Special Issue Editors

Prof. Dr. Gianluca Vadalà Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128, Rome, Italy Interests: Lumbar disc herniation, biomarkers, anulus fibrosus repair, microdiscectomy, spinal endoscopy.

Special Issue Information

Dear Colleagues,

We are pleased to propose a special issue in NeuroSpine dedicated to “Evolving Paradigms in Lumbar Disc Herniation: From Prediction to Precision Surgery.”

Currently, lumbar disc herniation (LDH) is diagnosed and treated based on the integration of patient history, physical examination, and radiological evidence from MRI. However, due to its diverse clinical presentations, there is still no consensus on the optimal treatment strategy, often leading to variable and suboptimal outcomes.

Recent research has identified several novel factors, including psychosocial and genetic influences, biomarkers, and the microbiome, which play a crucial role in LDH-related clinical outcomes. Moreover, emerging surgical techniques are revolutionizing the standards of surgical treatment, including strategies to prevent recurrence.

This issue will highlight the latest advancements and future directions in the diagnosis and management of LDH, with a particular focus on predicting disc reabsorption, identifying novel biomarkers, and integrating artificial intelligence for surgical decision-making.

Leading experts will discuss the efficacy of various surgical techniques, including discectomy versus sequestrectomy and annulus fibrosus repair, in reducing recurrence rates. Additionally, the evolving roles of endoscopic approaches, including unilateral biportal endoscopy (UBE), will be explored.

This special issue stems from the efforts of the AOSpine Knowledge Forum Degenerative initiative, aimed at driving innovation in the field of lumbar disc herniation management.

By gathering cutting-edge research and expert perspectives, this special issue aims to advance knowledge on optimizing patient outcomes through personalized surgical approaches and innovative technologies.

This Special Issue will be published in Neurospine (ISSN 2586-6591, https://www.e-neurospine.org/), and we are currently inviting submissions of original research articles and authoritative review papers for peer review and potential publication.

We look forward to your valuable contributions.

Prof. Dr. Gianluca Vadalà, Italy
Dr. Zorica Busar, USA
Prof. Dr Hans Jorg Meisel, Germany
Dr. Tim Yoon, USA
Dr. Stipe Ćorluka, Croatia
Dr. Sybille Grad, Switzerland
Dr. In Ho Han, Korea

Manuscript Submission Information

Manuscripts should be submitted online at www.e-neurospine.org by registering and logging in to the website. Once you are registered, you can access the submission form directly here. Manuscripts can be submitted until the deadline , and all submissions that pass the initial pre-check will proceed to peer review. Accepted papers will be published in the journal and featured on the Special Issue webpage.

We welcome submissions of research articles, review articles, and commentary. For planned contributions, authors may send a proposed title and a short abstract (approximately 100 words) to the Editorial Office for preliminary consideration and announcement on the website.
Please note the following guidelines:

• • Submitted manuscripts should not have been published previously or be under consideration for publication elsewhere (except in conference proceedings).
• • All manuscripts will undergo a rigorous single-blind peer-review process.
• • Detailed submission guidelines, including formatting requirements and other essential information, can be found on the Instructions for Authors page.

Neurospine is an international, peer-reviewed, open-access quarterly journal. Before submitting your manuscript, please ensure it is well-formatted and written in proficient English.

Keywords

• • Lumbar disc herniation
• • Anulus fibrosus repair
• • Biomarkers
• • Advanced MRI
• • Artificial intelligence
• • Microdiscectomy
• • Endoscopy

Gianluca Vadalà (Campus Bio-Medico University of Rome, Italy)	Zorica Buser (NYU Grossman School of Medicine, USA)

Hans Jorg Meisel (Halle/Saale, Germany)	Tim Yoon (Emory University, USA)

Stipe Ćorluka (University Hospital Centre Sestre Milosrdnice, Croatia)	Sybille Grad (AO Research Institute Davos, Switzerland)	In Ho Han (Pusan National University, Korea)