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Original Article

Postoperative Fever Evaluation Following Lumbar Fusion Procedures

Neurospine 2018;15(2):154-162.
Published online: June 19, 2018

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA

Corresponding Author Kern Singh https://orcid.org/0000-0002-6118-7273 Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. Harrison St, Suite #300, Chicago, IL 60612, USA Tel: +1-312-432-2373 Fax: +1-708-409-5179 E-mail: kern.singh@rushortho.com
• Received: February 17, 2018   • Revised: April 24, 2018   • Accepted: April 29, 2018

Copyright © 2018 by the Korean Spinal Neurosurgery Society

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Citations

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  • The Effect of the Severity of Preoperative Back Pain on Patient-Reported Outcomes, Recovery Ratios, and Patient Satisfaction Following Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF)
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Postoperative Fever Evaluation Following Lumbar Fusion Procedures
Image Image Image
Fig. 1. Number of fevers following lumbar fusion. Of those who developed fevers, 64 (61.0%) had only one documented fever, 15 (14.3%) had 2 documented fevers, and 26 (24.7%) had 3 or more documented fevers.
Fig. 2. Timing of postoperative fever. A 43.8% of first-documented fevers occurred during the first 24 hours following surgery, 53.3% during postoperative hours 24–48, and 2.9% following 48 hours. All patients diagnosed with a postoperative complication had their first documented fever during the first 48 postoperative hours. PNA, pneumonia; DVT, deep vein thrombosis; UTI, urinary tract infection. *Complication was diagnosed during the inpatient stay.
Fig. 3. Postoperative fever workups performed. At least one component of a fever workup was conducted in 47 of the 105 patients (44.8%) who had a fever. Urinalysis (UA) was performed in 43 patients (41.0%), urine culture (UCx) in 33 patients (31.4%), chest x-ray (CXR) in 25 patients (23.8%), blood cultures (BCx) in 8 patients (7.6%), duplex ultrasound in 2 patients (1.9%), CT chest in 2 patients (1.9%), and sputum culture (SCx) in 1 patient (1.0%).
Postoperative Fever Evaluation Following Lumbar Fusion Procedures
Characteristic Value
Age (yr) 52.1 ± 13.0
Sex
 Female 361 (41.59)
 Male 507 (58.41)
Obesity
 Nonobese (< 30 kg/m2) 457 (52.65)
 Obese (≥ 30 kg/m2) 411 (47.35)
Smoking status
 Nonsmoker 573 (77.22)
 Smoker 169 (22.78)
Ageless comorbidity burden (CCI) 1.26 ± 1.38
Diabetes mellitus
 Not diabetic 784 (90.32)
 Diabetic 84 (9.68)
Procedure type
 Primary 656 (83.25)
 Revision 132 (16.75)
Operative approach
 Anterior/lateral 191 (22.06)
 Posterior 675 (77.94)
Number of levels
 1 Level 760 (88.27)
 2 Level 91 (10.57)
 3 Level 10 (1.16)
Operative time (min) 142.66 ± 71.13
Estimated blood loss (mL) 77.29 ± 98.35
Length of stay (hr) 60.92 ± 39.63
POD 0 narcotic (OME) 88.53 ± 69.83
Variable No. (%) RR 95% CI p-value
Overall 98/861 (11.38)
Age (yr) 0.953
 18–59 69/604 (11.42) Reference -
 ≥ 60 29/228 (12.72) 0.99 0.66–0.49
Sex 0.039*
 Female 31/357 (8.68) Reference -
 Male 67/504 (13.29) 1.53 1.02–2.29
Obesity 0.215
 Nonobese (< 30 kg/m2) 46/455 (10.11) Reference -
 Obese (≥ 30 kg/m2) 52/406 (12.81) 1.27 0.87–1.84
Current smoker 0.112
 No 70/571 (12.26) Reference -
 Yes 13/168 (7.74) 0.63 0.36–1.11
Ageless CCI 0.827
 <2 70/623 (11.24) Reference -
 ≥2 28/238 (11.76) 1.05 0.69–1.58
Diabetes mellitus 0.092
 Not diabetic 84/778 (10.8) Reference -
 Diabetic 14/83 (16.87) 1.56 0.93–2.62
Procedure type 0.031*
 Primary 67/656 (10.21) Reference
 Revision 22/132 (16.67) 1.63 1.05–2.54
Operative approach 0.547
 Anterior/lateral 24/190 (12.63) Reference -
 Posterior 74/669 (11.06) 0.88 0.57–1.35
Number of operative levels 0.224
 Single level 82/753 (10.89) Reference -
 Multilevel 16/108 (14.81) 1.36 0.83–2.24
Operative duration (min) 0.006*
 < 150 57/604 (9.44) Reference -
 ≥ 150 41/257 (15.95) 1.69 1.16–2.46
Estimated blood loss (mL) 0.652
 < 100 80/688 (11.63) Reference -
 ≥ 100 18/173 (10.4) 0.89 0.55–1.45
Narcotics usage (OME) 0.066
 < 85 48/497 (9.66) Reference -
 ≥ 85 49/357 (13.73) 1.42 0.98–2.07
Variable RR 95% CI p-value
Narcotics usage* (OME) 0.027
 < 85 OME Reference -
 ≥ 85 OME 1.56 1.05–2.32
Operative duration (min) 0.009
 < 150 Reference -
 ≥ 150 1.70 1.14–2.54
Patient information Timeline of events Summary of hospital course
Patient A Inpatient POD 2 – Underwent second surgery for persistent dural bleb repair.
 29 Female  POD 0 – Fever 1 (38.9°C), 11 hr
 PNA during stay  POD 4 – Fever 2 (39.2°C), 95 hr POD 5 – Developed sore throat, shortness of breath, cough. CXR confirmed PNA. Given antibiotics for PNA and empirically for meningitis due to history of CSF leakage.
 Discharge POD 9  POD 4 – WBC max (17.7)
 LOS 219 hr  POD 5 – Fever 6 (40.0°C), 106 hr POD 7 – Continued to have fevers from POD 4 until POD 7.
  Revision MIS TLIF for pseudomeningocele, pseudarthrosis, 1 level  POD 5 – UA/UCx – Normal
 POD 6 – CXR – PNA*
 POD 6 – Duplex – Normal
Patient B Inpatient POD 2 – Foley catheter removed
 75 Female  POD 1 – Fever 1 (38.8°C), 24 hr POD 3 – No reported symptoms but due to fever acquired UA and UCx which was positive for bacteria and leukesterase. Started on antibiotics.
 UTI during stay  POD 3 – Fever 2 (38.8°C), 79 hr
 Discharge POD 4  POD 3 – UA/UCx – UTI* No WBC elevation during stay
 LOS 97 hr  POD 3 – CXR – Atelectasis
 PLF, 1 level  POD 3 – BCX – Normal
Patient C Inpatient POD 1 – Had urinary urgency and frequency, no burning or itching.
 73 Female  POD 1 – Fever 1 (39.1°C), 34 hr
 UTI during stay  POD 1 – Fever 2 (38.7°C), 35 hr POD 3 – Symptoms resolved without treatment but UA demon- strated blood, WBC, and leukesterase. Started on antibiotics.
 Discharge POD 3  POD 1&2 – UA/UCx – Normal
 LOS 78 hr  POD 2 – WBC max (12.0)
 PLF, 1 level  POD 3 – UA – UTI*
Patient D Inpatient POD 0 – Tachycardia overnight
 29 Male  POD 1 – Fever 1 (38.6°C), 39 hr POD 1 – Continued tachycardia. Complained of sore throat. Oxygen saturation percent dropped to high 80s overnight
 PNA during stay  POD 1 – UA/UCx – Normal
 Discharge POD 5  POD 1 – CXR, CT – Atelectasis POD 2 – Second CT demonstrated bibasilar opacities, treated for PNA. Did not complain of chest pain or shortness of breath.
 LOS 120 hr  POD 1 – WBC max (13.1), CRP (63.2)
 MIS TLIF, 1 level  POD 2 – BCX – Normal
 POD 2 – CT – PNA*
Patient E Inpatient POD 1 – Had urinary retention and received straight catheteriza- tion. Fevers resolved after POD 1.
 53 Male  POD 0 – Fever 1 (38.9°C), 13 hr
 DVT after discharge  POD 1 – Fever 3 (39.2°C), 18 hr POD 4 – Discharged. No DVT symptoms during stay.
 Discharge POD 4  POD 1 – WBC max (18.3) POD 18 – Developed pain and swelling in calf. Outside ER diag- nosed DVT with Duplex ultrasound. Started on anticoagulation.
 LOS 103 hr Outpatient
 MIS TLIF, 1 level  POD 18 – Duplex – DVT*
Patient F Inpatient POD 1 – Had urinary retention, frequency. Received straight catheterization.
 72 Female  POD 1 – Fever 1 (38.9°C), 16 hr
 DVT, UTI after discharge  POD 2 – WBC max (15.0) POD 6 –Transfer to rehabilitation facility for further physical therapy, pain management.
 Discharge POD 6  POD 4 – UA/UCx – Normal POD 7 – Continued urinary frequency. UA demonstrated bacte- ria, leukesterase. Started on antibiotics.
 LOS 142 hr Rehabilitation facility
 PLF, 1 level  POD 7 – UA/UCx – UTI* POD 19 – Developed leg edema without tenderness. Duplex ultrasound demonstrated right calf DVT.
 POD 19 – Duplex – DVT*
Outpatient POD 34 – Presented to ER with leg pain, swelling. Duplex ultra- sound demonstrated left calf DVT. Started on anticoagulation.
 POD 34 – Duplex – DVT*
Patient G Inpatient POD 2 – Developed abdominal distention and urinary retention.
 63 Male  POD 1 – Fever 1 (38.6°C), 35 hr POD 24 – Called office reporting urinary symptoms. Went to outside ER and diagnosed UTI based on UA.
 UTI after discharge  POD 2 – UA/UCx – Normal
 Discharge POD 3 Outpatient No WBC elevation during stay
 LOS 79 hr  POD 24 – UA/UCx – UTI*
 ALIF, 1 level
Table 1. Patient characteristics (n=868)

Values are presented as mean±standard deviation or number (%).

CCI, Charlson Comorbidity Index; POD, postoperative day; OME, oral morphine equivalent.

Table 2. Risk factors for postoperative fever

No. (%), number with fever/total in group (rate of fever).

RR, relative risk; CI, confidence interval; CCI, Charlson Comorbidity Index; OME, oral morphine equivalent; POD, postoperative day.

p<0.05, statistically significance.

p-value determined using Poisson regression with robust error variance.

Average OME consumed on POD 0.

Table 3. Independent risk factors for postoperative fever

RR, relative risk; CI, confidence interval; OME, oral morphine equivalent; POD, postoperative day.

Average OME consumed on POD 0.

p-value calculated using stepwise Poisson regression with robust error variance controlling for age, gender, obesity, smoking status, comorbidity burden, diabetes mellitus, operative approach, procedure type, number of levels fused, operative time, estimated blood loss, average narcotic use on postoperative day 0.

Table 4. Summary of patients who had positive diagnoses

POD, postoperative day; LOS, length of stay; POD, postoperative day; MIS TLIF, minimally invasive transforaminal lumbar interbody fusion; PLF, posterior lumbar fusion; ALIF, anterior lumbar interbody fusion; UA, urinalysis; UCx, urine culture; CXR, chest x-ray; CT, computed tomography; BCX, blood culture; PNA, pneumonia; UTI, urinary tract infection; DVT, deep vein thrombosis; ER, emergency room; CSF, cerebrospinal fluid; WBC, white blood count (K/μL); CRP, C-reactive protein (mg/L).

Signifies final diagnosis.

Indicates peak fever.