. However, with the use of fluoroscopy, intraoperative radiation exposure remains a major concern. Here, we aim...

Original Article

May 13, 2022

Biomechanical Analysis of 3-Level Anterior Cervical Discectomy and Fusion Under Physiologic Loads Using a Finite Element Model

Lee A. Tan, Narayan Yoganandan, Hoon Choi, Yuvaraj Purushothaman, Davidson Jebaseelan, Aju Bosco

Neurospine. 2022;19(2):385-392.

Objective: Pseudarthrosis and adjacent segment degeneration (ASD) are 2 common complications after multilevel anterior cervical discectomy and fusion (ACDF). We aim to identify the potential biomechanical factors contributing to pseudarthrosis...

Original Article

May 13, 2022

Prevalence and Clinical Impact of Cervical Facet Joint Degeneration on Degenerative Cervical Myelopathy: A Novel Computed Tomography Classification Study

Ai Okamoto, Yasuhiro Takeshima, Shohei Yokoyama, Fumihiko Nishimura, Ichiro Nakagawa, Young-Soo Park, Hiroyuki Nakase

Neurospine. 2022;19(2):393-401.

Objective: To evaluate cervical facet joint degeneration using a newly developed classification, investigate its prevalence and relationship with cervical degenerative spondylolisthesis, and clarify its clinical significance in patients with degenerative...

Original Article

May 15, 2022

Analysis of Associating Radiologic Parameters With Clinical Outcomes After Posterior C1–2 Fusion

Jong-Hyeok Park, Jong Tae Kim, Il Sup Kim, Jae Taek Hong

Neurospine. 2022;19(2):402-411.

Objective: To evaluate which radiologic parameters affect clinical outcomes in patients underwent posterior C1–2 fusion for atlantoaxial dislocation. Methods: From January 2014 to December 2017, among 98 patients underwent C1–2 posterior...

Original Article

May 13, 2022

What Type of Incision for Anterior Cervical Spine Surgery Involving Long Segments Can Bring Better Cosmetic and Functional Outcomes?

Hyung Rae Lee, Dong-Ho Lee, Sang Yun Seok, Sehan Park, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee

Neurospine. 2022;19(2):412-421.

Objective: To determine whether double transverse incisions could provide superior cosmetic and functional outcomes, including rates of dysphagia and dysphonia, compared with longitudinal incisions in patients undergoing anterior cervical spine...

Original Article

May 15, 2022

Psychometric Properties of the Scoliosis Research Society Questionnaire (Version 22r) Domains Among Adults With Spinal Deformity: A Rasch Measurement Theory Analysis

Kati Kyrölä, Susanna Hiltunen, Mikko M. Uimonen, Jari Ylinen, Arja Häkkinen, Jussi P. Repo

Neurospine. 2022;19(2):422-433.

Objective: Adult spinal deformity (ASD) have lower health-related quality of life (HRQoL) compared to the general population. Applying Rasch measurement theory (RMT), this study tested the revised Scoliosis Research Society-22...

Original Article

May 15, 2022

Impact of Radiation Therapy on Outcomes After Spinal Instrumentation for Craniocervical Junction Malignancies

Matthew Muir, Laurence Rhines, Franco Demonte, Claudio Tatsui, Shaan M. Raza

Neurospine. 2022;19(2):434-440.

Objective: Spinal reconstruction after resection of invasive craniocervical junction malignancies is fraught with technical and management considerations as well as a paucity of data in the existing literature. In this...

Original Article

June 30, 2022

Current Trends in the Surgical Management of Intramedullary Tumors: A Multicenter Study of 1,033 Patients by the Neurospinal Society of Japan

Toshiki Endo, Tomoo Inoue, Masaki Mizuno, Ryu Kurokawa, Kiyoshi Ito, Shigeo Ueda, Toshihiro Takami, Kazutoshi Hida, Minoru Hoshimaru,

Neurospine. 2022;19(2):441-452.

Objective: We performed a retrospective observational study to demonstrate the surgical risks and long-term prognoses of intramedullary tumors in Japan using a multicenter registry authorized by the Neurospinal Society of...

Original Article

June 23, 2022

Impact of Surgical Timing on Neurological Outcomes for Spinal Arachnoid Cyst: A Single Institution Series

Grégoire P. Chatain, Keshari Shrestha, Michael W. Kortz, Stephanie Serva, Patrick Hosokawa, Ryan C. Ward, Akal Sethi, Michael Finn

Neurospine. 2022;19(2):453-462.

Objective: Spinal arachnoid cysts (SACs) are rare lesions that often present with back pain and myelopathy. There is a paucity of literature evaluating the impact of surgical timing on neurological...

Original Article

June 30, 2022

Odontoid Incidence: A Novel Cervical Parameter Influencing Cervical Alignment From Top to Bottom

Jae-Koo Lee, Seung-Jae Hyun, Ki-Jeong Kim

Neurospine. 2022;19(2):463-471.

Objective: By using angulation of the axis itself, this study aims to define and analyze odontoid incidence (OI) and odontoid tilt (OT) as novel cervical alignment parameters and investigate their...

Curcumin as a Promising Neuroprotective Agent for the Treatment of Spinal Cord Injury: A Review of the Literature Subum Lee, Dae-Chul Cho, Inbo Han, Kyoung-Tae Kim Neurospine. 2022;19(2):249-261. Review Article June 30, 2022 Cited By 6 Full text PubReader ePub PDF	Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Junya Yamaguchi, Shoichi Haimoto, Fumiharu Ohka, Masakazu Takayasu, Ryuta Saito Neurospine. 2022;19(2):262-271. Review Article May 16, 2022 Cited By 7 Full text PubReader ePub PDF
The Role of Alginate Hydrogels as a Potential Treatment Modality for Spinal Cord Injury: A Comprehensive Review of the Literature Ryan Jarrah, Sally El Sammak, Chiduziem Onyedimma, Abdul Karim Ghaith, F.M. Moinuddin, Archis R. Bhandarkar, Ahad Siddiqui, Nicolas Madigan, Mohamad Bydon Neurospine. 2022;19(2):272-280. Review Article June 30, 2022 Cited By 11 Full text PubReader ePub PDF	Commentary on “The Role of Alginate Hydrogels as a Potential Treatment Modality for Spinal Cord Injury: A Comprehensive Review of the Literature” Hemant Kumar Neurospine. 2022;19(2):281-282. Editorial June 30, 2022 Cited By 1 Full text PubReader ePub PDF
Established and Emerging Therapies in Acute Spinal Cord Injury Ron Gadot, David N. Smith, Marc Prablek, Joey K. Grochmal, Alfonso Fuentes, Alexander E. Ropper Neurospine. 2022;19(2):283-296. Review Article June 30, 2022 Cited By 8 Full text PubReader ePub PDF	Commentary on “Established and Emerging Therapies in Acute Spinal Cord Injury” Lingbo Kong Neurospine. 2022;19(2):297-298. Editorial June 30, 2022 Full text PubReader ePub PDF
Genetic Odyssey to Ossification of the Posterior Longitudinal Ligament in the Cervical Spine: A Systematic Review Young Il Won, Chang-Hyun Lee, Woon Tak Yuh, Shin Won Kwon, Chi Heon Kim, Chun Kee Chung Neurospine. 2022;19(2):299-306. Review Article June 30, 2022 Cited By 4 Full text PubReader ePub PDF	What Can Legacy Patient-Reported Outcome Measures Tell Us About Participation Bias in Patient-Reported Outcomes Measurement Information System Scores Among Lumbar Spine Patients? Conor P. Lynch, Elliot D.K. Cha, Caroline N. Jadczak, Shruthi Mohan, Cara E. Geoghegan, Kern Singh Neurospine. 2022;19(2):307-314. Original Article January 2, 2022 Cited By 3 Full text PubReader ePub PDF
Effects of Anterior Plating on Achieving Clinically Meaningful Improvement Following Single-Level Anterior Cervical Discectomy and Fusion Conor P. Lynch, Elliot D.K. Cha, Madhav R. Patel, Caroline N. Jadczak, Shruthi Mohan, Cara E. Geoghegan, Kern Singh Neurospine. 2022;19(2):315-322. Original Article January 2, 2022 Cited By 4 Full text PubReader ePub PDF	Analysis of the Incidence and Risk Factors of Postoperative Delirium in Patients With Degenerative Cervical Myelopathy Namhoo Kim, Tae-Hwan Kim, Jae Keun Oh, Jeongsup Lim, Kang Uk Lee, Seok Woo Kim Neurospine. 2022;19(2):323-333. Original Article May 12, 2022 Full text PubReader ePub PDF
Cost-Utility Analysis Compared Between Radiotherapy Alone and Combined Surgery and Radiotherapy for Symptomatic Spinal Metastases in Thailand Pasawat Taechalertpaisarn, Sirichai Wilartratsami, Pochamana Phisalprapa, Chayanis Kositamongkol, Achiraya Teyateeti, Panya Luksanapruksa Neurospine. 2022;19(2):334-347. Original Article May 12, 2022 Cited By 2 Full text PubReader ePub PDF	Conversational Artificial Intelligence for Spinal Pain Questionnaire: Validation and User Satisfaction Kyoung Hyup Nam, Da Young Kim, Dong Hwan Kim, Jung Hwan Lee, Jae Il Lee, Mi Jeong Kim, Joo Young Park, Jae Hyun Hwang, Sang Seok Yun, Byung Kwan Choi, et al. Neurospine. 2022;19(2):348-356. Original Article May 12, 2022 Cited By 3 Full text PubReader ePub PDF Supplementary Material
Difference in the Cobb Angle Between Standing and Supine Position as a Prognostic Factor After Vertebral Augmentation in Osteoporotic Vertebral Compression Fractures In-Suk Bae, Byung Gwan Moon, Hee In Kang, Jae Hoon Kim, Cheolsu Jwa, Deok Ryeong Kim Neurospine. 2022;19(2):357-366. Original Article May 17, 2022 Cited By 5 Full text PubReader ePub PDF	Learning Curve of ROSA ONE Spine System for Transpedicular Screw Placement Bing-Hung Hsu, Heng-Wei Liu, Kha-Liang Lee, Ming-Chin Lin, Gao Chen, Jang Yu, Chiao-Ling Chen, I-Chang Su, Chien-Min Lin Neurospine. 2022;19(2):367-375. Original Article May 12, 2022 Cited By 3 Full text PubReader ePub PDF
Radiation Dose Reduction and Surgical Efficiency Improvement in Endoscopic Transforaminal Lumbar Interbody Fusion Assisted by Intraoperative O-arm Navigation: A Retrospective Observational Study Junfeng Gong, Xinle Huang, Liwen Luo, Huan Liu, Hao Wu, Ying Tan, Changqing Li, Yu Tang, Yue Zhou Neurospine. 2022;19(2):376-384. Original Article June 30, 2022 Cited By 12 Full text PubReader ePub PDF	Biomechanical Analysis of 3-Level Anterior Cervical Discectomy and Fusion Under Physiologic Loads Using a Finite Element Model Lee A. Tan, Narayan Yoganandan, Hoon Choi, Yuvaraj Purushothaman, Davidson Jebaseelan, Aju Bosco Neurospine. 2022;19(2):385-392. Original Article May 13, 2022 Cited By 3 Full text PubReader ePub PDF
Prevalence and Clinical Impact of Cervical Facet Joint Degeneration on Degenerative Cervical Myelopathy: A Novel Computed Tomography Classification Study Ai Okamoto, Yasuhiro Takeshima, Shohei Yokoyama, Fumihiko Nishimura, Ichiro Nakagawa, Young-Soo Park, Hiroyuki Nakase Neurospine. 2022;19(2):393-401. Original Article May 13, 2022 Cited By 6 Full text PubReader ePub PDF	Analysis of Associating Radiologic Parameters With Clinical Outcomes After Posterior C1–2 Fusion Jong-Hyeok Park, Jong Tae Kim, Il Sup Kim, Jae Taek Hong Neurospine. 2022;19(2):402-411. Original Article May 15, 2022 Cited By 1 Full text PubReader ePub PDF
What Type of Incision for Anterior Cervical Spine Surgery Involving Long Segments Can Bring Better Cosmetic and Functional Outcomes? Hyung Rae Lee, Dong-Ho Lee, Sang Yun Seok, Sehan Park, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee Neurospine. 2022;19(2):412-421. Original Article May 13, 2022 Full text PubReader ePub PDF	Psychometric Properties of the Scoliosis Research Society Questionnaire (Version 22r) Domains Among Adults With Spinal Deformity: A Rasch Measurement Theory Analysis Kati Kyrölä, Susanna Hiltunen, Mikko M. Uimonen, Jari Ylinen, Arja Häkkinen, Jussi P. Repo Neurospine. 2022;19(2):422-433. Original Article May 15, 2022 Full text PubReader ePub PDF Supplementary Material
Impact of Radiation Therapy on Outcomes After Spinal Instrumentation for Craniocervical Junction Malignancies Matthew Muir, Laurence Rhines, Franco Demonte, Claudio Tatsui, Shaan M. Raza Neurospine. 2022;19(2):434-440. Original Article May 15, 2022 Full text PubReader ePub PDF	Current Trends in the Surgical Management of Intramedullary Tumors: A Multicenter Study of 1,033 Patients by the Neurospinal Society of Japan Toshiki Endo, Tomoo Inoue, Masaki Mizuno, Ryu Kurokawa, Kiyoshi Ito, Shigeo Ueda, Toshihiro Takami, Kazutoshi Hida, Minoru Hoshimaru, Neurospine. 2022;19(2):441-452. Original Article June 30, 2022 Cited By 17 Full text PubReader ePub PDF
Impact of Surgical Timing on Neurological Outcomes for Spinal Arachnoid Cyst: A Single Institution Series Grégoire P. Chatain, Keshari Shrestha, Michael W. Kortz, Stephanie Serva, Patrick Hosokawa, Ryan C. Ward, Akal Sethi, Michael Finn Neurospine. 2022;19(2):453-462. Original Article June 23, 2022 Cited By 2 Full text PubReader ePub PDF	Odontoid Incidence: A Novel Cervical Parameter Influencing Cervical Alignment From Top to Bottom Jae-Koo Lee, Seung-Jae Hyun, Ki-Jeong Kim Neurospine. 2022;19(2):463-471. Original Article June 30, 2022 Cited By 6 Full text PubReader ePub PDF
Original Surgical Treatment and Long-term Follow-up for Chronic Inflammatory Demyelinating Polyradiculoneuropathy Causing a Compressive Cervical Myelopathy: Review of the Literature Julien Rigal, Emanuele Quarto, Lisa Boue, Laurent Balabaud, Wendy Thompson, Thibault Cloché, Stephane Bourret, Jean Charles Le Huec Neurospine. 2022;19(2):472-477. Case Report May 17, 2022 Cited By 1 Full text PubReader ePub PDF