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New Issue Alert: Neurospine, Volume 23(2); April 2026
NameNeurospineDate2026-07-31
e-mailsupport@e-neurospine.orgHit5046
Neurospine - Table of Contents
Volume 23(2); April 2026 http://e-neurospine.org

Neurospine 2026 April Issue eTOC

Inbo Han
(Korea)
Editor-in-Chief

In this editorial, we highlight the most noteworthy articles featured in the April 2026 issue of Neurospine.

Michal Ziga
(Switzerland)

Article 1: "Physical Performance Continues to Improve After Surgery for Sciatica, Exceeding Recovery Periods of Physical Capacity and Patient-Reported Outcomes: Multicenter Prospective Observational Study"

This prospective observational study compared daily step counts measured by smart phones with conventional clinical measurement tools to evaluate the recovery trajectory of patients who underwent lumbar spine surgery for sciatica. An analysis of data over 6 months postoperatively revealed significant differences in long-term recovery tracking. While conventional objective performance measures, such as the 6-minute walk test, and patient-reported outcomes showed an initial pattern of improvement before reaching a plateau after 6 weeks, smartphone-derived activity data showed a continuous and linear increase in physical activity. These results clearly demonstrate the “ceiling effects” inherent in conventional clinical assessments. This study suggests that incorporating continuous monitoring of real world activity may reflect sustained functional recovery and long-term surgical success more sensitively and accurately

Shibao Lu
(China)

Article 2: "Frailty-Muscle Phenotypes Predict Outcomes After Lumbar Fusion in Adults Aged ≥75 Years: A Retrospective Cohort Study"

This integrative study identifies pre- and postoperative risk phenotypes in adults aged 75 years or older undergoing lumbar fusion by combining clinical frailty assessments with posterior paravertebral muscle degeneration measured by MRI. The researchers retrospectively analyzed 248 patients and classified them into 4 clinico-radiological phenotypes. The results are remarkable. Patients exhibiting clinical frailty, severe muscle degeneration, or both had a significantly higher incidence of complications during hospitalization, up to 57.1%, and a significantly increased risk of prolonged hospital stays compared with patients who were neither frail nor had severe muscle degeneration. Additionally, the effect of postoperative pain improvement was significantly reduced in the frail subgroup. Ultimately, this study demonstrates that integrating routine MRI muscle analysis with frailty screening is a highly effective tool for predicting surgical outcomes in older adults

John H. Chi
(USA)

Article 3: "A Comprehensive Review of Spinal Arthroplasty"

In this comprehensive review article, the authors explore the development of spinal arthroplasty over over the past 30 years and present a comprehensive review of the field. While spinal fusion remains the standard stabilization technique, its nonphysiological nature often restricts mobility and exacerbates adjacent segment disease. To address these limitations, motion-preserving implants aim to restore normal spinal biomechanics. This extensive review evaluates the history, clinical outcomes, and biomechanical principles of cervical and lumbar disc replacements and lumbar arthroplasty. Although currently applied only to specific degenerative diseases, the authors emphasize that the scope of its application will expand through continuous innovation. This insightful paper envisions a future in which spinal surgery moves in a fundamentally reconstructive and motion-preserving direction.

Masatoshi Teraguchi
(Japan)

Article 4: "Functional Resilience in Chronic Low Back Pain: Dissociating Magnetic Resonance Imaging Abnormalities From Real-World Disability in the Wakayama Spine Study"

This radiological study provides important insights into the “functional resilience” of patients with chronic low back pain. By analyzing 347 participants in the Wakayama Spine Study, the researchers explored why many people maintain normal daily life despite chronic symptoms and structural changes visible on imaging. Surprisingly, 63% of symptomatic participants were found to maintain functional capacity. The results show that male sex and the absence of obesity are independent predictors of preserved functional capacity. Importantly, common magnetic resonance imaging (MRI) abnormalities, such as disc degeneration, do not reliably predict functional disability. In essence, this study highlights that function-centered measures may be more informative than structural imaging features in distinguishing actual functional status, challenging the conventional approach of relying on radiological findings in clinical evaluation.

Vivek Sanker
(USA)

Article 5: "From Pixels to Precision: Generative Artificial Intelligence as a Paradigm Shift in Spine Imaging—Technical Foundations, Clinical Applications, and the Path to Safe Clinical Deployment"

This study provides a comprehensive descriptive overview of generative artificial intelligence (GenAI) as an innovative paradigm shift in the field of spinal imaging. Addressing the limitations of existing AI, the authors explore how GenAI, including GANs (generative adversarial networks) and diffusion models, can synthesize high-quality images to reduce MRI scan times by approximately 40% and enable radiation-free synthetic computed tomography for surgical planning. However, this review candidly points out significant barriers hindering clinical implementation, such as algorithmic bias, anatomical hallucinations, and performance degradation in real-world cohorts. To overcome these challenges, the authors propose a strategic roadmap emphasizing multi-institutional datasets, federated learning, and outcome-linked clinical validation. Ultimately, this paper provides a balanced and forward-looking framework for safely integrating advanced GenAI technologies into complex diagnostic and surgical workflows.

Inbo Han, MD, PhD
Editor-in-Chief

Wen-Cheng Huang, MD, PhD
Deputy Editor

Masahito Hara, MD, PhD
Deputy Editor

Jin Sung Kim, MD, PhD
Deputy Editor


Volume 23(2); Apr 2026

 

- Current Issue: http://e-neurospine.org/current/
- Aims and Scope: http://e-neurospine.org/about/
- Instructions for Authors: http://e-neurospine.org/authors/authors.php
- Editorial Board: http://e-neurospine.org/about/editorial.php

The articles are now available at http://e-neurospine.org

Table of Contents
Editorial
From the Editor-in-Chief: Featured Articles in the April 2026 Issue
Inbo Han
DOI: http://doi.org/10.14245/ns.26520494.0247
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Editor’s Pick (p. 229-315)
Degenerative
Original Article
Physical Performance Continues to Improve After Surgery for Sciatica, Exceeding Recovery Periods of Physical Capacity and Patient-Reported Outcomes: Multicenter Prospective Observational Study
Michal Ziga, Linda Bättig ... Ondra Petr
DOI: http://doi.org/10.14245/ns.2551798.899
Commentary
Real-World Effectiveness Versus Efficacy in a Study Environment: How Smartphones Help Capture Meaningful Patient Recovery Trajectories – A Commentary on “Physical Performance Continues to Improve After Surgery for Sciatica, Exceeding Recovery Periods of Physical Capacity and Patient-Reported Outcomes: Multicenter Prospective Observational Study”
Victor E. Staartjes
DOI: http://doi.org/10.14245/ns.26520534.0267
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Original Article
Frailty-Muscle Phenotypes Predict Outcomes After Lumbar Fusion in Adults Aged ≥75 Years: A Retrospective Cohort Study
Ma Chao Guo, Xiangyu Li ... Shibao Lu
DOI: http://doi.org/10.14245/ns.2551838.919
Commentary
A Commentary on “Frailty-Muscle Phenotypes Predict Outcomes After Lumbar Fusion in Adults Aged ≥75 Years: A Retrospective Cohort Study”
Julie L. Chan, Daniel J. Hoh
DOI: http://doi.org/10.14245/ns.26520620.0310
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Review Article
A Comprehensive Review of Spinal Arthroplasty
David D Liu, Evan Dennis ... John H. Chi
DOI: http://doi.org/10.14245/ns.2551696.848
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Commentary
A Commentary on “A Comprehensive Review of Spinal Arthroplasty”
Sonja Häckel, Fabienne Pohle
DOI: http://doi.org/10.14245/ns.26520618.0309
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Special Issue: BioSpine
Epidemiology
Original Article
Functional Resilience in Chronic Low Back Pain: Dissociating Magnetic Resonance Imaging Abnormalities From Real-World Disability in the Wakayama Spine Study
Masatoshi Teraguchi, Marinko Rade ... Hiroshi Yamada
DOI: http://doi.org/10.14245/ns.26520312.0156
Commentary
A Commentary on “Functional Resilience in Chronic Low Back Pain: Dissociating Magnetic Resonance Imaging Abnormalities From Real-World Disability in the Wakayama Spine Study”
Shigeo Ueda
DOI: http://doi.org/10.14245/ns.26520512.0256
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Artificial Intelligence
Review Article
From Pixels to Precision: Generative Artificial Intelligence as a Paradigm Shift in Spine Imaging—Technical Foundations, Clinical Applications, and the Path to Safe Clinical Deployment
Daniyal Ashraf, Vivek Sanker ... Atman Desai
DOI: http://doi.org/10.14245/ns.2551862.931
Commentary
A Commentary on “From Pixels to Precision: Generative Artificial Intelligence as a Paradigm Shift in Spine Imaging—Technical Foundations, Clinical Applications, and the Path to Safe Clinical Deployment”
Fabrizio Russo, Luca Ambrosio ... Vincenzo Denaro
DOI: http://doi.org/10.14245/ns.26520650.0325
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Special Issues: BioSpine (p. 316-364)
Review Article
Adapt, Mitigate, and Target: The Role of Oxidative Stress in Intervertebral Disc Homeostasis and Disc Degeneration
Shota Tamagawa, Jordy Schol ... Daisuke Sakai
DOI: http://doi.org/10.14245/ns.26420332.0166
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Original Articles
Comparative Accuracy Assessment of Thoraco-Lumbo-Sacral Orthosis Fabrication: Conventional Contact Casting Versus Noncontact 3-Dimensional Digital Scanning
Naotoshi Kumagai, Takashi Yurube ... Kenichiro Kakutani
DOI: http://doi.org/10.14245/ns.2551610.805
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Agonist-Induced Activation of Transient Receptor Potential Vanilloid 4 Promotes Autophagy and Extracellular Matrix Synthesis in the Rat Intervertebral Disc
Kohei Kuroshima, Yoshiki Takeoka ... Kenichiro Kakutani
DOI: http://doi.org/10.14245/ns.2551582.791
Regular Submissions (p. 365-512)
Pain
Review Article
Contemporary Management of Coccydynia
Victor E. Staartjes, Daniel De Wilde ... Gunnar Nilsson
DOI: http://doi.org/10.14245/ns.2551726.863
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Artificial Intelligence
Original Articles
Automated Measurement of Occipito-Axial Angle on Cervical Radiographs Using a Deep Learning Object Detection Model: A Proof-of-Concept Study
Shun Yamamoto, Yutaro Fuse ... Ryuta Saito
DOI: http://doi.org/10.14245/ns.2551878.939
Deep Learning-Assisted Lumbar Degeneration Evaluation Using Plain Radiographs: Development and Validation of a Novel Dual-Mechanism Architecture
Ziqian Ma, Aobo Wang ... Lei Zang
DOI: http://doi.org/10.14245/ns.2551672.836
Cervical Spine
Original Articles
Occipital Bone Erosion Following C1–2 Posterior Fixation: A Comparative Per-Screw Analysis of Tan versus Harms-Goel Techniques
Shigeo Ueda, Nobuaki Naito ... Minoru Hoshimaru
DOI: http://doi.org/10.14245/ns.2551796.898
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Reducibility-Based Posterior Reduction and Fusion Strategies for Atlantoaxial Dislocation: A Clinical and Radiological Study
Guipeng Zhao, Haotian Long ... Jinping Liu
DOI: http://doi.org/10.14245/ns.2551762.881
Deformity
Original Articles
Sagittal Imbalance Deterioration After S2-Alar-Iliac Fixation in Adult Spinal Deformity: What Role Does Dynamic Hip Joint Coverage Play?
Dongyue Li, Jie Li ... Zhen Liu
DOI: http://doi.org/10.14245/ns.2551804.902
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The Prioritized Correction at Osteotomy Site: A Novel Technique for Preventing Sagittal Translation During 3-Column Osteotomies in Adult Spinal Deformity Surgery
Chen Ling, Jie Li ... Zhen Liu
DOI: http://doi.org/10.14245/ns.2551794.897
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Degenerative
Original Articles
Real-Time Location System Assessment of Early Postoperative Recovery After Lumbar Decompression According to Surgical Approach
Sub-Ri Park, Jaenam Lee ... Byung Ho Lee
DOI: http://doi.org/10.14245/ns.26520018.0009
Data-Driven Clustering for Risk Stratification of Unfavorable Outcomes After Lumbar Fusion Surgery: A Development Study
Peng Cui, Hu Tao ... Shibao Lu
DOI: http://doi.org/10.14245/ns.2551770.885
Infection
Original Article
Diagnostic Value of Metagenomic Next-Generation Sequencing for Suspected Native Spinal Brucella Infection: A Multicenter Study
Zhaohui Li, Qiang Zhang ... Ting Wang
DOI: http://doi.org/10.14245/ns.2551698.849
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Letter to the Editor
Letters to the Editor
Enhancing Predictive Accuracy in Finite Element Analysis of Cement Augmentation: Methodological Considerations – A Commentary on “Biomechanical Impact of Cement Augmentation on Pedicle Screw Fixation and Adjacent Segment Disease in Multilevel Lumbar Fusion: A Finite Element Analysis”
Fan Mo, Shaoqi He
DOI: http://doi.org/10.14245/ns.2551682.841
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Reply Letter: A Commentary on “Biomechanical Impact of Cement Augmentation on Pedicle Screw Fixation and Adjacent Segment Disease in Multilevel Lumbar Fusion: A Finite Element Analysis”
Hyung-Youl Park
DOI: http://doi.org/10.14245/ns.2551864.932
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A Commentary on “Disuse Bone Loss in Fusion Constructs After Multilevel Lumbar Fusion: A Computed Tomography Hounsfield Unit Analysis”
Jiajun Deng, Hongsheng Lin
DOI: http://doi.org/10.14245/ns.26520424.0212
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Reply Letter: A Commentary on “Disuse Bone Loss in Fusion Constructs After Multilevel Lumbar Fusion: A Computed Tomography Hounsfield Unit Analysis”
Hyun-Jun Jang, Dongkyu Kim ... Dong-Kyu Chin
DOI: http://doi.org/10.14245/ns.26520308.0154
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A Commentary on “Romosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone: A Rabbit Model Study”
Bin Liu, Hongsheng Lin
DOI: http://doi.org/10.14245/ns.26520116.0058
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Early Implant Fixation as a Clinically Important Endpoint – A Commentary on “Romosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone: A Rabbit Model Study”
Ji-Won Kwon, Byung Ho Lee
DOI: http://doi.org/10.14245/ns.26520182.0091
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Editorial Office
Department of Neurosurgery, CHA Bundang Medical Center,
CHA University School of Medicine,
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